-
1
-
-
0037570372
-
-
and references therein
-
a) B. Schneider, Dtsch. Apoth. Ztg. 1994, 134, 3389-3400, and references therein;
-
(1994)
Dtsch. Apoth. Ztg.
, vol.134
, pp. 3389-3400
-
-
Schneider, B.1
-
3
-
-
0003702923
-
-
Oxford University Press, Oxford
-
c) J. Mann, in Murder, Magic and Medicine, Oxford University Press, Oxford, 1992, pp. 1-2.
-
(1992)
Murder, Magic and Medicine
, pp. 1-2
-
-
Mann, J.1
-
4
-
-
85033156581
-
-
note
-
a) Taxol is now a registered trademark of Bristol-Myers-Squibb; the generic name is paclitaxel; taxotère is a registered trademark of Rhône-Poulenc Rorer; its generic name is docetaxel. Because of the greater familiarity of the words taxol and taxotère, only these are used in the text in lieu of the corresponding generic names;
-
-
-
-
5
-
-
85033134112
-
-
note
-
b) There are other microtubuli-stabilizing compounds which, however, are not cytostatics. Therefore the simple equation depolymerization inhibitor = cytotoxic compound is questionable.
-
-
-
-
6
-
-
0001448991
-
-
a) G. Höfle, N. Bedorf, H. Steinmetz, D. Schomburg, K. Gerth, H. Reichenbach, Angew. Chem. 1996, 108, 1671-1673; Angew. Chem. Int. Ed. Engl. 1996, 35, 1567-1569;
-
(1996)
Angew. Chem.
, vol.108
, pp. 1671-1673
-
-
Höfle, G.1
Bedorf, N.2
Steinmetz, H.3
Schomburg, D.4
Gerth, K.5
Reichenbach, H.6
-
7
-
-
0029776766
-
-
a) G. Höfle, N. Bedorf, H. Steinmetz, D. Schomburg, K. Gerth, H. Reichenbach, Angew. Chem. 1996, 108, 1671-1673; Angew. Chem. Int. Ed. Engl. 1996, 35, 1567-1569;
-
(1996)
Angew. Chem. Int. Ed. Engl.
, vol.35
, pp. 1567-1569
-
-
-
8
-
-
0030018666
-
-
b) K. Gerth, N. Bedorf, G. Höfle, H. Irschik, H. Reichenbach, J. Antibiot. 1996, 49, 560-563;
-
(1996)
J. Antibiot.
, vol.49
, pp. 560-563
-
-
Gerth, K.1
Bedorf, N.2
Höfle, G.3
Irschik, H.4
Reichenbach, H.5
-
9
-
-
0001405842
-
-
c) L. Wessjohann, Angew. Chem. 1997, 109, 739-742; Angew. Chem. Int. Ed. Engl. 1997, 36, 738-742.
-
(1997)
Angew. Chem.
, vol.109
, pp. 739-742
-
-
Wessjohann, L.1
-
10
-
-
84889628606
-
-
c) L. Wessjohann, Angew. Chem. 1997, 109, 739-742; Angew. Chem. Int. Ed. Engl. 1997, 36, 738-742.
-
(1997)
Angew. Chem. Int. Ed. Engl.
, vol.36
, pp. 738-742
-
-
-
11
-
-
0642288119
-
-
Kloster Irsee
-
a) P. Poitier, 5. Irseer Naturstofftage, Kloster Irsee, 1993, see also: J. Rohr, Nachr. Chem. Tech. Lab. 1993, 41, 559-564;
-
(1993)
Irseer Naturstofftage
-
-
Poitier, P.1
-
12
-
-
0642288126
-
-
a) P. Poitier, 5. Irseer Naturstofftage, Kloster Irsee, 1993, see also: J. Rohr, Nachr. Chem. Tech. Lab. 1993, 41, 559-564;
-
(1993)
Nachr. Chem. Tech. Lab.
, vol.41
, pp. 559-564
-
-
Rohr, J.1
-
13
-
-
0002767594
-
-
b) K. C. Nicolaou, W.-M. Dai, R. K. Guy, Angew. Chem. 1994, 106, 38-69; Angew. Chem. Int. Ed. Engl. 1994, 33, 45-76.
