Plasma leptin is directly related to body adiposity in subjects with spinal cord injury

Hormone and Metabolic Research

Volumn 28, Issue 12, 1996, Pages 732-736

  Bauman, W A ^a,b   Spungen, A M ^a   Zhong, Y G ^a   Mobbs, C V ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

body mass index; dual energy x ray absorptiometry; fat mass; paraplegia; plasma leptin; triglycerides

Indexed keywords

GLUCOSE; LEPTIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD ANALYSIS; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LIPID METABOLISM; MALE; OBESITY; PRIORITY JOURNAL; SPINAL CORD INJURY; X RAY ANALYSIS;

EID: 0030454030     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979889     Document Type: Article

References (32)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the obese gene and its human homologue. Nature (London) 372: 425-231 (1994).
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546 (1995).
3. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese Gene product on body weight regulation in ob/ob mice. Science 269: 540-543 (1994).
4. Maffei M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Friedman JM: Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci 92: 6957-6960 (1995).
5. Lee G-H, Proenca R, Montez JM, Carroll KM, Darvishzaded JG, Lee JI, Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635 (1996).
6. Mizuno TM, Bergen H, Tunabashi T, Kleopoulof SP, Zhong G, Bauman WA, Mobbs CV: Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci 93: 3434-3438 (1996).
7. Funabashi T, Shimomura I, Hiraoka H, Aral T, Takahashi M, Nakamura T, Noraki S, Yamashita S, Takemura K, Tokunaga K, Matsusawa Y: Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem Biophys Res Commun 211: 469-475 (1995).
8. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161 (1995).
9. Saladin R, Vos PD, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529 (1995).
10. MacDougald OA, Hwang CS, Fan H, Lane MD: Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci 92: 9034-9037 (1995).
11. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295 (1996).
12. Dagogo-Jack S, Fanelli C, Paramore ÖD, Brothers J, Landt M: Plasma leptin and insulin relationships in obese and nonobese humans. Diab 45: 695-698 (1996).
13. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF: Acute and chronic effect of insulin on leptin production in humans. Diab 45: 699-701 (1996).
14. McGregor GP, Desaga JF, Ehlenz K, Fischer A, Heese F, Hegele A, Lammer C, Peiser C, Lang RE: Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinol 137: 1501-1504 (1996).
15. Bauman WA, Spungen AM: Disorders of carbohydrate and lipid metabolism in veterans with paraplegia or quadriplegia: A model of premature aging. Metab 43: 749-756 (1994).
16. Berson SA, Yalow RS: Radioimmunoassay. In: Methods in Investigative and Diagnostic Endocrinology, vol 1. Berson SA and Yalow RS (eds). North-Holland, Amsterdam, The Netherlands (1973), 84-120.
17. Yalow RS, Berson SA: Radioimmunoassay In: Methods in Investigative and Diagnostic Endocrinology, vol 2. Berson SA and Yalow RS (eds). North-Holland, Amsterdam, The Netherlands (1973), 864-870.
18. WHO Expert Committee on Diabetes Mellitus: Second report. WHO Tech Rep Ser No 646 (1980).
19. Health implications of obesity. National Institutes of Health Consensus Development Conference Statement. Ann Int Med 103: 1073-1077 (1985).
20. Wang J, Heymsfield SB, Aule TM, Thornton JC, Pierson Jr RN: Body fat from body density: Underwater weighing vs. dual-photon absorptiometry. Am J Physiol 256 (Endocrinol Metab 19): E829-E834 (1989).
21. Heymsfield SB, Wang J, Heshka S, Kehayias JJ, Pierson Jr RN: Dual-photon absorptiometry: Comparison of bone mineral and soft tissue mass measurements in vivo with established methods. Am J Clin Nutr 49: 1283-1289 (1989).
22. Mazess RB, Peppler WW, Gibbons M: Total body composition by dual photon absorptiometry. Am J Clin Nutr 40: 834-839 (1984).
23. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte Jr D: Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nat Med 2: 589-593 (1996).
24. Segal KR, Gutin B, Presta E, Van Italie TB: Estimation of human body composition by electrical impedance methods: A comparative study. J Appl Physiol 58: 1565-1571 (1985).
25. Jebb SA, Elia M: Techniques for the measurement of body composition: A practical guide. Int J Obes Relat Metab Disord 17: 611-621 (1993).
26. Spungen AM, Bauman WA, Wang J, Pierson Jr RN: Measurement of percent body fat in individuals with quadriplegia: a comparison of clinical methods. Paraplegia 33: 402-408 (1995).
27. George CM, Wells CL, Dugan NL: Validity of hydrodensitometry for determinations of body composition in spinal cord injured subjects. Human Biology 60: 771-800 (1988).
28. Wang J, Kotler DP, Russell M, Burastero S, Mazariegos M, Thornton JC, Dilmanian FA, Pierson Jr RN: Body-fat measurement in patients with acquired immunodeficiency syndrome: Which method should be used? Am J Clin Nutr 56: 963-967 (1992).
29. Pierson Jr RN, Thornton JC, Wang J, Kotler DP, Heymsfield SB, Weber DA: Bone mineral and body fat measurements by two absorptiometry systems: Comparisons with neutron activation analysis. Calcif Tissue Int 56: 93-98 (1995).
30. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1: 953-956 (1995).
31. Rentsch J, Chiesi M: Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Letters 379: 55-59 (1996).
32. Malmström R, Taskinen M-R, Karonen S-L, Yki-Harvinen H: Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39: 993-996 (1996).