Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle

Journal of Virology

Volumn 71, Issue 10, 1997, Pages 7312-7317

  Enssle, Jörg ^a   Fischer, Nicole ^a   Moebes, Astrid ^a   Mauer, Bettina ^a   Smola, Ute ^a,b   Rethwilm, Axel ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; PROTEIN PRECURSOR; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; HAMSTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPUMA VIRUS; VIRION; VIRUS INFECTIVITY; VIRUS REPLICATION;

EID: 0030775620     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.10.7312-7317.1997     Document Type: Article

References (38)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. John Wiley, New York, N.Y.
2. Baunach, G., B. Maurer, H. Hahn, M. Kranz, and A. Rethwilm. 1993. Functional analysis of human foamy virus accessory reading frames. J. Virol. 67:5411-5418.
3. Bieniasz, P. D., R. A. Weiss, and M. O. McClure. 1995. Cell cycle dependence of foamy retrovirus infection. J. Virol. 69:7295-7299.
4. Bodem, J., M. Löchelt, I. Winkler, R. P. Flower, H. Delius, and R. M. Flügel. 1996. Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses. J. Virol. 70:9024-9027.
5. Boyle, W. J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201:110-149.
6. Campbell, M., C. Eng, and P. A. Luciw. 1996. The simian foamy virus type 1 transcriptional transactivator (Tas) binds and activates an enhancer element in the gag gene. J. Virol. 70:6847-6855.
7. Duclos, B., S. Marcandier, and A. J. Cozzone. 1991. Chemical properties and separation of phosphoamino acids by thin-layer chromatography and/or electrophoresis. Methods Enzymol. 201:10-21.
8. Enssle, J., I. Jordan, B. Mauer, and A. Rethwilm. 1996. Foamy virus reverse transcriptase is expressed independently from the gag protein. Proc. Natl. Acad. Sci. USA 93:4137-4141.
9. Fischer, N., and A. Rethwilm. Unpublished observation.
10. Freed, E. O., G. Englund, F. Maldarelli, and M. A. Martin, 1997. Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection. Cell 88:171-173.
11. Gallay, P., S. Swingler, C. Aiken, and D. Trono. 1995. HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell 80:379-388.
12. Giron, M.-L., S. Colas, J. Wybier, F. Rozain, and R. Emanoil-Ravier. 1997. Expression and maturation of human foamy virus Gag precursor polypeptides. J. Virol. 71:1635-1639.
13. Goepfert, P. A., G. Wang, and M. J. Mulligan. 1995. Identification of an ER retrieval signal in a retroviral glycoprotein. Cell 82:543-544.
14. Goepfert, P. A., K. L. Shaw, G. D. Ritter, Jr., and M. J. Mulligan. 1996. A sorting motif localizes the foamy virus glycoprotein to the endoplasmic reticulum. J. Virol. 71:778-784.
15. Göttlinger, H. G., T. Dorfman, J. G. Sodroski, and W. A. Haseltine. 1991. Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release. Proc. Natl. Acad. Sci. USA 88:3195-3199.
16. Graham, F., and A. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
17. Hahn, H., G. Baunach, S. Bräutigam, A. Mergia, D. Neumann-Haefelin, M. D. Daniel, M. O. McClure, and A. Rethwilm. 1994. Reactivity of primate sera to foamy virus gag and bet proteins. J. Gen. Virol. 75:2635-2644.
18. Higuchi, R. 1990. Recombinant PCR, p. 177-183. In M. A. Innis, D. H. Gelfand, and T. J. White (ed.), PCR protocols, a guide to methods and applications. Academic Press, San Diego, Calif.
19. Jordan, I., J. Enssle, E. Güttler, B. Mauer, and A. Rethwilm. 1996. Expression of human foamy virus reverse transcriptase involves a spliced pol mRNA. Virology 224:314-319.
20. gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles. J. Virol. 69:2759-2764.
21. Konvalinka, J., M. Löchelt, H. Zentgraf, R. M. Flügel, and H.-G. Kräusslich. 1995. Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein. J. Virol. 69:7264-7268.
22. Löchelt, M., and R. M. Flügel. 1996. The human foamy virus pol gene is expressed as a pro-Pol polyprotein and not as a Gag-Pol fusion protein. J. Virol. 70:1033-1040.
23. Merkulov, G. V., K. M. Swiderek, C. B. Brachmann, and J. D. Boeke. 1996. A critical cleavage site near the C terminus of the yeast retrotransposon Ty 1 Gag protein. J. Virol. 70:5548-5556.
24. Moebes, A., J. Enssle, P. D. Bieniasz, M. Heinkelein, D. Lindemann, M. Bock, M. O. McClure, and A. Rethwilm. 1997. Human foamy virus reverse transcription that occurs late in the viral replication cycle. J. Virol. 71:7305-7311.
25. Morozov, V. A., T. D. Copeland, K. Nagashima, M. A. Gonda, and S. Oroszlan. 1997. Protein composition and morphology of human foamy virus intracellular cores and extracellular particles. Virology 228:307-317.
26. Netzer, K.-O., A. Rethwilm, B. Maurer, and V. ter Meulen. 1990. Identification of the major immunogenic structural proteins of human foamy virus. J. Gen. Virol. 71:1237-1241.
27. Netzer, K.-O., A. Schliephake, B. Maurer, R. Watanabe, A. Aguzzi, and A. Rethwilm. 1993. Identification of pol-related gene products of human foamy virus. Virology 192:336-338.
28. Parent, L. J., R. P. Bennett, R. C. Craven, T. D. Nelle, N. K. Krishna, J. B. Bowzard, C. B. Wilson, B. A. Puffer, R. C. Montelaro, and J. W. Wills. 1995. Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins. J. Virol. 69:5455-5460.
29. ELI. Virology 185:661-672.
30. Rethwilm, A. 1996. Unexpected replication pathways of foamy viruses. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 13(Suppl. 1):S248-S253.
31. Russel, D. W., and A. D. Miller. 1996. Foamy virus vectors. J. Virol. 70:217-222.
32. Saïb, A., F. Puvion-Dutilleul, M. Smid, J. Périès, and H. de Thé. 1997. Nuclear targeting of incoming human foamy virus Gag proteins involves a centriolar step. J. Virol. 71:1155-1161.
33. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
34. Schliephake, A. W., and A. Rethwilm. 1994. Nuclear localization of foamy virus Gag precursor protein. J. Virol. 68:4946-4954.
35. Schmidt, M., and A. Rethwilm. 1995. Replicating foamy virus-based vectors directing high level expression of foreign genes. Virology 210:167-178.
36. Weiss, R. A. 1996. Foamy viruses bubble on. Nature 380:201.
37. Yu, S. F., D. N. Baldwin, S. R. Gwynn, S. Yendapalli, and M. L. Linial. 1996. Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses. Science 271:1579-1582.
38. Yu, S. F., K. Edelmann, R. K. Strong, A. Moebes, A. Rethwilm, and M. L. Linial. 1996. The carboxyl terminus of the human foamy virus Gag protein contains separable nucleic acid binding and nuclear transport domains. J. Virol. 70:8255-8262.