Antisense oligonucleotide binding to U5 snRNP induces a conformational change that exposes the conserved loop of U5 snRNA

Nucleic Acids Research

Volumn 25, Issue 17, 1997, Pages 3508-3513

  Ast, Gil ^a   Weiner, Alan M ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; SMALL NUCLEAR RNA;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; EXON; PRIORITY JOURNAL; RNA BINDING; RNA STRUCTURE; SPLICEOSOME;

BASE COMPOSITION; BASE SEQUENCE; BINDING SITES; CROSS-LINKING REAGENTS; CYTOSINE; FICUSIN; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; RIBONUCLEOPROTEIN, U5 SMALL NUCLEAR; RNA SPLICING; SPLICEOSOMES; URIDINE;

EID: 0030740710     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/25.17.3508     Document Type: Article

References (64)

1. Moore, J.M., Query, C.C. and Sharp, P.A. (1993) In Gesteland, R.F. and Atkins, J.F. (eds), The RNA World. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 303-357.
2. Ares, M. and Weiser, B. (1995) Prog. Nucleic Acid Res. Mol. Biol., 50, 131-159.
3. Newman, A.J. (1994) Curr Opin. Genet. Dev., 4, 298-304.
4. Zhuang, Y. and Weiner, A.M. (1986) Cell, 46, 827-835.
5. Seraphin, B., Kretzner, L. and Rosbash, M. (1988) EMBO J., 7, 2533-2538.
6. Siliciano, P.G. and Guthrie, C. (1988) Genes Dev., 2, 1258-1267.
7. Michaud, S. and Reed, R. (1993) Genes Dev., 7, 1008-1020.
8. Wu, J.Y. and Maniatis, T. (1993) Cell, 75, 1061-1070.
9. Abovich, N., Liao, X.C. and Rosbash, M. (1994) Genes Dev., 8, 843-854.
10. Kohtz, J.D., Jamison, S.F., Will, C.L., Zuo, R. Lührmann, R., Garcia-Blanco, M.A. and Manley, J.L. (1994) Nature, 368, 119-124.
11. Parker, R., Siliciano, P.G. and Guthrie, C. (1987) Cell, 49, 229-239.
12. Wu, J. and Manley, J.L. (1989) Genes Dev., 3, 1553-1561.
13. Zhuang, Y. and Weiner, A.M. (1989) Genes Dev., 3, 1545-1552.
14. Konarska, M.M. and Sharp, P.A. (1988) Proc. Natl. Acad. Sci. USA, 85, 5459-5462.
15. Hausner, T.P., Giglio, L.M. and Weiner, A.M. (1990) Genes Dev., 4, 2146-2156.
16. Behrens, S.-E. and Lührmann, R. (1991) Genes Dev., 5, 1439-1452.
17. Wassarman, D.A. and Steitz J.A. (1992) Science, 257, 1918-1925.
18. Konforti, B.B., Koziolkiewicz, M.J. and Konarska, M.M. (1993) Cell, 75, 863-873.
19. Konforti, B.B. and Konarska, M.M. (1994) Genes Dev., 8, 1962-1973.
20. Pikielny, C.W., Rymond, B.C. and Rosbash, M. (1986) Nature, 324, 341-345.
21. Cheng, S.C. and Abelson, J. (1987) Genes Dev., 1, 1014-1027.
22. Konarska, M.M. and Sharp, P.A. (1987) Cell, 49, 763-774.
23. Yean, S.L. and Lin, R.J. (1991) Mol. Cell. Biol., 11, 5571-5577.
24. Datta, B. and Weiner, A.M. (1991) Nature, 352, 821-824.
25. Wu, J. and Manley, J.L. (1991) Nature, 352, 818-821.
26. Madhani, H.D. and Guthrie, C. (1992) Cell, 71, 803-817.
27. Madhani, H.D. and Guthrie, C. (1994) Annu. Rev. Genet., 28, 1-26.
28. Sun, J.S. and Manley, J.L. (1995) Genes Dev., 9, 843-854.
