Microbiology of hospital-acquired pneumonia

Seminars in Respiratory and Critical Care Medicine

Volumn 18, Issue 2, 1997, Pages 111-120

  Loeb, Mark ^a   Mandell, Lionel A ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b HENDERSON GENERAL HOSPITAL   (Canada)

Author keywords

Microbiology; Nosocomial; Pneumonia

Indexed keywords

ACINETOBACTER; ARTICLE; BACTERIAL PNEUMONIA; BACTERIUM DETECTION; ENTEROBACTERIACEAE; HAEMOPHILUS INFLUENZAE; HOSPITAL INFECTION; HUMAN; INFECTION RISK; LEGIONELLA; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0030745986     PISSN: 10693424     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1009338     Document Type: Article

References (110)

1. Campbell GD, Niederman MS, Broughton DE, et al. Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventative strategies. A consensus statement of the American Thoracic Society. Am J Respir Crit Care Med 1996;153: 1711-25
2. Leu HS, Kaiser DL, Mori M, Woolson RF, Wenzel RP. Hospital-acquired pneumonia attributable mortality and morbidity. Am J Epidemiol 1989;129:1258-67
3. Mandell LA, Niederman MS, and the Canadian Community Acquired Pneumonia Consensus Conference Group. Antimicrobial treatment of community acquired pneumonia in adults: A conference report. Can J Infect Dis 1993; 4:25-8
4. Niederman MS, Bass Jr JB, Campbell GD, et al. Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. Am Rev Respir Dis 1993;148:1418-26
5. Mandell LA, Marrie TJ, Niederman MS, and the Canadian Hospital Acquired Pneumonia Consensus Conference Group. Initial antimicrobial treatment of hospital acquired pneumonia in adults: a conference report. Can J Infect Dis 1993;4:317-21
6. Valenti WM, Trudell RG, Bentley DW. Factors predisposing to oropharyngeal colonization with gram-negative bacilli in the aged. N Engl J Med 1978;298:1108-11
7. Johanson WG, Pierce AK, Sanford JP. Changing pharyngeal bacterial flora of hospitalized patients: emergence of gram-negative bacilli. N Engl J Med 1969;281:1137-40
8. Higuchi JH, Johanson Jr WG. The relationship between adherence of Pseudomonas aeruginosa to upper respiratory cells in vitro and susceptibility to colonization in vivo. J Lab Clin Med 1980;95:698-705
9. Abraham SN, Beachey EH, Simpson WA, et al. Adherence of Streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa to fibronectin-coated and uncoated epithelial cells. Infect Immun 1983;41:1261-8
10. Woods DE, Straus DC, Johanson WG, Bass JA. Role of fibronectin in the prevention of adherence of Pseudomonas aeruginosa to buccal cells. J Infect Dis 1981;143:784-90
11. Vercellotti GM, Lussenhop D, Peterson PK, et al. Bacterial adherence to fibronectin and endothelial cells: a possible mechanism for bacterial tissue tropism. J Lab Clin Med 1984;103:330-43
12. Lepine G: Bacterial structure. In Murray PR, Kobayashi GS, Pfaller MA, Rosenthal KS eds. Medical Microbiology, 2nd ed. St. Louis, Mosby, 1994;6-16
13. NicasTI, Eisenstein BI. Bacterial diseases. Introduction. In Mandell GL, Bennett JE, Dolan R eds. Principles and Practice of Infectious Diseases, 4th ed. New York, Churchill Livingston Inc., 1995;1752-4
14. Kreig NR, Holt JG eds: Bergey's Manual of Systemic Bacteriology. Baltimore, MD, Williams and Wilkins, 1994;408-516
15. Farmer III JJ. Enterobacteriaceae: Introduction and Identification. In Baron EJ, Murray PR, Ferraro MJ, et al. eds. Manual of Clinical Microbiology, 6th ed. Washington, DC, American Society for Microbiology, 1995;438-49
16. CDC NNIS System. National Nosocomial Infections Surveillance Report, May 1996. Am J Infect Control 1996; 24:380-8
