Induced differentiation of cancer cells: Second generation potent hybrid polar compounds target cell cycle regulators

European Journal of Cancer Prevention

Volumn 5, Issue SUPPL. 2, 1996, Pages 75-77

  Marks, P A ^a   Richon, V M ^a   Rifkind, R A ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAMETHYLENEBISACETAMIDE;

CANCER; CELL DIFFERENTIATION; CLINICAL TRIAL; CONFERENCE PAPER; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; TUMOR CELL;

EID: 0030499846     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008469-199612002-00011     Document Type: Conference Paper

References (9)

1. Andreeff M, Stone RM, Michaeli J, et al. (1992) Hexamethylene bisacetamide in myelo-dysplastic syndrome (MDS) and acute myelogenous leukemia (AML): A phase II clinical trial with a differentiation inducing agent. Blood 80:2604-2609.
2. Friend C, Scher WM, Holland J, Sato T (1971) Hemoglobin synthesis in murine erythroleukemia cells in vitro: Stimulation of erythroid differentiation by dimethyl-sulfoxide. Proc Natl Acad Sci USA 68:378-382.
3. Kiyokawa H, Richon VM, Rifkind RA, Marks PA (1995) Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol Cell Biol 15:2612-2624.
4. Marks PA, Richon VM, Rifkind RA (1996) Cell cycle regulatory proteins are targets for induced differentiation of transformed cells: Molecular and clinical studies employing hybrid polar compounds. Int J Hematol 63:1-17.
5. Marks PA, Rifkind RA (1984) Differentiation modifiers. Cancer 54:2766-2769.
6. Reuben RC, Wife RL, Breslow R, Rifkind RA, Marks PA (1976) A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci USA 73:862-866.
7. Richon VM, Rifkind RA, Marks PA (1992) Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells. Cell Growth Differ 3:414-420.
8. Richon VM, Venta-Perez G (1996) Changes in E2F binding activity during induced erythroid differentiation. Cell Growth Diff 7:31-42.
9. Richon VM, Webb Y, Merger R, et al. (1996) Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci USA 93:5705-5708.