Cobalamin analogues modulate the growth of leukemia cells in vitro

Cancer Research

Volumn 57, Issue 18, 1997, Pages 4015-4022

  McLean, Gary R ^a   Pathare, Pradip M ^b   Wilbur, D Scott ^b   Morgan, A Charles ^c   Woodhouse, Clive S ^c   Schrader, John W ^a   Ziltener, Hermann J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Receptagen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALAMIN DERIVATIVE; CYANOCOBALAMIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; GROWTH INHIBITION; LEUKEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL DIVISION; GROWTH INHIBITORS; HUMANS; LEUKEMIA, EXPERIMENTAL; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCOBALAMINS; TUMOR CELLS, CULTURED; VITAMIN B 12;

EID: 0030774314     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Beck, W. S. Metabolic features of cobalamin deficiency in man. In: B. M. Babior (ed.), Cobalamin Biochemistry and Pathophysiology, pp. 403-450. New York: John Wiley & Sons, Inc., 1975.
2. Seetharam, B., and Alpers, D. H. Cellular uptake of cobalamin. Nutr. Rev., 43: 97-110, 1985.
3. Hall, C. A. Transcobalamins I and II as natural transport proteins of vitamin B12. J. Clin. Invest., 65: 1125-1131, 1975.
4. DiGirolamo, P. M., and Huennekens, F. M. Transport of vitamin B12 into mouse leukemia cells. Arch. Biochem. Biophys., 168: 386-391, 1975.
5. Jones, S. J., Yu, Y. L., Rudge, P., Kriss, A., Gilois, C., Hirani, N., Nijhawan, R., Norman, P., and Will, R. Central and peripheral SEP defects in neurologically symptomatic and asymptomatic subjects with low vitamin B12 levels. J. Neurol. Sci., 82: 55-62, 1987.
6. Stabler, S. P., Allen, R. H., Savage, D. G., and Lindenbaum, J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood, 76: 871-881, 1990.
7. Hakami, N., Neiman, P. E., Canellos, G. P., and Lazerson, J. Neonatal megaloblastic anemia due to inherited transcobalamin II deficiency in two siblings. N. Engl. J. Med., 285: 1163-1171, 1971.
8. Qureshi, A. A., Rosenblatt, D. S., and Cooper, B. A. Inherited disorders of cobalamin metabolism. Crit. Rev. Oncol. Hematol. 17: 133-151, 1994.
9. Kondo, H., Kolhouse, J. F., and Allen, R. H. Presence of cobalamin analogues in animal tissues. Proc. Natl. Acad. Sci. USA, 77: 817-821, 1980.
10. Stabler, S. P., Brass, E. P., Marcell, P. D., and Allen, R. H. Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats. J. Clin. Invest., 87: 1422-1430, 1991.
11. Kondo, H., Binder, M. J., Kolhouse, J. F., Smythe, W. R., Podell, E. R., and Allen, R. H. Presence and formation of cobalamin analogues in multivitamin-mineral pills. J. Clin. Invest., 70: 889-898, 1982.
12. Kolhouse, J. F., Stabler, S. P., and Allen, R. H. Identification and perturbation of mutant human fibroblasts based on measurements of methylmalonic acid and total homocysteine in the culture media. Arch. Biochem. Biophys., 303: 355-360, 1993.
13. Matthews, J. H. Cyanocobalamin [c-lactam] inhibits vitamin B12 and causes cytotoxicity in HL60 cells: methionine protects cells completely. Blood, 89: 4600-4607, 1997.
14. Fujii, K., Nagasaki, T., and Heunnekens, F. M. Vitamin B12-dependent replication of L1210 mouse leukemia cells. J. Biol. Chem., 256: 10329-10334, 1981.
15. Kondo, H., Iseki, T., Goto, S., Ohio, M., and Okuda, K. Effects of cobalamin, cobalamin analogues and cobalamin binding proteins on P388D mouse leukemic cells in culture. Int. J. Hematol., 56: 167-177, 1992.
16. McLean, G. R., Quadros, E. V., Rothenberg, S. P., Morgan, A. C., Schrader, J. W., and Ziltener, H. J. Antibodies to transcobalamin II block in vitro proliferation of leukemic cells. Blood, 89: 235-242, 1997.
