Therapeutic botulinum type a toxin: Factors affecting potency

Toxicon

Volumn 34, Issue 9, 1996, Pages 975-985

  McLellan, Kay ^a   Gaines Das, Rose E ^a   Ekong, Theresa A N ^a   Sesardic, Dorothea ^a  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A;

ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG FORMULATION; DRUG STABILITY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030245670     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/0041-0101(96)00070-0     Document Type: Article

References (27)

1. Anderson, T. J., Rivest, J., Stell, R., Steiger, M. J., Cohen, H., Thompson, P. D. and Marsden, C. D. (1992) Botulinum toxin treatment of spasmodic torticollis. J. R. Soc. Med. 85, 524-529.
2. Borodic, G., Johnson, E., Goodnough, M. and Schantz, E. (1996) Botulinum toxin therapy, immunologic resistance, and problems with available materials. Neurology 46, 25-29.
3. Brin, M. F. (1991) Interventional neurology: treatment of neurological conditions with local injection of botulinum toxin. Arch. Neurobiol. 54, 7-23.
4. Brin, M. F. and Blitzer, A. (1993) Botulinum toxin: dangerous terminology errors (Letter). J. R. Soc. Med. 86, 493-494.
5. Corran, P. H. and Sesardic, D. (1994) Meeting Report. International Workshop on Bacterial Toxins in Medical Use. Biologicals 22, 83-84.
6. Ekong, T. A. N., McLellan, K. and Sesardic, D. (1995) Immunological detection of Clostridium botulinum toxin type A in therapeutic preparations. J. immun. Meth. 180, 181-191.
7. Finney, D. J. (1971) Probit Analysis, 3rd Edn. Cambridge: Cambridge University Press.
8. Gartlan, M. G. and Hoffman, H. T. (1993) Crystalline preparation of botulinum toxin type A (Botox): degradation in potency with storage. Otolaryngal. Head Neck Surg. 108, 135-140.
9. Hallett, M. (1995) Clinical mode of action: critical review of potential mechanisms. Mov. Disord. 10, 363.
10. Hallett, M., Glocker, F. X. and Deuschl, G. (1994) Mechanism of action of botulinum toxin (Letter). Ann. Neurol. 36, 449-450.
11. Hambleton, P. (1992) Clostriadium hotulinum toxins: a general review of involvement in disease, structure, mode of action and preparation for clinical use. J. Neurol. 239, 16-20.
12. Hambleton, P. and Pickett, A. M. (1994) Potency equivalence of botulinum toxin preparations (Letter). J. R. Soc. Med. 87, 719.
13. Jankovic, J. and Brin, M. F. (1991) Therapeutic uses of botulinum toxin. New Engl. J. Med. 324, 1186-1194.
14. Jankovic, J. and Schwartz, K. S. (1993) Longitudinal experience with botulinum toxin injections for the treatment of blepharospasm and cervical dystonia. Neurology 43, 834-836.
15. Jankovic, J. and Schwartz, K. S. (1995) Response and immunoresistancc to botulinum toxin injections. Neurology 45, 1743-1746.
16. Kirkwood, T. B. L. (1979) Geometric means and measures of dispersion (Letter). Biometrics 35, 908.
17. Lamanna, C., Spero, L. and Schantz, E. J. (1970) Dependence of time to death on molecular size of botulinum toxin. Infect. Immun. 1, 423-424.
18. Montecucco, C. and Schiavo, G. (1994) MicroReview: mechanisms of action of tetanus and botulinum neurotoxins. Molec. Microbiol. 13, 1-8.
19. Pearce, L. B., Borodic, G. F., First, E. R. and MacCallum, R. D. (1994) Measurement of botulinum toxin activity: evaluation of the lethality assay. Toxic. appl. Pharmac. 128, 69-77.
20. Pearce, L. B., Borodic, G. F., Johnson, E. A., First, E. R. and MacCallum, R. (1995a) The median paralysis unit: a more pharmacologically relevant unit of biological activity for botulinum toxin. Toxicon 33, 217-227.
21. Pearce, L. B., First, E. R. and Borodic, G. E. (1995b) Botulinum toxin: death versus localized denervation (Letter). J. R. Soc. Med. 88, 239-240.
22. Schantz, E. J. and Johnson, E. A. (1992) Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol. Rev. 56, 80-99.
23. Schantz, E. J. and Kautter, D. A. (1978) Microbiological methods: standardized assay for clostridium botulinum toxins. J. Ass. analyt. Chem. 61, 96-99.
24. Scott, A. B. (1981) Botulinum toxin injection of eye muscles to correct strabismus. Trans. Am. ophtalmol. Soc. 79, 734-770.
25. Sesardic, D., Games Das, R. E. and Corbel, M. J. (1994) Botulinum toxin (Letter). J. R. Soc. Med. 87, 307.
26. Sesardic, D., McLellan, K., Ekong, T. A. N. and Gaines Das, R. (1996) Refinement and validation of an alternative bioassay for potency testing of therapeutic botulinum type A toxin. Pharmac. Toxic. 78, 283-288.
27. Shaari, C. M. and Sanders, I. (1993) Quantifying how location and dose of botulinum toxin injections affect muscle paralysis. Muscle Nerre 16, 964-969.