Pathogenesis of chronic progressive myelopathy associated with human T-cell lymphotropic virus type I

Acta Neurologica Scandinavica

Volumn 95, Issue S169, 1997, Pages 86-93

  Hollsberg P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Autoimmunity; Cytokine; Cytotoxicity; Demyelination; Human T cell lyrnphotropic virus type I; Pathogenesis; Retrovirus; T lymphocyte

Indexed keywords

AUTOANTIBODY; CYTOKINE; MYELIN PROTEIN;

BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HETEROZYGOTE; HUMAN; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IMMUNOLOGY; MULTIPLE SCLEROSIS; REVIEW; SPASTIC PARAPLEGIA; VIROLOGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOIMMUNITY; CHRONIC DISEASE; CONFERENCE PAPER; CYTOTOXICITY; DEMYELINATION; HELPER CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MICROGLIA; MOUSE; NONHUMAN; RAT; RETROVIRUS INFECTION; SPASTIC PARESIS; SPINAL CORD DISEASE; T LYMPHOCYTE SUBPOPULATION;

AUTOANTIBODIES; CARRIER STATE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; HTLV-I INFECTIONS; HUMANS; MULTIPLE SCLEROSIS; MYELIN PROTEINS; PARAPARESIS, TROPICAL SPASTIC;

EID: 0030625946     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1997.tb08156.x     Document Type: Article

References (62)

