Cell biology of the β-amyloid precursor protein and the genetics of Alzheimer's disease

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 61, Issue , 1996, Pages 587-596

  Selkoe, D J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; PRESENILIN;

ALZHEIMER DISEASE; AMNESIA; AMYLOIDOSIS; CONFERENCE PAPER; DEMENTIA; GENE MUTATION; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; ARTICLE; CELL MIGRATION; CEREBROSPINAL FLUID; CYTOLOGY; ENDOPLASMIC RETICULUM; GENETICS; GENOTYPE PHENOTYPE CORRELATION; MISSENSE MUTATION; PROTEIN DEGRADATION; PROTEIN PROCESSING; SEQUENCE ANALYSIS;

EID: 0030433777     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1996.061.01.059     Document Type: Conference Paper

References (35)

1. Biere, A.L., B. Ostaszewski, H. Zhao, S. Gillespie, S.G. Younkin, and D.J. Selkoe. 1995. Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: Analysis of βAPP processing. Neurobiol. Dis. 2: 177.
2. Cai, X.-D., T.E. Golde, and G.S. Younkin. 1993. Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259: 514.
3. Citron, M., D.B. Teplow, and D.J. Selkoe. 1995. Generation of amyloid β-protein from its precursor is sequence specific. Neuron 14: 661.
4. Citron, M., T. Oltersdorf, C. Haass, L. McConlogue, A.Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg, and D.J. Selkoe. 1992. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360: 672.
5. Citron, M., C. Vigo-Pelfrey, D.B. Teplow, C. Miller, D. Schenk, J. Johnston, B. Winblad, N. Venizelos, L. Lannfelt, and D.J. Selkoe. 1994. Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer's disease mutation. Proc. Natl. Acad. Sci. 91: 11993.
6. Corder, E.H., A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, Jr., G.W. Small, A.D. Roses, J.L. Haines, and M.A. Pericak-Vance. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921.
7. Evans, K.C., E.P. Berger, C.-G. Cho, K.H. Weisgraber, and P.T. Lansbury, Jr. 1995. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease. Proc. Natl. Acad. Sci 92: 763.
8. Games, D., D. Adams, R. Alessandrini, R. Barbour, P. Berthelette, C. Blackwell, T. Carr, J. Clemens, T. Donaldson, F. Gillespie, T. Guido, S. Hagopian, K. Johnson-Wood, K. Khan, M. Lee, P. Leibowitz, I. Lieberburg, S. Little, E. Masliah, L. McConlogue, M. Montoya-Zavala, L. Mucke, L. Paganini, E. Penniman, M. Power, D. Schenk, P. Seubert, B. Snyder, F. Soriano, H. Tan, J. Vitale, S. Wadsworth, B. Wolozin, and J. Zhao. 1995. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373: 523.
9. Haass, C., A.Y. Hung, D.J. Selkoe, and D.B. Teplow. 1994. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor. J. Biol. Chem. 269: 17741.
10. Haass, C., C.A. Lemere, A. Capell, M. Citron, P. Seubert, D. Schenk, L. Lannfelt, and D.J. Selkoe. 1995. Swedish mutation causes early-onset AD by β-secretase cleavage within the secretory pathway. Nat. Med. 1: 1291.
11. Hyman, B.T., H.L. West, G.W. Rebeck, S.V. Buldyrev, R.N. Mantegna, M. Ukleja, S. Havlin, and H.E. Stanley. 1995. Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc. Natl. Acad. Sci. 92: 3586.
12. Iwatsubo, T., A. Odaka, N. Suzuki, H. Mizwa, N. Nukina, and Y. Ihara. 1995. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43). Neuron 13: 45.
13. Kang, J., H.-G. Lemaire, A. Unterbeck, J.M. Salbaum, C.L. Masters, K.-H. Grzeschik, G. Multhaup, K. Beyreuther, and B. Muller-Hill. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733.
14. Kovacs, D. M., H.J. Fausett, K.J. Page, T.-W. Kim, R.D. Moir, D.E. Merriam, R.D. Hollister, O.G. Hallmark, R. Mancini, K.M. Felsenstein, B.T. Human, R.E. Tanzi, and W. Wasco. 1996. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2: 224.
15. Lemere, C.A., J.K. Blustzjan, H. Yamaguchi, T. Wisniewski, T.C. Saido, and D.J. Selkoe. 1996a. Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation. Neurobiol. Dis. 3: 16.
16. Lemere, C.A., F. Lopera, K.S. Kosik, C.L. Lendon, J. Ossa, T.C. Saido, H. Yamaguchi, A. Ruiz, A. Martinez, L. Madrigal, L. Hincapie, J.C. Arango I., L.D.C. Anthony, E.H. Koo, A.M. Goate, D.J. Selkoe, and J.C. Arango V. 1996b. The E280A presenilin 1 mutation leads to a distinct Alzheimer's disease phenotype: Increased Aβ42 deposition and severe cerebellar pathology. Nat. Med. 2: 1146.
