The carboxyl terminus of the human foamy virus Gag protein contains separable nucleic acid binding and nuclear transport domains

Journal of Virology

Volumn 70, Issue 12, 1996, Pages 8255-8262

  Yu, Shuyuarn F ^a   Edelmann, Kurt ^b   Strong, Roland K ^a   Moebes, Astrid ^c   Rethwilm, Axel ^c   Linial, Maxine L ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; GAG PROTEIN; NUCLEIC ACID;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA BINDING; HEPATITIS B VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RETROVIRUS; RNA BINDING; SEQUENCE ANALYSIS; VIRUS INFECTION; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

EID: 0029864543     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.12.8255-8262.1996     Document Type: Article

References (44)

1. Achong, B. G., W. A. Mansell, M. A. Epstein, and P. Clifford. 1971. An unusual virus in cultures from a human nasopharyngeal carcinoma. J. Natl. Cancer Inst. 46:299-307.
2. Bieniasz, P. D., A. Rethwilm, R. Pitman, M. D. Daniel, I. Chrystie, and M. O. McClure. 1995. A comparative study of higher primate foamy viruses, including a new virus from a gorilla. Virology 207:217-228.
3. Burd, C. G., and G. Dreyfuss. 1994. Conserved structures and diversity of functions of RNA-binding proteins. Science 265:615-621.
4. Craven, R. C., A. E. Leure-duPree, R. A. Weldon, Jr., and J. W. Wills. 1995. Genetic analysis of the major homology region of the Rous sarcoma virus Gag protein. J. Virol. 60:4213-4227.
5. Dannull, J., A. Surovoy, G. Jung, and K. Moelling. 1994. Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues. EMBO J. 13:1525-1533.
6. Davis, N. L., and R. R. Rueckert. 1972. Properties of a ribonucleoprotein particle isolated from nonidet P-40-treated Rous sarcoma virus. J. Virol. 10:10111-1020.
7. de Rocquigny, H., C. Gabus, A. Vincent, M. C. Fournie-Zaluski, B. Roques, and J. L. Darlix. 1992. Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers. Proc. Natl. Acad. Sci. USA 89:6472-6476.
8. Facke, M., A. Janetzo, R. L. Shoeman, and H.-G. Krausslich. 1993. A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic rcticulum. J. Virol. 67:4972-4980.
9. Field, J., J. I. Nikawa, D, Broek, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
10. Fleming, W. A., and J. K. Clarke. 1970. Fluorescence assay of foamy virus. J. Gen. Virol. 6:277-284.
11. Flugel, R. M. 1992. Spumaviruses: a group of complex retroviruses. J. Acquired Immune Defic. Syndr. 4:739-759.
12. Flugel. R. M., A. Rethwilm, B. Maurer, and G. Darai. 1987. Nucleotide sequence analysis of the env gene and its flanking regions of the human spumaretrovirus reveals two novel genes. EMBO J. 6:2077-2084.
13. Gelfand, C. A., Q. Wang, S. Randall, and J. E. Jentoft. 1993. Interactions of avian mycloblastosis virus nucleocapsid protein with nucleic acids. J. Biol. Chem. 268:18450-18456.
14. Gorelick, R. J., S. M. Nigida, Jr., J. W. Bess, Jr., L. O. Arthur, L. E. Henderson, and A. Rein. 1990. Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol. 64:3207-3211.
15. Hatton, T., S. Zhou, and D. N. Standring. 1992. RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in virus replication. J. Virol. 66:5232-5241.
16. Housset, V., H. de Rocquigny, B. P. Roques, and J. L. Darlix. 1993. Basic amino acids flanking the zinc finger of Motoney murine leukemia virus nucleocapsid protein NCp10 are critical for virus infectivity. J. Virol. 67: 2537-2545.
17. Katz, R. A., and J. E. Jentoft. 1989. What is the role of the Cys-His motif in retroviral nucleocapsid (NC) proteins? Bioessays 11:176-181.
18. Khan, R., and D. P. Giedroc. 1992. Recombinant human immunodeficiency virus type I nucleocapsid (NCp7) protein unwinds tRNA. J. Biol. Chem. 267:6689-6695.
19. Konvalinka, J., M. Lochelt, H. Zentgraf, R. M. Flugel, and H.-G. Krausslich. 1995. Active spumavirus proteinase is essential for virus infectivity but not for formation of the Pol polyprotein. J. Virol. 69:7264-7268.
