-
2
-
-
0027686386
-
The production of heterologous plasma proteins
-
Goodey AR. The production of heterologous plasma proteins. Trends Biotechnol. 11:1993;430-433.
-
(1993)
Trends Biotechnol
, vol.11
, pp. 430-433
-
-
Goodey, A.R.1
-
3
-
-
14744299579
-
Recent advances in the expression of foreign genes in Pichia pastoris
-
Cregg JM, Vedvick TS, Raschke WC. Recent advances in the expression of foreign genes in Pichia pastoris. Bio-Technology. 11:1993;905-909.
-
(1993)
Bio-Technology
, vol.11
, pp. 905-909
-
-
Cregg, J.M.1
Vedvick, T.S.2
Raschke, W.C.3
-
4
-
-
0028827506
-
Methylotrophic yeasts as factories for the production of foreign proteins
-
of special interest. This paper (see also [3]) reviews recent developments in the production of heterologous proteins in methylotrophic yeast.
-
Faber KN, Harder W, Ab G, Veenhuis M. Methylotrophic yeasts as factories for the production of foreign proteins. of special interest Yeast. 11:1995;1331-1344 This paper (see also [3]) reviews recent developments in the production of heterologous proteins in methylotrophic yeast.
-
(1995)
Yeast
, vol.11
, pp. 1331-1344
-
-
Faber, K.N.1
Harder, W.2
Ab, G.3
Veenhuis, M.4
-
5
-
-
0028081167
-
High-level secretion and very efficient isotopic labeling of tick anticoagulant peptide (TAP) expressed in the methylotrophic yeast, Pichia pastoris
-
Laroche Y, Storme V, De Meutter J, Messens J, Lauwereys M. High-level secretion and very efficient isotopic labeling of tick anticoagulant peptide (TAP) expressed in the methylotrophic yeast, Pichia pastoris. Bio-Technology. 12:1994;1119-1124.
-
(1994)
Bio-Technology
, vol.12
, pp. 1119-1124
-
-
Laroche, Y.1
Storme, V.2
De Meutter, J.3
Messens, J.4
Lauwereys, M.5
-
6
-
-
0028046767
-
Optimization of the expression system using galactose-inducible promoter for the production of anticoagulant hirudin in Saccharomyces cerevisiae
-
Choi ES, Sohn JH, Rhee SK. Optimization of the expression system using galactose-inducible promoter for the production of anticoagulant hirudin in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 42:1994;587-594.
-
(1994)
Appl Microbiol Biotechnol
, vol.42
, pp. 587-594
-
-
Choi, E.S.1
Sohn, J.H.2
Rhee, S.K.3
-
7
-
-
0028152841
-
C-terminal proteolytic degradation of recombinant desulfato-hirudin and its mutants in the yeast Saccharomyces cerevisiae
-
Heim J, Takabayashi K, Meyhack B, Marki W, Pohlig G. C-terminal proteolytic degradation of recombinant desulfato-hirudin and its mutants in the yeast Saccharomyces cerevisiae. Eur J Biochem. 226:1994;341-353.
-
(1994)
Eur J Biochem
, vol.226
, pp. 341-353
-
-
Heim, J.1
Takabayashi, K.2
Meyhack, B.3
Marki, W.4
Pohlig, G.5
-
8
-
-
0028978231
-
2-mu vectors containing the Saccharomyces cerevisiae metallothionein gene as a selectable marker: Excellent stability in complex media, and high-level expression of a recombinant protein from a CUP1 - Promoter-controlled expression cassette in cis
-
of special interest. Describes a selection for plasmid maintenance in complex medium. It cleverly links the intensity of the selective pressure to the degree of expression of the recombinant protein.
-
Hottiger T, Kuhla J, Pohlig G, Fuerst P, Spielmann A, Garn M, Haemmerli S, Heim J. 2-mu vectors containing the Saccharomyces cerevisiae metallothionein gene as a selectable marker: excellent stability in complex media, and high-level expression of a recombinant protein from a CUP1 - promoter-controlled expression cassette in cis. of special interest Yeast. 11:1995;1-14 Describes a selection for plasmid maintenance in complex medium. It cleverly links the intensity of the selective pressure to the degree of expression of the recombinant protein.
