Intestinal absorption of stable cyclic glycylphenylalanine: Comparison with the linear form

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 11, 1997, Pages 1067-1071

  Mizuma, Takashi ^a   Masubuchi, Satoshi ^a   Awazu, Shoji ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CEFALEXIN; CYCLOPEPTIDE; GLYCYLPHENYLALANINE; GLYCYLSARCOSINE; PHENYLALANYLGLYCINE;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG ELIMINATION; DRUG STABILITY; DRUG TISSUE LEVEL; DRUG TRANSPORT; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; NONHUMAN; RAT; SEROSA;

EID: 0030696809     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06043.x     Document Type: Article

References (11)

1. Doluisio, J. T., Billups, N. F., Dittert, L. W., Sugita, E. T., Swintosky, J. V. (1969) Drug absorption I: an in situ rat gut technique yielding realistic absorption rates. J. Pharm. Sci. 58: 1196-1200
2. Fei, Y.-J., Kanai, Y., Nussberger, S., Ganapathy, V., Leibach, F. H., Romero, M. F., Singh, S. K., Boron, W. F., Hediger, M. A. (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368: 563-566
3. Ganapathy, V., Leibach, F. H. (1985) Is intestinal peptide transport energized by a proton gradient? Am. J. Physiol. 249: G153-G160
4. Gibaldi, M., Perrier, D. (1982) Pharmacokinetics 2nd edition, Marcel Dekker, New York, pp 1-43
5. + coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes. J. Pharmacol. Exp. Ther. 260: 482-486
6. Mizuma, T., Ohta, K., Hayashi, M., Awazu, S. (1992) Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs. Biochem. Pharmacol. 43: 2037-2039
7. Mizuma, T., Ohta, K., Koyanagi, A., Awazu, S. (1996) Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors. J. Pharm. Sci. 85: 854-857
8. Mizuma, T., Koyanagi, A., Awazu, S. (1997) Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: rate-limiting factor in intestinal absorption of peptide as drug. Biochim. Biophys. Acta 1335: 111-119
9. Nakashima, E., Tsuji, A., Mizuo, H., Yamana, T. (1984) Kinetics and mechanism of in vitro uptake of amino-β-lactam antibiotics by rat small intestine and relation to the intact-peptide transport system. Biochem. Pharmacol. 33: 3345-3352
10. Sakurada, S., Sakurada, T., Jin, H., Sato, T., Kisara, K., Sakai, Y., Suzuki, K. (1982) Antinociceptive activities of synthetic dipeptides in mice. J. Pharm. Pharmacol. 34: 750-751
11. Tamai, I., Tomizawa, N., Kadowaki, A., Terasaki, T., Nakayama, K., Higasida, H., Tsuji, A. (1994) Functional expression of intestinal dipeptide/β-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem. Pharmacol. 48: 881-888