Cell mediated immunity in virus infections

Bioscience Reports

Volumn 17, Issue 4, 1997, Pages 367-387

  Doherty, Peter C ^a  

^a St Jude Children's Research Hospital   (United States)

Author keywords

Cell mediated immunity; Histocompatibility complex; Immunity; Inflammatory MHC; T cell; Virus infection

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; INFLAMMATION; INFLUENZA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; RESPIRATORY TRACT INFECTION; REVIEW; SENDAI VIRUS; T LYMPHOCYTE; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS PATHOGENESIS;

ANIMALS; HUMANS; IMMUNITY, CELLULAR; VIRUS DISEASES;

CHORIOMENINGITIS VIRUS; INFLUENZA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; SENDAI VIRUS;

EID: 0030717427     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027305300453     Document Type: Review

References (121)

1. Fazekas de St. Groth, S. (1962) The neutralization of viruses. Adv. Virus Res. 9:1.
2. Colman, P. M. et al. (1987) Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature 326:358.
3. Doherty, P. C. and Zinkernagel, R. M. (1974) T-cell-mediated immunopathology in viral infections. Transplant Rev. 19:89.
4. Zinkernagel, R. M. and Doherty, P. C. (1974) Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248:701.
5. Zinkernagel, R. M. and Doherty, P. C. (1974) Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 251:547.
6. Doherty, P. C. and Zinkernagel, R. M. (1975) A biological role for the major histocompatibility antigens. Lancet 1:1406.
7. Fenner, F. (1948) The clinical features and pathogenesis of mouse-pox (infectious ectromelia of mice). J. Path. Bact. 4:529.
8. Burnet, F. M. (1957) A modification of Jerne's theory of antibody production using the concept of clonal selection. Aust. J. Sci. 20:67.
9. Mims, C. A. (1966) Pathogenesis of rashes in virus diseases. Bacteriol. Rev. 30:739.
10. Mackaness, G. B. and Blanden, R. V. (1967) Cellular immunity. Prog. Allergy 11:89.
11. Blanden, R. V. (1970) Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J. Exp. Med. 132:1035.
12. Blanden, R. V. (1971) Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J. Exp. Med. 133:1074.
13. Blanden, R. V. (1971) Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. J. Exp. Med. 133:1090.
14. Doherty, P. C. (1973) Quantitative studies of the inflammatory process in fatal viral meningoencephalitis. Am. J. Pathol. 73:607.
15. Merz, P. A., Merz, G. S. and Carp, R. I. (1973) Higher frequency of a protein band in the cerebrospinal fluid from scrapie mice. Res. Vet. Sci. 14:392.
16. Rowe, W. P., Black, P. H. and Levey, R. H. (1963) Protective effect of neonatal thymectomy on mouse LCM infection. Proc. Soc. Exp. Biol. Med. 114:248.
17. Hotchin, J. and Sikora, E. (1964) Protection against the lethal effects of lymphocytic choriomeningitis in mice by neonatal thymectomy. Nature 202:214.
18. Gilden, D. H., Cole, G. A. and Nathanson, N. (1972) Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers. J. Exp. Med. 135:874.
19. Cerottini, J. C. and Brunner, K. T. (1974) Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv. Immunol. 18:67.
20. Oldstone, M. B. and Dixon, F. J. (1970) Tissue injury in lymphocytic choriomeningitis viral infection: virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells. Virology 42:805.
21. Marker, O. and Volkert, M. (1973) Studies on cell-mediated immunity to lymphocytic choriomeningitis virus in mice. J. Exp. Med. 137:1511.
22. Zinkernagel, R. M. and Doherty, P. C. (1973) Cytotoxic thymus-derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis. J. Exp. Med. 138:1266.
23. Katz, D. H., Hamaoka, T., Dorf, M. E. and Benacerraf, B. (1973) Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions. Proc. Natl. Acad. Sci. U.S.A. 70:2624.
24. Rosenthal, A. S. and Shevach, E. M. (1973) Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J. Exp. Med. 138:1194.
25. Benacerraf, B. and Katz, D. H. (1975) The histocompatibility-linked immune response genes. Adv. Cancer Res. 21:121.
26. Klein, J. (1975) "Biology of the Mouse Histocompatibility-2 Complex", Springer-Verlag, Berlin and New York.
27. Oldstone, M. B., Dixon, F. J., Mitchell, G. F. and McDevitt, H. O. (1973) Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection. J. Exp. Med. 137:1201.
28. Zinkernagel, R. M. and Doherty, P. C. (1975) Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro. J. Immunol. Methods 8:263.
