Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells

Journal of Neuroscience Research

Volumn 45, Issue 6, 1996, Pages 786-794

  Scholz, C ^a   Hafler, D A ^a   Hollsberg P ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

adhesion molecules; cytokines; myelopathy; retrovirus; T cell activation

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; HLA B7 ANTIGEN; HLA DR2 ANTIGEN; INTERLEUKIN 10; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN T CELL LEUKEMIA VIRUS 1; INTERFERON PRODUCTION; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD DISEASE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; CHO CELLS; CLONE CELLS; CRICETINAE; DOWN-REGULATION; EPITOPES; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HTLV-I INFECTIONS; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MYELIN BASIC PROTEINS; SOLUBILITY; T-LYMPHOCYTES; UP-REGULATION;

EID: 0029780342     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR15>3.0.CO;2-U     Document Type: Article

References (39)

1. Bouchonnet F, Lecossier D, Bellocq A, Hamy I, Hance A (1994): Activation of T cells by previously activated T cells. J Immunol 153:1921-1935.
2. Brady JN (1996): Biology of HTLV-I: Host cell interactions. In Höllsberg P, Hafler DA (eds): "Human T Cell Lymphotropic Virus Type I." Chichester: John Wiley & Sons, pp 79-112.
3. Brod S, Purvee M, Benjamin D, Hafler D (1990): T-T cell interactions are mediated by adhesion molecules. Eur J Immunol 20: 2239-2268.
4. Buckle GJ, Hafler DA, Höllsberg P (1996): HTLV-I-induced T cell activation. J Acquir Immune Defic Syndr Hum Retrovir, in press.
5. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G (1993): Interleukin 10(IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 178:1041-1048.
6. de Waal Malefyt R, Haanen J, Spits H, Roncarolo M-G, te Velde R, Figdor C, Johnson K, Kastelein R, Yssel H, de Vries JE (1991): Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 174:915-924.
7. de Waal Malefyt R, Yssel H, de Vries JE (1993): Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. J Immunol 150:4754-4765.
8. Elovaara I, Koenig S, Brewah Y, Woods R. M, Lehky T, Jacobson S (1993): High human T cell lymphotropic virus type I (HTLV-I)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-I-associated neurological disease. J Exp Med 177:1567-1573.
9. Franchini G (1995): Molecular mechanisms of human T cell leukemia/lymphotropic virus type I infection. Blood 86:3619-3639.
10. Gessain A, Barin F, Vernant J, Gout O, Maurs L, Calender A, deThé G (1985): Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 2:407-410.
11. Höllsberg P, Ausubel LJ, Hafler DA (1994): Human T cell lymphotropic virus type I-induced T cell activation. Resistence to TGF-β1-induced suppression. J Immunol 153:566-573.
12. Höllsberg P, Hafler DA (1993): Pathogenesis of diseases induced by human lymphotropic virus type I infection. N Eng J Med 328: 1173-1182.
13. Höllsberg P, Hafler DA (1995): What is the pathogenesis of HTLV-I associated myelopathy/tropical spastic paraparesis? Ann Neurol 37:143-145.
14. Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA (1992): Characterization of HTLV-I in vivo infected T cell clones. IL-2 independent growth of nontransformed T cells. J Immunol 148:3256-3263.
15. Hsu D-H, Malefyt RdW, Fiorentino DF, Dang M-N, Vieira P, de Vries J, Spits H, Mosmann TR, Moore KW (1990): Expression of interleukin-10 by Epstein-Barr virus protein BCRF1. Science 250:830-832.
16. Ijichi S, Izumo S, Eiraku N, Machigashira K, Kubota R, Nagai M, Ikegami N, Kashio N, Umehara F, Maruyama I, Osame M (1993): An autoaggressive process against bystander tissues in HTLV-I-infected individuals: A possible pathomechanism of HAM/TSP. Med Hypoth 41:542-547.
