Are engineered proteins getting competition from RNA?

Current Opinion in Biotechnology

Volumn 7, Issue 4, 1996, Pages 442-448

  Breaker, Ronald R ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPETITION; GENETIC ENGINEERING; LIGAND BINDING; MODEL; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; RNA ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0030220588     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(96)80122-4     Document Type: Article

References (54)

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46. -1.
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49. 5-fold a reaction at a carbonyl carbon.
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53. 2+-dependent catalysts can accelerate RNA cleavage by ~100 000-fold and can operate under temperature and ionic strength conditions that exist in vivo.
54. 2+ and accelerates the reaction ~3 400-fold faster that the rate observed using a simple DNA template as a catalyst.