-
(1995)
Yeast
, vol.11
, pp. 1-14
-
-
Hottiger, T.1
Kuhla, J.2
Pohlig, G.3
Fuerst, P.4
Spielmann, A.5
Garn, M.6
Haemmerli, S.7
Heim, J.8
-
9
-
-
0029967478
-
Effect of soybean oil on the enhanced expression of hirudin gene in Hansenula polymorpha
-
of special interest. An unexpected and very original observation that the addition of soybean oil increases the yield of recombinant hirudin in H. polymorpha.
-
Kim CH, Sohn JH, Choi ES, Rhee SK. Effect of soybean oil on the enhanced expression of hirudin gene in Hansenula polymorpha. of special interest Biotechnol Lett. 18:1996;417-422 An unexpected and very original observation that the addition of soybean oil increases the yield of recombinant hirudin in H. polymorpha.
-
(1996)
Biotechnol Lett
, vol.18
, pp. 417-422
-
-
Kim, C.H.1
Sohn, J.H.2
Choi, E.S.3
Rhee, S.K.4
-
10
-
-
0027935699
-
Expression of hirudin in fed-batch cultures of recombinant Saccharomyces cerevisiae
-
Lee DH, Park JB, Seo JH, Choi ES, Lee SK. Expression of hirudin in fed-batch cultures of recombinant Saccharomyces cerevisiae. Biotechnol Lett. 16:1994;667-670.
-
(1994)
Biotechnol Lett
, vol.16
, pp. 667-670
-
-
Lee, D.H.1
Park, J.B.2
Seo, J.H.3
Choi, E.S.4
Lee, S.K.5
-
11
-
-
0028288344
-
Production of recombinant hirudin by high cell density fed-batch cultivations of a Saccharomyces cerevisiae strain: Physiological considerations during the bioprocess design
-
Mendozavega O, Hebert C, Brown SW. Production of recombinant hirudin by high cell density fed-batch cultivations of a Saccharomyces cerevisiae strain: physiological considerations during the bioprocess design. J Biotechnol. 32:1994;249-259.
-
(1994)
J Biotechnol
, vol.32
, pp. 249-259
-
-
Mendozavega, O.1
Hebert, C.2
Brown, S.W.3
-
12
-
-
0028809379
-
Production of hirudin by recombinant Saccharomyces cerevisiae in a membrane-recycle fermentor
-
Park JB, Kweon YE, Rhee SK, Seo JH. Production of hirudin by recombinant Saccharomyces cerevisiae in a membrane-recycle fermentor. Biotechnol Lett. 17:1995;1031-1036.
-
(1995)
Biotechnol Lett
, vol.17
, pp. 1031-1036
-
-
Park, J.B.1
Kweon, Y.E.2
Rhee, S.K.3
Seo, J.H.4
-
13
-
-
0029591388
-
High-level secretion of hirudin by Hansenula polymorpha - Authentic processing of three different preprohirudins
-
Weydemann U, Keup P, Piontek M, Strasser AWM, Schweden J, Gellissen G, Janowicz ZA. High-level secretion of hirudin by Hansenula polymorpha - authentic processing of three different preprohirudins. Appl Microbiol Biotechnol. 44:1995;377-385.
-
(1995)
Appl Microbiol Biotechnol
, vol.44
, pp. 377-385
-
-
Weydemann, U.1
Keup, P.2
Piontek, M.3
Strasser, A.W.M.4
Schweden, J.5
Gellissen, G.6
Janowicz, Z.A.7
-
14
-
-
0028944846
-
Generation of rabbit monoclonal antibody fragments from a combinatorial phage display library and their production in the yeast Pichia pastoris
-
of outstanding interest. The efficient expression of antibody fragments in P. pastoris is a major advance. This is a major area in biotechnology. Previous attempts in S. cerevisiae have been disappointing.
