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1
-
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0028723494
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Membrane-associated tyrosine kinases as molecular switches
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(1994)
Semin Cell Biol
, vol.5
, pp. 377-387
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Cooper1
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4
-
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0027289232
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Disruption of the csk gene, encoding a negative regular of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
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of special interest, This paper and [3] demonstrate that Csk, shown in biochemical assays to phosphorylate the regulatory tail of Src family kinases, is also the major regulator of phosphorylation of this site in vivo.
-
(1993)
Cell
, vol.73
, pp. 1117-1124
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Imamoto1
Soriano2
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6
-
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0028941630
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Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions
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(1995)
EMBO J
, vol.14
, pp. 963-975
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-
Erpel1
Superti-Furga2
Courtneidge3
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7
-
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0028014460
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Signal transduction by lymphocyte antigen receptors
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(1994)
Cell
, vol.76
, pp. 263-274
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Weiss1
Littmann2
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8
-
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0026705734
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c-src by overexpression of a protein tyrosine phosphatase
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(1992)
Nature
, vol.359
, pp. 336-339
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-
Zheng1
Wang2
Pallen3
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10
-
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0009651402
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The product of the proto-oncogene c-src is modified during the cellular response to platelet-derived growth factor
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(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 7845-7849
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Ralston1
Bishop2
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17
-
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0021970413
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Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
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(1985)
Nature
, vol.313
, pp. 241-243
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Mulcahy1
Smith2
Stacey3
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25
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0028795721
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DNA synthesis induced by some, but not all, growth factors requires Src family protein tyrosine kinases
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of special interest, This paper shows that whereas Src family kinases are required for DNA synthesis induced by platelet-derived growth factor, colony stimulating factor-1 and epidermal growth factor, they are not involved in the mitogenic responses to ligands that activate G proteins, such as lysophosphatidic acid and bombesin.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1102-1109
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Roche1
Koegl2
Barone3
Roussel4
Courtneidge5
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27
-
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0024478058
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c-src tyrosine kinase, myristylation and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src
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(1989)
Mol Cell Biol
, vol.9
, pp. 1536-1544
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-
Wilson1
Luttrell2
Parsons3
Parsons4
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28
-
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0028171075
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Epidermal growth factor dependent activation of the Src family kinases
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of special interest, This paper demonstrates, using several cell lines, that activation of Src by epidermal growth factor (EGF) correlates with high levels of EGF receptor expression. Together with the observations in [25,26,27] demonstrating a requirement for Src family kinases in EGF signalling, this result has implications for tumours that overexpress the EGF receptor.
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(1994)
Eur J Biochem
, vol.225
, pp. 1047-1053
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Osherov1
Levitzki2
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31
-
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0028176477
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A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling
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(1994)
Cell
, vol.78
, pp. 5-8
-
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Carraway1
Cantley2
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33
-
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0026488321
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Platelet activation leads to increased c-src kinase activity and association of c-src with an 85-kDa tyrosine phosphoprotein
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(1992)
Oncogene
, vol.7
, pp. 2407-2415
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Wong1
Reynolds2
Papkoff3
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37
-
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0027411213
-
ras by G protein-coupled receptor agonists in fibroblasts
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of outstanding interest, An interesting demonstration that Ras proteins are activated by ligands (lysophosphatidic acid and thrombin) that activate G protein coupled receptors. The activation is sensitive to both pertussis toxin and kinase inhibitors.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1257-1261
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-
Van Corven1
Hordijk2
Medema3
Bos4
Moolenaar5
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39
-
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0028306464
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Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130
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(1994)
J Biol Chem
, vol.269
, pp. 9345-9351
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Seufferlein1
Rozengurt2
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42
-
-
0026759309
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Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
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(1992)
Nature
, vol.358
, pp. 690-692
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Guan1
Shalloway2
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43
-
-
0024382542
-
Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton
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(1989)
J Cell Biol
, vol.108
, pp. 2401-2408
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Glenney1
Zokas2
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46
-
-
0027340192
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c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets
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(1993)
Mol Cell Biol
, vol.13
, pp. 1863-1871
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Clark1
Brugge2
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47
-
-
0026739248
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src with Triton X-100 insoluble residue in human blood platelets requires platelet aggregation and actin polymerization
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(1993)
J Biol Chem
, vol.267
, pp. 20075-20081
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-
Oda1
Druker2
Smith3
Salzman4
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49
-
-
0028095620
-
Structure, regulation and function of phosphoinositide 3-kinases
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(1994)
Biochim Biophys Acta
, vol.1226
, pp. 237-268
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Fry1
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50
-
-
0028429961
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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
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of special interest, This paper provides a link between the cytoskeletal rearrangements resulting in membrane ruffling that are seen shortly after the addition of platelet-derived growth factor (PDGF), and the activity of the PDGF receptor associated phosphatidylinositol 3-kinase (P13-K). Three different methods are used: a PDGF receptor mutated in the P13-K binding sites; overexpression of a form of the regulatory, receptor-associated subunit to which the catalytic subunit cannot bind; and wortmannin, an inhibitor of P13-Ks.
