Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors

Journal of Cell Biology

Volumn 135, Issue 6, 1996, Pages 1471-1483

  Austin, Cary D ^a   Shields, Dennis ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TYRPHOSTIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CELL SECRETION; CELL VACUOLE; CONTROLLED STUDY; GOLGI COMPLEX; HYPOPHYSIS CELL; INTRACELLULAR TRANSPORT; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ADP-RIBOSYLATION FACTOR 1; ADP-RIBOSYLATION FACTORS; AMINO ACID SEQUENCE; ANIMALS; ENZYME INHIBITORS; GOLGI APPARATUS; GTP-BINDING PROTEINS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NITRILES; PHOSPHORYLATION; PHOSPHOTYROSINE; PITUITARY GLAND; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RATS; TYROSINE; TYRPHOSTINS; VANADATES; ZINC;

ANIMALIA;

EID: 0030454535     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.6.1471     Document Type: Article

References (63)

1. Austin, C.D., and D. Shields. 1996. Prosomatostatin processing in permeabilized cells. Calcium is required for prohorrnone processing but not formation of nascent secretory vesicles. J. Biol. Chem. 271:1194-1199.
2. Baass, P.C., G.M. Di Guglielmo, F. Authier, B.I. Posner, and J.J.M. Bergeron. 1995. Compartmentalized signal transduction by receptor tyrosine kinases. Trends Cell Biol. 5:465-470.
3. Beckers, C.J.M., D.S. Keller, and W.E. Balch. 1987. Semi-intact cells permeable to macromolecules: use in reconstitution of protein transport from the endoplasmic reticulum to the golgi complex. Cell. 50:523-534.
4. Bennett, M.K., and R.H. Schelter. 1993. The molecular machinery for secretion is conserved from yeast to neurons. Proc. Natl. Acad. Sci. USA. 90:2559-2563.
5. Boman, A.L., and R.A. Kahn. 1995. Arf proteins: the membrane traffic police. Trends Biochem. Sci. 20:147-150.
6. Bomsel, M, and K. Mostov. 1992. Role of heterotrimeric G proteins in membrane traffic. Mol. Biol. Cell. 3:1317-1328.
7. Bordier, C. 1981. Phase separation of intergral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256:1604-1607.
8. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
9. Briscoe, C.P., A. Martin, M. Cross, and M.J.O. Wakelam. 1995. The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. Biochem. J. 306:115-122.
10. Brown, H.A., S. Gutowski, C.R. Moomaw, C. Slaughter, and P.C. Sternweis. 1993. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity, Cell. 75:1137-1144.
11. Chen, Y.-G., and D. Shields. 1996. ADP-ribosylation factor-1 stimulates formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells. J. Biol. Chem. 271:5297-5300.
12. Cockcroft, S., G.M.H. Thomas, A. Fensome, B. Geny, E. Cunningham, I. Gout, I. Hiles, N.F. Totty, O. Truong, and J.J. Hsuan. 1994. Phospholipase D: a downstream effector of ARF in granulocytes. Science (Wash. DC). 263:523-526.
13. Colombo, M.I., J. Inglese, C. D'Souza-Schorey, W. Beron, and P.D. Stahl. 1995. Heterotrimeric G proteins interact with the small GTPase ARF. Possibilities for the regulation of vesicular traffic. J. Biol. Chem. 270: 24564-24571.
14. De Camilli, P., S.D. Emr, P.S. McPherson, and P. Novick. 1996. Phosphoinositides as regulators in membrane traffic. Science (Wash. DC). 271: 1533-1539.
15. Donaldson, J.G., and R.D Klausner. 1994. ARF: a key regulatory switch in membrane traffic and organelle structure. Curr. Opin. Cell Biol. 6:527-532.
16. 3 cells. Identification and secretion of the intact propeptide. J. Biol. Chem. 269:30668-30675.
