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1
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0000942113
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Epstein-Barr virus
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B.N. Fields, D.M. Knipe, Howley P.M. Philadelphia: Lippincott-Raven
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Rickinson AB, Kieff E. Epstein-Barr virus. Fields BN, Knipe DM, Howley PM. Fields Virology. 1996;2397-2446 Lippincott-Raven, Philadelphia.
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(1996)
Fields Virology
, pp. 2397-2446
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Rickinson, A.B.1
Kieff, E.2
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2
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0026734842
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Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): Implications for the immune control of EBV-positive malignancies
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Murray RJ, Kurilla MG, Brooks JM, Thomas WA, Rowe M, Kieff E, Rickinson AB. Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies. J Exp Med. 176:1992;157-168.
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(1992)
J Exp Med
, vol.176
, pp. 157-168
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Murray, R.J.1
Kurilla, M.G.2
Brooks, J.M.3
Thomas, W.A.4
Rowe, M.5
Kieff, E.6
Rickinson, A.B.7
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3
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0026681729
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Localisation of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: Implications for vaccine development
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Khanna R, Burrows SR, Kurilla MG, Jacob CA, Misko IS, Sculley TB, Kieff E, Moss DJ. Localisation of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development. J Exp Med. 176:1992;169-178.
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(1992)
J Exp Med
, vol.176
, pp. 169-178
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Khanna, R.1
Burrows, S.R.2
Kurilla, M.G.3
Jacob, C.A.4
Misko, I.S.5
Sculley, T.B.6
Kieff, E.7
Moss, D.J.8
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4
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0029096458
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Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children
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Tamaki H, Beaulieu BL, Somasundaran M, Sullivan JL. Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children. J Infect Dis. 172:1995;739-746.
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(1995)
J Infect Dis
, vol.172
, pp. 739-746
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Tamaki, H.1
Beaulieu, B.L.2
Somasundaran, M.3
Sullivan, J.L.4
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5
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0029021708
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Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours
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Snudden DK, Smith PR, Lai D, Ng MH, Griffin BE. Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours. Oncogene. 10:1995;1545-1552.
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(1995)
Oncogene
, vol.10
, pp. 1545-1552
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Snudden, D.K.1
Smith, P.R.2
Lai, D.3
Ng, M.H.4
Griffin, B.E.5
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6
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0029040720
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Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1
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Wrightham MN, Stewart JP, Janjua NJ, Pepper SDV, Sample C, Rooney CM, Arrand JR. Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1. Virology. 208:1995;521-530.
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(1995)
Virology
, vol.208
, pp. 521-530
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Wrightham, M.N.1
Stewart, J.P.2
Janjua, N.J.3
Pepper, S.D.V.4
Sample, C.5
Rooney, C.M.6
Arrand, J.R.7
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7
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0028102982
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The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: Strain variation, genetic recombination, and transcriptional expression
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Walling DM, Perkins AG, Webster-Cyriaque J, Resnick L, Raab-Traub N. The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression. J Virol. 68:1994;7918-7926.
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(1994)
J Virol
, vol.68
, pp. 7918-7926
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Walling, D.M.1
Perkins, A.G.2
Webster-Cyriaque, J.3
Resnick, L.4
Raab-Traub, N.5
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8
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0030063292
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Common Epstein-Barr virus (EBV) type 1 variant strains in both malignant and benign EBV-associated disorders
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Schuster V, Ott G, Seidenspinner S, Kreth HW. Common Epstein-Barr virus (EBV) type 1 variant strains in both malignant and benign EBV-associated disorders. Blood. 87:1996;1579-1585.
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(1996)
Blood
, vol.87
, pp. 1579-1585
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Schuster, V.1
Ott, G.2
Seidenspinner, S.3
Kreth, H.W.4
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9
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0028133001
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Sequence variation in the Epstein-Barr virus latent membrane protein 1
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Miller WE, Edwards RH, Walling DM, Raab-Traub N. Sequence variation in the Epstein-Barr virus latent membrane protein 1. J Gen Virol. 75:1994;2729-2740.
