Visualizing immune responses in vivo

Current Opinion in Immunology

Volumn 8, Issue 3, 1996, Pages 321-326

  McHeyzer Williams, Michael G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELLULAR IMMUNITY; HELPER CELL; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; LYMPHOID ORGAN; SHORT SURVEY;

EID: 0030175491     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80119-1     Document Type: Article

References (60)

1. Sprent J. T and B memory cells. Cell. 76:1994;315-322.
2. Janeway CJ, Bottomly K. Signals and signs for lymphocyte responses. Cell. 76:1994;275-285.
3. Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis. Science. 259:1993;1457-1460.
4. McHeyzer-Williams MG, Davis MM. Antigen-specific development of primary and memory T cells in vivo. of outstanding interest Science. 268:1995;106-111 Direct molecular and cellular analysis of an antigen-specific primary and memory T-cell response in normal mice. Clonal expansion and contraction are quantitatively monitored with single-cell repertoire analysis providing, evidence for clonal maturation in vivo.
5. MacDonald HR, Casanova JL, Maryanski JL, Cerottini JC. Ollgocional expansion of major histocompatibility complex class I-restricted cytolytic T lymphocytes during a primary immune response in vivo: direct monitoring by flow cytometry and polymerase chain reaction. J Exp Med. 177:1993;1487-1492.
6. + T cells emerge at different stages of an in vivo immune response. of special interest J Immunol. 155:1995;3443-3452 A study of the progression of phenotypic change over the course of a cytotoxic T lymphocyte response in vivo.
7. + response is comprised of very few clones. of special interest Immunity. 4:1996;47-55 Single cell PCR analysis of a dominant cytotoxic T lymphocyte response, where the same animal can be followed through multiple rounds of antigenic exposure, shows no apparent change in the TCR repertoire over the course of the response.
8. Kearney ER, Pape KA, Loh DY, Jenkins MK. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. of special interest Immunity. 1:1994;327-339 An elegant use of TCR transgenic T cells in an adoptive transfer model that defines distinct physical outcomes for the progression of antigen-specific T-cell immunity versus the induction of tolerance.
9. Fuller KA, Kanagawa O, Nahm MH. T cells within germinal centers are specific for the immunizing antigen. J Immunol. 151:1993;4505-4512.
10. Kelly KA, Bucy RP, Nahm MH. Germinal center T cells exhibit properties of memory helper T cells. of special interest Cell Immunol. 163:1995;206-214 Staining of Vβ8 is four times more frequent in germinal centers 3-8 weeks after immunization with myelin basic protein.
11. Zheng B, Xue W, Kelsoe G. Locus-specific somatic hypermutation in germinal centre T cells. of special interest Nature. 372:1994;556-559 A powerful approach to the analysis of antigen-specific immunity in vivo: microdissection of histologically defined subpopulations followed by gene amplification and sequence analysis of particular TCRs.
12. Kelsoe G. Life and death in germinal centers (redux). of special interest Immunity. 4:1996;107-111 A concise review of the current data and thinking on the germinal center reaction.
13. Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. of special interest Nature. 375:1995;148-151 A very informative study on the stoichiometry of TCR-MHC/peptide interactions and their functional outcomes in vitro. A single complex can serially trigger up to 200 TCRs over a 24 hour period of culture.
14. Matsui K, Boniface JJ, Steffner P, Reay PA, Davis MM. Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc Natl Acad Sci USA. 91:1994;12862-12866.
15. Corr M, Slanetz AE, Boyd LF, Jelonek MT, Khiko S, Al-Ramadi YS, Kim YS, Maher SE, Bothwell AL, Margulies DH. T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity. Science. 265:1994;946-949.
16. + T cells. J Exp Med. 182:1995;1591-1596.
17. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J Exp Med. 182:1995;1579-1584.
18. Brocke S, Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, et al. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. of special interest Nature. 379:1996;343-346 Describes the control of the secondary infiltrate to a site of inflammation by selectively targeting the initiating cells using an altered peptide ligand that deviates the cytokine profile produced.