29. Doherty, P. C. and Zinkernagel, R. M. (1975) H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. J. Exp. Med. 141:502.
30. Doherty, P. C., Biddison, W. E., Bennink, J. R. and Knowles, B. B. (1978) Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype. J. Exp. Med. 148:534.
31. Zinkernagel, R. M., et al. (1978) Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness. J. Exp. Med. 148:592.
32. Gardner, I. D., Bowern, A. and Blanden, R. V. (1975) Cell-mediated cytotoxicity against ectromelia virus-infected target cells. III. Role of the H-2 gene complex. Eur. J. Immunol. 5:122.
33. Blanden, R. V., Doherty, P. C., Dunlop, M. B., Gardner, I. D., Zinkernagel, R. M. and David, C. S. (1975) Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex. Nature 254:269.
34. Doherty, P., Blanden, R. V. and Zinkernagel, R. M. (1976) Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant. Rev. 29:89.
35. Zinkernagel, R. M. (1996) Cellular immune recognition and the biological role of Major transplantation antigens. Nobel Lecture.
36. Bevan, M. J. (1975) The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens. J. Exp. Med. 142:1349.
37. Gordon, R. D., Simpson, E. and Samelson, L. E. (1975) In vitro cell-mediated immune response to the male specific (H-Y) antigen in mice. J. Exp. Med. 142:1108.
38. Doherty, P. C. and Zinkernagel, R. M. (1975) Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex. Nature 256:50.
39. Doherty, P. C., Knowles, B. B. and Wettstein, P. J. (1984) Immunological surveillance of tumors in the context of major histocompatibility complex restriction of T cell function. Adv. Cancer Res. 42:1.
40. Burnet, F. M. (1971) Immunological surveillance in neoplasia. Transplant. Rev. 7:3.
41. Bennink, J. R. and Doherty, P. C. (1981) The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment. Cell. Immunol. 61:220.
42. Doherty, P. C. (1987) Historical developments in understanding the function of class I MHC genes in: "H-2 Antigens, Genes Molecules and Functions", C. S. David ed, NATO ASI series, Plenum Press, New York and London, p. 341.
43. Townsend, A. R., Rothbard, J., Gotch, F. M., Bahadur, G., Wraith, D. and McMichael, A. J. (1986) The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44:959.
44. Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L. and Wiley, D. C. (1987) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512.
45. Davis, M. M. (1990) T cell receptor gene diversity and selection. Annu. Rev. Biochem. 59:475.
46. Garcia, K. C., et al. (1996) An αβ T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274:209.
47. Garboczi, D. N., Ghosh, P., Fan, Q. R., Biddison, W. E. and Wiley, D. C. (1996) Structure of the complex between human T cell receptor, viral peptide and HLA-A2. Nature 384:134.
48. + lymphocyte subsets. Microb. Pathog. 14:75.
49. Blanden, R. V. and Mims, C. A. (1973) Macrophage activation in mice infected with ectromelia or lymphocyte choriomeningitis viruses. Aust. J. Exp. Biol. Med. Sci. 51:393.
50. Lynch, F., Doherty, P. C. and Ceredig, R. (1989) Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection. J. Immunol. 142:3592.
51. Doherty, P. C. and Zinkernagel, R. M. (1975) Capacity of sensitized thymus-derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H-2 gene complex. J. Immunol. 114:30.
52. Doherty, P. C., Dunlop, M. B., Parish, C. R. and Zinkernagel, R. M. (1976) Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions. J. Immunol. 117:187.
53. Guidotti, L. G., et al. (1996) Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc. Natl. Acad. Sci. U.S.A. 93:4589.
54. Doherty, P. C. and Allan, J. E. (1986) Role of the major histocompatibility complex in targeting effector T cells into a site of virus infection [published erratum appears in Eur J Immunol 1986 Dec; 16(12):1646]. Eur. J. Immunol. 16:1237.
55. Doherty, P. C., Ceredig, R. and Allan, J. E. (1988) Immunogenetic analysis of cellular interactions governing the recruitment of T lymphocytes and monocytes in lymphocytic choriomeningitis virus-induced immunopathology. Clin. Immunol. Immunopathol. 47:19.
56. + T cells. Immunol. Today 11:55.
57. Kagi, D., et al. (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
58. Fung-Leung, W. P., Kundig, T. M., Zinkernagel, R. M. and Mak, T. W. (1991) Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J. Exp. Med. 174:1425.
59. Doherty, P. C., Hou, S. and Southern, P. J. (1993) Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins. J. Neuroimmunol. 46:11.
