Delayed xenograft rejection

World Journal of Surgery

Volumn 21, Issue 9, 1997, Pages 917-923

  Hancock, Wayne W ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL ACTIVATION; CELL INFILTRATION; COMPLEMENT ACTIVATION; GENE CONTROL; GENETIC ENGINEERING; GRAFT REJECTION; HOST RESISTANCE; MACROPHAGE FUNCTION; NATURAL KILLER CELL; PATHOPHYSIOLOGY; REGULATORY MECHANISM; THROMBOCYTE AGGREGATION; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; ENDOTHELIUM, VASCULAR; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; KILLER CELLS, NATURAL; MACROPHAGES; ORGAN TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030669715     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900327     Document Type: Article

References (46)

1. White, D.J.G.: hDAF transgenic pig organs: are they concordant for human transplantation? Xenotransplantation 4:50, 1996
2. Hancock, W.W., Blakely, M.L., van der Werf, W., Bach, F.H.: Rejection of guinea pig cardiac xenografts post-cobra venom factor therapy is associated with infiltration by mononuclear cells secreting interferon-gamma and diffuse endothelial activation. Transplant. Proc. 25:2932, 1993
3. Blakely, M.L., van der Werf, W.J., Berndt, M.C., Dalmasso, A.P., Bach, F.H., Hancock, W.W.: Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58:1059, 1994
4. Candinas, D., Koyamada, N., Miyatake, T., Hechenleitner, P., Mark, W., Bach, F.H., Hancock, W.W.: T cell-independence of macrophage and NK cell infiltration, cytokine production and endothelial activation during delayed xenograft rejection. Transplantation 62:1920, 1996
5. Hancock, W.W., Miyatake, T., Koyamada, N., Kut, J.P., Soares, M., Russell, M.E., Bach, F.H., Sayegh, M.H.: Effects of leflunomide and deoxyspergualin in the guinea pig→rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin. Transplantation (in press)
6. Candinas, D., Lesnikoski, B.A., Robson, S.C., Miyatake, T., Scesney, S.M., Marsh, H.C., Ryan, U.S., Dalmasso, A.P., Hancock, W.W., Bach, F.H.: Effect of repetitive high-dose treatment with soluble complement receptor type I and cobra venom factor on discordant xenograft survival. Transplantation 62:336, 1996
7. Hancock, W.W., Koyamada, N., Miyatake, T., Candinas, D., Meo, T., Carroll, M., Bach, F.H.: Delayed xenograft rejection in sensitized mice with genetically induced interruptions of complement activation. Transplant. Proc. (in press)
8. Otsu, I., Candinas, D.R., Lesnikoski, B.A., Goodman, D.J., Robson, S.C., Hancock, W.W., Bach, F.H.: A model of discordant xenograft rejection: mouse cardiac xenografts in sensitized Lewis rat recipients. Transplant. Proc. (in press)
9. Kobayashi, T., Neethling, F.A., Taniguchi, S., Ye, Y., Niekrasz, M., Koren, E., Hancock, W.W., Takagi, H., Cooper, D.K.C.: Investigation of the anti-complement agents, FUT-175 and K76COOH, in discordant xenotransplantation. Xenotransplantation 3:237, 1996
10. Kobayashi, T., Taniguchi, S., Hancock, W.W., Ye, Y., Niekrasz, M., Kosanke, S., Neethling, F., Rose, A.G., Wright, L.J., White, D.J.G., Cooper, D.K.C.: Delayed xenograft rejection of pig-to-primate cardiac transplants post-cobra venom factor therapy. Transplantation (in press)
11. Rajasinghe, H.A., Reddy, M., Hancock, W.W., Sayegh, M.H., Hanley, F.L.: Towards correction of congenital cardiac defects by discordant xenotransplantation: key role of the alternate pathway of complement in a rat→sheep model. Transplantation 62:407, 1996
12. Xu, H., Hancock, W.W., Izutani, H., Morimoto, T., Hill, A.C., Zuppan, C.W., Bailey, L.L., Gundry, S.R.: Delayed xenograft rejection in a newborn discordant cardiac xenograft model. Transplantation (in press)
13. Coughlan, A., Berndt, M., Dunlop, L., Hancock, W.W.: In vivo studies of P-selectin and platelet-activating factor during endotoxemia, accelerated allograft rejection, and discordant xenograft rejection. Transplant. Proc. 25:2930, 1993
14. Peerschke, E.I.B., Reid, K.B.M., Ghebrehiwet, B.: Platelet activation by C1q results in the induction of alpha(IIb)/beta(3) integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity. J. Exp. Med. 178:579, 1993
15. Weyrich, A.S., McIntyre, T.M., McEver, R.P., Prescott, S.M., Zimmerman, G.A.: Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion: signal integration and NF-kappa B translocation. J. Clin. Invest. 95:2297, 1995
16. Celi, A., Pellegrini, G., Lorenzet, R., Deblasi, A., Ready, N., Furie, B.C., Furie, B.: P-Selectin induces the expression of tissue factor on monocytes. Proc. Natl. Acad. Sci. U.S.A. 91:8767, 1994
17. Power, C.A., Clemetson, J.M., Clemetson, K.J., Wells, T.N.C.: Chemokine and chemokine receptor mRNA expression in human platelets. Cytokine 7:479, 1995
18. Candinas, D., Lesnikoski, B.A., Hancock, W.W., Otsu, I., Koyamada, N., Dalmasso, A.P., Robson, S.C., Bach, F.H.: Inhibition of platelet integrin GPIIb/IIIa prolongs survival of discordant cardiac xenografts. Transplantation 62:1, 1996