17. Levy-Lahad, E., W. Wasco, P. Poorkaj, D.M. Romano, J. Oshima, H. Pettingell, C. Yu, P.D. Jondro, S.D. Schmidt, K. Wang, A.C. Crowley, Y.-H. Fu, S.Y. Guenette, D. Galas, E. Nemens, E.M. Wijsman, T.D. Bird, G.D. Schellenberg, and R.E. Tanzi. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269: 973.
18. Lorenzo, A. and B. Yankner. 1994. β-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. 91: 12243.
19. Ma, J., A. Yee, H.B. Brewer, Jr., S. Das, and H. Potter. 1994. The amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer β-protein into filaments. Nature 372: 92.
20. Mann, D.M.A., A. Brown, D. Prinja, C.A. Davies, M. Landon, C.L. Masters, and K. Beyreuther. 1989. An analysis of the morphology of senile plaques in Down's syndrome patients of different ages using immunocytochemical and lectin histochemical techniques. Neuropathol. Appl. Neurobiol. 15: 317.
21. Morris, J.C., M. Storandt, D.W. McKeel, Jr., E.H. Rubin, J.L. Price, E.A. Grant, and L. Berg. 1996. Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease. Neurology 46: 707.
22. Oltersdorf, T., P.J. Ward, T. Henriksson, E.C. Beattie, R. Neve, I. Lieberburg, and L.C. Fritz. 1990. The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway. J. Biol. Chem. 265: 4492.
23. Pike, C.J., D. Burdick, A.J. Walencewicz, C.G. Glabe, and C.W. Cotman. 1993. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state. J. Neurosci. 13: 1676.
24. Rebeck, G.W., J.S. Reiter, D.K. Strickland, and B.T. Hyman. 1993. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11: 575.
25. Rogaev, E.I., R. Sherrington, E.A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang, H. Chi, C. Lin, K. Holamn, T. Tsuda, L. Mar, S. Sorbi, B. Nacmias, S. Piacentini, L. Amaducci, I. Chumakov, D. Cohen, L. Lannfelt, P.E. Fraser, J.M. Rommens, and P.H. St. George-Hyslop. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 775.
26. Scheuner, D., X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, E.L. Lannfelt, E. Levy-Lahad, E.R. Peskind, P. Poorkaj, G.D. Schellenberg, R.E. Tanzi, M. Viitanen, W. Wasco, D.J. Selkoe, and S.G. Younkin. 1996. The presenilin 1 and 2 mutations linked to familial Alzheimer's disease increase the extracellular concentration of amyloid β protein (Aβ) ending at Aβ42(43). Nat. Med. 2: 864.
27. Schmechel, D.E., A.M. Saunders, W.J. Strittmatter, B.J. Crain, C.M. Hulette, S.H. Joo, M.A. Pericak-Vance, D. Goldgaber, and A.D. Roses. 1993. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E gentoype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. 90: 9649.
28. Selkoe, D.J. 1994. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 10: 373.
29. _. 1996. Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271: 18295.
30. Sherrington, R., E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, T. Tsuda, L. Mar, J.-F. Foncin, A.C. Bruni, M.P. Montesi, S. Sorbi, I. Rainero, L. Pinessi, L. Nee, I. Chumakov, D.A. Pollen, A.D. Roses, P.E. Fraser, J.M. Rommens, and P.H. St. George-Hyslop. 1995. Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease. Nature 375: 754.
31. Suzuki, N., T.T. Cheung, X.-D. Cai, A. Odaka, L. Otvos, Jr., C. Eckman, T.E. Golde, and S.G. Younkin. 1994. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants. Science 264: 1336.
32. Thinakaran, G., D.R. Borchelt, M.K. Lee, H.H. Slunt, L. Spitzer, G. Kim, T. Rotovitsky, F. Davenport, C. Nordstedt, M. Seeger, J. Hardy, A.I. Levey, S.E. Gandy, N.A. Jenkins, N.G. Copeland, D.L. Price, and S.S. Sisodia. 1996. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181.
33. Weidemann, A., G. Konig, D. Bunke, P. Fischer, J.M. Salbaum, C.L. Masters, and K. Beyreuther. 1989. Identification, biogenesis and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57: 115.
34. Wisniewski, T., J. Ghiso, and B. Frangione. 1991. Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. Biochem. Biophys. Res. Commun. 179: 1247.
35. Yamazaki, T., E.H. Koo, and D.J. Selkoe. 1996. Trafficking of cell-surface amyloid β-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. J. Cell Sci. 109: 999.