Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma

Cancer Research

Volumn 56, Issue 4, 1996, Pages 715-718

  Anderson, Ian C ^a,c   Shipp, Margaret A ^a   Docherty, Andrew J P ^b   Teicher, Beverly A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UCB PHARMA   (Belgium)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (4 CHLOROPHENYL)PROPYL] N1 (3,3 DIMETHYL 2 BUTANAMIDYL) N4 HYDROXYSUCCINAMIDE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; ENZYME INHIBITOR; GELATINASE B; GELATINASE INHIBITOR; N1 (1 CARBAMOYL 2,2 DIMETHYLPROPYL) 2 [3 (4 CHLOROPHENYL)PROPYL] N4 HYDROXYBUTANEDIAMIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER SIZE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LEWIS CARCINOMA; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

AMIDES; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, LEWIS LUNG; CELL DIVISION; CISPLATIN; CYCLOPHOSPHAMIDE; GELATINASES; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS;

EID: 0030042145     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Liotta, I A., and Kohn, E. Cancer invasion and metastases. J. Am. Med. Assoc., 263: 1123-1126, 1990.
2. Matrisian, L. M Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet., 6: 121-125, 1990
3. Liotta, I. A., Steeg, P. S., and Stetler-Stevenson, W. G. Cancer metastasis and angiosenesis: an imbalance of positive and negative regulation. Cell, 64. 327-336, 1991.
4. Morphy, J. R., Baker, T. S., Beeley, N. R A , Birch, M., Noyce, B. A., Cockett, M. I., Crabbe, T., Docherty, A. J. P., Eaton, D., Hart, I , Hynds, P., Leonard, J , Mason, B., Millican, T. A., O'Connell, J. P , Porter, J., Tickle, S. P., Willenbrock, F., and Willmott, N. Potent, selective inhibitors of human gelatinase and their potential in the treatment of rumour metastasis. Peptides: Chemistry, Structure and Biology. Proceedings of the 13th American Peptide Symposium, pp 583-585, 1994.
5. Bernhard, E. J., Gruber, S. B., and Muschel, R. J. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci USA, 91: 4293-4297, 1994.
6. Ray, J M , and Stetler-Stevenson, W G. Gelatinase A activity directly modulates melanoma cell adhesion and spreading EMBO J. 14: 908-917, 1995.
7. Mignatti, P., Tsuboi, R., Robbins, E., and Rifkin, D. B. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J. Cell Biol , 108: 671-682, 1989
8. Schnaper, H. W , Grant, D. S., Stetler-Stevenson, W. G , Fridman, R., D'Orazi, G., Murphy, A. N , Bird, R. E , Hoythya, M., Fuerst, T R., French, D L , Quigley, J. P., and Kleinman, H. K. Type IV collagenase(s) and TlMPs modulate endothelial cell morphogenesis in vitro. J. Cell. Physiol., 156: 235-246, 1993.
9. Momiki, S., Baba, M., Caamano, J , Iizasa, T , Nakajima, M , Yamaguchi, Y., and Klein-Szanto, A In vivo and in vitro invasiveness of human lung carcinoma cell lines. Invasion & Metastasis, 11: 66-75, 1991
10. Brown, P. D., Bloxide, R. E., Stuart, N. S. A., Gatter, K. C , and Carmichael, J. Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. J. Natl Cancer Inst., 85: 574-578, 1993.
11. Garbisa, S , Scagliotti, G , Masiero, L., Di Francesco, C., Caenazzo, C., Onisto, M , Micela, M., Stetler-Stevenson, W. G., and Liotta, L. A. Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. Cancer Res., 52: 4548-4549, 1992.
12. Teicher, B. A., Holden, S. A., Ara, G , Alvarez Sotomayor, E., Huang, Z. D , Chen, Y-N , and Brem, H. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int J. Cancer, 57. 920-925, 1994.
13. Steel, G. G., Nill, R. P., and Peckham, M. J. Combined radiotherapy-chemotherapy of Lewis lung carcinoma. Int. J Radiat. Oncol. Biol Phys., 4: 49-52, 1978.
14. Heussen, C., and Dowdle, E. B. Electrophoretic analysts of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem., 102: 196-202, 1980.
15. Chander, S. K. Antoniw, P., Beeley, N. R. A., Boyce, N., Crabbe, T., Docherty, A. J. P , Leonard, J , Mason, B., Millar, K., Millican, T. A., Morphy, R , Mountain, A., O'Connell, J P., Porter, J R., and Willmott, N. An in vivo model for screening peptidomimetic inhibitors of gelatinase-A. J. Pharm. Sci., 84: 404-409, 1995.
16. Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst , 82: 4-6, 1990.
17. Macchiarini, P., Fontanini, G., Hardin, M. J , Squartini, F., and Angeletti, C A Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet, 340: 145-146, 1992.