-
Ridder R, Schmitz R, Legay F, Gram H. Generation of rabbit monoclonal antibody fragments from a combinatorial phage display library and their production in the yeast Pichia pastoris. of outstanding interest Bio-Technology. 13:1995;255-260 The efficient expression of antibody fragments in P. pastoris is a major advance. This is a major area in biotechnology. Previous attempts in S. cerevisiae have been disappointing.
-
(1995)
Bio-Technology
, vol.13
, pp. 255-260
-
-
Ridder, R.1
Schmitz, R.2
Legay, F.3
Gram, H.4
-
15
-
-
0030040517
-
Production of a recombinant bovine enterokinase catalytic subunit in the methylotrophic yeast Pichia pastoris
-
Vozza LA, Wittwer L, Higgins DR, Purcell TJ, Bergseid M, Collins RLA, Lavallie ER, Hoeffler JP. Production of a recombinant bovine enterokinase catalytic subunit in the methylotrophic yeast Pichia pastoris. Bio-Technology. 14:1996;77-81.
-
(1996)
Bio-Technology
, vol.14
, pp. 77-81
-
-
Vozza, L.A.1
Wittwer, L.2
Higgins, D.R.3
Purcell, T.J.4
Bergseid, M.5
Collins, R.L.A.6
Lavallie, E.R.7
Hoeffler, J.P.8
-
16
-
-
0028215126
-
High level expression of the b. microplus bm86 antigen in the yeast Pichia pastoris forming highly immunogenic particles for cattle
-
Rodriguez M, Rubiera R, Penichet M, Montesinos R, Cremata J, Falcon V, Sanchez G, Bringas R, Cordoves C, Valdes M, Lleonart R, Herrera L, De La Fuenta J. High level expression of the b. microplus bm86 antigen in the yeast Pichia pastoris forming highly immunogenic particles for cattle. J Biotechnol. 33:1994;135-146.
-
(1994)
J Biotechnol
, vol.33
, pp. 135-146
-
-
Rodriguez, M.1
Rubiera, R.2
Penichet, M.3
Montesinos, R.4
Cremata, J.5
Falcon, V.6
Sanchez, G.7
Bringas, R.8
Cordoves, C.9
Valdes, M.10
Lleonart, R.11
Herrera, L.12
De La Fuenta, J.13
-
17
-
-
0028126804
-
Saccharomyces cerevisiae recombinant pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum
-
Kaslow DC, Bathurst IC, Lensen T, Ponnudurai T, Barr PJ, Keister DB. Saccharomyces cerevisiae recombinant pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum. Infect Immun. 62:1994;5576-5580.
-
(1994)
Infect Immun
, vol.62
, pp. 5576-5580
-
-
Kaslow, D.C.1
Bathurst, I.C.2
Lensen, T.3
Ponnudurai, T.4
Barr, P.J.5
Keister, D.B.6
-
18
-
-
0029940930
-
Foreign gene expression in Hansenula polymorpha. A system for the synthesis of small functional peptides
-
of outstanding interest. Two important developments are reported in this paper: firstly, the targeting of a recombinant protein to peroxisomes, and secondly, fusion to a carrier protein to stabilize small peptides.
-
Faber KN, Westra S, Waterham HR, Keizergunnink I. Foreign gene expression in Hansenula polymorpha. A system for the synthesis of small functional peptides. of outstanding interest Appl Microbiol Biotechnol. 45:1996;72-79 Two important developments are reported in this paper: firstly, the targeting of a recombinant protein to peroxisomes, and secondly, fusion to a carrier protein to stabilize small peptides.
-
(1996)
Appl Microbiol Biotechnol
, vol.45
, pp. 72-79
-
-
Faber, K.N.1
Westra, S.2
Waterham, H.R.3
Keizergunnink, I.4
-
19
-
-
0028840683
-
Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway
-
of outstanding interest. See annotation [21].
-
Price LA, Kajkowski EM, Hadcock JR, Ozenberger BA, Pausch MH. Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. of outstanding interest Mol Cell Biol. 15:1995;6188-6195 See annotation [21].
