Identification of amino acids in the τ2-region of the mouse glucocorticoid receptor that contribute to hormone binding and transcriptional activation

Molecular Endocrinology

Volumn 11, Issue 12, 1997, Pages 1795-1805

  Milhon, Jon ^a   Lee, Sunyoung ^a   Kohli, Kulwant ^a   Chen, Dagang ^a   Hong, Heng ^a   Stallcup, Michael R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; GLUCOCORTICOID RECEPTOR; GLYCINE; MUTANT PROTEIN;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; HORMONE RECEPTOR INTERACTION; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSACTIVATION; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; GLUCOCORTICOIDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RATS; RECEPTORS, GLUCOCORTICOID; TRANS-ACTIVATION (GENETICS);

ANIMALIA;

EID: 0030671031     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.11.12.1795     Document Type: Article

References (33)

1. Tsai M-J, O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486
2. Beato M, Herrlich P, Schütz G 1995 Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857
3. Danielsen M 1991 Structure and function of the glucocorticoid receptor. In: Parker MG (ed) Nuclear Hormone Receptors: Molecular Mechanisms, Cellular Functions, Clinical Abnormalities. Academic Press, London, pp 39-78
4. Ing NH, Beekman JM, Tsai SY, Tsai M-J, O'Malley BW 1992 Members of the steroid hormone receptor superfamily interact directly with TFIIB (S300II) to mediate transcriptional induction. J Biol Chem 267:17617-17623
5. Sadovsky Y, Webb P, Lopez G, Baxter JD, Fitzpatrick PM, Gizang-Ginsberg E, Cavaillès V, Parker MG, Kushner PJ 1995 Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein. Mol Cell Biol 15:1554-1563
6. II30 is present in a distinct TFIID complex and is required for transcriptional activation by estrogen receptor. Cell 79:107-117
7. Oñate SA, Tsai SY, Tsai M-J, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354-1357
8. Hong H, Kohli K, Trivedi A, Johnson DL, Stallcup MR 1996 GRIP1, a novel mouse protein that serves as a transcriptional co-activator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci USA 93:4948-4952
9. Voegel JJ, Heine MJS, Zechel C, Chambon P, Gronemeyer H 1996 TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 15:3667-3675
10. Hollenberg SM, Evans RM 1988 Multiple and cooperative transactivation domains of the human glucocorticoid receptor. Cell 55:899-906
11. Lees JA, Fawell SE, Parker MG 1989 Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res 17:5477-5489
12. Pierrat B, Heery DM, Chambon P, Losson R 1994 A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast. Gene 143:193-200
13. Milhon J, Kohli K, Stallcup MR 1994 Genetic analysis of the N-terminal end of the glucocorticoid receptor hormone binding domain. J Steroid Biochem Mol Biol 51:11-19
14. Koelle MR, Talbot WS, Segraves WA, Bender MT, Cherbas P, Hogness DS 1991 The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67:59-77
15. Giguère V, Hollenberg SM, Rosenfeld MG, Evans RM 1986 Functional domains of the human glucocorticoid receptor. Cell 46:645-652
16. Rusconi S, Yamamoto KR 1987 Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. EMBO J 6:1309-1315
17. Lee S, Duncan KA, Chou H, Chen D, Kohli K, Huang C-F, Stallcup MR 1995 A somatic cell genetic method for identification of untargeted mutations in the glucocorticoid receptor that cause hormone binding deficiencies. Mol Endocrinol 9:826-837
18. Danielsen M, Northrop JP, Ringold GM 1986 The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins. EMBO J 5:2513-2522
19. Byravan S, Milhon J, Rabindran SK, Olinger B, Garabedian MJ, Danielsen M, Stallcup MR 1991 Two point mutations in the hormone-binding domain of the mouse glucocorticoid receptor that dramatically reduce its function. Mol Endocrinol 5:752-758
20. Ashraf J, Thompson EB 1993 Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol Endocrinol 7:631-642
21. Danielian PS, White R, Lees JA, Parker MG 1992 Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J 11:1025-1033
22. Kohno H, Bocchinfuso WP, Gandini O, Curtis SW, Korach KS 1996 Mutational analysis of the estrogen receptor ligand-binding domain: influence of ligand structure and stereochemistry on transactivation. J Mol Endocrinol 16:277-285
23. Pakdel F, Reese JC, Katzenellenbogen BS 1993 Identification of charged residues in an N-terminal portion of the hormone-binding domain of the human estrogen receptor important in transcriptional activity of the receptor. Mol Endocrinol 7:1408-1417
24. Wurtz J-M, Bourguet W, Renaud J-P, Vivat V, Chambon P, Moras D, Gronemeyer H 1996 A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 3:87-94
25. Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ 1995 A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697
26. Renaud J-P, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature 378:681-689
27. Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375:377-382
28. Xu M, Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons Jr SS 1996 Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. J Biol Chem 271:21430-21438
29. Chen D, Kohli K, Zhang S, Danielsen M, Stallcup MR 1994 Phenylalanine-780 near the C-terminus of the mouse glucocorticoid receptor is important for ligand binding affinity and specificity. Mol Endocrinol 8:422-430
30. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM 1987 Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268-275
31. Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E 1987 Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem Biophys Res Commun 143:740-748
32. Lubahn DB, Joseph DR, Sar M, Tan J, Higgs HN, Larson RE, French FS, Wilson EM 1988 The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol Endocrinol 2:1265-1275
33. Green S, Walter P, Kumar V, Krust A, Bornert J-M, Argos P, Chambon P 1986 Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320:134-139