No difference in the proportion of insulin receptor exon 11 +/- isoform mRNA in the liver of rats after development of hypertension

Clinical and Experimental Pharmacology and Physiology

Volumn 23, Issue 6-7, 1996, Pages 602-604

  Lou, Yi Kun ^a   Zee, Robert Y L ^a   Li, Ming ^b   Morris, Brian J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ST GEORGE HOSPITAL   (Australia)

Author keywords

ACTH induced hypertension; Differential splicing; Insulin receptor; Polymerase chain reaction; Reverse transcription; Spontaneously hypertensive rat

Indexed keywords

CORTICOTROPIN; INSULIN RECEPTOR; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; EXON; HYPERTENSION; LIVER; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SPONTANEOUSLY HYPERTENSIVE RAT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; EXONS; HYPERTENSION; ISOMERISM; LIVER; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTOR, INSULIN; RNA, MESSENGER;

EID: 0029951013     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1996.tb02793.x     Document Type: Article

References (19)

1. Rao RH. Insulin resistance in spontaneously hypertensive rats. Difference in interpretation based on insulin infusion rate or on plasma insulin in glucose clamp studies. Diabetes 1993; 42: 1364-71.
2. Swislocki A, Tsuzuki A. Insulin resistance and hypertension: Glucose intolerance, hyperinsulinemia, and elevated free fatty acids in the lean spontaneously hypertensive rat. Am. J. Med. Sci. 1993; 306: 282-6.
3. Flack JM, Sowers JR. Epidemiological and clinical aspects of insulin resistance and hyperinsulinemia. Am. J. Med. 1991; 91 Suppl. 1A: S11-21.
4. Allemann Y, Horber FF, Colombo M et al. Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Lancet 1993; 341: 327-31.
5. Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Otsuka K, Saruta T. Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: Possible role of disturbed calcium metabolism. J. Hypertens. 1993; 11: 421-6.
6. Ying L-H, Zee RYL, Griffiths LR, Morris BJ. Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension. Biochem. Biophys. Res. Commun. 1991; 181: 486-92.
7. Zee RYL, Lou Y-k, Morris BJ. Insertion variant in intron 9, but not microsatellite in intron 2, of the insulin receptor gene is associated with essential hypertension. J. Hypertens. 1993; 11: 1283-8.
8. Schrader AP, Zee RYL, Morris BJ. Association analyses of nsil RFLP of human insulin receptor gene in hypertensives. Clin. Genet. 1996; 49 (in press).
9. Seino S, Bell GI. Alternative splicing of human insulin receptor messenger RNA. Biochem. Biophys. Res. Commun. 1989; 159: 312-16.
10. Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, McClain DA. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J. 1990; 9: 2409-13.
11. McClain DA. Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action. Mol. Endocrinol. 1991; 5: 734-9.
12. Mosthaf L, Vogt B, Häring HU, Ullrich A. Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc. Natl Acad. Sci. USA 1991; 88: 4728-30.
13. Kellerer M, Lammers R, Ermels B et al. Distinct α-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry 1992; 31: 4588-96.
14. Vogt B, Carrascosa JM, Ermel B, Ullrich A, Häring HU. The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem. Biophys. Res. Commun. 1991; 177: 1013-18.
15. Norgren S, Zierath J, Galuska D, Wallberg-Henriksson H, Luthman H. Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. Diabetes 1993; 42: 675-81.
16. Sesti G, Marini MA, Tullio AN et al. Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. Biochem. Biophys. Res. Commun. 1991; 181: 1419-24.
17. Norgren S, Zierath J, Wedell A, Wallberghenriksson H, Luthman H. Regulation of human insulin receptor RNA splicing in vivo. Proc. Natl Acad. Sci. USA 1994; 91: 1465-9.
18. Lou Y-k, Liu DT, Whitworth JA, Morris BJ. Renin mRNA, quantified by polymerase chain reaction, in renal hypertensive rat tissues. Hypertension 1995; 26: 656-64.
19. Goldstein BJ, Dudley AL. The rat insulin receptor: Primary structure and conservation of tissue-specific alternative messenger RNA splicing. Mol. Endocrinol. 1990; 4: 235-44.