-
(1994)
Angew. Chem.
, vol.106
, pp. 38-69
-
-
Nicolaou, K.C.1
Dai, W.-M.2
Guy, R.K.3
-
14
-
-
0007359922
-
-
b) K. C. Nicolaou, W.-M. Dai, R. K. Guy, Angew. Chem. 1994, 106, 38-69; Angew. Chem. Int. Ed. Engl. 1994, 33, 45-76.
-
(1994)
Angew. Chem. Int. Ed. Engl.
, vol.33
, pp. 45-76
-
-
-
15
-
-
19644376049
-
-
a) J.-N. Denis, A. Correa, A. E. Greene, J. Org. Chem. 1990, 55, 1957-1959;
-
(1990)
J. Org. Chem.
, vol.55
, pp. 1957-1959
-
-
Denis, J.-N.1
Correa, A.2
Greene, A.E.3
-
16
-
-
0001529383
-
-
b) G. Li, H.-T. Chang, K. B. Sharpless, Angew. Chem. 1996, 108, 449-452; Angew. Chem. Int. Ed. Engl. 1996, 35, 448-451;
-
(1996)
Angew. Chem.
, vol.108
, pp. 449-452
-
-
Li, G.1
Chang, H.-T.2
Sharpless, K.B.3
-
17
-
-
33750247077
-
-
b) G. Li, H.-T. Chang, K. B. Sharpless, Angew. Chem. 1996, 108, 449-452; Angew. Chem. Int. Ed. Engl. 1996, 35, 448-451;
-
(1996)
Angew. Chem. Int. Ed. Engl.
, vol.35
, pp. 448-451
-
-
-
18
-
-
0344218095
-
-
c) C. Gennari, A. Vulpetti, M. Donghi, N. Mongelli, E. Vanotti, ibid. 1996, 108, 1809-1812 and 1996, 35, 1723-1725, and references therein.
-
(1996)
Angew. Chem. Int. Ed. Engl.
, vol.108
, pp. 1809-1812
-
-
Gennari, C.1
Vulpetti, A.2
Donghi, M.3
Mongelli, N.4
Vanotti, E.5
-
19
-
-
0029742395
-
-
and references therein
-
c) C. Gennari, A. Vulpetti, M. Donghi, N. Mongelli, E. Vanotti, ibid. 1996, 108, 1809-1812 and 1996, 35, 1723-1725, and references therein.
-
(1996)
Angew. Chem. Int. Ed. Engl.
, vol.35
, pp. 1723-1725
-
-
-
20
-
-
0028213668
-
-
a) R. A. Holton, C. Somoza, H.-B. Kim, F. Liang, R. J. Biediger, P. D. Boatman, M. Shindo, C. C. Smith, S. Kim, H. Nadizadeh, Y. Suzuki, C. Tao, P. Vu, S. Tang, P. Zhang, K. K. Murthi, L. N. Gentile, J. H. Liu, J. Am. Chem. Soc. 1994, 116, 1597-1600;
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 1597-1600
-
-
Holton, R.A.1
Somoza, C.2
Kim, H.-B.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.12
Vu, P.13
Tang, S.14
Zhang, P.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
21
-
-
0028012837
-
-
b) K. C. Nicolaou, Z. Yang, J. J. Liu, H. Ueno, P. G. Nantermet, R. K. Guy, C. F. Claiborne, J. Renaud, E. A. Couladouros, K. Paulvannan, E. J. Sorensen, Nature 1994, 367, 630-634;
-
(1994)
Nature
, vol.367
, pp. 630-634
-
-
Nicolaou, K.C.1
Yang, Z.2
Liu, J.J.3
Ueno, H.4
Nantermet, P.G.5
Guy, R.K.6
Claiborne, C.F.7
Renaud, J.8
Couladouros, E.A.9
Paulvannan, K.10
Sorensen, E.J.11
-
22
-
-
11044223276
-
-