20. Linial, M. L., and A. D. Miller. 1990. Retroviral RNA packaging: sequence requirements and implications. Curr. Top. Microbiol. Immunol. 157:125-152.
21. Lochelt, M., R. M. Flugel, and M. Aboud. 1994. The human foamy virus internal promoter directs the expression of the functional bell transactivator and Bet protein early after infection. J. Virol. 68:638-645.
22. Lochelt, M., W. Muranyi, and R. M. Flugel. 1993. Human foamy virus genome possesses an internal, bel-1 dependent and functional promoter. Proc. Natl. Acad. Sci. USA 90:7317-7321.
23. Lochelt, M., H. Zenlgraf, and R. M. Flugel. 1991. Construction of an infectious DNA clone of the full-length human spumaretrovirus genome and mutagenesis of the bei 1 gene. Virology 184:43-54.
24. Mammano, F., A. Ohagen, S. Hoglund, and H. G. Gottlinger. 1994. Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis. J. Virol. 68:4927-4936.
25. Meric, C., and S. P. Goff. 1989. Characterization of Moloney murine leukemia virus mutants with single-amino-acid substitutions in the Cys-His box of the nucleocapsid protein. J. Virol. 63:1558-1568.
26. Nassal, M. 1992. The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis hut not for virus assembly. J. Virol. 66:4107-4116.
27. Nassal, M., and H. Schaller. 1993. Hepatitis B virus replication. Trends. Microbiol. 1:221-228.
28. Neumann-Haefelin, D., U. Fleps, R. Renne, and M. Schweizer. 1993. Foamy viruses. Intervirology 35:196-207.
29. Oertle, S., and P. F. Spahr. 1990. Role of the Gag polyprotein precursor in packaging and maturation of Rous sarcoma virus genomic RNA. J. Virol. 64:5757-5763.
30. Pepinsky, R. B., and V. M. Vogt. 1984. Fine-structure analyses of lipid-protein and protein-protein interactions of Gag protein p19 of the avian sarcoma and leukemia viruses by cyanogen bromide mapping. J. Virol. 52: 145-153.
31. Rethwilm, A. 1995. Regulation of foamy virus gene expression. Curr. Top. Microbiol. Immunol. 193:1-24.
32. Rethwilm, A., O. Erlwein, G. Baunach, B. Maurer, and V. ter Meulen. 1991. The transcriptional transactivator of human foamy virus maps to the bel 1 genomic region. Proc. Natl. Acad. Sci. USA 88:941-945.
33. Schliephake, A. W., and A. Rethwilm. 1994. Nuclear localization of foamy virus Gag precursor protein. J. Virol. 68:4946-4954.
34. Smith, B. J., and J. M. Bailey. 1979. The binding of an avian myeloblastosis virus basic 12,000 dalton protein to nucleic acids. Nucleic Acids Res. 7:2055-2072.
35. Srinivaskumar, N., M-L. Hammarskjold, and D. Rekosh. 1995. Characterization of deletion mutants in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation. J. Virol. 69:6106-6114.
36. gug) of avian sarcoma and leukemia viruses. J. Virol. 64:847-855.
37. Surovoy, A., J. Dannull, K. Moelling, and G. Jung. 1993. Conformational and nucleic acid binding studies on the synthetic nucleocapsid protein of HIV-1. J. Mol. Biol. 229:94-104.
38. Swack, N. S., and G. D. Hsiung. 1975. Pathogenesis of simian foamy virus infection in natural and experimental hosts. Infect. Immun. 12:470-474.
39. Tsuchihashi, Z., and P. O. Brown. 1994. DNA strand exchange and selective DNA annealing promoted by the human immunodeficiency virus type 1 nucleocapsid protein. J. Virol. 68:5863-5870.
40. Weldon, R. A., Jr., and J. W. Wills. 1993. Characterization of a small (25-kilodalton) derivative of the Rous sarcoma virus Gag protein competent for particle release. J. Virol. 67:5550-5561.
41. Wills, J. W., and R. C. Craven. 1991. Form, function, and use of retroviral Gag proteins. AIDS 5:639-654.
42. Yu, S. F., D. N. Baldwin, S. R. Gwynn, S. Yendapalli, and M. L. Linial. 1996. Human foamy virus replication - a pathway distinct from that of retroviruses and hepadnaviruses. Science 271:1579-1582.
43. Yu, S. F., and M. L. Linial. 1993. Analysis of the role of the bel and bet open reading frames of human foamy virus by using a new quantitative assay. J. Virol. 67:6618-6624.
44. Yu, X., X. Yuan, Z. Matsuda, T.-H. Lee, and M. Essex. 1992. The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions. J. Virol. 66:4966-4971.