Differential ability of Th1 and Th2 T cells to express fas ligand and to undergo activation-induced cell death

International Immunology

Volumn 6, Issue 10, 1994, Pages 1545-1553

  Ramsdell, Fred ^a   Seaman, Michael S ^a   Miller, Robert E ^a   Picha, Kathleen S ^a   Kennedy, Mary K ^a   Lynch, David H ^a  

^a AMGEN INC   (United States)

Author keywords

AICD; Fas; Fas ligand; Th1 cell; Th2 cell

Indexed keywords

LIGAND; FAS ANTIGEN; FASL PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; RECEPTORS, ANTIGEN, T CELL, ALPHA BETA;

APOPTOSIS; ARTICLE; BIOASSAY; CELL DEATH; CELL STIMULATION; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BIOSYNTHESIS; CELL CLONE; COMPARATIVE STUDY; CYTOTOXICITY TEST; IMMUNOLOGY; TH1 CELL; TH2 CELL;

ANIMAL; ANTIGENS, CD95; ANTIGENS, SURFACE; APOPTOSIS; CLONE CELLS; COMPARATIVE STUDY; CYTOTOXICITY TESTS, IMMUNOLOGIC; FLOW CYTOMETRY; HUMAN; MEMBRANE GLYCOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH1 CELLS; TH2 CELLS;

EID: 0028172588     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/6.10.1545     Document Type: Article

References (55)