17. Jiminez P, Torres A, Rodriguez-Roisin R, et al. Incidence and etiology of pneumonia acquired during mechanical ventilation. Crit Care Med 1988;17:882-5
18. Rello J, Quintana E, Ausina V, et al. Incidence, etiology, and outcome of nosocomial pneumonia in mechanically ventilated patients. Chest 1991;100:439-44
19. Schwartz SN, Dowling JN, Benkovic C, et al. Sources of gram-negative bacilli colonizing the tracheae of intubated patients. J Infect Dis 1978;138:227-31
20. Niederman MS, Rafferty TD, Sasaki CT, et al. Comparison of bacterial adherence to ciliated and squamous epithelial cells obtained from the human respiratory tract. Am Rev Respir Dis 1983;127:85-90
21. Johanson WG, Pierce AK, Sanford JP, et al. Nosocomial respiratory infections with gram-negative bacilli: the significance of colonization of the respiratory tract. Ann Intern Med 1972;77:701-6
22. Verghese A, Berk SL. Bacterial pneumonia in the elderly. Medicine 1983;62:271-85
23. Carpenter JL. Klebsiella pulmonary infections: Occurrence at one medical centre and review. Rev Infect Dis 1990; 12:672-82
24. Jacoby GA, Medeiros AA. More extended spectrum β-lactamases. Antimicrob Agents Chemother 1991;35:1697-1704
25. Yu VL. Serratia marcescens: Historical perspective and clinical review. N Engl J Med 1979;300:887-93
26. Sanders CV, Luby JP, Johanson Jr WG, et al. Serratia marcescens infections from inhalation therapy medications: Nosocomial outbreak. Ann Intern Med 1970;73:15
27. Webb SF, Vall-Spinosa A. Outbreak of Serralia marcescens associated with the flexible fiber bronchoscope. Chest 1975;68:703
28. Kostman JR, Sherry BL, Fligner CL, et al. Invasive Haemophilus influenzae infections in older children and adults in Seattle. Clin Infect Dis 1993;17:389-96
29. Sanderson PJ. The sources of pneumonia in ICU patients. Infect Control 1986;7:104-6
30. Fagon JY, Chastre J, Domart Y, et al. Nosocomial pneumonia in patients receiving continuous mechanical ventilation: prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis 1989;139:877-84
31. Davies AJ, Hawkey PM, Simpson RA, O'Connor KM. Pneumoccocal cross-infection in hospital. Br Med J 1984; 288:1195
32. Reagan DR, Doebbeling BN, Pfaller MA, et al. Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment. Ann Intern Med 1991;114:101-6
33. Rammelkamp C, Mortimer E, Wolinsky E. Transmission of streptococcal and staphylococcal infections. Ann Intern Med 1964;60:753-8
34. Bradley S. Methicillin resistant Staphylococcus aureus infection. Clin Geriatr Med 1992;8:853-68
35. Phillips I, Spencer G. P. aeruginosa cross-infection: due to contaminated respiratory apparatus. Lancet 1965;2: 1325-7
36. Cross AS, Sadoff JC, Iglewski BH, Sokol PA. Evidence for the role of toxin A in the pathogenesis of infection with Pseudomonas aeruginosa in humans. J Infect Dis 1980;142:538-46
37. Stover GB, Drake DR, Montie TC. Virulence of different Pseudomonas species in a burned out mouse model: tissue colonization by Pseudomonas cepacia. Infect Immun 1983; 41:1099-1104
38. Bartlett JG, O'Keefe P, Talley F, et al. Bacteriology of hospital-acquired pneumonia. Arch Intern Med 1986;146: 868-71
39. Lorber B. Bacteroides, prevotella, and fusobacterium species (and other medically important anaerobic gramnegative bacilli). In Mandell GL, Bennett JE, Dolin R eds. Principles and practice of Infectious Diseases, 4th ed. New York, Churchill Livingstone, 1995;2195-204
40. Edelstein PH. Legionnaires' disease. Clin Infect Dis 1993; 16:741-9
