Effector molecules of the host defence mechanism against Mycobacterium avium complex: The evidence showing that reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids each alone are not decisive in expression of macrophage antimicrobial activity against the parasites

Clinical and Experimental Immunology

Volumn 109, Issue 2, 1997, Pages 248-254

  Tomioka, H ^a   Sato, K ^a   Sano, C ^a   Akaki, T ^a   Shimizu, T ^a   Kajitani, H ^a   Saito, H ^b  

^a SHIMANE UNIVERSITY   (Japan)

^b National Institute Leprosy Research   (Japan)

Author keywords

Free fatty acids; H2O2 mediated halogenation system; Mycobacterium avium complex macrophage; Reactive nitrogen intermediates; Reactive oxygen intermediates

Indexed keywords

FATTY ACID; HYDROGEN PEROXIDE; MEPACRINE; N(G) METHYLARGININE; NITRITE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; COLONY FORMING UNIT; HOST RESISTANCE; MACROPHAGE; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; VIRULENCE;

EID: 0030750181     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.4511349.x     Document Type: Article

References (38)

1. Benson CA. Disease due to Mycobacterium avium complex in patients with AIDS: epidemiology and clinical syndrome. Clin Infect Dis 1994; 18:S218-S222.
2. Ellner JJ, Goldberger MJ, Parenti DM. Mycobacterium avium infection and AIDS: a therapeutic dilemma in rapid evolution. J Infect Dis 1991; 163:1326-35.
3. Benson CA, Ellner JJ. Mycobacterium avium complex infection and AIDS: advances in theory and practice. Clin Infect Dis 1993; 17:7-20.
4. Shiratsuchi H, Johnson JL, Ellner JJ. Mycobacterium avium: pathogenicity in HIV infection. Res Microbiol 1994; 145:230-6.
5. Lepay DA, Steinman RM, Nathan CF, Murray HW, Cohn ZA. Liver macrophages in murine listeriosis. Cell mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J Exp Med 1985; 161:1503-12.
6. Edwards CK III, Ghiasuddin SM, Yunger LY, Lorence RM, Arkins S, Dantzer R, Kelley KW. In vivo administration of recombinant growth hormone or gamma interferon activates macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates. Infect Immun 1992; 60:2514-21.
7. Bermudez LE, Young LS. Tumor necrosis factor, alone or in combination with IL-2, but not with INF-γ, is associated with macrophage killing of Mycobacterium avium complex. J Immunol 1988; 140:3006-13.
8. Chan J, Xing X, Magliozzo RS, Bloom BR. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med 1992; 175: 1111-22.
9. Chan J, Kaufmann SHE. Immune mechanisms of protection. In: Bloom BR, ed. Tuberculosis, pathogenesis, protection, and control. Washington, DC: ASM Press, 1994:389-415.
10. Warwick-Davies J, Lowrie DB, Cole PJ. Growth hormone activation of human monocytes for superoxide production but not tumor necrosis factor production, cell adherence, or action against Mycobacterium intracellulare. Infect Immun 1995; 63:4312-6.
11. Warwick-Davies J, Lowrie DB, Cole PJ. Selective deactivation of human monocyte functions by TGF-β. J Immunol 1995; 155:3186-93.
12. Yamada Y, Saito H, Tomioka H, Jidoi J. Susceptibility of microorganisms to active oxygen species: sensitivity to the xanthine oxidase-mediated antimicrobial system. J Gen Microbiol 1987; 133:2007-14.
13. Yamada Y, Saito H, Tomioka H, Jidoi J. Relationship between the susceptibility of various bacteria to active oxygen species and to intracellular killing by macrophages. J Gen Microbiol 1987; 133:2015-21.
14. 2-Fe-mediated halogenation system supplemented with antimicrobial agents. Int J Lepr 1989; 57:628-32.
