Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis

Journal of Neuroscience Research

Volumn 45, Issue 3, 1996, Pages 276-281

  Fujita, Kimikazu ^a,d   Yamauchi, M ^a   Shibayama, K ^a   Ando, M ^b   Honda, M ^c   Nagata, Y ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUSEN UNIVERSITY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

amyotrophic lateral sclerosis; cytochrome c oxidase; glutathione peroxidase; human spinal cord; superoxide dismutase

Indexed keywords

CYTOCHROME C OXIDASE; GLUTATHIONE PEROXIDASE; MEMBRANE LIPID; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; DEGENERATIVE DISEASE; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; MITOCHONDRIAL MEMBRANE; MOTONEURON; OXIDATIVE PHOSPHORYLATION; POINT MUTATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SPINAL CORD TRANSSECTION; TISSUE DEGENERATION;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ELECTRON TRANSPORT COMPLEX IV; FEMALE; GLUTATHIONE PEROXIDASE; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONS; OXIDATIVE STRESS; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 0029744863     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960801)45:3<276::AID-JNR9>3.0.CO;2-A     Document Type: Article

References (24)

1. Almeida A, Allen KL, Bates TE, Clark JB (1995): Effect of reperfusion following cerebral ischemic on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 65:1698-1703.
2. Bowling AC, Mitisya EM, Walken LC, Price DL, Cork LC, Beal MF (1993a): Age-dependent impairment of mitochondrial in primate brain. J Neurochem 60:1964-1967.
3. Bowling AC, Schulz JB, Brown RH Jr, Beal MF (1993b): Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 61:2322-2325.
4. Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Caroscio JT, Mulvihill MM, Sterling R, Abrams B (1987): Amyotrophic lateral sclerosis; its natural history. Neurol Clin 5:1-8.
6. 2 in erythrocytes. Biochemistry 2:1420-1428.
7. Deng H-X, Hentati A, Tainer JA, Iqbal Z, Gayabyab A, Hung W-Y, Geetzoof ED, Hu P, Herzfeld B, Roos RP, Warber C, Deng G, Soriano E, Smyth C, Ahmed A, Roses AD, Hallewell RA, Pericak-Vance MA, Siddique T (1993): Amyotrophic lateral sclerosis and structural defect in Cu, Zn superoxide dismutase. Science 261:1047-1051.
8. Fujita K, Ando M, Yamauchi M, Nagata Y, Honda M (1995): Alteration of transglutaminase activity in rat and human spinal cord after neuronal degeneration. Neurochem Res 20:1195-1201.
9. Gsell W, Conrad R, Hickethier M, Sofic E, Fralich L, Wichart I, Jellinger K, Moll G, Ransmayer G, Beckman H, Riederer P (1995): Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J Neurochem 64:1216-1223.
10. Hattori N, Tanaka M, Ozawa T, Mizuno Y (1995): Immunohistochemical studies on complexes I, II, III, and IV of mitochondrial in Parkinson's disease. Ann Neurol 30:563-571.
11. Ikebe SI, Tanaka M, Ozawa T (1995): Point mutations of mitochondrial genome in Parkinson's disease. Mol Brain Res 28:281-295.
12. Kumar R, Agarwal AK, Seth PK (1995): Free radical-generated neurotoxicity of 6-hydroxydopamine. J Neurochem 64:1703-1707.
13. Lawrence RA, Burk RF (1976): Glutathione peroxidase in selenius-deficient rat liver. Biochem Biophys Res Commun 71:952-957.
14. Linnane AW, Marzuki S, Ozawa T, Tanaka M (1989): Mitochondrial DNA mutations as an important contributor to aging and degenerative disease. Lancet 1:642-645.
15. Misra HP, Fridovich I (1972): The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170-3175.
16. Mizuno Y, Ikebe SI, Hattori N, Nakagawa-Hattori Y, Mochozuki H, Tanaka M, Ozawa T (1995): Role of mitochondria in the etiology and pathogenesis of Parkinson's disease. Biochim Biophys Acta 1271:265-274.
17. Mügge HP, Elwell JH, Peterson TE, Harrison DG (1991): Release of intact endothelium-derived relaxing factor depends on endothelial SOD activity. Am J Physiol 260:C219-C222.
18. Nagata Y, Okuya M, Watanabe R, Honda M (1982): Regional distribution of cholinergic neurons in human spinal cord in the patients with and without motor neuron disease. Brain Res 244:223-229.
19. Ogasawara M, Matsubara Y, Narisawa K, Aoki M, Nakamura S, Itoyama Y, Abe K (1993): Mild ALS in Japan associated with novel SOD mutation. Nat Genet 5:323-324.
20. Przedborski S, Jackson-Lewis V, Kostic V, Carlson E, Epstein CJ, Cadet JL (1992): Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/zinc-superoxide dismutase transgenic mice. J Neurochem 58:1760-1767.
21. Richter C, Park J-W, Ames BN (1988): Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85:6465-6467.
22. Robberecht W, Sapp P, Viaene MK, Rosen D, McKenna-Yasek D, Haines J, Horocitz R, Theys P, Brown R Jr (1994): Cu/Zn superoxide dismutase in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 62:384-387.
23. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentai A, Donaldson D, Goto J, O'Regan JP, Deng H-X, Rahmani Z, Krizus A, McKenna-Ysek D, Cayabyab A, Gaston SM, Berger R, Tanzi R, Halperin JJ, Herzfeld B, Van den Bergh R, Hung W, Bird T, Deng G, Mulder DW, Smyth C, Laing NG, Soriano E, Pericak-Vance MA, Haines J, Rouleau GA, Gusella JS, Horovitz HR, Brown RH Jr (1993): Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62.
24. Wharton DC, Tzagoloff A (1967): Cytochrome oxidase from beef heart mitochondria. Methods Enzymol 10:245-250.