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Volumn 8, Issue 4, 1996, Pages 492-497

Cytotoxic T lymphocyte responses to Epstein-Barr virus

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; VIRUS ANTIGEN;

EID: 0030219914     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80036-7     Document Type: Article
Times cited : (64)

References (44)
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    • of outstanding interest. This paper provides strong evidence that EBNA1 is protected from the HLA class I processing pathway, and shows that such protection can be transferred to an otherwise immunogenic protein (EBNA3B) by insertion of the EBNA1 glycine-alanine repeat domain.
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    • of outstanding interest. This paper provides the first evidence to suggest that immunodominance amongst EBV peptide epitopes correlates with their level of representation as peptide-HLA complexes on the LCL cell surface; it also shows that the level of surface representation may not be easily predicted on the basis of work with peptide-HLA complexes in cell-free systems.
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    • of special interest. Evidence which, in contrast to [32], implies that mutations in A11-restricted CTL epitopes may be a coincidental feature of SE Asian virus isolates and not the specific result of immune selection.
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    • of outstanding interest. The impaired antigen-presenting function of BL cells is shown to be associated with downregulation of the TAP1/TAP2 heterodimer and with reduced levels of HLA class I expression; LMP1 gene transfection can reverse these effects and restore antigen processing function.
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    • of special interest. A very interesting strategy for vaccine design involving the serial linkage of CTL epitope sequences into a single polypeptide expressed from a recombinant viral vector.
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