Molecular characterization of pharmacological properties of T-0509 for β-adrenoceptors

European Journal of Pharmacology

Volumn 315, Issue 3, 1996, Pages 363-367

  Sato, Yoji ^a   Kurose, Hitoshi ^a   Isogaya, Masafumi ^a   Nagao, Taku ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

1 Adrenoceptor agonist; 3 Adrenoceptor; Adenylyl cyclase; Intrinsic activity; T 0509

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HAMSTER; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOLAMINES; HUMANS; ISOPROTERENOL; RECEPTORS, ADRENERGIC, BETA;

EID: 0030597325     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00648-6     Document Type: Article

References (20)

1. Cullen, B.R., 1987, Use of eukaryotic expression technology in the functional analysis of a cloned genes, in: Methods in Enzymology, eds. S.L. Berger and A.R. Kimmel (Academic Press, San Diego, CA), 152, 684.
2. DeLean, A., J.M. Stadel and R.J. Lefkowitz, 1982, A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor, J. Biol. Chem. 255, 7108.
3. s, Mol. Pharmacol. 41, 889.
4. 3H]PN200-110 to rabbit T-tuble calcium channels, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 208, 199.
5. Kaumann, A.J., 1981, In Kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the β-adrenoceptors, Naunyn-Schmiedeberg's Arch. Pharmacol. 317, 13.
6. Kenakin, T.P., 1981, An in vitro quantitative analysis of alpha adrenoceptor partial agonist activity of dobutamine and its relevance to inotropic selectivity, J. Pharmacol. Exp. Ther. 216, 210.
7. Kobilka, B., 1992, Adrenergic receptors as models for G protein-coupled receptors, Annu. Rev. Neurosci. 15, 87.
8. 2-adrenoceptors, Biol. Pharm. Bull. 17, 1023.
9. 1-specific and non-adrenergic stimulant effects of denopamine, Naunyn-Schmiedeberg's Arch. Pharmacol. 339, 113.
10. 2-adrenergic receptors, Proc. Natl. Acad. Sci. USA 90, 10798.
11. 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells, Mol. Pharmacol. 42, 634.
12. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265.
13. Nagao, T. and H. Nakajima, 1989, Denopamine, Cardiovas. Drug Rev. 7,310.
14. Salomon, Y., C. Londos and M. Rodbell, 1974, A high sensitive adenylate cyclase assay, Anal. Biochem. 58, 541.
15. Sambrook, J., E.F. Fritsch and T. Maniatis, 1989, Introduction of recombinant vectors into mammalian cells: expression of cloned genes in cultured mammalian cells, in: Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY) p. 16.30.
16. Sanger, F., S. Nicklen and A.R. Coulson, 1977, DNA sequencing with chain-terminating inhibitors, Proc. Natl. Acad. Sci. USA 74, 5463.
17. Tate, K.M., M.-M. Briend-Sutren, L.J. Emorine, C. Delavier-Klutchko, S. Marullo and A.D. Strosberg, 1991, Expression of three human β-adrenergic-receptor subtypes in transfected Chinese hamster ovary cells, Eur. J. Biochem. 196, 357.
18. 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors, J. Biol. Chem. 267, 3530.
19. Wilson, I.A., H.L. Niman, R.A. Houghten, A.R. Cherenson, M.L. Connolly and R.A. Lerner, 1984, The structure of an antigenic determinant in a protein, Cell 37, 767.
20. 1-adrenoceptor agonist action of a catechol derivative of denopamine (T-0509) in the guinea-pig cardiac muscle and trachea: comparison with denopamine, xamoterol and isoprenaline, Br. J. Pharmacol. 106, 335.