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85
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15644366961
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Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform selective inhibitor
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in press
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Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla •• TA, Ways K, Jirousek M, et al.: Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform selective inhibitor. Diabetes 1997, in press. Intraocular injections of VEGF at concentrations observed clinically resulted in rapid, dose-dependent increases in retinal vascular permeability as assessed by vitreous fluorophotometry in rats. Retinal vascular permeability was increased over threefold by VEGF. Selective inhibition of the β isoform of PKC, however, abolished VEGF's ability to stimulate retinal vascular permeability, even when the inhibitor was administered orally.
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(1997)
Diabetes
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Aiello, L.P.1
Bursell, S.E.2
Clermont, A.3
Duh, E.4
Ishii, H.5
Takagi, C.6
Mori, F.7
Ciulla, T.A.8
Ways, K.9
Jirousek, M.10
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