60. Lehmann-Grube, F., Lohler, J., Utermohlen, O. and Gegin, C. (1993) Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene. J. Virol. 67:332.
61. Zijlstra, M., Bix, M., Simister, N. E., Loring, J. M., Raulet, D. H. and Jaenisch, R. (1990) Beta 2-microglobulin deficient mice lack CD4-8 + cytolytic T cells. Nature 344:742.
62. Doherty, P. C. and Zinkernagel, R. M. (1976) Specific immune lysis of paramyxovirus-infected cells by H-2-compatible thymus-derived lymphocytes. Immunology 31:27.
63. Koszinowski, U. and Ertl, H. (1975) Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus. Nature 255:552.
64. + T cells. J. Immunol. 149:1319.
65. Hou, S., Mo, X. Y., Hyland, L. and Doherty, P. C. (1995) Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins. J. Virol. 69:1429.
66. Webster, R. G., Bean, W. J., German, O. T., Chambers, T. M. and Kawaoka, Y. (1992) Evolution and ecology of influenza A viruses. Microbiol. Rev. 56:152.
67. Effros, R. B., Doherty, P. C., Gerhard, W. and Bennink, J. (1977) Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses. J. Exp. Med. 145:557.
68. Doherty, P. C., Effros, R. B. and Bennink, J. (1977) Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses. Proc. Natl. Acad. Sci. U.S.A. 74:1209.
69. Zweerink, H. J., Courtneidge, S. A., Skehel, J. J., Crumpton, M. J. and Askonas, B. A. (1977) Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses. Nature 267:354.
70. Zinkernagel, R. M. and Doherty, P. C. (1979) MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv. Immunol. 27:51.
71. Effros, R. B., Bennink, J. and Doherty, P. C. (1978) Characteristics of secondary cytotoxic T-cell responses in mice infected with influenza A viruses. Cell. Immunol. 36:345.
72. Andrew, M. E., Coupar, B. E., Boyle, D. B. and Ada, G. L. (1987) The roles of influenza virus haemagglutinin and nucleoprotein in protection: analysis using vaccinia virus recombinants. Scand. J. Immunol. 25:21.
73. Doherty, P. C., Allan, W., Boyle, D. B., Coupar, B. E. and Andrew, M. E. (1989) Recombinant vaccinia viruses and the development of immunization strategies using influenza virus. J. Infect Dis. 159:1119.
74. Lawson, C. M., Bennink, J. R., Restifo, N. P., Yewdell, J. W. and Murphy, B. R. (1994) Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge. J. Virol. 68:3505.
75. Zinkernagel, R. M. and Rosenthal, K. L. (1981) Experiments and speculation on antiviral specificity of T and B cells. Immunol. Rev. 58:131.
76. Marshak, A., Doherty, P. C. and Wilson, D. B. (1977) The control of specificity of cytotoxic T lymphocytes by the major histocompatibility complex (AG-B) in rats and identification of a new alloantigen system showing no AG-B restriction. J. Exp. Med. 146:1773.
77. McMichael, A. J., Ting, A., Zweerink, H. J. and Askonas, B. A. (1977) HLA restriction of cell-mediated lysis of influenza virus-infected human cells. Nature 270:524.
78. Townsend, A. R., McMichael, A. J., Carter, N. P., Huddleston, J. A. and Brownlee, G. G. (1984) Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells. Cell 39:13.
79. Bennink, J. R. and Yewdell, J. W. (1990) Recombinant vaccinia viruses as vectors for studying T lymphocyte specificity and function. Curr. Top. Microbiol. Immunol. 163:153.
80. Lukacher, A. E., Braciale, V. L. and Braciale, T. J. (1984) In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J. Exp. Med. 160:814.
81. Openshaw, P. J. (1989) Flow cytometric analysis of pulmonary lymphocytes from mice infected with respiratory syncytial virus. Clin. Exp. Immunol. 75:324.
82. Doherty, P. C., Allan, W., Eichelberger, M. and Carding, S. R. (1992) Roles of alpha beta and gamma delta T cell subsets in viral immunity. Annu. Rev. Immunol. 10:123.
83. Doherty, P. C. (1996) Immune response to viruses. in: Clinical Immunology, Principles and Practice. R. R. Rich, T. A. Fleischer, B. D. Schwartz, W. T. Shearer, and W. Strober eds, Mosby, St. Louis, p. 535.
84. Eichelberger, M., C., Wang, M., Allan, W., Webster, R. G. and Doherty, P. C. (1991) Influenza virus RNA in the lung and lymphoid tissue of immunologically intact and CD4-depleted mice. J. Gen. Virol. 72:1695.
85. + T cell memory. Immunol. Rev. 150:23.
86. + T cells requires direct targeting to virus-infected epithelium. Eur. J. Immunol. 25:111.
87. + T cells. J. Exp. Med. 174:875.
88. Bender, B. S., Croghan, T., Zhang, L. and Small, P. A., Jr. (1992) Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J. Exp. Med. 175:1143.