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(1994)
J Gen Virol
, vol.75
, pp. 2729-2740
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Miller, W.E.1
Edwards, R.H.2
Walling, D.M.3
Raab-Traub, N.4
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10
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0028930958
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HLA-A0201 and HLA-B7 binding peptides in the EBV-encoded EBNA-1, EBNA-2 and BZLF-1 proteins detected in the MHC class I stabilization assay: Low proportion of binding motifs for several HLA class I alleles in EBNA-1
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Stuber G, Dillner J, Modrow S, Wolf H, Szekely L, Klein G, Klein E. HLA-A0201 and HLA-B7 binding peptides in the EBV-encoded EBNA-1, EBNA-2 and BZLF-1 proteins detected in the MHC class I stabilization assay: low proportion of binding motifs for several HLA class I alleles in EBNA-1. Int Immunol. 7:1995;653-663.
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(1995)
Int Immunol
, vol.7
, pp. 653-663
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Stuber, G.1
Dillner, J.2
Modrow, S.3
Wolf, H.4
Szekely, L.5
Klein, G.6
Klein, E.7
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11
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0029003999
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Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen 1
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of outstanding interest. This paper provides strong evidence that EBNA1 is protected from the HLA class I processing pathway, and shows that such protection can be transferred to an otherwise immunogenic protein (EBNA3B) by insertion of the EBNA1 glycine-alanine repeat domain.
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Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwald-Mullen PM, Klein G, Kurilla MG, Masucci MG. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen 1. of outstanding interest Nature. 375:1995;685-688 This paper provides strong evidence that EBNA1 is protected from the HLA class I processing pathway, and shows that such protection can be transferred to an otherwise immunogenic protein (EBNA3B) by insertion of the EBNA1 glycine-alanine repeat domain.
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(1995)
Nature
, vol.375
, pp. 685-688
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Levitskaya, J.1
Coram, M.2
Levitsky, V.3
Imreh, S.4
Steigerwald-Mullen, P.M.5
Klein, G.6
Kurilla, M.G.7
Masucci, M.G.8
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12
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0029590163
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Isolation of cytotoxic T lymphocytes from healthy seropositive individuals specific for peptide epitopes from Epstein-Barr virus nuclear antigen 1: Implications for viral persistence and tumour surveillance
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Khanna R, Burrows SR, Steigerwald-Mullen PM, Thomson SA, Kurilla MG, Moss DJ. Isolation of cytotoxic T lymphocytes from healthy seropositive individuals specific for peptide epitopes from Epstein-Barr virus nuclear antigen 1: implications for viral persistence and tumour surveillance. Virology. 214:1995;633-637.
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(1995)
Virology
, vol.214
, pp. 633-637
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Khanna, R.1
Burrows, S.R.2
Steigerwald-Mullen, P.M.3
Thomson, S.A.4
Kurilla, M.G.5
Moss, D.J.6
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13
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0027365433
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HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2
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Lee SP, Thomas WA, Murray RJ, Khanim F, Kaur S, Young LS, Rowe M, Kurilla M, Rickinson AB. HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2. J Virol. 67:1993;7428-7435.
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(1993)
J Virol
, vol.67
, pp. 7428-7435
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Lee, S.P.1
Thomas, W.A.2
Murray, R.J.3
Khanim, F.4
Kaur, S.5
Young, L.S.6
Rowe, M.7
Kurilla, M.8
Rickinson, A.B.9
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14
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0029811941
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Transporter (TAP)-independent processing of a multiple membrane spanning protein, the Epstein-Barr virus latent membrane protein 2
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negative cells, and discusses a novel mechanism whereby such presentation might occur. of outstanding interest
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Lee SP, Thomas WA, Blake NW, Rickinson AB. Transporter (TAP)-independent processing of a multiple membrane spanning protein, the Epstein-Barr virus latent membrane protein 2. of outstanding interest Eur J Immunol. 1996; This paper shows that two CTL epitopes within transmembrane domains of LMP2 are presented in TAP-negative cells, and discusses a novel mechanism whereby such presentation might occur.
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(1996)
Eur J Immunol
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Lee, S.P.1
Thomas, W.A.2
Blake, N.W.3
Rickinson, A.B.4
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15
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0029985369
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Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
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Biederer T, Volkwein C, Sommer T. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J. 15:1996;2069-2076.