17. Itoyama Y, Kira J, Fujii N, Goto I, Yamamoto N (1989): Increases in helper inducer T cells an activated T cells in HTLV-I-associated myelopathy. Ann Neurol 26:257-262.
18. Jacobson S (1996): Role of cellular immune responses in the pathogenesis of HTLV-I-associated neurologic disease. In Höllsberg P, Hafler DA (eds): "Human T Cell Lymphotropic Virus Type I." Chichester: John Wiley & Sons, pp 141-166.
19. Jacobson S, Zaninovic V, Mora C, Rodgers-Johnson P, Sheremata WA, Gibbs CJ Jr, Gajdusek C, McFarlin DE (1988): Immunological findings in neurologic diseases associated with antibodies to HTLV-I activated lymphocytes in tropical spastic paraparesis. Ann Neurol 23:S196-S200.
20. Jacobson S, Gupta A, Mattson D, Mingioli E, McFarlin DE (1990a): Immunological studies in tropical spastic paraparesis. Ann Neurol 27:149-156.
21. Jacobson S, Shida H, McFarlin DE, Fauci AS, Koenig S (1990b): Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 348:245-248.
22. Kehrl J, Wakefield L, Roberts A, Jakowlew S, Alverez-Mon M, Derynck R, Sporn M, Fauci A (1986): Production of transforming growth factor b by human T lymphocytes and its potential role in regulation of T cell growth. J Exp Med 163: 1037-1050.
23. Kimata J, Palker T, Ratner L (1993): The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway. J Virol 67:3134-3141.
24. Koralnik I. J (1996): Structure of HTLV-I. In Höllsberg P, Hafler DA (eds): "Human T Cell Lymphotropic Virus Type I." Chichester: John Wiley & Sons, pp 65-78.
25. Lamb J, Skidmore B, Green N, Chiller J, Feldman M (1983): Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med 157:1434-1447.
26. Lanzavecchia A, Roosnek E, Gregory T, Berman P, Abrignani S (1988): T cells can present antigen such as HIV gp120 targeted to their own surface molecules. Nature 334:530-532.
27. Mitsuya H, Guo H-G, Cossman J, Megson M, Reitz MS Jr, Broder S (1984): Functional properties of antigen-specific T cells infected by human T-cell leukemia-lymphoma virus (HTLV-I): Science 225:1484-1486.
28. Moore G, Traugott U, Scheinberg L, Raine R (1989): Tropical spastic paraparesis: a model fo virus-induced cytotoxic T-cell mediated demyelination. Ann Neurol 26:523-530.
29. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M (1986): HTLV-I associated myelopathy, a new clinical entity. Lancet 1:1031-1032.
30. Richardson JH, Edwards AJ, Cruickshank JK, Rudge P, Dalgleish AG (1990): In vivo cellular tropism of human T-cell leukemia virus type I. J Virol 64:5682-5687.
31. Richardson JH, Höllsberg P, Windhagen A, Child LA, Hafler DA, Lever AML (1996): Variable immortalizing potential and frequent viral latency in blood derived T cell clones infected with HTLV-I. Submitted.
32. Schreiber S (1991): Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251:283-87.
33. Taga K, Tosato G (1992): IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 148:1143-1148.
34. Wong-Staal F, Gallo RC (1985): Human T-lymphotropic retroviruses. Nature 317:395-403.
35. Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA (1990): Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248:1016-1019.
36. Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA (1992): T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc Natl Acad Sci USA 89:2110-2114.
37. Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA (1994): Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 179:279-290.
38. Yssel H, de Waal Malefyt R (1995): IL-10 and human T cells. In de Vries JE, de Waal Malefyt R (eds): "Interleukin 10." Austin: RG Landes, pp 19-27.
39. Yssel H, de Waal Malefyt R, Due Dodon M, Blanchard D, Gassolo L, de Vries JE, Spits H (1989): Human T cell leukemia/lymphoma virus type I infection of a CD4 proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells. J Immunol 142:2279-2289.