89. 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase. J. Immunol. 150:5484.
90. + T cells promote the clearance of influenza virus from major histocompatibility complex class II - / - respiratory epithelium. J. Virol. 70:1288.
91. Palladino, G., Mozdzanowska, K., Washko, G. and Gerhard, W. (1995) Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J. Virol. 69:2075.
92. Doherty, P. C., Reid, H. W. and Smith, W. (1971) Louping-ill encephalomyelitis in the sheep. IV. Nature of the perivascular inflammatory reaction. J. Comp. Pathol. 81:545.
93. Doherty, P. C. and Reid, H. W. (1971) Louping-ill encephalomyelitis in the sheep. II. Distribution of virus and lesions in nervous tissue. J. Comp. Pathol. 81:531.
94. Reid, H. W., Doherty, P. C. and Dawson, A. M. (1971) Louping-ill encephalomyelitis in the sheep. 3. Immunoglobulins in cerebrospinal fluid. J. Comp. Pathol. 81:537.
95. Tyor, W. R. and Griffin, D. E. (1993) Virus specificity and isotype expression of intraparenchymal antibody-secreting cells during Sindbis virus encephalitis in mice. J. Neuroimmunol. 48:37.
96. Ceredig, R., Allan, J. E., Tabi, Z., Lynch, F. and Doherty, P. C. (1987) Phenotypic analysis of the inflammatory exudate in murine lymphocyte choriomeningitis. J. Exp. Med. 165:1539.
97. Doherty, P. C., Allan, J. E. and Ceredig, R. (1988) Contributions of host and donor T cells to the inflammatory process in murine lymphocytic choriomeningitis. Cell. Immunol. 116:475.
98. Allan, W., Tabi, Z., Cleary, A. and Doherty, P. C. (1990) Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells. J. Immunol. 144:3980.
99. Tripp, R. A., Hou, S., McMickle, A., Houston, J. and Doherty, P. C. (1995) Recruitment and proliferation of CD8+ T cells in respiratory virus infections. J. Immunol. 154:6013.
100. Hou, S., Hyland, L., Ryan, K. W., Portner, A. and Doherty, P. C. (1994) Virus-specific CD8+ T-cell memory determined by clonal burst size. Nature 369:652.
101. b gene. J. Immunol. 155:2955.
102. Bodner, H., Obert, G., Chan, S., Benoist, C. and Mathis, D. (1993) Environmental modulation of the autonomy of cytotoxic T lymphocytes. Eur. J. Immunol. 23:1649.
103. Bennink, J. R. and Doherty, P. C. (1979) Reciprocal stimulation of negatively selected high-responder and low-responder T cells in virus-infected recipients. Proc. Natl. Acad. Sci. U.S.A. 76:3482.
104. Androwlewicz, M. J. and Creswell, P. (1996) How selective is the transporter associated with antigen processing? Immunity 5:1.
105. Owen, J. A., Allouche, M. and Doherty, P. C. (1982) Limiting dilution analysis of the specificity of influenza-immune cytotoxic T cells. Cell. Immunol. 67:49.
106. b. J. Immunol. 129:689.
107. Webb, S., Morris, C. and Sprent, J. (1990) Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
108. McCormack, J. E., Callahan, J. E., Kappler, J. and Marrack, P. C. (1993) Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785.
109. + memory T cells. J. Immunol. 154:5870.
110. Ahmed, R. and Gray, D. (1996) Immunological memory and protective immunity: Understanding their relation. Science 272:54.
111. Paul, W. E., Shevach, E. M., Pickeral, S., Thomas, D. W. and Rosenthal, A. S. (1977) Independent populations of primed F1 guinea pig T lymphocytes respond to antigen-pulsed parental peritoneal exudate cells. J. Exp. Med. 145:618.
112. Tripp, R. A., Lahti, J. M. and Doherty, P. C. (1995) Laser light suicide of proliferating virus-specific CD8+ T cells in an in vivo response. J. Immunol. 155:3719.
113. Tough, D. F. and Sprent, J. (1994) Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127.
114. Freitas, A. A. and Rocha, B. B. (1993) Lymphocyte lifespans: homeostasis, selection and competition. Immunol. Today 14:25.
115. Matzinger, P. (1994) Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991.
116. Perelson, A. S., Neumann, A. U., Markowit, M., Leonard, J. M. and Ho, D. D. (1996) HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span and viral generation time. Science 271:1582.
117. Waldrop, M. W. (1992) "Complexity: the emerging science at the edge of chaos." Simon and Shuster, New York.
118. Doherty, P. C. (1995) Immunity to viruses. The Immunologist 3:231.
119. + T cell memory in the absence of B cells and Ig. J. Immunol. 157:2947.
120. + T cells. J. Exp. Med. 184:863.
121. + T cells in lymph node and lung of mice with Sendai virus pneumonia by LECAM-1 and CD45RB phenotype. J. Immunol. 150:5494.