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(1996)
EMBO J
, vol.15
, pp. 2069-2076
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Biederer, T.1
Volkwein, C.2
Sommer, T.3
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16
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0025169718
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An Epstein-Barr virus-specific cytotoxic T cell epitope in EBNA3
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Burrows SR, Sculley TB, Misko IS, Schmidt C, Moss DJ. An Epstein-Barr virus-specific cytotoxic T cell epitope in EBNA3. J Exp Med. 171:1990;345-350.
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(1990)
J Exp Med
, vol.171
, pp. 345-350
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Burrows, S.R.1
Sculley, T.B.2
Misko, I.S.3
Schmidt, C.4
Moss, D.J.5
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17
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0027464975
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Multiple HLA-A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4
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Gavioli R, Kurilla MG, De Campos-Lima PO, Wallace LE, Dolcetti R, Murray RJ, Rickinson AB, Masucci MG. Multiple HLA-A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4. J Virol. 67:1993;1572-1578.
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(1993)
J Virol
, vol.67
, pp. 1572-1578
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Gavioli, R.1
Kurilla, M.G.2
De Campos-Lima, P.O.3
Wallace, L.E.4
Dolcetti, R.5
Murray, R.J.6
Rickinson, A.B.7
Masucci, M.G.8
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18
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0027261331
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Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide
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Brooks JM, Murray RJ, Thomas WA, Kurilla MG, Rickinson AB. Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide. J Exp Med. 178:1993;879-887.
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(1993)
J Exp Med
, vol.178
, pp. 879-887
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Brooks, J.M.1
Murray, R.J.2
Thomas, W.A.3
Kurilla, M.G.4
Rickinson, A.B.5
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19
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0027991831
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Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3
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Burrows SR, Gardner J, Khanna R, Stewart T, Moss DJ, Rodda S, Suhrbier A. Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3. J Gen Virol. 75:1994;2489-2493.
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(1994)
J Gen Virol
, vol.75
, pp. 2489-2493
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Burrows, S.R.1
Gardner, J.2
Khanna, R.3
Stewart, T.4
Moss, D.J.5
Rodda, S.6
Suhrbier, A.7
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20
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0028926385
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Characterization of two Epstein-Barr virus epitopes restricted by HLA-B7
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Hill A, Worth A, Elliott T, Rowland-Jones S, Brooks J, Rickinson A, McMichael AJ. Characterization of two Epstein-Barr virus epitopes restricted by HLA-B7. Eur J Immunol. 25:1995;18-24.
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(1995)
Eur J Immunol
, vol.25
, pp. 18-24
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Hill, A.1
Worth, A.2
Elliott, T.3
Rowland-Jones, S.4
Brooks, J.5
Rickinson, A.6
McMichael, A.J.7
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21
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0029034074
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Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV) nuclear antigens fail to lyse the EBV-transformed B lymphoblastoid cell lines against which they were raised
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of special interest. The first paper to highlight a paradox frequently seen with EBV-epitope-specific CTL clones, namely their inability to lyse the naturally infected autologous LCL target.
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Hill AB, Lee SP, Haurum JS, Murray N, Yao Q-Y, Rowe M, Signoret N, Rickinson AB, McMichael AJ. Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV) nuclear antigens fail to lyse the EBV-transformed B lymphoblastoid cell lines against which they were raised. of special interest J Exp Med. 181:1995;2221-2228 The first paper to highlight a paradox frequently seen with EBV-epitope-specific CTL clones, namely their inability to lyse the naturally infected autologous LCL target.
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(1995)
J Exp Med
, vol.181
, pp. 2221-2228
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Hill, A.B.1
Lee, S.P.2
Haurum, J.S.3
Murray, N.4
Yao Q-Y5
Rowe, M.6
Signoret, N.7
Rickinson, A.B.8
McMichael, A.J.9
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22
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0028908939
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Epstein-Barr virus isolates with the major HLA B35.01-restricted cytotoxic T-lymphocyte epitope are prevalent in a highly B35.01-positive African population
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Lee SP, Morgan S, Skinner J, Thomas WA, Jones SR, Sutton J, Khanna R, Whittle HC, Rickinson AB. Epstein-Barr virus isolates with the major HLA B35.01-restricted cytotoxic T-lymphocyte epitope are prevalent in a highly B35.01-positive African population. Eur J Immunol. 25:1995;102-110.
