Thiolations, 99mTc labelings, and animal in vivo biodistributions of divalent monoclonal antibody fragments

Bioconjugate Chemistry

Volumn 7, Issue 3, 1996, Pages 290-297

  Govindan, Serengulam V ^a,c   Goldenberg, David M ^b   Grebenau, Ruth C ^a   Hansen, Hans J ^a   Griffiths, Gary L ^a  

^a IMMUNOMEDICS INC   (United States)

^b CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; MAMMALS;

ANTIBODY-FRAGMENT; BIFUNCTIONAL REAGENTS; DIVALENTS; GLUCOHEPTONATE; IN-VIVO; LABELINGS; THIOL GROUPS; THIOLATION; TWO-STEP PROCEDURE; VIVO BIODISTRIBUTION;

MONOCLONAL ANTIBODIES;

DIAGNOSTIC AGENT; HYDROXYLAMINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FRAGMENT; MONOCLONAL ANTIBODY; PERTECHNETIC ACID TC 99M; SUGAR ACID; TECHNETIUM COMPLEX; TECHNETIUM TC 99M GLUCEPTATE; THIOL REAGENT;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CARCINOMA; CELL CULTURE; CHEMISTRY; COLON TUMOR; COMPARATIVE STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; TIME; TISSUE DISTRIBUTION; ULTRAVIOLET SPECTROPHOTOMETRY; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOMA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; HYDROXYLAMINE; HYDROXYLAMINES; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FRAGMENTS; KIDNEY; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; ORGANOTECHNETIUM COMPOUNDS; SODIUM PERTECHNETATE TC 99M; SPECTROPHOTOMETRY, ULTRAVIOLET; SUGAR ACIDS; SULFHYDRYL REAGENTS; TIME FACTORS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0030135704     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc960010i     Document Type: Article

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