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6188-6195
-
-
Price, L.A.1
Kajkowski, E.M.2
Hadcock, J.R.3
Ozenberger, B.A.4
Pausch, M.H.5
-
20
-
-
0029917331
-
A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases
-
of outstanding interest. See annotation [21].
-
Superati-Furga G, Jonsson K, Courtneidge SA. A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases. of outstanding interest Nat Biotechnol. 14:1996;600-605 See annotation [21].
-
(1996)
Nat Biotechnol
, vol.14
, pp. 600-605
-
-
Superati-Furga, G.1
Jonsson, K.2
Courtneidge, S.A.3
-
21
-
-
0028848299
-
The identification of two novel ligands for FGF receptor by a yeast screening method and their activity in Xenopus development
-
of outstanding interest. These three papers [19-21] fully exploit the power of yeast genetics to establish functional models of important cell regulators.
-
Kinoshita N, Minshull J, Kirschner MW. The identification of two novel ligands for FGF receptor by a yeast screening method and their activity in Xenopus development. of outstanding interest Cell. 83:1995;621-630 These three papers [19-21] fully exploit the power of yeast genetics to establish functional models of important cell regulators.
-
(1995)
Cell
, vol.83
, pp. 621-630
-
-
Kinoshita, N.1
Minshull, J.2
Kirschner, M.W.3
-
22
-
-
0030058257
-
Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae
-
of outstanding interest. This paper establishes S. cerevisiae as a model system to study a medically important area.
-
Ruetz S, Brault M, Kast C, Hemenway C. Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. of outstanding interest J Biol Chem. 271:1996;4154-4160 This paper establishes S. cerevisiae as a model system to study a medically important area.
-
(1996)
J Biol Chem
, vol.271
, pp. 4154-4160
-
-
Ruetz, S.1
Brault, M.2
Kast, C.3
Hemenway, C.4
-
23
-
-
0028909926
-
Functional expression of fused enzymes between human cytochrome p4501a1 and human NADPH - Cytochrome p450 oxidoreductase in Saccharomyces cerevisiae
-
of outstanding interest. This paper, together with [24], describes elegant manipulation of S. cerevisiae to increase expression of human cytochrome P450s.
-
Wittekindt NE, Wurgler FE, Sengstag C. Functional expression of fused enzymes between human cytochrome p4501a1 and human NADPH - cytochrome p450 oxidoreductase in Saccharomyces cerevisiae. of outstanding interest DNA Cell Biol. 14:1995;273-283 This paper, together with [24], describes elegant manipulation of S. cerevisiae to increase expression of human cytochrome P450s.
-
(1995)
DNA Cell Biol
, vol.14
, pp. 273-283
-
-
Wittekindt, N.E.1
Wurgler, F.E.2
Sengstag, C.3
-
24
-
-
0029133420
-
Targeting of heterologous membrane proteins into proliferated internal membranes in Saccharomyces cerevisiae
-
of outstanding interest. See annotation [23].
-
Wittekindt NE, Wurgler FE, Sengstag C. Targeting of heterologous membrane proteins into proliferated internal membranes in Saccharomyces cerevisiae. of outstanding interest Yeast. 11:1995;913-928 See annotation [23].
-
(1995)
Yeast
, vol.11
, pp. 913-928
-
-
Wittekindt, N.E.1
Wurgler, F.E.2
Sengstag, C.3
-
25
-
-
0028109032
-
Overexpression of the gene for polyubiquitin in yeast confers increased secretion of a human leucocyte protease inhibitor
-
Chen Y, Pioli D, Piper PW. Overexpression of the gene for polyubiquitin in yeast confers increased secretion of a human leucocyte protease inhibitor. Bio-Technology. 12:1994;819-823.
-
(1994)
Bio-Technology
, vol.12
, pp. 819-823
-
-
Chen, Y.1
Pioli, D.2
Piper, P.W.3
-
26
-
-
0028219869
-
Protein disulphide isomerase overexpression increases secretion of foreign proteins in Saccharomyces cerevisiae
-
Robinson AS, Hines V, Wittrup KD. Protein disulphide isomerase overexpression increases secretion of foreign proteins in Saccharomyces cerevisiae. Bio-Technology. 12:1994;381-384.