1. Poiesz BJ, Ruscetti FW, Gazdar AF et al. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A 1980: 77: 7415-9.
2. Miyoshi I., Kubonishi I., Yoshimoto S. et al. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukemic T cells. Nature 1981: 294: 770-1.
3. Richardson JH, Edwards AJ, Cruickshank JK, Rudge P., Dalgleish AG. In vivo cellular tropism of human T-cell leukemia virus type I. J Virol 1990: 64: 5682-7.
4. Gessain A. Epidemiology of HTLV-I and associated diseases. In: Höllsberg P. Hafler DA. ed. Human T cell lymphotropic virus type I. Chichester : Wiley & Sons, 1996: 33-64.
5. Höllsberg P., Hafler DA. Pathogenesis of diseases induced by human lymphotropic virus type I infection. N Engl J Med 1993: 328: 1173-82.
6. Takatsuki K., Uchiyama T., Sagawa K., Yodoi J. Adult T cell leukemia in Japan. In: Seno S., Takaku F., Irino S., ed. Topics in hematology. Amsterdam : Excerpta Medica, 1977: 73-7.
7. Gessain A., Barin F., Vernant J. et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985: 2: 407-10.
8. Osame M., Usuku K., Izumo S. et al. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986: 1: 1031-2.
9. Mochizuki M., Watanabe T., Yamaguchi K. et al. Uveitis associated with human T lymphotropic virus type I: seroepidemiologic, clinical, and virologic studies. J Infect Dis 1992: 166: 943-4.
10. LaGrenade L., Hanchard B., Fletcher V., Cranston B., Blattner W. Infective dermatitis of Jamaican children: a marker for HTLV-I infection. Lancet 1990: 336: 1345-7.
11. Nishioka K., Maruyama I., Sato K. et al. Chronic inflammatory arthropathy associated with HTLV-I. Lancet 1989: 1: 441.
12. Morgan O., Rodgers J., Mora C., Char G. HTLV-I and polymyositis in Jamaica. Lancet 1989: 2: 1184-7.
13. Kaplan J., Osame M., Kubota H. The risk of development of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) among persons infected with HTLV-I. J Acquir Immune Defic Syndr 1990: 3: 1096-101.
14. Osame M., Igata A., Matsumoto M. et al. HTLV-I-associated myelopathy (HAM), treatment trials, retrospective survey and clinical and laboratory findings. Hematol Rev 1990: 3: 271-84.
15. Iwasaki Y. Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP). J Neurol Sci 1990: 96: 103-23.
16. Mattson D., McFarlin D., Mora C., Zaninovic V. Central-nervous-system lesions detected by magnetic resonance imaging in an HTLV-I antibody positive symptomless individual. Lancet 1987: 2: 49.
17. Ogata A., Nagashima K., Tashiro K., Miyakawa A., Mikuni C. MRI-pathological correlate of brain lesions in a necropsy case of HTLV-I associated myelopathy. J Neurol Neurosurg Psychiatry 1993: 56: 194-6.
18. Cruickshank JK, Rudge P., Dalgleish AG et al. Tropical spastic paraparesis and human T cell lymphotropic virus type I in the United Kingdom. Brain 1989: 112: 1057-90.
19. Moore GRW, Traugott U., Scheinberg LC, Raine CS. Tropical spastic paraparesis: a model of virus-induced cytotoxic T-cell mediated demyelination. Ann Neurol 1989: 26: 523-30.
20. Iwasaki Y., Ohara Y., Kobayashi I., Akizuki S. Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection. Am J Pathol 1992: 140: 1003-8.
21. Engelhard V. Structure of peptides associated with class I and class II MHC molecules. Annu Rev Immunol 1994: 12: 181-207.
22. Sonoda S., Fujiyoshi T., Yashiki S. Immunogenetics of HTLV-I/II and associated diseases. J Acquir Immune Defic Syndr Hum Retrovir 1996: 13(suppl 1): S119-23.
23. Tsujimoto A., Teruuchi T., Imamura J. et al. Nucleotide sequence analysis of a provirus derived from HTLV-I-associated myelopathy (HAM). Mol Biol Med 1988: 5: 29-42.
24. Daenke S., Nightingale S., Cruickshank JK, Bangham CRM. Sequence variants of human T-lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates. J Virol 1990: 64: 1278-82.
25. Shirabe S., Nakamura T., Tsujihata M. et al. Retrovirus from human T-cell leukemia virus type I associated myelopathy is the same strain as prototype human T-cell leukemia virus type I. Arch Neurol 1990: 47: 1258-60.
26. Cann AJ, Chen ISY. Human T-cell leukemia virus type I and II. In: Fields BN, Knipe DM, Chanock RM et al., ed. Field's virology. 2nd edn. New York : Raven Press, 1990: 1501-27.
27. Yoshida M., Osame M., Kawai H. et al. Increased replication of HTLV-I in HTLV-I-associated myelopathy. Ann Neurol 1989: 26: 331-5.
28. Gessain A., Saal F., Gout O. et al. High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. Blood 1990: 75: 428-33.
29. Kira J., Koyanagi Y., Yamada T. et al. Increased HTLV-I proviral DNA in HTLV-I-associated myelopathy: a quantitative polymerase chain reaction study. Ann Neurol 1991: 29: 194-201.
30. Kubota R., Fujiyoshi T., Yashiki S. et al. Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy. J Neuroimmunol 1993: 42: 147-54.
31. Mita S., Sugimoto M., Nakamura M. et al. Increased human T- lymphotropic virus type I (HTLV-I) proviral DNA in peripheral blood mononuclear cells and bronchoalveolar lavage cells from Japanese patients with HTLV-I-associated myelopathy. Am J Trop Med Hyg 1993: 48: 170-7.
32. Niewiesk S., Daenke S., Parker C. et al. The transactivator gene of human T-cell leukemia virus type I is more variable within an between healthy carriers than patients with tropical spastic paraparesis. J Virol 1994: 68: 6778-81.