17. Erpel, T., and S.A. Courtneidge. 1996. Src family protein tyrosine kinases and cellular signal transduction pathways. Curr. Opin. Cell Biol. 7:176-182.
18. Fantus, G., S. Kadota, G. Deragon, B. Foster, and B.I. Posner. 1989. Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase. Biochemistry. 28:8864-8871.
19. Ferro-Novick, S., and R. Jahn. 1994. Vesicle fusion from yeast to man. Nature(Lond.). 370:191-193.
20. Gazit, A., P. Yaish, C. Gilon, and A. Levitzki. 1989. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32:2344-2352.
21. Gordon, J.A. 1991. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 201:477-482.
22. Green, R., and D. Shields. 1984. Somalostatin discriminates between the intracellular pathways of secretory and membrane proteins. J. Cell Biol. 99:97-104.
23. 2+-activated secretion. Nature (Lond.). 366:572-575.
24. 2+-activated secretion. Nature (Land.). 374:173-177.
25. 2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J. Biol. Chem. 265:2896-2902.
26. Huber, L.A., S. Pimplikar, R.G. Parton, H. Virta, M. Zerial, and K. Simons. 1993. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J. Cell Biol. 123:35-45.
27. 2+-dependent amylase secretion from pancreatic acini. J. Biol. Chem. 266:17744-17746.
28. Jiang, H., Z. Lu, J.-Q. Luo, A. Wolfman, and D.A. Foster. 1995. Ras mediates the activation of phospholipase D by v-Src. J. Biol. Chem. 270:6006-6009.
29. Jiang, H., J.-Q. Luo, T. Urano, P. Frankel, Z. Lu, D.A. Foster, and L.A. Feig. 1995. Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature (Lond.). 378:409-412.
30. Jones, S.M., J.R. Crosby, J. Salamero, and K.E. Howell. 1993. A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network. J. Cell Biol. 122:775-788.
31. Ktistakis, N.T., H.A. Brown, P.C. Sternweis, and M.G. Roth. 1995. Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A. Proc. Natl. Acad. Sci. USA. 92:4952-4956.
32. Ktistakis, N.T., H.A. Brown, M.G. Waters, P.C. Sternweis, and M.G. Roth. 1996. Evidence that phospholipase D mediates ADP ribosylation factordependent formation of Golgi coated vesicles. J. Cell Biol. 134:295-306.
33. Lamaze, C., and S.L. Schmid. 1995. Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase. J. Cell Biol. 129:47-54.
34. Levitzki, A., and A. Gazit. 1995. Tyrosine kinase inhibition: an approach to drug development. Science (Wash. DC). 267:1782-1788.
35. Leyte, A., F.A. Barr, R.H. Kehlenbach, and W.B. Huttner. 1992. Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. EMBO (Eur. Mol. Biol. Organ.) J. 11:4795-4804.
36. Li, R.Y., F. Gaits, A. Rageb, J.M. Rageb-Thomas, and H. Chap. 1995. Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via pertussis toxin-sensititive heterotrimeric G-protein. EMBO (Eur. Mol. Biol. Organ.) 7.14: 2519-2526.
37. Ling, W.L.W., and D. Shields. 1996. Formation of secretory vesicles in permeabilized cells: a salt extract from yeast membranes promotes budding of nascent secretory vesicles from the trans-Golgi network of endocrine cells. Biochem. J. 314:723-726.
38. Liscovitch, M., and L.C. Cantley. 1995. Signal transduction and membrane traffic: the PITP/phosphoinositide connection. Cell. 81:659-662.
39. Malarkey, K., CM. Belham, A. Paul, A. Graham, A. McLees, P.H. Scott, and R. Plevin. 1995. The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem. J. 309: 361-375.
40. Narula, N., I. McMorrow, G. Plopper, J. Doherty, K.S. Matlin, B. Burke, and J.L. Stow. 1992. Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes. J. Cell Biol. 117:27-38.
