Diallyl disulfide suppresses the growth of human colon tumor cell xenografts in athymic nude mice

Journal of Nutrition

Volumn 126, Issue 5, 1996, Pages 1355-1361

  Sundaram, Sujatha C ^a   Milner, John A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

5 fluorouracil; colon; diallyl disulfide; nude mice; tumors

Indexed keywords

DIALLYL DISULFIDE; FLUOROURACIL;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE COUNT; MOUSE; NONHUMAN; NUDE MOUSE; SPLEEN WEIGHT; TUMOR VOLUME;

EID: 0029872293     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.5.1355     Document Type: Article

References (30)

1. Amagase, H. & Milner, J. A. (1993) Impact of various sources of garlic and their constituents on 7,12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis 14: 1627-1631.
2. Awad, A. B., Herrmann, T., Fink, C. S. & Horvath, P. J. (1995) 18:1 n7 fatty acids inhibit growth and decrease inositol phosphate release in HT-29 cells compared to n9 fatty acids. Cancer Lett. 91: 55-61.
3. Belman, S. (1983) Onion and garlic oils inhibit tumor promotion. Carcinogenesis 4: 1063-1067.
4. Belman, S., Solomon, J., Segal, A., Bloçk, E. & Barany, G. N. (1989) Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components. J. Biochem. Toxicol. 4: 1063-1065.
5. Block, E. (1992) The organosulfur chemistry of the genus allium - implications for the organic chemistry of sulfur. Angewandte Chemie International Edition in English 31: 1135-1178.
6. Blumenthal, R. D., Sharkey, R. M., Natale, A. M., Kashi, R., Wong, G. & Goldberg, D. M. (1994) Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic xenografts. Cancer Res. 54: 142-151.
7. Boyum, A. (1968) Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. (Suppl. 97): 7.
8. Burns, C. P. & Wagner, B. A. (1993) Effects of exogenous lipids on cancer and cancer chemotherapy. Implications for treatment. Drug Safety 8: 57-68.
9. Criss, W. E., Fakunle, J., Night, E., Adkins, J., Morris, H. P. & Dhillon, G. (1982) Inhibition of tumor growth with low dietary protein and with dietary garlic extracts. Fed. Proc. 41: A281 (abs.).
10. Dausch, J. G. & Nixon, D. W. (1990) Garlic: a review of its relationship to malignant disease. Prev. Med. 19: 346-361.
11. Dexter, D. L., Spermulli, E. N., Matook, G. M., Diamond, I. & Calabresi, P. (1982) Inhibition of the growth of human colon cancer xenografts by polar solvents. Cancer Res. 42: 5018-5022.
12. Eriksson, L., Hydbring, E., Tuomisto, L., MacDonald, E., Kokkonen, U. M. & Olsson, K. (1994) Intraruminal fluid administration to goats: effects of handling and fluid temperature. Acta Vet. Scand. 35: 289-298.
13. Goya, L., Edwards, C. P., Glennemeier, K. A. & Firestone, G. L. (1991) In vivo effects of dexamethasone on the tumor growth of glucocorticoid-sensitive Fu5-derived rat hepatoma cells. Cancer Lett. 58: 211-219.
14. Ip, C., Lisk, D. J. & Stoewsand, G. S. (1992) Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutr. Cancer 17: 279-286.
15. Kuroki, M., Nakano, S., Mitsugi, K., Ichinose, I., Anzal, K., Nakamura, M., Nagafuchi, S. & Niho, Y. (1992) In vivo comparative therapeutic study of optimal administration of 5-fluorouracil and cisplatin using a newly established HST-1 human squamous carcinoma cell line. Cancer Chemother. Pharmacol. 29: 273-276.
16. Lau, B.H.S., Wooley, J. L., Marsh, C. L., Barker, G. R., Koobs, D. H. & Torrey, R. R. (1986) Superiority of intralesional immunotherapy with Corynebacterium parvum and Allium sativum in control of murine transitional cell carcinoma. J. Urol. 136: 701-705.
17. Lin, X. Y., Liu, J.-Z. & Milner, J. A. (1994) Dietary garlic suppresses DNA adducts caused by N-nitroso compounds. Carcinogenesis 15: 349-352.
18. Liu, J.-Z., Lin, R. I. & Milner, J. A. (1992) Inhibition of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by garlic powder. Carcinogenesis 13: 1847-1851.
19. Marsh, C. L., Torrey, R. R., Wooley, J. L., Barker, G. R. & Lau, B.H.S. (1987) Superiority of intravesical immunotherapy with Corynebacterium parvum and Allium sativum in control of murine bladder cancer. J. Urol. 137: 359-362.
20. Milner, J A. (1994) Reducing the risk of cancer. In: Functional Foods (Goldberg, I., ed.), pp. 39-70. Van Norstrand Reinhold, New York, NY.
21. Naguib, F.N.M., Hao, S. & el Kouni, M. H. (1994) Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5-benzyloxybenzyluracil. Cancer Res. 54: 5166-5170.
22. Ohta, T., Tawara, M., Tasuka, M., Abe, H. & Odashima, S. (1983) An approach to prolongation of survival rate in tumor bearing mice using 5-fluorouracil in combination with various kinds of herb medicine. Jpn. J. Cancer Chemother. 10: 1858-1865.
23. Sadhana, A. S., Rao, A. R., Kucheria, K. & Bijani, V. (1988) Inhibitory action of garlic oil on the initiation of benzo[a]pyrene-induced skin carcinogenesis in mice. Cancer Lett. 40: 193-197.
24. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, E. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J. S. Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85.
25. Steel, R. G. & Torrie, J. M. (1980) Principles and Procedures of Statistics: A Biometrical Approach (Napier, C. & Maisel J. W., eds.), pp. 182-183. McGraw-Hill Book Co., New York, NY.
26. Steinmetz, K. A., Kushi, L. H., Bostick, R. M., Folsom, A. R. & Potter, J. D. (1994) Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am. J. Epidemiol. 139: 1-15.
27. Sundaram, S. G. & Milner, J. A. (1993) Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett. 74: 85-90.
28. Sundaram, S. G. & Milner, J. A. (1996) Diallyl disulfide inhibits the proliferation of human tumor cells in culture. Biochim. Biophys. Acta 1315: 15-20.
29. Wargovich, M. J. (1987) Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis 8: 487-489.
30. Wargovich, M. J., Woods, C., Eng, V.W.S., Stephens, L. C. & Gray, K. N. (1988) Chemoprevention of nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide. Cancer Res. 48: 6872-6875.