41. Keller DW, Hajjeh R, Demaria A, et al. Community outbreak of Legionnaires' disease: an investigation confirming the potential for cooling towers to transmit Legionella species. Clin Infect Dis 1996;22:257-61
42. Blatt SP, Parkinson MD, Pace E, et al. Nosocomial Legionnaires' disease: aspiration as a primary mode of disease acquisition. Am J Med 1993;95:16-22
43. Mermel LA, Josephson SL, Giorgio CH, Dempsey J, Parenteau S. Association of Legionnaires' disease with construction: contamination of potable water? Infect Control Hospital Epidemiol 1995;16:76-81
44. Hart GA, Makin T. Legionella in hospitals: a review. J Hospital Infect 1991;18:481-9
45. Plouffe JF, File TM, Breiman RF, et al. Reevaluation of the definition of Legionnaires' disease: use of the urinary antigen assay. Clin Infect Dis 1995;20:1286-91
46. Tablan OC, Anderson LJ, Arden NH, et al. Guidelines for prevention of nosocomial pneumonia. Infect Control Hospital Epidemiol 1994;15:587-627
47. Craven DE, Steger KA, Barber TW. Preventing nosocomial pneumonia: state of the art and perspectives for the 1990s. Am J Med 1991;91:44S-53S
48. Celis R, Torres JM, Gatell M, et al. Nosocomial pneumonia: a multivariate analysis of risk and prognosis. Chest 1988;93:318-24
49. Kappstein I, Friedrich T, Hellinger P. Incidence of pneumonia in mechanically ventilated patients treated with sucralfate or cimetidine as prophylaxis for stress bleeding: bacterial colonization of the stomach. Am J Med 1991; 91(Suppl 2A):125S-131S
50. Donowitz LG, Page MC, Mileur BL, Guenthner SH. Alteration of normal gastric flora in critical patients receiving antacid and cimetidine therapy. Infect Control 1986; 7:23-6
51. Huxley EJ, Viroslav J, Gray WR, Pierce AK. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med 1973;64:564-8
52. Jacobs S, Chang RWS, Lee B, Bartlett FW. Continuous enteral feeding: a major cause of pneumonia among ventilated intensive care unit patients. J Parenteral Enteral Nutr 1990;14:353-6
53. Rello J, Ricart M, Ausina V, Net A, Prats G. Pneumonia due to Haemophilus influenzae among mechanically ventilated patients. Incidence, outcome, and risk factors. Chest 1992;102:1562-5
54. Espersen F, Gabrielsen J. Pneumonia due to Staphylococcus aureus during mechanical ventilation. J Infect Dis 1981; 144:19-23
55. Espersen F, Gabrielsen J. Staphylococcus aureus pneumonia as a complication during treatment of neurosurgical patients with mechanical ventilation. Scand J Infect Dis. 1981;13:161-3
56. Schleupner CJ, Cobb DK. A study of the etiologies and treatment of nosocomial pneumonia in a community-based teaching hospital. Infect Control Hospital Epidemiol 1992;13:515-25
57. Pallares R, Gudiol F, Linares J, et al. Risk factors and response to antibiotic therapy in adults with bacteremic pneumonia caused by penicillin-resistant pneumococci. N Engl J Med 1987;317:18-22
58. Nava JM, Bella F, Garau J, et al. Predictive factors for invasive disease due to penicillin-resistant Staphylococcus pneumoniae: a population-based study. Clin Infect Dis 1994; 19:884-90
59. Rello J, Quintana E, Ausina C, et al. Risk factors for Staphylococcus aureus nosocomial pneumonia in critically ill patients. Am Rev Respir Dis 1990;142:1320-4
60. Daschner FD. The transmission of infections in hospitals by staff carriers, methods of prevention and control. Infect Control 1985;6:97-8
61. Lowbury EJL, Lilly HA, Bull JP. Disinfection of hands: removal of transient organisms. Br J Med 1964;2:230-3
62. Niederman MS. Gram-negative colonization of the respiratory tract: pathogenesis and clinical consequences. Semin Respir Infect 1990;5:173-81