19. Jenkins MK. The ups and downs of T cell costimulation. Immunity. 1:1994;443-446.
20. June CH, Bluestone JA, Nadler LM, Thompson CB. The B7 and CD28 receptor families. Immunol Today. 15:1994;321-331.
21. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. of outstanding interest J Immunol. 155:1995;1032-1036 A follow-up study to [8] that evaluates the opposing roles of CD28 and CTLA-4 in the developing T-cell response to antigen.
22. of special interest Waterhouse P, Penninger JM, Timms E, Wakeman A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. of special interest Science. 270:1995;985-988 Together with [23], this paper reports a dramatic phenotype that highlights an important role for Ctla-4 in the regulation of the developing immune response. The lymphoproliferative disorder implicates a defect in the contraction phase of an effector response and an important role for Ctla-4 in controlling lymphocyte homeostasis.
23. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. of outstanding interest Immunity. 3:1995;541-547 See annotation [22].
24. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 constimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. of special interest Cell. 80:1995;707-718 This paper highlights the importance of costimulatory signals through CTLA-4 and CD28 on the profile of cytokines produced by antigen-activated T cells and provides a means by which autoimmune disease can be modulated.
25. Grewall IS, Xu J, Flavell RA. Impairement of antige-specific T-cell priming in mice lacking CD40 ligand. of outstanding interest Nature. 378:1995;617-620 See annotation [26].
26. Van Essen D, Kikutani H, Gray D. CD40 ligand-transduced costimulation of T cells in the development of helper function. of outstanding interest Nature. 378:1995;620-623 Together with [25] this work highlights the importance of not only giving, but also receiving, signals through CD4OL for the completion of effective immunity in vivo. Soluble CD40 restores the signals to initiate germinal center formation and isotype switch in animals lacking CD40.
27. Jorgensen JL, Esser U, Fazekas de St Groth B, Reay PA, Davis MM. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 355:1992;224-230.
28. McHeyzer-Williams MG, Altman JD, Davis MM. Enumeration and characterization of memory cells in the Th compartment. Immunol Rev. 150:1996.
29. Cochet M, Pannetier C, Regnault A, Darche S, Leclerc C, Kourilsky P. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur J Immunol. 22:1992;2639-2647.
30. Cibotti R, Cabaniols JP, Pannetier C, Delarbre C, Vergnon I, Kanellopoulos JM, Kourilsky P. Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice. J Exp Med. 180:1994;861-872.
31. Dietrich PY, Caignard A, Lim A, Chung V, Pico JL, Pannetier C, Kourilsky P, Hercend T, Even J, Triebel F. In vivo T-cell clonal amplification at time of acute graft-versus-host disease. Blood. 84:1994;2815-2820.
32. + T cell population bearing a distinctive beta chain in MRL Ipr/Ipr mice suggests a role for the fas protein in peripheral T cell selection. Eur J Immunol. 24:1994;2761-2766.
33. + T cells with a predominant V beta usage during the primary immune response to HIV. Nature. 370:1994;463-467.
34. McHeyzer-Williams MG, Altman JD, Davis MM. Tracking antigen-specific T cell responses. Curr Opin Immunol. 8:1996;. in press.
35. Swain SL. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. of special interest Immunity. 1:1994;543-552 The analysis of antigen-specific clonal stability in vivo using an adoptive transfer approach coupled to antigen-specific manipulation in vitro. These data provide important clues to the nature and development of T-cell memory.
36. Freer G, Burkhart C, Rulicke T, Ghelardi E, Rohrer UH, Pircher H, Zinkernagel RM, Hegartner H. Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor beta chain transgenic mouse. Eur J Immunol. 25:1995;1410-1416.
37. + T lymphocytes different from unprimed cells? Eur J Immunol. 24:1994;1073-1079.
38. MacLennan IC. Germinal centers. Annu Rev Immunol. 12:1994;117-139.
39. Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature. 354:1991;389-392.
40. Kuppers R, Zhao M, Hansmann ML, Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12:1993;4955-4967.
41. McHeyzer-Williams MG, Nossal JGV, Lalor PA. Molecular characterization of single memory B cells. Nature. 350:1991;502-505.
