The antiproliferative effect of calcitriol on human peripheral blood mononuclear cells

Journal of Clinical Endocrinology and Metabolism

Volumn 63, Issue 2, 1986, Pages 394-400

  Manolagas, S C ^a,b,c   Provvedini, D M ^a,b,c   Murray, E J ^a,b,c   Tsoukas, C D ^a,b,c   Deftos, L J ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCITRIOL H 3; CALCITRIOL RECEPTOR; CALCIUM; INTERLEUKIN 2; PHYTOHEMAGGLUTININ; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD AND HEMOPOIETIC SYSTEM; CELL CULTURE; CELL CYCLE; CYTOFLUOROMETRY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE TRANSFORMATION; METHODOLOGY; PHARMACOKINETICS; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

ANTIGENS, SURFACE; CALCITRIOL; CALCIUM; CELL DIVISION; EGTAZIC ACID; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; RECEPTORS, CALCITRIOL; RECEPTORS, STEROID; TIME FACTORS;

EID: 0022477497     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-63-2-394     Document Type: Article

References (37)

1. 3 receptors in human leukocytes. Science 221:1181
2. 3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 57:1308
3. 3: a novel immunoregulatory hormone. Science 224:1438
4. 3 (calcitriol). J Clin Invest 74:1451
5. 3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 74:657
6. Haussier MR, McCain TA 1977 Basic and clinical concepts related to Vitamin D metabolism and action. N Engl J Med 297:974
7. Norman AW 1979 Vitamin D, the Calcium Homeostatic Steroid Hormone. Academic Press, New York, p 199
8. Norman AW, Ross FP 1979 Vitamin D seco-steroids: unique molecules with both hormone and possible membranophilic properties. Life Sci 24:759
9. 3. Endocrinology 115:1476
10. Rlaus GGB, Hawrylowicz CM 1984 Cell-cycle control in lymphocyte stimulation. Immunol Today 5:15
11. Darzynkiewicz Z, Sharpless T, Staiano-Coico L, Melamed MR 1980 Subcompartments of the Gi phase of cell cycle detected by flow cytometry. Proc Natl Acad Sci USA 77:6696
12. Bonnard GD, Yasaka R, Jacobson D 1979 Ligand-activated T cell growth factor-induced proliferation: absorption of T cell growth factor by activated T cells. J Immunol 123:2704
13. Lichtman AH, Segel GB, Lichtman MA 1983 The role of calcium in lymphocyte proliferation (an interpretive review). Blood 61:413
14. Nishizuka Y 1984 The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308:693
15. Rristensen F, Walker C, Bettens F, Joncourt F, deWeck AL 1982 Assessment of Interleukin-1 and Interleukin-2 effects on cycling and noncycling murine thymocytes. Cell Immunol 74:140
16. Brown RL, Griffith RL, Neubauer RH, Rabin H 1982 The effect of T cell growth factor on the cell cycle of primate T cells. J Immunol 129:1849
17. Stadler BM, Dougherty SF, Farrar JJ, Oppenheim JJ 1981 Relationship of cell cycle to recovery of IL-2 activity from human mononuclear cells, human and mouse T cell lines. J Immunol 127:1936
18. Rung PC, Goldstein G, Reinherz EL, Schlossman SF 1979 Monoclonal antibodies defining distinctive human T cell surface antigens. Science 206:347
19. Goding JW, Burns GF 1981 Monoclonal antibody OKT9 recognizes the receptor for transferrin on human acute lymphocytic leukemia cells. J Immunol 127:1256
20. Leonard WI, Kepper JW, Uchiyama T, Smith KA, Waldmann TA, Greene WC 1982 A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature 300:267
21. Fox RI, Fong S, Sabharwal N, Carstens SA, Rung PC, Vaughan JH 1982 Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis. J Immunol 128:351
22. Boyum A 1968 Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21 (Suppl 97):77
23. Smith RA 1980 T cell growth factor. Immunol Rev 51:337
24. 3. Biochem Biophys Res Commun 95:596
25. 3 receptor-like macromolecule in rat osteogenic sarcoma cell lines. J Biol Chem 255:4414
26. Scatchard G 1949 The attractions of proteins for small molecules and ions. Ann NY Acad Sci 57:660
27. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248
28. Darzynkiewicz Z, Traganos F, Sharpless T, Melamed MR 1976 Lymphocyte stimulation: a rapid multiparameter analysis. Proc Natl Acad Sci USA 73:2881
29. Wetzel GD, Swain SL, Dutton RW, Retteman JR 1984 Evidence for two distinct activation states available to B lymphcytes. J Immunol 133:2327
30. Prowedini DM, Tsoukas CD, Deftos LJ, Manolagas SC 1985 Temporal relationship of 1, 25-Dihydroxycholecalciferol receptor expression and effects on activated lymphocytes. In: Norman AW, Schaefer R, Grigoleit H-G, von Herrath D (eds). Vitamin D. A Chemical, Biochemical and Clinical Update. Walter deGruyter, Berlin, p 133
31. 3 on human T lymphocyte activation and proliferation: a cell cycle analysis. J Immunol 135:2279
32. Wahl SM, Altman LC, Rosenstreich DL 1975 Inhibition of in vivo lymphokine synthesis by glucocorticosteroids. J Immunol 115:476
33. Bettens F, Rristensen F, Walker C, Schwulera U, Bonnard GD, deWeck AL 1984 Lymphokine regulation of activated (Gi) lymphocytes II. Glucocorticoid and anti-Tac-induced inhibition of human T lymphocytes. J Immunol 132:261
34. Harmon JM, Norman MR, Fowlkes BJ, Thompson EB 1979 Dex-amethasone induces irreversible Gi arrest and death of a human lymphoid cell line. J Cell Physiol 98:267
35. Lipkowitz S, Greene WC, Rubin AL, Novogrodsky A, Stenzel RH 1984 Expression of receptors for Interleukin-2: role in the commitment of T lymphocytes to proliferate. J Immunol 132:31
36. Winchester RJ, Runkel HG 1979 The human la system. Adv Immunol 28:221
37. Taniguchi N, Miyawaki T, Yachie A, Ikuta N, Ohzeki S 1983 Rinetics of expression of T cell activation antigens on in vivo- and in wtro-stimulated T cells. Diagn Immunol 1:104