29. Sawa, H. and Abelson, J. (1992) Proc. Natl. Acad. Sci. USA, 89, 11269-11273.
30. Sawa, H. and Shimura, Y. (1992) Genes Dev., 6, 244-254.
31. Kandels-Lewis, S. and Seraphin, B. (1993) Science, 262, 2035-2039.
32. Lesser, C.F. and Guthrie, C. (1993) Science, 262, 1982-1988.
33. Li, Z. and Brow, D.A. (1996) RNA, 2, 879-894.
34. Frank, D.N., Roiha, H. and Guthrie, C. (1994) Mol. Cell. Biol., 14, 2180-2190.
35. Newman, A.J. and Norman, C. (1991) Cell, 65, 115-123.
36. Newman, A.J. and Norman, C. (1992) Cell, 68, 743-753.
37. Wyatt, J.R., Sontheimer, E.J. and Steitz, J.A. (1992) Genes Dev., 6, 2542-2553.
38. Sontheimer, E.J. and Steitz, J.A. (1993) Science, 262, 1989-1996.
39. Cortes, J.J., Sontheimer, E.J., Seiwert, S.D. and Steitz, J.A. (1993) EMBO J., 12, 5181-5189.
40. Newman, A.J., Teigelkamp, S. and Beggs, J.D. (1995) RNA, 1, 968-980.
41. O'Keefe, R.T., Norman, C. and Newman, A.J. (1996) Cell, 86, 679-689.
42. Patterson, B. and Guthrie, C. (1987) Cell, 49, 613-624.
43. Winkelmann, G., Bach, M. and Lührmann, R. (1989) EMBO J., 8, 3105-3112.
44. Seraphin, B., Abovich, N. and Rosbash, M. (1991) Nucleic Acids Res., 19, 3857-3860.
45. Lamm, G.M., Blencowe, B.J., Sproat, B.S., Iribarren, A.M., Ryder, U. and Lamond, A.I. (1991) Nucleic Acids Res., 19, 3193-3198.
46. Segault, V., Will, C.L., Sproat, B.S. and Lührmann, R. (1995) EMBO J., 14, 4010-4021.
47. MacMillan, A.M., Query, C.C., Allerson, C.R., Chen, S., Verdine, G.L. and Sharp, P.A. (1994) Genes Dev., 8, 3008-3020.
48. Teigelkamp, S., Newman, A.J. and Beggs, J.D. (1995) EMBO J., 14, 2602-2612.
49. Umen, J.G. and Guthrie, C. (1995) Genes Dev., 9, 855-868.
50. Reyes, J.L., Kois, P., Konforti, B.B. and Konarska, M.M. (1996) RNA, 2, 213-225.
51. Garcia-Blanco, M.A., Anderson, G.J., Beggs, J. and Sharp, P.A. (1990) Proc. Natl. Acad. Sci. USA, 87, 3082-3086.
52. Whittaker, E. and Beggs, J.D. (1991) Nucleic Acids Res., 19, 5483-5489.
53. Ast, G. and Weiner, A.M. (1996) Science, 272, 881-884.
54. Ast, G. and Weiner, A.M. (1997) RNA, 3, 371-381.
55. Krol, A. and Ebel, J.-P. (1983) Nucleic Acids Res., 11, 8583-8594.
56. Black, D.L. and Pinto, A.L. (1989) Mol. Cell. Biol., 9, 3350-3359.
57. Dignam, J.D., Lebovitz, R.M. and Roeder, R.E. (1983) Nucleic Acids Res., 11, 1475-1489.
58. Cimino, G.D., Gamper, H.B., Isaacs, S.T. and Hearst, J.E. (1985) Annu. Rev. Biochem., 54, 1151-1193.
59. Ussery, D.W., Hoepfner, R.W. and Sinden, R.R. (1992) Methods Enzymol., 212, 242-262.
60. Bach, M. and Lührmann, R. (1991) Biochim. Biophys. Acta, 1088, 139-143.
61. Jandrositz, A. and Guthrie, C. (1995) EMBO J., 14, 820-832.
62. Guthrie, C. and Patterson, B. (1988) Annu. Rev. Genet., 22, 387 -419.
63. Ruby, S.W. (1997) J. Biol. Chem., in press.
64. Bennett, M., Michaud, S., Kingston, J. and Reed, R. (1992) Genes Dev., 6, 1986-2000.