Synergistic action of NS-004 and internal Ca2+ concentration in modulating pulmonary artery K+ channels

European Journal of Pharmacology

Volumn 295, Issue 1, 1996, Pages 53-60

  Vandier, Christophe ^a   Bonnet, Pierre ^a,b  

^a CNRS EP 21   (France)

^b UNIVERSITY HOSPITAL OF TOURS   (France)

Author keywords

K+ channel, Ca2+ activated; K+ channel, delayed rectifier; Membrane potential; NS 004; Pulmonary artery smooth muscle cell; Whole cell patch clamp; Ca2+ i, free

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; 4 AMINOPYRIDINE; 9 ANTHROIC ACID; CALCIUM; IBERIOTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; TETRYLAMMONIUM CHLORIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPERPOLARIZATION; MEMBRANE STEADY POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PULMONARY ARTERY; RABBIT; SMOOTH MUSCLE FIBER;

4-AMINOPYRIDINE; ANIMALS; BENZIMIDAZOLES; CALCIUM; CHLOROPHENOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; POTASSIUM CHANNELS; PULMONARY CIRCULATION; RABBITS; TETRAETHYLAMMONIUM; TETRAETHYLAMMONIUM COMPOUNDS;

EID: 0030049382     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00648-6     Document Type: Article

References (28)

1. + channels in pulmonary arterial smooth muscle cells isolated from rat, Pflügers Arch. 428, 446.
2. Bonnet, P., C. Vandier, C. Cheliakine and D. Gamier, 1994, Hypoxia activates a potassium current in isolated smooth muscle cells from large pulmonary arteries of the rabbit, Exp. Physiol. 79, 597.
3. Brayden, J.E. and M.T. Nelson, 1992, Regulation of arterial tone by activation of calcium-dependent potassium channels, Science 256, 532.
4. Clapp, L.H. and A.M. Gurney, 1991, Outward currents in rabbit pulmonary artery cells dissociated with a new technique, Exp. Physiol. 76, 677.
5. + channels regulate resting potential of pulmonary arterial smooth muscle cells, Am. J. Physiol. 262, H916.
6. Dworetzky, S.I., J.T. Trojnacki and V.K. Gribkoff, 1994, Cloning and expression of a human large-conductance calcium-activated potassium channel, Mol. Brain Res. 27, 189.
7. Ca channel opener, in vascular smooth muscle, Br. J. Pharmacol. 113, 1538.
8. Evans, A.M., L.H. Clapp and A.M. Gurney, 1994, Augmentation by intracellular ATP of the delayed rectifier current independently of the glibenclamide-sensitive K-current in rabbit arterial myocytes, Br. J. Pharmacol. 111, 972.
9. Evans, A.M., O.N. Osipenko and A.M. Gurney, 1995, A novel K-conductance may determine the resting potential in rabbit pulmonary arterial myocytes, Biophys. J. 68, A252.
10. + channels, Circ. Res. 73, 24.
11. Godt, R.E. and B.D. Lindley, 1982, Influence of temperature on contractile activation and isometric force production in mechanically skinned muscle fibers of the frog, J. Gen. Physiol. 80, 279.
12. Gribkoff, V.K., G. Champigny, P. Barbry, S.I. Dworetzky, N.A. Meanwell and M. Lazdunski, 1994, The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel, J. Biol. Chem. 269, 10983.
13. Hamill, O.P., A. Marty, E. Neher, B. Sakmann and F.J. Sigworth, 1981, Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pflügers Arch. 391, 85.
14. Knaus, H.G., A. Eberhart, H. Glossmann, P. Munujos, G.J. Kaczorowski and M.L. Garcia, 1994, Pharmacology and structure of high conductance calcium-activated potassium channels, Cell. Signal. 6, 8, 861.
15. + channels activity in tracheal myocytes by phosphorylation, Nature 341, 152.
16. Ca channel activity in rat cortical neurones, Eur. J. Pharmacol. 280, 215.
17. Okabe, K., K. Kitamura and H. Kuriyama, 1987, Features of 4-aminopyridine sensitive outward current observed in single smooth muscle cells from the rabbit pulmonary artery, Pflügers Arch. 409, 561.
18. + channels in aortic smooth muscle, Br. J. Pharmacol. 110, 25P.
19. + channels by novel benzimidazolone, Eur. J. Pharmacol. 151, 53.
20. + channels in cerebellar granule cells, Neuroreport 5, 1001.
21. Post, J.M., J.R. Hume, S.L. Archer and E.K. Weir, 1992, Direct role for potasium channel inhibition in hypoxic pulmonary vasoconstriction, Am. J. Physiol. 262, C882.
22. 2+ and Mg-ATP activated potassium channels from rat pulmonary artery, Pflügers Arch. 421, 94.
23. + channel in cultured smooth muscle cells of rat aortas, Am. J. Physiol. 255, H754.
24. 2+ sensitivities of BK(Ca) isochannels in bovine mesenteric vascular smooth muscle, Am. J. Physiol. 266, C1182.
25. + current in rat pulmonary artery muscle cells, Am. J. Physiol. 266, H365.
26. + current in canine coronary smooth muscle cells, Pflügers Arch. 427, 110.
27. + currents in canine coronary artery smooth muscle cells by NS-004, or 1-(2′-hydroxy-5′-chlorophenyl)-5-trifluoromethyl-2(3H)- benzimidazolone, J. Pharmacol. Exp. Ther. 266, 1422.
28. Yuan, X.J., W.F. Goldman, M.L. Tod, L.J. Rubin and M.P. Blaustein, 1993, Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes, Am. J. Physiol. 264, L116.