15. Sarmento A, Appelberg R. Involvement of reactive oxygen intermediates in tumor necrosis factor alpha-dependent bacteriostasis of Mycobacterium avium. Infect Immun 1996; 64:3224-30.
16. Flesch IEA, Kaufmann SHE. Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. Infect Immun 1991; 59:3213-8.
17. O'Brien L, Carmichael J, Lowrie DB, Andrew PW. Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro. Infect Immun 1994; 62:5187-90.
18. Chan J, Tanaka K, Carroll D, Flynn J, Bloom BR. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun 1995; 63:736-40.
19. Doi T, Ando M, Akaike T, Suga M, Sato K, Maeda H. Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis. Infect Immun 1993; 61:1980-9.
20. Brennan PJ, Belisle JT. Molecular basis of colony morphology in Mycobacterium avium. Res Microbiol 1994; 145:237-42.
21. Kanai K, Kondo E. Antibacterial and cytotoxic aspects of long-chain fatty acids as cell surface events: selected topics. Jap J Med Sci Biol 1970; 32:135-74.
22. Saito H, Tomioka H, Yoneyama T. Growth of group IV mycobacteria on medium containing various saturated and unsaturated fatty acids. Antimicrob Agents Chemother 1984; 26:164-9.
23. Saito H, Tomioka H. Susceptibilities of transparent, opaque, and rough colonial variants of Mycobacterium avium complex to various fatty acids. Antimicrob Agents Chemother 1998; 32:400-2.
24. 2-induced antimycobacterial activity in the membrane fraction from peritoneal exudate cells of guinea pigs. Jap J Med Sci Biol 1980; 33:87-101.
25. Tomioka H, Saito H, Sato K, Dawson DJ. Comparison of the virulence for mice of Mycobacterium avium and Mycobacterium intracellulare identified by DNA probe test. Microbiol Immunol 1993; 37:259-64.
26. Hibs JB Jr, Vabrin Z, Taintor Z. Macrophage cytotoxicicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science 1987; 235:473-6.
27. 2. Brit Med Bull 1983; 39:260-4.
28. H-1 cells. Immunol Today 1993; 14:335-7.
29. Castro AG, Silva RA, Appelberg R. Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice. J Immunol 1995; 155:2013-9.
30. Blanchard DK, Michelini-Norris MB, Pearson CA, McMillen S, Djeu JY. Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by monocytes and large granular lymphocytes stimulated with Mycobacterium avium-M. intracellulare: activation of bactericidal activity by GM-CSF. Infect Immun 1991; 59:2396-402.
31. Bermudez LE, Kaplan G. Recombinant cytokines for controlling mycobacterial infections. Trends Microbiol 1995; 3:22-27.
32. Mosman TR, Moore KW. The role of IL-10 in crossregulation of Th1 and Th2 responses. Immunol Today 1991; 12:A49-A53.
33. Wahl SM. Transforming growth factor-beta (TGF-β) in inflammation: a cause and a care. J Clin Immunol 1992; 12:61-73.
34. Bermudez LE. Production of transforming growth factor-β by Mycobacterium avium infected human macrophages is associated with unresponsiveness to IFN-γ. J Immunol 1993; 150:1838-45.
35. Bermudez LE, Champsi LA. Infection with Mycobacterium avium induced production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice. Infect Immun 1993; 61:3093-7.
36. Tomioka H, Sato K, Shimizu T, Sano C, Akaki T, Saito H, Fujii K, Hidaka T. Effects of benzoxazinorifamycin KRM-1648 on cytokine production at sites of Mycobacterium avium complex infection induced in mice. Antimicrob Agents Chemother 1997; 41:363-73.
37. Paul S, Laochumroonvorapong P, Kaplan G. Comparable growth of virulent and avirulent Mycobacterium tuberculosis in human macrophages in vitro. J Infect Dis 1996; 174:105-12.
38. Miyakawa Y, Ratnakar P, Rao AG, Costello ML, Mathieu-Costello O, Lehrer RI, Catanzaro A. In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis. Infect Immun 1996; 64:926-32.