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(1995)
Eur J Immunol
, vol.25
, pp. 102-110
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Lee, S.P.1
Morgan, S.2
Skinner, J.3
Thomas, W.A.4
Jones, S.R.5
Sutton, J.6
Khanna, R.7
Whittle, H.C.8
Rickinson, A.B.9
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23
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0029920909
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The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4
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of outstanding interest. This paper provides the first evidence to suggest that immunodominance amongst EBV peptide epitopes correlates with their level of representation as peptide-HLA complexes on the LCL cell surface; it also shows that the level of surface representation may not be easily predicted on the basis of work with peptide-HLA complexes in cell-free systems.
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Levitsky V, Zhang Q-J, Levitskaya J, Masucci MG. The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. of outstanding interest J Exp Med. 183:1996;915-926 This paper provides the first evidence to suggest that immunodominance amongst EBV peptide epitopes correlates with their level of representation as peptide-HLA complexes on the LCL cell surface; it also shows that the level of surface representation may not be easily predicted on the basis of work with peptide-HLA complexes in cell-free systems.
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(1996)
J Exp Med
, vol.183
, pp. 915-926
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Levitsky, V.1
Zhang Q-J2
Levitskaya, J.3
Masucci, M.G.4
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24
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0028096713
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Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus
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Argaet VP, Schmidt CW, Burrows SR, Silins SL, Kurilla MG, Doolan DL, Suhrbier A, Moss DJ, Kieff E, Sculley TB, Misko IS. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J Exp Med. 180:1994;2335-2340.
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(1994)
J Exp Med
, vol.180
, pp. 2335-2340
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Argaet, V.P.1
Schmidt, C.W.2
Burrows, S.R.3
Silins, S.L.4
Kurilla, M.G.5
Doolan, D.L.6
Suhrbier, A.7
Moss, D.J.8
Kieff, E.9
Sculley, T.B.10
Misko, I.S.11
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25
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0028349005
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An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: Implications for graft versus host disease
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Burrows SR, Khanna R, Burrows JM, Moss DJ. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: Implications for graft versus host disease. J Exp Med. 179:1994;1155-1161.
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(1994)
J Exp Med
, vol.179
, pp. 1155-1161
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Burrows, S.R.1
Khanna, R.2
Burrows, J.M.3
Moss, D.J.4
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26
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0028783395
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T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen
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of outstanding interest. Following on from [24] and [25], this report shows that HLA-BB-restricted responses to the EBNA3A 325-333 epitope in B8, B44.02-positive individuals involve a different set of TCRs which do not cross-react with B44.02.
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Burrows SR, Silins SL, Moss DJ, Khanna R, Misko IS, Argaet VP. T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. of outstanding interest J Exp Med. 182:1995;1703-1715 Following on from [24] and [25], this report shows that HLA-BB-restricted responses to the EBNA3A 325-333 epitope in B8, B44.02-positive individuals involve a different set of TCRs which do not cross-react with B44.02.
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(1995)
J Exp Med
, vol.182
, pp. 1703-1715
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Burrows, S.R.1
Silins, S.L.2
Moss, D.J.3
Khanna, R.4
Misko, I.S.5
Argaet, V.P.6
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27
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0029863557
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Influenza A virus: A model for viral antigen presentation to cytotoxic T lymphocytes
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Parker CP, Gould KG. Influenza A virus: a model for viral antigen presentation to cytotoxic T lymphocytes. Semin Virol. 7:1996;61-73.
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(1996)
Semin Virol
, vol.7
, pp. 61-73
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Parker, C.P.1
Gould, K.G.2
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28
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0025744720
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Cytotoxic T-cell recognition of HIV proteins and peptides
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Nixon DF, McMichael AJ. Cytotoxic T-cell recognition of HIV proteins and peptides. AIDS. 5:1991;1049-1059.
