Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells

Annals of Hematology

Volumn 75, Issue 5-6, 1997, Pages 207-213

  Gotoh, A ^a,b   Ritchie, A ^a   Takahira, H ^a   Broxmeyer, H E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; ERYTHROPOIETIN; FIBRINOGEN RECEPTOR; FIBRONECTIN; FOCAL ADHESION KINASE; INTEGRIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; THROMBOPOIETIN;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CELL ADHESION; CELL LINE; CELLS, CULTURED; ERYTHROPOIETIN; FIBRONECTINS; GENE TRANSFER TECHNIQUES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; INTEGRINS; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION; THROMBOPOIETIN;

EID: 0030734744     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050344     Document Type: Article

References (33)

1. Torok-Storb B (1988) Cellular interactions. Blood 73:373-385
2. Gordon MY (1988) Extracellular matrix of the bone marrow microenvironment. Br J Haematol 70:1-4
3. Kerst JM, Sanders JB, Slaper-Cortenbach ICM, Doorakkers MC, Hooibrink B, van Oers RHJ, von dem Borne AEGK, van der School CE (1993) a4b1 and a5b1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34+ cells to fibronectin in an activation-dependent way. Blood 81:344-351
4. Hynes RO (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell 69:11-25
5. Verfaillie CM, McCarthy JB, McGlave PB (1991) Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alteration in their interaction with fibronectin. J Exp Med 174:693-703
6. Williams DA, Rios M, Stephens C, Patel VP (1991) Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature 352:438-441
7. Levesque JP, Leavesley DI, Niutta S, Vadas M, Simmons PJ (1995) Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. J Exp Med 181:1805-1815
8. 3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI 3 kinase. Blood 89:883-895
9. Carver-Moore K, Broxmeyer HE, Luoh SM, Cooper S, Peng J, Burstein S, Moore MW, de Sauvage FJ (1996) Low levels of erythroid and myeloid progenitors in TPO and c-mpl-deficient mice. Blood 88:803-808
10. Ritchie A, Vadhan-Raj S, Broxmeyer HE (1996) Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth-factor-dependentcell line M07e. Stem Cells 14:330-336
11. Gotoh A, Takahira H, Geahlen RL, Broxmeyer HE (1997) Cross-linking of integrins induces tyrosine phosphorylation of proto-oncogene product Vav and protein tyrosine kinase Syk in human factor-dependent myeloid cells. Cell Growth Differ 8:721-729
12. Avanzi GC, Lista P, Giovinazzo B, Miniero R, Saglio G, Benetton G, Coda R, Cattoretti G, Pegoraro L (1988) Selective growth response to IL-3 of a human leukemic cell line with megakaryoblastic features. Br J Haematol 69:359-366
13. Tauchi T, Feng GS, Shen R, Hoatlin M, Bagby GC Jr, Kabat D, Lu L, Broxmeyer HE (1995) Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem 270:5631-5635
14. Hanks SK, Calalb MB, Harper MC, Patel SK (1992) Focal adhesion protein-tyrosine kinase phosphorylation in response to cell attachment to fibronectin. Proc Natl Acad Sci USA 89:8487-8491
15. FAK) and paxillin. Blood 89:1574-1584
16. Miyazawa K, Williams DA, Gotoh A, Nishimaki J, Broxmeyer HE, Toyama K (1995) Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85:641-649
17. FAK) by BCR-ABL oncoprotein. Exp Hematol 23:1153-159
18. Levesque JP, Haylock DN, Simmons PJ (1996) Cytokine regulation and cell adhesion are correlated events in human CD34+ hematopoietic progenitors. Blood. 88:1168-1176
19. Richardson A, Parsons JT (1995) Signal transduction through intearins: a central for focal adhesion kinase. BioEssay 17:229-236
20. Hardy CL (1995) The homing of hematopoietic stem cells to the bone marrow. Am J Med Sci 309:260-266
21. Aizawa S, Tavassoli M (1987) In vitro homing of hemopoietic stem cells is mediated by a recognition system with galactosyl and mannosyl specificities. Proc Natl Acad Sci USA. 84:4485-4489
22. Aizawa S, Tavassoli, M (1987) Interaction of murine granulocyte-macrophage progenitors and supporting stroma involves a recognition mechanism with galactosyl and mannosyl specificities. J Clin Invest 80:1698-1705
23. Aizawa S, Tavassoli M (1988) Kinetics of inhibition ot CFU-C homing in long-term marrow culture. Exp Hematol 16:217-220
24. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D (1996) Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl. Blood 87:2162-2170
25. Broudy VC, Lin NL, Kaushansky K (1995) Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719-1726
26. Kaushansky K, Broudy VC, Grossman A, Humes J, Lin N, Ren HP, Bailey MC, Papayannopoulou T, Forstrom JW, Sorugel KH (1995) Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683-1687
27. Kaushansky K (1995) Thrombopoietin: the primary regulator of platelet production. Blood 86:419-431
28. Vadhan-Raj S, Murray LJ, Bueso-Ramos C, Patel S, Reddy SP, Hoots WK, Johnston T, Papadopolous NE, Hittelman WN, Johnston DA, Yang TA, Paton VE, Cohen RL, Hellmann SD, Benjamin RS, Broxmeyer HE (1997) Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Intern Med 126:673-681
29. Zhang Z, Vuori K, Wang H-G, Reed JC, Ruoslahti E (1996) Integrin activation by R-RAS. Cell 85:61-69
30. Nagata Y, Todokoro K (1995) Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett 377:497-501
31. Marshall MA (1995) Ras target proteins in eukaryotic cells. FASEB J 9:1311-1318
32. Serve H, Nelson SY, Stella G, Sepp-Lorenzino L, Tan JC, Besmer P (1995) Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J 14:473-483
33. Kinashi T, Escobedo JA, Williams LT, Takatsu K, Springer TA (1995) Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-g1 pathways. Blood 86:2086-2090