63. Favero MS, Carson LA, Bond WW. Pseudomonas aeruginosa growth in distilled water from hospitals. Science 1971; 173:836-8
64. Fagon JY, Chastre J, Hance AJ, et al. Detection of nosocomial lung infection in ventilated patients: use of a protected specimen brush and quantitative culture techniques in 147 patients. Am Rev Respir Dis 1988;138:110-6
65. Lorber B, Swenson RM. Bacteriology of aspiration pneumonia. Ann Intern Med 1974;81:329
66. Marston BJ, Lipman HB, Breiman RF. Surveillance for Legionnaires' disease. Risk factors for morbidity and mortality. Arch Intern Med 1994;154:2417-22
67. Kirby BD, Snyder KM, Meyer RD, et al. Legionnaires' disease. Report of 65 nosocomially acquired cases and review of the literature. Medicine 1980;59:188-205
68. Morris GK, Patton CM, Feeley JC, et al. Isolation of the Legionnaires' disease bacterium from environmental samples. Ann Intern Med 1979;90:664-6
69. Tison DL, Seidler RJ. Legionella incidence and density in potable drinking water. Appl Environ Microbiol 1983; 45:337-9
70. Abraham EP, Chain E. An enzyme from bacteria able to destroy penicillin. Nature 1940;146:837-9
71. Phelps CE. Bug/drug resistance: sometimes less is more. Med Care 1989;27:194-203
72. Holmberg SD, Solomon SL, Blake PA. Health and economic impacts of antimicrobial resistance. Rev Infect Dis 1987;9:1065-78
73. Levy SB. The Antibiotic Paradox: How Miracle Drugs are Destroying the Miracle. New York, Plenum Press, 1992;74
74. Gardner P, Smith DH, Beer H, et al. Recovery of resistance (R) factors from a drug-free community. Lancet 1968; 2:407-9
75. Benveniste R, Davies J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci USA 1973;170:2276-80
76. Telenti A, Imboden P, Marchesi F, et al. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 1993;341:647-50
77. Nikaido H. Outer membrane barrier as a mechanism of antimicrobial resistance. Antimicrob Agents Chemother 1989;33:1831-6
78. Timmins KN, Gonalez-Carrero MI, Sekizaki T, Rojo F. Biological activities specified by antibiotic resistance plasmids. J Antimicrob Chemother 1986;18:1-12
79. Lupski JR. Molecular mechanisms for transposition of drug-resistance genes and other movable genetic elements. Rev Infect Dis 1987;9:357-68
80. Tenover FC, Hughes JM. The challenges of emerging infectious diseases: development and spread of multiply-resistant bacterial pathogens. JAMA 1996;275:300-4
81. Cohen M. Epidemiology of drug resistance: implications for a post-antimicrobial era. Science 1992;257:1050-5
82. Bryan LE. Aminoglycoside resistance. In Bryan LE ed. Antimicrobial Drug Resistance. Orlando FL, Academic Press, 1984;241-77
83. Rubens CE, McNeill WF, Farrar Jr WE: Evolution of multiple-antibiotic-resistance plasmids mediated by transposable plasmid deoxyribonucleic acid sequences. J Bacteriol 1979;140:713-9
84. Gaffney DF, Foster TJ, Shaw WV. Chloramphenicol acetyl transferases determined by R-plasmids from gram (-) bacteria. J Gen Microbiol 1978;109:351-8
85. Knothe H, Shah P, Kremery V, et al. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxíme in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection 1983;11:315-7
86. Kliebe C, Nies BA, Meyer JF, Tolxdorff-Neutzling RM, Wiedemann B. Evolution of plasmid-coded resistance to broad-spectrum cephalosporins. Antimicrob Agents Chemother 1985;28:302-7
87. Livermore DM. B-Lactamases in laboratory and clinical resistance. Clin Microbiol Rev 1995;8:557-84
88. Philippon A, Labia R, Jacoby GA. Extended spectrum B-lactamases, Antimicrob Agents Chemother 1989;33:1131-6