c) S. J. Danishesfsky, J. J. Masters, W. B. Young, J. T. Link, L. B. Snyder, T. V. Magee, D. K. Jung, R. C. A. Isaacs, W. G. Bornmann, C. A. Alaimo, C. A. Coburn, M. J. DiGrandi, J. Am. Chem. Soc. 1996, 118, 2843-2859;
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2843-2859
-
-
Danishesfsky, S.J.1
Masters, J.J.2
Young, W.B.3
Link, J.T.4
Snyder, L.B.5
Magee, T.V.6
Jung, D.K.7
Isaacs, R.C.A.8
Bornmann, W.G.9
Alaimo, C.A.10
Coburn, C.A.11
Digrandi, M.J.12
-
23
-
-
0030936927
-
-
d) P. A. Wender, N. F. Badham, S. P. Conway, P. E. Floreancig, T. E. Glass, J. B. Houze, N. E. Krauss, D. Lae, D. G. Marquess, P. L. McGrane, W. Meng, M. G. Natchus, A. J. Shuker, J. C. Sutton, R. E. Taylor, ibid. 1997, 119, 2757-2758;
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 2757-2758
-
-
Wender, P.A.1
Badham, N.F.2
Conway, S.P.3
Floreancig, P.E.4
Glass, T.E.5
Houze, J.B.6
Krauss, N.E.7
Lae, D.8
Marquess, D.G.9
McGrane, P.L.10
Meng, W.11
Natchus, M.G.12
Shuker, A.J.13
Sutton, J.C.14
Taylor, R.E.15
-
24
-
-
0000922774
-
-
e) L. Wessjohann, Angew. Chem. 1994, 106, 1011-1013; Angew. Chem. Int. Ed. Engl. 1994, 33, 959-961.
-
(1994)
Angew. Chem.
, vol.106
, pp. 1011-1013
-
-
Wessjohann, L.1
-
25
-
-
33748234559
-
-
e) L. Wessjohann, Angew. Chem. 1994, 106, 1011-1013; Angew. Chem. Int. Ed. Engl. 1994, 33, 959-961.
-
(1994)
Angew. Chem. Int. Ed. Engl.
, vol.33
, pp. 959-961
-
-
-
26
-
-
0027270462
-
-
a) A. Stierle, G. Strobel, D. Stierle, Science 1993, 260, 214-216;
-
(1993)
Science
, vol.260
, pp. 214-216
-
-
Stierle, A.1
Strobel, G.2
Stierle, D.3
-
27
-
-
85033134789
-
-
Novopharm Ltd., WO 9632490 A1, 1996
-
b) J. S. Dahiya (Novopharm Ltd.), WO 9632490 A1, 1996 [Chem. Abstr. 1996, 125, 326547];
-
(1996)
Chem. Abstr.
, vol.125
, pp. 326547
-
-
Dahiya, J.S.1
-
28
-
-
85033138044
-
-
note
-
c) Horizontal gene transfer may also have been performed the other way around, or could have even developed co-evolutively. However, since taxoids are typical plant products, the direction favored here seems to be most likely;
-
-
-
-
31
-
-
0026556079
-
-
b) A. I. Scott, Tetrahedron 1992, 48, 2559-2578;
-
(1992)
Tetrahedron
, vol.48
, pp. 2559-2578
-
-
Scott, A.I.1
-
32
-
-
0642379920
-
-
personal communication
-
c) personal communication, 1996.
-
(1996)
-
-
-
34
-
-
0026801417
-
-
b) L. O. Zamir, M. E. Nedea, F. X. Garneau, Tetrahedron Lett. 1992, 33, 5235-5236;
-
(1992)
Tetrahedron Lett.
, vol.33
, pp. 5235-5236
-
-
Zamir, L.O.1
Nedea, M.E.2
Garneau, F.X.3
-
35
-
-
0030199999
-
-
c) Y. Boulanger, A. Khiat, Z.-H. Zhou, G. Caron, L. O. Zamir, Tetrahedron 1996, 52, 8957-8968.
