Synthesis of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and evaluation as inhibitors of 17α-hydroxylase-C17,20-lyase (P450 17)

Archiv der Pharmazie

Volumn 330, Issue 11, 1997, Pages 359-361

  Zhuang, Yan ^a   Zapp, Josef ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

17 Hydroxylase C17,20 lyase (P450 17); Atypical Friedel Crafts acetylation; Nonsteroidal P450 17 inhibitors; Oximes; Z,E 1 methyl 2 (1 hydroximinoethyl) 6 methoxy 3,4 dihydro naphthalenes

Indexed keywords

3,4 DIHYDRO 2 (1 HYDROXYIMINOETHYL) 6 METHOXY 1 METHYLNAPHTHALENE; CYTOCHROME P450; STEROID 17,20 LYASE; UNCLASSIFIED DRUG;

CHIRALITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MALE; MASS SPECTROMETER; MICROSOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; SHORT SURVEY; TESTIS;

EID: 0030666711     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19973301108     Document Type: Short Survey

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