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(1991)
AIDS
, vol.5
, pp. 1049-1059
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Nixon, D.F.1
McMichael, A.J.2
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29
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0029796554
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+ T cells in infectious mononucleosis
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driven, not induced by a superantigen. of special interest
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+ response seen in IM patients is antigen-driven, not induced by a superantigen.
-
(1996)
Nat Med
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Callen, M.F.C.1
Steven, N.2
Krausa, P.3
Wilson, J.D.K.4
Moss, P.A.H.5
Gillespie, G.M.6
Bell, J.I.7
Rickinson, A.B.8
McMichael, A.J.9
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30
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0029924889
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+ virus-specific cytotoxic T cells which recognise Epstein-Barr virus lytic antigen BHRF1
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+ virus-specific cytotoxic T cells which recognise Epstein-Barr virus lytic antigen BHRF1. Virology. 219:1996;489-492.
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(1996)
Virology
, vol.219
, pp. 489-492
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-
White, C.A.1
Cross, S.M.2
Kurilla, M.G.3
Kerr, B.M.4
Schmidt, C.5
Misko, I.S.6
Khanna, R.7
Moss, D.J.8
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31
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0029076356
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Specific cytotoxic T lymphocytes recognise the immediate-early transactivator Zta of Epstein-Barr virus
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+ CTL responses to an EBV lytic cycle antigen, BZLF1, involved the reactivation of memory cells by in vitro stimulation with synthetic peptides.
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+ CTL responses to an EBV lytic cycle antigen, BZLF1, involved the reactivation of memory cells by in vitro stimulation with synthetic peptides.
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(1995)
J Virol
, vol.69
, pp. 4872-4879
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Bogedain, C.1
Wolf, H.2
Modrow, S.3
Stuber, G.4
Jilg, W.5
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33
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0028218246
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T cell responses and virus evolution: Loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues
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De Campos-Lima P-O, Levitsky V, Brooks J, Lee SP, Hu LF, Rickinson AB, Masucci MG. T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues. J Exp Med. 179:1994;1297-1305.
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(1994)
J Exp Med
, vol.179
, pp. 1297-1305
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-
De Campos-Lima P-O1
Levitsky, V.2
Brooks, J.3
Lee, S.P.4
Hu, L.F.5
Rickinson, A.B.6
Masucci, M.G.7
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34
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0030009308
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Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: Implications for virus evolution
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of special interest. Evidence which, in contrast to [32], implies that mutations in A11-restricted CTL epitopes may be a coincidental feature of SE Asian virus isolates and not the specific result of immune selection.
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Burrows JM, Burrows SR, Pulsen LM, Sculley TB, Moss DJ, Khanna R. Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: implications for virus evolution. of special interest J Virol. 70:1996;2490-2496 Evidence which, in contrast to [32], implies that mutations in A11-restricted CTL epitopes may be a coincidental feature of SE Asian virus isolates and not the specific result of immune selection.
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(1996)
J Virol
, vol.70
, pp. 2490-2496
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-
Burrows, J.M.1
Burrows, S.R.2
Pulsen, L.M.3
Sculley, T.B.4
Moss, D.J.5
Khanna, R.6
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35
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0028288519
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Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation
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Papadopoulos EB, Ladanyi M, Emmanuel D, Mackinnon S, Boulad F, Carabasi MH, Castro-Melaspina H, Childs BH, Gillio AP, Small TN, et al. Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N Engl J Med. 330:1994;1185-1191.
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(1994)
N Engl J Med
, vol.330
, pp. 1185-1191
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Papadopoulos, E.B.1
Ladanyi, M.2
Emmanuel, D.3
Mackinnon, S.4
Boulad, F.5
Carabasi, M.H.6
Castro-Melaspina, H.7
Childs, B.H.8
Gillio, A.P.9
Small, T.N.10
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36
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0028816546
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Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr virus-related lymphoproliferation
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of outstanding interest. This report describes the first clinical use of in vitro reactivated EBV-specific CTL preparations and demonstrates their ability not only to reverse the development of EBV-positive lymphoproliferative lesions but also, when used prophylactically, to reduce viral loads in the B-cell pool.
