Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia

Brain Research

Volumn 773, Issue 1-2, 1997, Pages 61-65

  Umemura, K ^a   Shimakura, A ^a   Nakashima, M ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

AMPA receptor antagonist; Focal cerebral ischaemia; YM90K

Indexed keywords

6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOEMBOLISM;

ANIMALS; CEREBRAL ARTERIES; CEREBRAL CORTEX; CEREBRAL INFARCTION; CORPUS STRIATUM; ENDOTHELIUM, VASCULAR; EXCITATORY AMINO ACID ANTAGONISTS; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; PLATELET ADHESIVENESS; PLATELET AGGREGATION; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, AMPA;

EID: 0030704290     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00894-9     Document Type: Article

References (25)

1. Baldwin H.A., Williams J.L., Snares M., Ferreria T., Cross A.J., Gree A.R. Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat. Br. J. Pharmacol. 112:1994;188-194.
2. Benveniste H., Drejer J., Schousboe A., Diemer N.H. Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
3. Buchan A.M., Li H., Cho S., Pulsinelli W.A. Blockade of the AMPA receptor prevent CA1 hippocampal injury following severe but transient forebrain ischaemia in adult rats. Neurosci. Lett. 132:1991;255-258.
4. Buchan A.M., Slivka A., Xue D. The effect of the NMDA antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke. Brain Res. 574:1992;171-177.
5. Bullock R., Graham D.I., Swanson S., McCulloch J. Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat. J. Cereb. Blood Flow Metab. 14:1994;466-471.
6. Butcher S.P., Bullock R., Graham D.I., McCulloch J. Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion. Stroke. 21:1990;1727-1733.
7. Choi D.W. Glutamate neurotoxicity and diseases in the nervous system. Neuron. 1:1988;623-634.
8. Gill R., Nordholm L., Lodge D. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemic model. Brain Res. 580:1992;35-43.
9. Globus M.Y., Busto R., Dietrich W.D., Martinez E., Valdes I. Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neurosci. Lett. 91:1988;36-40.
10. Hagberg H., Anderson P., Lacarewicz J., Jacobson I., Butcher S., Sandberg M. Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purine in rat striatum during transient ischemia. J. Neurochem. 49:1987;227-231.
11. Hillered L., Hallstrom A., Segersvard S., Persson L., Ungerstedt U. Dynamics of extracellular metabolites in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis. J. Cereb. Flow Metab. 9:1989;607-616.
12. Lekieffre D., Meldrum B.S. The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study. Neuroscience. 56:1993;93-99.
13. Le Peillet E., Arvin B., Moncada C., Meldrum B.S. The non-NMDA antagonist, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat. Brain Res. 571:1992;115-120.
14. Nellgard B., Weiloch T. Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia. J. Cereb. Flow Metab. 12:1992;2-11.
15. Ohmori J., Kubota H., Shimizu-Sasamata M., Okada M., Sakamoto S. Novel α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: synthesis and structure-activity relationships of 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds. J. Med. Chem. 39:1996;1331-1338.
16. Prehn J.H.M., Lippert K., Krieglstein J. Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury? Eur. J. Pharmacol. 292:1995;179-189.
17. Saniabadi A.R., Umemura K., Matsumoto S., Sakuma S., Nakashima M. Arterial thrombosis initiated by photochemical reaction: a consequence of vessel wall injury. Thromb. Haemostasis. 73:1995;868-872.
18. Sheardown M.J., Nielsen E.O., Hansen A.J., Jacobsen P., Honore T. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo-(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science. 247:1990;571-574.
19. Shimizu-Sasamata M., Kawasaki-Yatsugi S., Okada M., Sakamoto S., Yatsugi S., Togami J., Hatanaka K., Ohmori J., Koshiya K., Usuda S., Murase K. YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist. J. Pharmacol. Exp. Ther. 276:1996;84-92.
20. Smith S.E., Lekieffre D., Sowinski P., Meldrum B.S. Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat. NeuroReport. 4:1993;1339-1342.
21. Uchiyama-Tsuyuki Y., Araki H., Yae T., Otomo S. Changes in the extracellular concentrations of amino acids in the rat striatum during transient focal cerebral ischemia. J. Neurochem. 62:1994;1074-1078.
22. 2 receptor antagonist, vapiprost in rat middle cerebral artery thrombosis model. Stroke. 24:1993;1077-1081.
23. Umemura K., Gemba T., Mizuno A., Nakashima M. Inhibitory effect of MS-153 on elevated brain glutamate level induced by the rat middle cerebral artery occlusion. Stroke. 27:1996;1624-1628.
24. Wahl F., Obrenovitch T.P., Hardy A.M., Plotkine M., Boulu R., Symon L. Extracellular glutamate during focal cerebral ischaemia in rats: time course and calcium dependency. J. Neurochem. 63:1994;1003-1011.
25. Yatsugi S., Takahashi M., Kawasaki-Yatsugi S., Koshiya K., Sakamoto S., Uematsu D., Shimizu-Sasamata M. Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonist, in focal cerebral ischemia in cats. J. Cereb. Blood Flow Metab. 16:1996;959-966.