33. Szurek P., Yuen P., Jerzy R., Wong P. Identification of point mutations in the envelope gene of moloney murine leukemia virus tb temperature-sensitive paralytogenic mutants tsl: molecular determinants for neurovirulence. J Virol 1988: 62: 357-60.
34. Koenig S., Woods R., Brewah Y. et al. Characterization of MHC class I restricted cytotoxic T cell responses to Tax in HTLV-I-infected patients with neurologic disease. J Immunol 1993: 156: 3874-83.
35. Jacobson S., Shida H., McFarlin DE, Fauci AS, Koenig S. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 1990: 348: 245-8.
36. Elovaara I., Koenig S., Brewah Y. et al. High human T cell lymphotropic virus type I (HTLV-I)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-I-associated neurological disease. J Exp Med 1993: 177: 1567-73.
37. Jacobson S. Role of cellular immune responses in the pathogenesis of HTLV-I-associated neurologic disease. In: Hollsberg P., Hafler DA, ed. Human T cell lymphotropic virus type I. Chichester : Wiley and Sons, 1996: 141-166.
38. Bhigjee A., CAWiley W., Amenori T. et al. HTLV-I-associated myelopathy. Clinopathologic correlation with localization of provirus in the spinal cord. Neurology 1991: 41: 1990-2.
39. Kuroda Y., Matsui M., Kikuchi M. et al. In situ demonstration of the HTLV-I genome in the spinal cord of a patients with HTLV-I-associated myelopathy. Neurology 1994: 44: 2295-9.
40. Hara H., Morita M., Iwaki T. et al. Detection of human T lymphotropic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor Vβ CDR3 sequences in the spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Exp Med 1994: 180: 831-9.
41. Kira Y., Koyanagi Y., Yamada T. et al. Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy. Ann Neurol 1994: 36: 149-56.
42. Lehky TJ, Fox CH, Koenig S. et al. Detection of human T -lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/ tropical spastic paraparesis patients by in situ hybridization. Ann Neurol 1995: 37: 167-75.
43. Moritoyo T., Reinhart TA, Moritoyo H. et al. Human T-lymphotropic virus type I-associated myelopathy and tax gene expression in CD4 T lymphocytes. Ann Neurol 1996: 40: 84-90.
44. Höllsberg P., Weber WEJ, Dangond F. et al. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc Natl Acad Sci U S A 1995: 92: 4036-40.
45. Utz U., Banks D., Jacobson S., Biddison WE. Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type I (HTLV-I) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-I-associated disease: evidence for oligoclonal expansion. J Virol 1996: 70: 843-51.
46. Oldstone M. Molecular mimicry and autoimmune disease. Cell 1987: 50: 819-20.
47. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1996: 80: 695-705.
48. Ausubel LJ, Kwan CK, Sette A., Kuchroo V., Hafler DA. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proc Natl Acad Sci U S A 1996: 93: 15317-22.
49. Nagai M., Yashiki S., Fujiyoshi T. et al. Characterization of a unique T-cell clone established from a patient with HAM/TSP which recognized HTLV-I-infected T-cell antigens as well as spinal cord tissue antigens. J Neuroimmunol 1996: 65: 97-106.
50. Zhang J., Medaer R., Hashim GA et al. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Ann Neurol 1992: 32: 330-8.
51. Tsuchida T., Parker KC, Turner RV et al. Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides. Proc Natl Acad Sci U S A 1994: 91: 10859-63.
52. June C., Bluestone J., Nadler L., Thompson C. The B7 and CD28 receptor families. Immunol Today 1994: 15: 321-31.
53. Guerder S., Meyerhoff J., Flavell R. The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. Immunity 1994: 1: 155-66.
54. Harlan D., Hengartner H., Huang M. et al. Transgenic mice expressing both B7 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T lymphocyte unresponsiveness. Proc Natl Acad Sci U S A 1994: 91: 3137-41.
55. Scholz C., Freeman GJ, Greenfield EA, Hafler DA, Hollsberg P. Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. J Immunol 1996: 157: 2932-8.
56. Brosnan CF, Selmaj K., Raine CS. Hypothesis: a role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J Neuroimmunol 1988: 18: 87-94.
57. Ijichi S., Izumo S., Eiraku N. et al. An autoaggressive process against bystander tissues in HTLV-I-infected individuals: a possible pathomechanism of HAM/TSP. Med Hypotheses 1993: 41: 542-7.
58. Scholz C., Hafler DA, Höllsberg P. Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells. J Neurosci Res 1996: 45: 186-94.
59. Buckle GJ, Hafler DA, Höllsberg P. HTLV-I-induced T cell activation. J Acquir Immune Defic Syndr Hum Retrovir 1996: 13(suppl 1): S107-13.
60. Ratner L. Animal models of HTLV-I infection. In: Höllsberg P., Hafler DA, ed. Human T cell lymphotropic virus type I. Chichester : Wiley & Sons, 1996: 287-307.
61. Ishiguro N., Abe M., Seto K. et al. A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in seronegative HTLV-I carrier rats. J Exp Med 1992: 176: 981-9.
62. Yoshiki T. HAM rat disease, an animal model of HAM/ TSP in humans. AIDS Res Hum Retrovir 1994: 10: 455.