Cloning and localization of a double-pore K channel, KCNK1: Exclusive expression in distal nephron segments

American Journal of Physiology - Renal Physiology

Volumn 273, Issue 4 42-4, 1997, Pages

  Orias, Marcelo ^a   Velázquez, Heino ^a   Tung, Freeman ^a   Lee, George ^a   Desir, Gary V ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Connecting tubules; Cortical ascending limb; Cortical collecting ducts; Human gene; Potassium channel; Reverse transcription polymerase chain reaction

Indexed keywords

POTASSIUM CHANNEL;

ARTICLE; HUMAN; HUMAN TISSUE; KIDNEY COLLECTING TUBULE; KIDNEY PROXIMAL TUBULE; MOLECULAR CLONING; NEPHRON; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0030703601     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.273.4.f663     Document Type: Article

References (9)

1. Goldstein, S. A. N., L. A. Price, D. N. Rosenthal, and M. H. Pausch. ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93: 13256-13261, 1996.
2. Ho, K., C. G. Nichols, W. J. Lederer, J. Lytton, P. M. Vassilev, M. V. Kanazirska, and S. C. Hebert. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362: 31-37, 1993.
3. Ketchum, K. A., W. J. Joiner, A. J. Sellers, L. K. Kaczmarek, and S. A. N. Goldstein. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376: 690-695, 1995.
4. Kozak, M. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266: 19867-19870, 1991.
5. Kubo, Y., E. Reuveny, P. A. Slesinger, Y. N. Jan, and L. Y. Jan. Primary structure and functional expression of a rat G-coupled muscarinic potassium channel. Nature 364: 802-806, 1993.
6. + channel with a novel structure. EMBO J. 15: 1004-1011, 1996.
7. + channel with two pore domains and novel gating properties. J. Biol. Chem. 271: 4183-4187, 1996.
8. Timpe, L. C., T. L. Schwarz, B. L. Tempel, D. M. Papazian, Y. N. Jan, and L. Y. Jan. Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature 331: 143-145, 1988.
9. Wei, A., T. Jegla, and L. Salkoff. Eight potassium channel families revealed by the C. elegans genome project. Neuropharmacology 35: 805-829, 1996.