Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells

Cytogenetics and Cell Genetics

Volumn 75, Issue 4, 1996, Pages 216-221

  Shao, C ^a   Gupta, P K ^a   Sun, Y ^a   Sahota, A ^a   Tischfield, J A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; CELL CLONE; CHROMOSOME 16; CHROMOSOME PAINTING; CONTROLLED STUDY; COSMID; DIPLOIDY; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; KARYOTYPING; PRIORITY JOURNAL; TETRAPLOIDY;

ADENINE PHOSPHORIBOSYLTRANSFERASE; ALLELES; ANEUPLOIDY; CELL LINE; CELL SIZE; CHROMOSOMES, HUMAN, PAIR 16; CLONE CELLS; COSMIDS; DIPLOIDY; EVOLUTION, MOLECULAR; GENE DELETION; HETEROZYGOTE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROSATELLITE REPEATS; MODELS, GENETIC; POLYPLOIDY; RECOMBINATION, GENETIC;

EID: 0030484939     PISSN: 03010171     EISSN: 1424859X     Source Type: Journal    
DOI: 10.1159/000134486     Document Type: Article

References (17)

1. Burholt DR, Shackney SE, Ketterer DM, Pollice AA, Smith CA, Brown A, Giles HR, Schepart BS: Ka-ryotypic evolution of a human undifferentiated large cell carcinoma of the lung in tissue culture. Cancer Res 49:3355-3361 (1989).
2. Caron H, van Sluis P, van Roy N, de Kraker J, Spele-man F, Voute PA, Wcsterveld A, Slater R, Versteeg R: Recurrent 1; 17 translocations in human neuroblastoma reveal nonhomologous mitotic recom-biantion during the S/G: phase as a novel mechanism for loss of heterozygosity. Am J hum Genet 55:341-347 (1994).
3. Cavenec WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallic BL. Murphee AL, Strong LC, White RL: Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779-784 (1983).
4. Devilec P, Comelisse CJ: Somatic genetic changes in human breast cancer. Biochim biophys Acta 1198:113-130 (1994).
5. Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh F-M, Lubenskv I, Duan DR, Florence C, Pozzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaacs WB, Lerman MI, Zbar B, Line-han WM: Mutation of the VHL tumour suppressor gene in renal carcinoma. Nature Genet 7:85-90 (1994).
6. Hansen MF, Koufos A, Gallic BL, Phillips RA, Fodstad O, Brogger A, Gcdde-Dahl T, Cavenee WK: Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc natl Acad Sci, USA 82:6216-6220 (1985).
7. Marshall CJ: Tumor suppressor genes. Cell 64:313-326 (1991).
8. Neuhausen SL, Marshal CJ: Loss of heterozygosity in familial tumors from three BRCAI -linked kindreds. Cancer Res 54:6069-6072 (1994).
9. Nowell PC: The clonal evolution of tumor cell population. Science 194:23-28 (1976).
10. Scrable HJ, Sapienza C, Cavenee WK: Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression. Adv Cancer Res 54:25-62 (1990).
11. Shachney SE, Smith CA, Miller BW, Burholt DR, Mur-tha K, Giles HR, Ketterer DM, Pollice AA: Model for the genetic evolution of human solid tumors. Cancer Res 49:3344-3354 (1989).
12. Shapiro JR, Shapiro WR: The subpopulations and isolated cell types of freshly resected high grade human gliomas: their influence on the tumor's evolution in vivo and behavior and therapy in vitro. Cancer Metastasis Rev 4:107-124 (1985).
13. Stambrook PJ, Dush MK, Trill JJ, Tischfield JA: Cloning ofa functional human adenine phosphoribosyl-(ransferase(APRT)gene: identification ofa restriction fragment length polymorphism and preliminary analysis of DNAs from APRT-deficient families and cell mutants. Somat Cell molec Genet 10:359-367 (1984).
14. Vogelsteir B, Kinzler KW: The multistep nature of cancer. Trends Genet 9:138-141 (1993).
15. Wijkstrom H, Granberg-Ohman I, Tribukait B: Chromosomal and DNA patterns in transitional cell bladder carcinoma: a comparative cytogenetic and flow-cytofiuorometric DNA study. Cancer 53:1718-1723 (1984).
16. Zhu X, Dunn JM, Goddard AD, Squire JA, Becker A, Phillips RA, Gallie BL: Mechanisms of loss of hete-rozvgosity in retinoblastoma. Cvtogencl Cell Genet 59:243-253 (1992).
17. Zhu Y, Stambrook PJ, Tischfield JA: Loss of heterozygosity: the most frequent cause of recessive phenotype expression at the heterozygous human adenine phosphoribosyltransfcrase locus. Molec Carcinogenesis 8:138-144 (1993).