42. McHeyzer-Williams MG, McLean MJ, Lalor PA, Nossal JG. Antigen-driven B cell differentiation in vivo. J Exp Med. 178:1993;295-307.
43. Zhang R, Alt FW, Davidson L, Orkin SH, Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 374:1995;470-473.
44. Tarakhovsky A, Turner M, Schaal S, Mee PJ, Duddy LP, Rajewsky K, Tybulewicz VL. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature. 374:1995;467-470.
45. Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, Watanabe T, Yamamoto T. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 3:1995;549-560.
46. Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity. 3:1995;301-312.
47. Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Muller S, Kantor AB, Herzenberg LA, et al. Defective B cell development and function in Btk-deficient mice. Immunity. 3:1995;283-299.
48. Engel P, Zhou LJ, Ord DC, Sato S, Koller B, Tedder TF. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. of special interest Immunity. 3:1995;39-50 Together with [49] these studies indicate that mice deficient in CD19 have a profound defect in their ability to respond to T cell dependent antigens and a severe defect in the development of the B1 B-cell subset.
49. Rickert RC, Rajewsky K, Roes J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. of special interest Nature. 376:1995;352-355 See annotation [48].
50. Betz AG, Milstein C, Gonzalez FA, Pannell R, Larson T, Neuberger MS. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. of special interest Cell. 77:1994;239-248 Indicates a critical role for the intron enhancer/matrix attachment region and 3′ κ enhancer for somatic hypermutation, whereas the promoter can be changed without significant effects.
51. Yelamos J, Klix N, Goyenechea B, Lozano F, Chui YL, Gonzalez FA, Pannell R, Neuberger MS, Milstein C. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. of outstanding interest Nature. 376:1995;225-229 Non-rearranged genes, of both eukaryotic and prokaryotic origins, can act as target substrate for somatic hypermutation.
52. Rada C, Gonzalez FA, Jarvis JM, Milstein C. The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron. Eur J Immunol. 24:1994;1453-1457.
53. Peters A, Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity. 4:1996;57-65.
54. Reynaud C-A, Garcia C, Hein WR, Weill J-C. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. of special interest Cell. 80:1995;115-125 A comprehensive study of sheep indicates that the hypermutation machinery can target replacement mutations into the CDR3 regions in the absence of exogeneous antigens. These data also demonstrate that somatic hypermutation can proceed in microenvironments other than the germinal center.
55. Kallberg E, Jainandunsing S, Gray D, Leanderson T. Somatic mutation of immunoglobulin V genes in vitro. of outstanding interest Science. 271:1996;1285-1289 A careful study in which hypermutation that was initiated in vivo is sustained in vitro with T-cell help and antigen cross-linking. The authors conclude that there is an initiation phase and a progression phase that are driven by distinct and exclusive signals.
56. Matsumoto M, Mariathasan S, Nahm MH, Baranyay F, Peschon JJ, Chaplin DD. Role of lymphotoxin and the type 1 TNF receptor in the formation of germinal centers. of outstanding interest Science. 271:1996;1289-1291 Germinal-center formation was restored in the spleens of mice deficient in LTα and TNFRI using cells from normal bone marrow.
57. De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, Smith SC, Carlson R, Shomick LP, Strauss SJ, et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 264:1994;703-707.
58. Pulendran B, Kannourakis G, Nouri S, Smith KC, Nossal GJ. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. of special interest Nature. 375:1995;331-334 Together with [59] and [60] these studies highlight a tolerance-susceptible phase during the development of B-cell memory in the germinal center reaction.
59. Shokat KM, Goodnow CC. Antigen-induced B-cell death and elimination during germinal-centre immune responses. of special interest Nature. 375:1995;334-338 See annotation [58].
60. Han S, Hathcock K, Zheng B, Kepler TB, Hodes R, Kelsoe G. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. of special interest J Immunol. 155:1995;556-567 See annotation [58].