1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis

Journal of Clinical Investigation

Volumn 87, Issue 3, 1991, Pages 1103-1107

  Lemire, Jacques M ^a   Clay Archer, D ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Antimyelin basic protein antibodies; Brain lesions; Dosage; Severity; Survival

Indexed keywords

CALCITRIOL;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENCEPHALOMYELITIS; FEMALE; HISTOLOGY; IMMUNE DEFICIENCY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; ANTIBODY FORMATION; AUTOANTIBODIES; AUTOANTIGENS; CALCITRIOL; ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE; MICE; MICE, INBRED STRAINS; MYELIN BASIC PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SURVIVAL ANALYSIS;

EID: 0025732356     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115072     Document Type: Article

References (23)

1. 3 and the immune system. Mol. Cell. Endocrinol. 43:113-122.
2. Rigby, W. F. C. 1988. The immunobiology of vitamin D. Immunol. Today. 9:54-58.
3. 3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J. Clin. Invest. 74:657-661.
4. 3 suppresses human helper/inducer lymphocyte activity in vitro. J. Immunol. 134:3032-3035.
5. 3: a novel immunoregulatory hormone. Science (Wash. DC) 224:1438-1440.
6. 3 (Calcitriol). J. Clin. Invest. 74:1451-1455.
7. 3 inhibits antigen-induced T cell activation. J. Immunol. 133:1748-1754.
8. Manolagas, S. C., D. M. Provvedini, E. J. Murray, C. D. Tsoukas, and L. J. Deftos. 1986. The antiproliferative effect of calcitriol on human peripheral blood mononuclear cells. J. Clin. Endorinol. Metab. 63:394-400.
9. 3 receptor distribution and effects in subpopulations of normal human T lymphocytes. J Clin. Endocrinol. Metab. 68:774-779.
10. Paterson, P. V. 1976. Experimental autoimmune encephalomyelitis: induction, pathogenesis and suppression. In Textbook of Immunopathology. P. A. Miescher and H. J. Müller-Eberhard, editors. Grune and Stratton. Inc., New York. 179-213.
11. Lassmann, H., G. Suchanek, K. Kitz, H. Stemberger, B. Schwerer, and H. Bernheimer. 1984. Antibodies in the pathogenesis of demyelination in chronic relapsing EAE. In Experimental Allergie Encephalomyelitis: A Useful Model for Multiple Sclerosis, E. C. Alvord, M. W. Kies, and A. J. Suckling, editors. Alan R. Liss, Inc., New York. 165-170.
12. +T cell clones possessing several functions. J. Immunol. 137:3169-3174.
13. Lassmann, H. 1983. Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Springer-Verlag New York Inc. p. 10.
14. 3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production. J. Immunol. 136:2734-2740.
15. 3. J Clin. Invest. 79:1659-1664.
16. 3 prolong survival time of mice inoculated with myeloid leukemia cells. Proc. Natl. Acad. Sci. USA. 80:201-204.
17. 3 analogues and other differentiation inducers in combination with antileukemic drugs: in vitro and in vivo studies. Cancer Res. 47:567-572.
18. 3. Cancer Res 47:21-25.
19. Paterson, P. Y., and E. D. Day. 1983. Neuroimmunologic disease: experimental and clinical aspects. In The Biology of Immunologic Disease. F. J. Dixon and D. W. Fisher, editors. Sinauer Associates, Inc., Sunderland, MA. 265-274.
20. 3 on the induction of experimental autoimmune thyroiditis. Clin Immunol. Immunopathol. 54:53-63.
21. Weigle, W. O. 1980. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30:159-273.
22. 3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice. Endocrinology. 124:2645-2647.
23. 3 prolongs survival time of leukemic mice. Proc. Natl. Acad. Sci. USA. 87:3929-3930.