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Rooney CM, Smith CA, Ng CYC, Loftin S, Li C, Krance RA, Brenner MK, Heslop HE. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr virus-related lymphoproliferation. of outstanding interest Lancet. 345:1995;9-13 This report describes the first clinical use of in vitro reactivated EBV-specific CTL preparations and demonstrates their ability not only to reverse the development of EBV-positive lymphoproliferative lesions but also, when used prophylactically, to reduce viral loads in the B-cell pool.
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(1995)
Lancet
, vol.345
, pp. 9-13
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-
Rooney, C.M.1
Smith, C.A.2
Ng, C.Y.C.3
Loftin, S.4
Li, C.5
Krance, R.A.6
Brenner, M.K.7
Heslop, H.E.8
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37
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0029924619
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Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes
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Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regression of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 ScidScid mice
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Lacerda JF, Ladanyi M, Louie DC, Fernandez JM, Papadopoulos EB, O'Reilly RJ. Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regression of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 ScidScid mice. J Exp Med. 183:1996;1215-1228.
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Endoplasmic reticulum signal sequence faciliated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumour cell line
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Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein 1: Co-ordinate up-regulation of peptide transporters and HLA-class I antigen expression
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of outstanding interest. The impaired antigen-presenting function of BL cells is shown to be associated with downregulation of the TAP1/TAP2 heterodimer and with reduced levels of HLA class I expression; LMP1 gene transfection can reverse these effects and restore antigen processing function.
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Rowe M, Khanna R, Jacob CA, Argaet V, Kelly A, Powis S, Belich M, Croom-Carter D, Lee S, Burrows SR, et al. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein 1: co-ordinate up-regulation of peptide transporters and HLA-class I antigen expression. of outstanding interest Eur J Immunol. 25:1995;1374-1384 The impaired antigen-presenting function of BL cells is shown to be associated with downregulation of the TAP1/TAP2 heterodimer and with reduced levels of HLA class I expression; LMP1 gene transfection can reverse these effects and restore antigen processing function.
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41
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Analysis of MHC class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus positive and negative Hodgkin's disease
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Oudejans JJ, Jiwa NM, Kummer JA, Horstman A, Vos W, Baak JPA, Kluin Ph M, Van der Valk P, Walboomers JMM, Meijer CJLM. Analysis of MHC class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus positive and negative Hodgkin's disease. Blood. 87:1996;3844-3851.
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42
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Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease
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Frisan T, Sjoberg J, Dolcetti R, Boiocchi M, De Re V, Carbone A, Brautbar C, Battat S, Biberfeld P, Eckman M, et al. Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease. Blood. 86:1995;1493-1501.
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43
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Minimal epitopes expressed in a recombinant polyepitope protein and processed and presented to CD8(+) cytotoxic T-cells - implications for vaccine design
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of special interest. A very interesting strategy for vaccine design involving the serial linkage of CTL epitope sequences into a single polypeptide expressed from a recombinant viral vector.
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Thomson SA, Khanna R, Gardner J, Burrows SR, Coupar B, Moss DJ, Suhrbier A. Minimal epitopes expressed in a recombinant polyepitope protein and processed and presented to CD8(+) cytotoxic T-cells - implications for vaccine design. of special interest Proc Natl Acad Sci USA. 92:1995;5845-5849 A very interesting strategy for vaccine design involving the serial linkage of CTL epitope sequences into a single polypeptide expressed from a recombinant viral vector.
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Thomson, S.A.1
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Moss, D.J.6
Suhrbier, A.7
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44
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0029929419
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A recombinant adenovirus expressing an Epstein-Barr virus (EBV) target antigen can selectively reactivate rare components of EBV cytotoxic T-lymphocyte memory in vitro
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Morgan SM, Wilkinson GWG, Floettmann E, Blake N, Rickinson AB. A recombinant adenovirus expressing an Epstein-Barr virus (EBV) target antigen can selectively reactivate rare components of EBV cytotoxic T-lymphocyte memory in vitro. J Virol. 70:1996;2394-2402.
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Morgan, S.M.1
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Rickinson, A.B.5
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