89. Jacoby GA, Carreras I. Activities of B-lactam antibiotics against Escherichia coli strains producing extended-spectrum β-lactamases. Antimicrob Agents Chemother 1990; 34:858-62
90. Sanders CC, Sanders WE. Clinical importance of inducible B-lactamases in gram-negative bacteria. Eur J Clin Microbiol 1987;6:435-8
91. Chow JW, Fine MJ, Shlaes DM, et al. Enterobacter bacteremia - Clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med 1991;115: 585-90
92. Urban C, Go E, Mariano N, Rahal JJ. Interactions of sulbactam, clavulanic acid and tazobactam with penicillin-binding proteins of imipenem-resistant and susceptible Acinetobacter baumannii. FEMS Microbiol Lett 1995;125:193-8
93. Papanicolaou GA, Medeiros AA, Jacoby GA. Novel plasmidmediated beta-lactamase (MIR-I) conferring resistance to oxyimino- and alphamethoxy-beta-lactams in clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother 1990;34:2200-9
94. Goldstein FW, Gutmann L, Williamson R, et al. In vivo and in vitro emergence of simultaneous resistance to both beta-lactam and aminoglycoside antibiotics in a strain of Serratia marcescens. Ann Microbiol (Inst Pasteur) 1983; 134A:329-38
95. Quinn JP, Dudek EJ, DiVincenzo CA, et al. Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections. J Infect Dis 1986;154:289-94
96. Trias J, Nikaido H. Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob Agents Chemother 1990;34:52-7
97. Hopkins JM, Towner KJ. Enhanced resistance to cefotaxime and imipenem associated with outer membrane protein alterations in Enterobacter aerogenes. J Antimicrob Chemother 1990;225:49-55
98. Sanders CC, Sanders Jr WE, Goering RV, Werner V. Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes. Antimicrob Agents Chemother 1984;26:797-801
99. Funada H, Hattori K, Kosaki N. Catalase-negative Escherichia, coli isolated from the blood. J Clin Microbiol 1978;7:474-8
100. McMurray L, Petrucci RE, Levy SB. Active efflux of tetracyclin encoded by four genetically different tetracycline resistance determinants in Escherichia coli. Proc Natl Acad Sci USA 1980;71:3974-7
101. Cohen SP, Hooper DC, Wolfson JS, et al. Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob Agents Chemother 1988;32:1187-90
102. Naraqi S, Kirkpatrick GP, Kabins S. Relapsing pneumococcal meningitis: isolation of an organism with decreased susceptibility to penicillin G. J Pediatr 1974;85:671-3
103. Lapointe J, Joncas JH. Meningitis in a Canadian infant due to pneumococcus resistant to penicillin and chloramphenicol. J Pediatr 1983;103:580-2
104. Austrian R. Confronting drug-resistant pneumococci. Ann Intern Med 1994;121:807-9
105. Figueiredo AMS, Connor JD, Severin A, Vaz Pato MV, Tomasz A. A pneumococcal clinical isolate with high-level resistance to cefotaxime and ceftriaxone. Antimicrob Agents Chemother 1992;36:886-9
106. Dowson CG, Johnson AP, Cercenado E, George RC. Genetics of oxacillin resistance in clinical isolates of Streptococcus pneumoniae that are oxacillin resistant and penicillin susceptible. Antimicrob Agents Chemother 1994;38:49-53
107. Jacoby GA, Archer GL. New mechanisms of bacterial resistance to antimicrobial agents. N Engl J Med 1991;324: 601-12
108. Nakamura S, Nakamura M, Kojima T, Yoshida H. gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob Agents Chemother 1989;33:128-30
109. Wolfson JS, Hooper DC. The fluoroquinolones: Structures, mechanisms of action resistance, and spectra of activity in vitro. Antimicrob Agents Chemother 1985;28:581-6
110. Robillard NJ, Scarpa AL. Genetic and physiological characterization of ciprofloxacin resistance in Pseudomonas aeruginosa PAO. Antimicrob Agents Chemother 1988;32: 535-9