17. Quadros, E. V., Sai, P., and Rothenberg, S. P. Functional human transcobalamin II isoproteins are secreted by insect cells using the baculovirus expression system Blood, 81: 1239-1245, 1993.
18. Jacob, E., and Herbert, V. Measurement of unsaturated "granulocyte-related" (TcI and TCIII) and "liver-related" (TCII) B12 binders by instant batch separation using a microfine precipitate of silica (QUSO 932). J. Lab. Clin. Med., 86: 505-512, 1975.
19. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65: 55-64, 1983.
20. Hansen, M. B., Nielsen, S. E., and Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods, 119: 203-210, 1989.
21. Pathare, P. M., Wilbur, D. S., Heusser, S., Quadros, E. V., McLoughlin, P., and Morgan, A. C. Synthesis of cobalamin-biotin conjugates that vary in the position of cobalamin coupling. Evaluation of cobalamin derivative binding to transcobalamin II Bioconjugate Chem., 7: 217-232, 1996.
22. Wilbur, D. S., Hamlin, D. K., Pathare, P. M., Heusser, S., Vesella, R. L., Buhler, K. R., Stray, J. E., Daniel, J., Quadros, E. V., McLoughlin, P., and Morgan, A. C. Synthesis and nca-radioiodination of arystannyl-cobalamin conjugates. Evaluation of aryliodo-cobalamin conjugate binding to transcobalamin II and biodistribution in mice. Bioconjugate Chem., 7: 461-474, 1996.
23. Pathare, P. M., Wilbur, D. S., Hamlin, D. K., Heusser, S., Quadros, E. V., McLoughlin, P., and Morgan, A. C. Synthesis of cobalamin dimers using isophthalate cross-linking of corrin ring carboxylates and evaluation of their binding to transcobalamin II. Bioconjugate Chem., 8: 161-172, 1997.
24. Kolhouse, J. F., Utley, C., Stabler, S. P., and Allen, R. H. Mechanism of conversion of human apo-to holomethionine synthase by various forms of cobalamin. J. Biol. Chem., 266: 23010-23015, 1991.
25. Bose, S., Komorowski, R., Seetharam, S., Gilfix, B., Rosenblatt, D. S., and Seetharam, B. In vitro and in vivo inactivation of transcobalamin II receptor by its antiserum. J. Biol. Chem., 271: 4195-4200, 1996.
26. Poydock, M. E., Fardon, J. C., Gallina, D., Ferro, V., and Heher, C. Inhibiting effect of vitamins C and B12 on the mitotic activity of ascites tumors. Exp. Cell. Biol., 47: 210-217, 1979.
27. Poydock, M. E., Reikert, D., and Rice, J. Influence of vitamins C and B12 on the survival rate of mice bearing ascites tumor. Exp. Cell. Biol., 50: 88-91, 1982.
28. Lassen, H. C. A., and Kristensen, H. S. Remission in chronic myeloid leukaemia following prolonged nitrous oxide inhalation. Dan. Med. Bull., 6: 252-254, 1959.
29. Eastwood, D. W., Green, C. D., Lambdin, M. A., and Gardner, R. Effect of nitrous oxide on the white-cell count in leukemia. N. Engl. J. Med., 268: 297-299, 1963.
30. Walker, P. R., Smith, B., Carson, C., LeBlanc, J., Sikorska, M., Woodhouse, C. S., and Morgan, A. C. Induction of apoptosis in neoplastic cells by depletion of vitamin B12. Cell Death Differ., 4: 233-241, 1997.
31. Herbert, V. The inhibition of some cancers and the promotion of others by folic acid, vitamin B12 and their antagonists. In: C. E. Butterworth, Jr., and M. L. Hutchinson (eds.), Nutritional Factors in the Induction and Maintenance of Malignancy, pp. 273-287. New York: Academic Press, 1983.
32. Corcino, J., Zalusky, R., Greenberg, M., and Herbert, V. Coexistence of pernicious anemia and chronic myeloid leukaemia: an experiment of nature involving vitamin B12 metabolism. Br. J. Haematol., 20: 511-520, 1971.