41. Nuoffer, C., and W.E. Balch. 1994. GTPases: multifunctional molecular switches regulating vesicular traffic. Annu. Rev. Biochem. 63:949-990.
42. Ohashi, M., and W.B. Huttner. 1994. An elevation of cytosolic protein phosphorylation modulates trimeric G-protein regulation of secretory vesicle formation from the trans-Golgi network. J. Biol. Chem. 269: 24897-24905.
43. Ohashi, M., K. Jan de Vries, R. Frank, G. Snoek, V. Bankaitis, K. Wirtz, and W. Huttner. 1995. A role for phosphatidylinositol transfer protein in secretory vesicle formation. Nature (Lond.). 377:544-547.
44. Pfeffer, S.R. 1994. Rab GTPases: master regulators of membrane trafficking. Curr. Opin. Cell Biol. 6:522-526.
45. s class of heterotrimeric G protein. Nature (Lond.). 362:456-458.
46. Pimplikar, S.W., and K. Simons. 1994. Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells. J. Biol. Chem. 269:19054-19059.
47. Posner, B.I., R. Faure, J.W. Burgess, A.P. Bevan, D. Lachance, G. ZhangSun, I.G. Fantus, J.B. Ng, D.A. Hall, B.S. Lum, and A. Shaver. 1994. Peroxovanadium compounds. J. Biol. Chem. 269:4596-4604.
48. Pryde, J.G. 1994. A group of integral membrane proteins of the rat liver Golgi contains a conserved protein of 100 kDa. J. Cell Sci. 107:3425-3436.
49. Pumiglia, K.M., L.-F. Lau, C.-K. Huang, S. Burroughs, and M.B. Feinstein. 1992. Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem. J. 286: 441-449.
50. s and ARF GTPase-activating protein. J. Biol. Chem. 269:29490-29494.
51. Rothman, J.E. 1994. Mechanisms of intracellular protein transport. Nature (Lond.). 372:55-63.
52. Santini, F., and J.H. Keen. 1996. Endocytosis of activated receptors and clathrin-coated pit formation: deciphering the chicken or egg relationship. J. Cell Biol. 132:1025-1036.
53. Slack, B.E., J. Breu, M.A. Petryniak, K. Srivastava, and R.J. Wurtman. 1995. Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor. J. Biol. Chem. 270:8337-8344.
54. Stack, J.H., B. Horazdovsky, and S.D. Emr. 1995. Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Annu. Rev. Cell Dev. Biol. 11:1-33.
55. Stanners, J., P.S. Kabouridis, K.L. McGuire, and C.D. Tsoukas. 1995. Interaction between G proteins and tyrosine kinases upon T cell receptorCD3-mediated signalling. J. Biol. Chem. 270:30635-30642.
56. Stoller, T.J., and D. Shields, 1988. Retrovirus-mediated expression of preprosomatostatin: posttranslational processing, intracellular storage, and secretion in GH3 Pituitary Cells. J. Cell Biol. 107:2087-2095.
57. Streuli, M. 1996. Protein tyrosine phosphatases in signaling. Curr. Opin. Cell Biol. 8:182-188.
58. Sun, H., and N.K. Tonks. 1994. The coordinated action of protein tyrosine phosphatases and kinases in cell signalling. Trends Biochem. Sci. 19:480-485.
59. Trudel, S., M.R. Paquet, and S. Grinstein. 1991. Mechanism of vanadateinduced activation of tyrosine phosphorylation and of the respiratory burst in HL60 cells. Biochem. J. 276:611-619.
60. Van der Geer, P., and T. Hunter. 1994. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:251-337.
61. Walton, K.M. and J.E. Dixon. 1993. Protein tyrosine phosphalases. Annu. Rev. Biochem. 62:101-120.
62. Xu, H., and D. Shields. 1993. Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells. J. Cell Biol. 122:1169-1184.
63. Xu, H., P. Greengard, and S. Gandy. 1995. Regulated formation of Golgi secretory vesicles containing Alzheimer β-amyloid precursor protein. J. Biol. Chem. 270:23243-23245.