Pyrethroid decrease in central nervous system from nervous agent pretreatment

Journal of Applied Toxicology

Volumn 17, Issue 4, 1997, Pages 231-234

  Buchholz, Bruce A ^a   Pawley, Norma H ^a   Vogel, John S ^a   Mauthe, Robert J ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

14C label; Accelerator mass spectrometry; AMS; Gulf War syndrome; Permethrin; Pyridostigmine bromide; Synergism

Indexed keywords

PERMETHRIN; PYRETHROID; PYRIDOSTIGMINE;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CHEMICAL WARFARE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG TISSUE LEVEL; MALE; MASS SPECTROMETER; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALS; CARBON RADIOISOTOPES; CENTRAL NERVOUS SYSTEM; CHOLINESTERASE INHIBITORS; INSECTICIDES; MALE; PERMETHRIN; PYRETHRINS; PYRIDOSTIGMINE BROMIDE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0030754873     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199707)17:4<231::AID-JAT434>3.0.CO;2-J     Document Type: Article

References (22)

1. I. Koplovitz, V C. Gresham, L W. Dochterman, A. Kaminskis and J. R Stewart, Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys. Arch. Toxicol 66, 622-628 (1992).
2. U. Ozkutlu, J. P Long, J G. Cannon, M F. Sahin and C. Liang, Prevention of organophosphate-induced toxicity in mice. Arch. Int. Pharmacodyn. Ther. 329, 331-342 (1993).
3. F Cantalamessa, Acute toxicity of two pyrethroids, permethrin, and cypermethrin in neonatal and adult rats. Arch. Toxicol. 67, 510-513 (1993).
4. D. M. Maxwell, K. M Brecht, B. P. Doctor and A. D. Wolfe, Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesterase. J. Pharmacol Exp. Ther 264, 1085-1089 (1993)
5. J. S. Vogel, K W Turteltaub, R Finkel and D. E Nelson, Accelerator Mass Spectrometry - isotope quantification at attomole sensitivity. Anal. Chem. 67, A353-A359 (1995).
6. K. W Turteltaub, J. S. Vogel, C E Frantz and N Shen, Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in mice at a human dietary equivalent dose. Cancer Res 52, 4682-4687 (1992)
7. C E Frantz, C. Bangerter, E Fultz, K M Mayer, J S. Vogel and K W Turteltaub. Dose-response studies of MelQx in rat liver and liver DNA at low doses. Carcinogenesis 16, 367-373 (1995).
8. K. T. Bogen, G. A. Keating and J. S. Vogel, Chloroform and trichloroethylene uptake from water into human skin in vitro: kinetics and risk implications. Prediction of Percutaneous Penetration 4B, 195-198 (1996).
9. M. B. Abou-Donia, K. R. Wilmarth, K. F. Jensen, F. W. Oehme and T. L. Kurt, Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: implications of Gulf War chemical exposures. J Toxicol. Environ Health 48, 35-56 (1996)
10. M. B. Abou-Donia, K. R. Wilmarth, A A Abdel-Rahman, K F Jensen, F. W. Oehme and T L. Kurt, Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos Fundam. Appl. Toxicol 34, 201-222 (1996).
11. Institute of Medicine, Health Consequence of Service During the Persian Gulf War: Initial Findings and Recommendations of Immediate Action. National Academy Press, Washington, DC (1995)
12. H Gavaghan, NIH panel rejects Persian Gulf syndrome. Nature 369, 8 (1994)
13. Menace in the mix, Environ Health Perspect 103, 792-793 (1995)
14. E. Pennisi, Chemicals behind Gulf War syndrome? Science 272, 479-480 (1996).
15. H L Snodgrass, Permethrin transfer from treated cloth to the skin surface: potential for exposure in humans. J. Toxicol. Environ. Health 35, 91-105 (1992).
16. M. C. Dunn and F. R. Sidell, Progress in medical defense against nerve agents JAMA 262, 649-652 (1989).
17. T. A. Loomis and A. W. Hays, Essentials of Toxicology. Academic Press, San Diego (1996).
18. J. S. Vogel, Rapid production of graphite without contamination for biomedical AMS. Radiocarbon 34, 344-350 (1992).
19. M. R. Creek, C. E. Frantz, E. Fultz, K. Haack, K. Redwine, N. Shen, K. W. Turteltaub and J. S. Vogel, C-14 AMS quantification of biomolecular interactions using microbore and plate separations. Nucl. Instrum. Methods Physics (Research Section B-Beam Interactions with Materials and Atoms) 92, 454-458 (1994).
20. J S. Vogel and K. W Turteltaub, Biomolecular tracing through accelerator mass spectrometry. Trends Anal. Chem. 11, 142-149 (1992).
21. A Anadon, M. R Martinez-Larrañaga, M. J. Diaz and P Bringas, Toxicokinetics of permethrin in the rat. Toxicol Appl. Pharmacol 110, 1-8 (1991)
22. S. S. Desphande, G. B. Viana, F. C. Kauffman, D. L. Rickett and E. X. Albuquerque, Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning Fundam Appl. Toxicol. 6, 566-577 (1986).