Thy/liv-SCID-hu mice implanted with human intestine: An in vivo model for investigation of mucosal transmission of HIV

AIDS Research and Human Retroviruses

Volumn 13, Issue 17, 1997, Pages 1453-1460

  Gibbons, Chris ^a   Kollmann, Tobias R ^a   Pettoello Mantovani, Massimo ^a   Kim, Ana ^a   Goldstein, Harris ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS TRANSMISSION;

EID: 0030776925     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1997.13.1453     Document Type: Article

References (28)

1. Friedland GH and Klein RS: Transmission of the human immunodeficiency virus. N Engl J Med 1987;317:1125-1135.
2. Francis DP and Chin J: The prevention of acquired immunodeficiency syndrome in the United States. JAMA 1987;257: 1357-1366.
3. Levy JA: Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 1993;57:183-289.
4. Berkelman RL, Heyward WL, Stehr-Green JK, and Curran JW: Epidemiology of human immunodeficiency virus infection and acquired immunodeficiency syndrome. Am J Med 1989;86:761-770.
5. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, and McCune JM: Infection of the SCID-hu mouse by HIV-1. Science 1988;242:1684-1686.
6. McCune JM, Peault B, Streeter PR, and Rabin L: Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse. Immunol Rev 1991;124:45-62.
7. Kollmann TR, Pettoello-Mantovani M, Zhuang X, Kim A, Hachamovitch M, Smarnworawong P, Rubinstein A, and Goldstein H: Disseminated HIV-1 infection in SCID-hu mice after peripheral inoculation with HIV-1. J Exp Med 1994;179:513-522.
8. Kollmann TR, Kim A, Pettoello-Mantovani M, Hachamovitch M, Rubinstein A, Goldstein MM, and Goldstein H: Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 1995;154:907-921.
9. Kollmann TR, Pettoello-Mantovani M, Katopodis N, Rubinstein A, Kim A, Hachamovitch M, and Goldstein H: Demonstration of in vivo inhibition of HIV infection by treatment of SCID-hu mice with IL-10. Proc Natl Acad Sci USA 1996;93:3126-3131.
10. Winter HS, Hendren RB, Fox CH, Russell GJ, Perez-Atayde A, Bhan AK, and Folkman J: Human intestine matures as nude mouse xenograft. Gastroenterology 1991;100:89-98.
11. Goldstein H, Pettoello-Mantovani M, Kollman TR, Calvelli TA, and Rubinstein A: Inhibition of HIV-1 infection by alkylureas. AIDS 1991;5:1447-1452.
12. Dimitrov DH, Melnick JL, and Holinger FB: Microculture assay for isolation of human immunodeficiency virus type 1 and for titration of infected peripheral blood cells. J Clin Microbiol 1990;28:734-737.
13. Ho DD, Moudgil T, and Alum M: Quantitation of human immunodeficiency virus type I in the blood of infected persons. N Engl J Med 1989;321:1621-1625.
14. Schnittman S, Greenhouse JJ, Lane HC Pierce PF, and Fauci AS: Frequent detection of HIV-1 specific mRNAs in infected individuals suggests ongoing active viral replication in all stages of disease. AIDS Res Hum Retroviruses 1991;7:361-366.
15. Kollman TR, Zhuang X, Rubinstein A, and Goldstein H: Design of PCR primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA. AIDS 1992;6:547-552.
16. Krone WJA, Sninsky JJ, and Goudsmit H: Detection and characterization of HIV-1 by PCR. J AIDS 1990;3:517-524.
17. Fox CH and Cottler-Fox M: In situ hybridization for detection of HIV RNA. In: Current Protocols in Immunology (Coligan JE, Kruisback AM, Margulies DH, Shevach EM, and Strober W, Eds.). John Wiley & Sons, New York, 1993, pp. 12.8.1-12.8.21.
18. Kollmann TR, Goldstein MM, and Goldstein H: The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-Beige-Nude-xid mice is associated with the reconstitution of the murine immune system. J Exp Med 1993;177:821-834.
19. Bosma MJ and Carrol AM: The SCID mouse mutant: Definition, characterization, and potential uses. Annu Rev Immunol 1991;9:323.
20. Goldstein H, Pettoello-Mantovani M, Katopodis N, Kim A, Yurasov S, and Kollmann TR: SCID-hu mice: A model for studying disseminated HIV infection. Semin Immunol 1996;8:223-231.
21. Winter HS, Fox CH, Hendren RB, Isselbacher KJ, Folkman J, and Letvin NL: Use of an animal model for the study of the role of human immunodeficiency virus 1 in the human intestine. Gastroenterology 1992;102:834-839.
22. Castro BA, Cheng-Mayer C, Evans LA, and Levy JA: HIV heterogeneity and viral pathogenesis. AIDS 1988;2:517-528.
23. Gendelman HE, Orenstein JM, Baca LM, Weiser B, Burger H, Kalter DC, and Meltzer MS: The macrophage in the persistence and pathogenesis of HIV infection. AIDS 1989;3:475-495.
24. Frankel SS, Wenig BM, Burke AP, Mannan P, Thompson LD, Abbondanzo SL, Nelson AM, Pope M, and Steinman RM: Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 1996;272:115-117.
25. Fleming SC, Kapembwa MS, MacDonald TT, and Griffin GE: Direct in vitro infection of human intestine with HIV-1. AIDS 1992;6:1099-1104.
26. Schuitemaker H, et al.: Monocytotropic HIV-1 variants detected in all stages of HIV infection predominantly lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J Virol 1991;66:1354-1360.
27. D'Souza P and Harden VA: Chemokines and HIV-1 second receptors. Nature Med 1997;2:1293-1300.
28. Schuitemaker H, et al.: Biological phenotype of HIV-1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell tropic virus populations. J Virol 1992;66:1354-1360.