1. Webb, S., Morris, C. and Sprent, J. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
2. Rocha, B. and von Boehmer, H. 1991. Peripheral selection of the T cell repertoire Science 251:1225.
3. Kawabe, Y. and Ochi, A. 1990. Selective anergy of Vß 8+, CD4+ T cells in Staphylococcus enterotoxin B-prined mice. J. Exp. Med. 172:1065.
4. Kabelte, D., Pohl, T. and Pechhold, K. 1993. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today 14:338.
5. Fowlkes, B. J. and Ramsdell, F. 1993. T-cell tolerance. Curr. Opin. Immunol. 5:873.
6. Schwartz, L M. and Osborne, B. A. 1993. Programmed cell death, apoptosis and killer genes. Immunol. Today 14:582.
7. Cohen, J. J. 1993. Apoptosis. Immunol. Today 14:126.
8. Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Möller, P, Falk, W., Debatin, K.-M. and Krammer, P. H. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301.
9. Yonehara, S., Ishii, A. and Yonehara, M. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747.
10. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. and Nagata, S. 1992. Lymphoprolifération disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
11. Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T. and Nagata, S. 1994. Generalized lymphoproliférative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969.
12. Russell, J. H., Rush, B., Weaver, C. and Wang, R. 1993. Mature T cells of autoimmune Iprflpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sd. USA. 90:4409.
13. Bossu, P., Singer, G. G., Andres, P, Ettinger, R., Marshak-Rothstein, A. and Abbas, A. K. 1993. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151:7233.
14. Russell, J. H. and Wang, R. 1993. Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated mature T cells. Eur. J. Immunol. 23:2379.
15. Russell, J. H., White, C. L., Loh, D. Y. and Meleedy-Rey, P. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl Acad. Sei. USA 88:2151.
16. Kubo, R. T., Bom, W., Kappler, J. W., Marrack, P. and Pigeon, M. 1989. Characterization of a monoclonal antibody which detects all murine a0 T cell receptors. J. Immunol. 142:2736.
17. Havran, W. L, Poenie, M., Klmura, J., Tsien, R., Weiss, A. and Allison, J. P. 1987. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature 330:170.
18. Ohara, J. and Paul, W. E. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315:333.
19. Gross, J. A., Callas, E. and Allison, J. P. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380.
20. Ramsdell, F., Seaman, M. S., Miller, R. E., Tough, T. W., Alderson, M. R. and Lynch, D. H. 1994. gldlgld mice are unable to express a functional ligand for Fas. Eur. J. Immunol. 24:928.
21. Hecht, T. T., Longo, D. L. and Matis, L. A. 1983. The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones. J. Immunol. 131:1049.
22. Mueller, D. L, Chiodetti, L., Bacon, P. A. and Schwartz, R. H. 1991. Clonal energy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones. J. Immunol. 147:4118.
23. Mosmann, T. R., Schumacher, J. H., Street, N. F., Budd, R., O'Garra, A., Fong, T. A. T, Bond, M. W., Moore, K. W. M. Sher, F and Fiorentino, D. F. 1991. Diversity of cytokine synthesis and function of mouse CD4+ T cells. Immunol. Rev. 123:209.
24. Dive, C., Gregory, C. D., Phipps, D. J., Evans, D. L., Milner, A. E. and Wyllie, A. H. 1992. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim. Biophys. Acta 1133:275.
25. Bottomly, K., Davis, L. S. and Lipsky, P. E. 1991. Measurement of human and murine interleukin 2 and interleukin 4. In Coligan, J. E., Kruisbeck, A. M., Margulies, D. H„ Shevach, E. M. and Straber, W., eds, Current Protocols in Immunology, p. 6. John Wiley, New York.
26. Hu-Li, J., Ohara, J., Watson, C., Tsang, W. and Paul, W. E. 1989. Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800.
27. Ramsdell, F, Picha, K. S., Seaman, M. S. and Kennedy, M. K. 1994. TNF abrogates the response of the CT.4S cell line to IL-4. J. Immunol. Methods 167:299.
28. Schreiber, R. D. 1991. Measurement of mouse and human interferon y. In Coligan, J. E„ Kruisbeck, A. M., Margulies, D. H„ Shevach, E. M. and Straber, W., eds, Current Protocols in Immunology, p. 6. John Wiley, New York.
29. Ramsdell, F. and Fowlkes, B. J. 1992. Maintenance of in vivo tolerance by persistence of antigen. Science 257:1130.
30. Ucker, D. S., Meyers, J. and Obermiller, P. S. 1992. Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol. 149:1583.
31. Groux, H., Monte, D., Plouvier, B., Capron, A. and Ameisen, J.-C. 1993. CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells, respective roles of interleukin-1, interteukin-2, interferon-y and accessory cells. Eur. J Immunol. 23:1623.
32. Liu, Y. and Janeway, C. A, Jr. 1990. Interferon y plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J. Exp. Med. 172:1735.
33. Wasselborg, S., Janssen, O. and Kabelitz, D. 1993. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150:4338.
34. Damle, N. K., Leytze, G., Klussman, K. and Ledbetter, J. A. 1993. Activation with superantigens induces programmed death in antigen-primed CD4+ class ll+ major histocompatibility complex T lymphocytes via a CD11a/CD18-dependent mechanism. Eur. J. Immunol. 23:1513.
35. Mufloz, E., Zubiaga, A. M., Merrow, M., Sauter, N. P. and Huber, T. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95.
36. Gajewski, T. F., Pinnas, M., Wong, T. and Rtch, F. W. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1750.
37. Betz, M. and Fox, B. S. 1991. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108.
38. Weaver, C. T. and Unanue, E. R. 1990. The costimulatory function of antigen-presenting cells. Immunol. Today 11:49.
39. Krammer, P. H., Behrmann, I., Daniel, R, Dhein, J. and Debatin, K.M. 1994. Regulation of apoptosis in the immune system. Curr. Opin. Immunol. 6:279.
40. Stalder, T., Hahn, S. and Erb, P. 1994. Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J. Immunol. 152:1127.
41. Miyawaki, T., Uehara, T., Nibu, R., Tsuji, l., Yachie, A., Yonehara, S. and Taniguchi, N. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 149:3753.
42. Klas, C., Debatin, K.-M., Jonker, R. R. and Krammer, P. H. 1993. Activation interferes with the AFO-1 pathway in mature human T cells. Int. Immunol. 5:625.
43. Hockenbery, D., Nufiez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J. 1990. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334.
44. Boise, L H., GonzAlez Garcla. M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuflez, G. and Thompson, B. 1993. bcl-x, a bct-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597.
45. Oltvai, Z. N., Milliman, C. L. and Korsmeyer, S. J. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609.
46. Itoh, N., Tsujimoto, Y. and Negate, S. 1993. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151:621.
47. Kabelitz, D. and Wesselborg, S. 1992. Life and death of a superantigen-reactive human CD4+ T cell clone: staphylococcal enterotoxins induce death by apoptosis but simultaneously trigger a proliferative response in the presence of HLA-DR+ antigen-presenting cells. Int. Immunol. 4:1381.
48. Russell, J. H., Rush, B. J., Abrams, S. I. and Wang, R. 1992. Sensitivity of T cells to anti-CD3-stimulated suicide is independent of functional phenotype. Eur. J. Immunol. 22:1655.
49. Alderson, M. R., Armitage, R. J., Maraskovsky, E., Tough, T. W., Roux, E., Ramsdell, F., and Lynch, D. H. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231.
50. Suda, T., Takahashi, T., Golstein, P., and Nagata, S. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
51. Kotzin, B. L, Babcock, S. K. and Herron, L. R. 1988. Deletion of potentially self-reactive T cell receptor specificities in L3T4", Lyt-2~ T cells of Ipr mice. J. Exp. Med. 168:2221.
52. Singer, P. A., Balderas, R. S., McEvilly, R. J., Bobardt, M. and Theofilopoulos, A. N. 1989. Tolerance-related Vp clonal deletions in normal CD4"8~, TCR-o/p+ and abnormal Ipr and gld cell populations. J Exp. Med. 170:1869.
53. Goldman, M., Druet, P. and Gleichmann, E. 1991. Tn2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today 12:223.
54. Clerici, M. and Shearer, G. M. 1993. A TH1-»Tn2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107.
55. Lynch, D. H., Watson, M. L., Alderson, M. R., Baum, P. R., Miller, R. E., Tough, T., Gibson, M., Davis-Smith, T., Smith, C. A., Hunter, K., Bhat, D., Din, W., Goodwin, R. G. and Seldin, M. F. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131.