-
(1994)
Current Biology
, vol.4
, pp. 385-393
-
-
Wennström1
Hawkins2
Cooke3
Hara4
Yonezawa5
Kasuga6
Jackson7
Claesson-Welsh8
Stephens9
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54
-
-
0028342938
-
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain
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of special interest, This paper and [52,53] describe the association of members of the Src family via their SH2 domains to a phosphorylation site in focal adhesion kinase (FAK). These findings have implications for the mechanism of action of FAK, as well as for signal transduction through integrins.
-
(1994)
Mol Biol Cell
, vol.5
, pp. 413-421
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-
Xing1
Chen2
Nowlen3
Taylor4
Shalloway5
Guan6
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55
-
-
0028877919
-
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
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of special interest, The data presented in this paper are consistent with a model in which, after autophosphorylation of focal adhesion kinase (FAK) and Src binding (see [52-54]), Src phosphorylates FAK on novel sites in the catalytic domain, and upregulates its kinase activity.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 954-963
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Calalb1
Polte2
Hanks3
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56
-
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0028609382
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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
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of outstanding interest, A phosphorylation site in the carboxyl terminus of focal adhesion kinase (FAK) is shown to be the site for binding of Grb2. This binding provides a mechanism whereby Ras may be activated in response to integrin engagement at the cell surface. In cells transformed with v-Src, the association of Grb2 with FAK and Src is independent of cell adhesion.
-
(1994)
Nature
, vol.372
, pp. 786-790
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-
Schlaepfer1
Hanks2
Hunter3
Van der Geer4
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58
-
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0028151515
-
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527
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of special interest, Mutation of the tyorsine in the regulatory tail of Src causes its redistribution from endosomes to focal adhesions. This redistribution does not require the catalytic activity of Src, but both the myristylation site and the SH3 domain are necessary. The level of phosphotyrosine in focal adhesions is shown to be increased when either catalytically active or inactive Src is present, suggesting non-enzymatic functions for Src in focal adhesions.
-
(1994)
EMBO J
, vol.13
, pp. 4745-4756
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Kaplan1
Bibbins2
Swedlow3
Arnaud4
Morgan5
Varmus6
-
60
-
-
0027049804
-
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
-
(1992)
Cell
, vol.71
, pp. 1081-1091
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Devary1
Gottlieb2
Smeal3
Karin4
-
66
-
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0028329195
-
An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis
-
(1994)
Nature
, vol.368
, pp. 867-871
-
-
Taylor1
Shalloway2
-
75
-
-
0028170518
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Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice
-
(1994)
Genes Dev
, vol.8
, pp. 1999-2007
-
-
Stein1
Vogel2
Soriano3
-
76
-
-
0028293147
-
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity
-
(1994)
Genes Dev
, vol.8
, pp. 387-398
-
-
Lowell1
Soriano2
Varmus3
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