-
(1994)
Bio-Technology
, vol.12
, pp. 381-384
-
-
Robinson, A.S.1
Hines, V.2
Wittrup, K.D.3
-
27
-
-
0028953840
-
Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
-
Mumberg D, Muller R, Funk M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene. 156:1995;119-122.
-
(1995)
Gene
, vol.156
, pp. 119-122
-
-
Mumberg, D.1
Muller, R.2
Funk, M.3
-
28
-
-
0028586017
-
Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use for heterologous expression
-
Mumberg D, Muller R, Funk M. Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22:1994;5767-5768.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 5767-5768
-
-
Mumberg, D.1
Muller, R.2
Funk, M.3
-
29
-
-
0028868957
-
Stable multicopy integration of vector sequences in Hansenula polymorpha
-
of special interest. An important strategy for increasing the copy number of an integrated expression construct.
-
Gatzke R, Weydemann U, Janowicz ZA, Hollenberg CP. Stable multicopy integration of vector sequences in Hansenula polymorpha. of special interest Appl Microbiol Biotechnol. 43:1995;844-849 An important strategy for increasing the copy number of an integrated expression construct.
-
(1995)
Appl Microbiol Biotechnol
, vol.43
, pp. 844-849
-
-
Gatzke, R.1
Weydemann, U.2
Janowicz, Z.A.3
Hollenberg, C.P.4
-
30
-
-
0028589448
-
Increase in copy number of an integrated vector during continuous culture of Hansenula polymorpha expressing functional human haemoglobin
-
Gilbert SC, Van UH, Greenfield AJ, McAvoy MJ, Denton KA, Coghlan D, Jones GD, Mead DJ. Increase in copy number of an integrated vector during continuous culture of Hansenula polymorpha expressing functional human haemoglobin. Yeast. 10:1994;1569-1580.
-
(1994)
Yeast
, vol.10
, pp. 1569-1580
-
-
Gilbert, S.C.1
Van, U.H.2
Greenfield, A.J.3
McAvoy, M.J.4
Denton, K.A.5
Coghlan, D.6
Jones, G.D.7
Mead, D.J.8
-
31
-
-
0028940737
-
Plasmid reorganization during integrative transformation in Hansenula polymorpha
-
of special interest. A cautionary tale for those who assume that integrated sequences are always stable. Probably results from the use of the homologous LEU2 gene.
-
Bogdanova AI, Agaphonov MO, Ter AMD. Plasmid reorganization during integrative transformation in Hansenula polymorpha. of special interest Yeast. 11:1995;343-353 A cautionary tale for those who assume that integrated sequences are always stable. Probably results from the use of the homologous LEU2 gene.
-
(1995)
Yeast
, vol.11
, pp. 343-353
-
-
Bogdanova, A.I.1
Agaphonov, M.O.2
Ter, A.M.D.3
-
32
-
-
0028785213
-
A disruption-replacement approach for the targeted integration of foreign genes in Hansenula polymorpha
-
of special interest. An elegant method for forced integration of an expression cassette.
-
Agaphonov MO, Beburov MY, Ter AMD, Smirnov VN. A disruption-replacement approach for the targeted integration of foreign genes in Hansenula polymorpha. of special interest Yeast. 11:1995;1241-1247 An elegant method for forced integration of an expression cassette.
-
(1995)
Yeast
, vol.11
, pp. 1241-1247
-
-
Agaphonov, M.O.1
Beburov, M.Y.2
Ter, A.M.D.3
Smirnov, V.N.4
-
33
-
-
0029914238
-
Plugging it in: Signalling circuits and the yeast cell cycle
-
Wittenberg C, Reed SI. Plugging it in: signalling circuits and the yeast cell cycle. Curr Opin Cell Biol. 8:1996;223-230.
-
(1996)
Curr Opin Cell Biol
, vol.8
, pp. 223-230
-
-
Wittenberg, C.1
Reed, S.I.2
|