19. Hancock, W.W.: Immunopathology of discordant xenograft rejection. In Xenotransplantation: The Transplantation of Organs and Tissues Between Species, D.K.C. Cooper, E. Kemp, J.L. Platt, D.J.G. White, editors. Berlin, Springer, 1997, pp. 303-313
20. Hancock, W.W.: Chemokines and the pathogenesis of T cell-dependent immune responses. Am. J. Pathol. 148:681, 1996
21. Benbaruch, A., Xu, L.L., Young, P.R., Bengali, K., Oppenheim, J.J., Wang, J.M.: Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors: C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. J. Biol. Chem. 270:22123, 1995
22. Horuk, R., Colby, T.J., Darbonne, W.C., Schall, T.J., Neote, K.: The human erythrocyte inflammatory peptide (chemokine) receptor: biochemical characterization, solubilization, and development of a binding assay for the soluble receptor. Biochemistry 32:5733, 1993
23. Robson, S.C., Candinas, D., Siegel, J.B., Kopp, C., Millan, M., Hancock, W.W., Bach, F.H.: Potential mechanism of abnormal thromboregulation in xenograft rejection: loss of ecto-ATPases upon endothelial cell activation. Transplant. Proc. 28:536, 1996
24. Robson, S.C., Kaczmarek, E., Siegel, J.B., Candinas, D., Koziak, K., Millan, M., Hancock, W.W., Bach, F.H.: Loss of ATP diphosphorylase following endothelial cell activation. J. Exp. Med. 185:153, 1997
25. Koyamada, N., Miyatake, T., Candinas, D., Hechenleitner, P., Siegel, J., Hancock, W.W., Bach, F.H., Robson, S.C.: Apyrase administration prolongs discordant xenograft survival. Transplantation 62:1739, 1996
26. Colotta, F., Sciacca, F.L., Sironi, M., Luini, W., Rabiet, M.J., Mantovani, A.: Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am. J. Pathol. 144:975, 1994
27. Medzhitov, R., Janeway, C.A.: Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4, 1997
28. Quesenberry, M.S., Drickamer, K.: Determination of the minimum carbohydrate-recognition domain in two C-type animal lectins. Glycobiology 1:615, 1991
29. Saton, M., Kawakami, K., Osawa, T., Toyoshima, S.: Molecular cloning and expression of cDNA encoding a galactose/N-acetylgalactosamine-specific lectin on mouse tumoricidal macrophages. J. Biochem. (Tokyo) 111:331, 1992
30. Hofer, E., Duchler, M., Fuad, S.A., Houchins, J.P., Yabe, T., Bach, F.H.: Candidate natural killer cell receptors. Immunol. Today 13:429, 1992
31. Galili, U.: Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol. Today 14:480, 1993
32. Millan, M.T., Geczy, C., Stuhlmeier, K., Goodman, D.J., Ferran, C., Bach, F.H.: Human monocytes activate porcine endothelial cells, resulting in increased E-selectin, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-type 1 expression. Transplantation 63:421, 1997
33. Goodman, D., von Albertini, M., Willson, A., Millan, M., Bach, F.H.: Direct activation of porcine endothelial cells by human natural killer cells. Transplantation 61:763, 1996
34. Fryer, J.P., Leventhal, J.R., Dalmasso, A.P., Chen, S., Simone, P.A., Goswitz, J.J., Reinsmoen, N.L., Matas, A.J.: Beyond hyperacute rejection: accelerated rejection in a discordant xenograft model by adoptive transfer of specific cell subsets. Transplantation 59:171, 1995
35. Wrighton, C., Kopp, C.W., McShea, A., Vetr, H., Bach, F.H.: High level expression of functional human thrombomodulin in cultured porcine aortic endothelial cells. Transplant. Proc. 27:288, 1995
36. Hancock, W.W., Bach, F.H.: Immunobiology and therapeutic applications of protein C/protein S/thrombomodulin in human and experimental allo-and xenotransplantation. Trends Cardiovasc. Med. 7: 174, 1997
37. Kopp, C.W., Siegel, J.B., Hancock, W.W., Anrather, J., Winkler, H., Geczy, C., Kaczmarek, E., Bach, F.H., Robson, S.C.: Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation 63:749, 1997
38. Marcus, A.J., Safier, L.B.: Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J. 7:516, 1993
39. Hancock, W.W.: The past, present and future of renal xenotransplantation. Kidney Int. 51:932, 1997
40. Hancock, W.W.: Beyond hyperacute rejection: strategies for development of pig→primate xenotransplantation. Kidney Int. 51:S36, 1997
41. Hamann, J., Vogel, B., Vanschijndel, G.M.W., Vanlier, R.A.W.: The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J. Exp. Med. 184:1185, 1996
42. Hahn, W.C., Burakoff, S.J., Bierer, B.E.: Signal transduction pathways involved in T-cell receptor-induced regulation of CD2 avidity for CD58. J. Immunol. 150:2607, 1993
43. Bach, F.H., Robson, S.C., Ferran, C., Winkler, H., Millan, M.T., Stuhlmeier, K., Vanhove, B., Blakely, M.L., van der Werf, W.J., Hofer, E., de Martin, R., Hancock, W.W.: Endothelial cell activation and thromboregulation during xenograft rejection. Immunol. Rev. 141:5, 1994
44. Bach, F.H., Winkler, H., Ferran, C., Hancock, W.W., Robson, S.C.: Delayed xenograft rejection. Immunol. Today 17:379, 1996
45. Bach, F.H., Ferran, C., Hechenleitner, P., Mark, W., Koyamada, N., Miyatake, T., Winkler, H., Badrichani, A., Candinas, D., Hancock, W.W.: Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3:196, 1997
46. Bach, F.H., Hancock, W.W., Ferran, C.: Protective genes expressed in endothelial cells: a regulatory response to injury. Immunol. Today (in press)