-
(1996)
Tetrahedron
, vol.52
, pp. 8957-8968
-
-
Boulanger, Y.1
Khiat, A.2
Zhou, Z.-H.3
Caron, G.4
Zamir, L.O.5
-
36
-
-
0030003383
-
-
W. Eisenreich, B. Menhard, P. J. Hylands, M. H. Zenk, A. Bacher, Proc. Natl. Acad. Sci. USA 1996, 93, 6431-6436.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 6431-6436
-
-
Eisenreich, W.1
Menhard, B.2
Hylands, P.J.3
Zenk, M.H.4
Bacher, A.5
-
37
-
-
0004081262
-
-
VCH, Weinheim
-
a) D. Voet, J. G. Voet, Biochemie, 1994, VCH, Weinheim, p. 639-659;
-
(1994)
Biochemie
, pp. 639-659
-
-
Voet, D.1
Voet, J.G.2
-
38
-
-
0027368126
-
-
b) M. Rohmer, M. Knani, P. Simonin, B. Sutter, H. Sahm, Biochem. J. 1993, 295, 517-524;
-
(1993)
Biochem. J.
, vol.295
, pp. 517-524
-
-
Rohmer, M.1
Knani, M.2
Simonin, P.3
Sutter, B.4
Sahm, H.5
-
39
-
-
0030605182
-
-
c) H. Seto, H. Watanabe, K. Furihata, Tetrahedron Lett. 1996, 37, 7979-7982.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 7979-7982
-
-
Seto, H.1
Watanabe, H.2
Furihata, K.3
-
40
-
-
0028964563
-
-
A. E. Koepp, M. Hezari, J. Zajicek, B. Stofer Vogel, R. E. LaFever, G. N. Lewis, R. Croteau, J. Biol. Chem. 1995, 270, 8686-8690.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 8686-8690
-
-
Koepp, A.E.1
Hezari, M.2
Zajicek, J.3
Stofer Vogel, B.4
LaFever, R.E.5
Lewis, G.N.6
Croteau, R.7
-
42
-
-
0029979356
-
-
X. Lin, M. Hezari, A. E. Koepp, H. G. Floss, R. Croteau, Biochemistry 1996, 35, 2968-2977.
-
(1996)
Biochemistry
, vol.35
, pp. 2968-2977
-
-
Lin, X.1
Hezari, M.2
Koepp, A.E.3
Floss, H.G.4
Croteau, R.5
-
43
-
-
0030154837
-
-
a) J. Hefner, S. M. Rubenstein, R. E. B. Ketchum, D. M. Gibson, R. M. Williams, R. Croteau, Chem. Biol. 1996, 3, 479-489;
-
(1996)
Chem. Biol.
, vol.3
, pp. 479-489
-
-
Hefner, J.1
Rubenstein, S.M.2
Ketchum, R.E.B.3
Gibson, D.M.4
Williams, R.M.5
Croteau, R.6
-
45
-
-
0023074211
-
-
a) F. Guéritte-Voegelein, D. Guénard, P. Poitier, J. Nat. Prod. 1987, 50, 9-18;
-
(1987)
J. Nat. Prod.
, vol.50
, pp. 9-18
-
-
Guéritte-Voegelein, F.1
Guénard, D.2
Poitier, P.3
-
46
-
-
0002553350
-
-
Ed.: M. Suffness, CRC Press, Boca Raton, FL, USA
-
b) H. G. Floss, U. Mocek, in Taxol: Science and Applications (Ed.: M. Suffness), 1995, CRC Press, Boca Raton, FL, USA, pp. 191-208.
-
(1995)
Taxol: Science and Applications
, pp. 191-208
-
-
Floss, H.G.1
Mocek, U.2
-
47
-
-
0027518386
-
-
a) P. E. Fleming, U. Mocek, H. G. Floss, J. Am. Chem. Soc. 1993, 115, 805-807;
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 805-807
-
-
Fleming, P.E.1
Mocek, U.2
Floss, H.G.3
-
48
-
-
0642288125
-
-
personal communication
-
b) H. G. Floss, personal communication, 1997.
-
(1997)
-
-
Floss, H.G.1
-
49
-
-
0028137438
-
-
K.-H. Han, P. Fleming, K. Walker, M. Loper, W. S. Chilton, U. Mocek, M. P. Gordon, H. G. Floss, Plant Sci. 1994, 95, 187.
-
(1994)
Plant Sci.
, vol.95
, pp. 187
-
-
Han, K.-H.1
Fleming, P.2
Walker, K.3
Loper, M.4
Chilton, W.S.5
Mocek, U.6
Gordon, M.P.7
Floss, H.G.8
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