Seed stage development for improved fermentation performance: Increased milbemycin production by Streptomyces hygroscopicus

Journal of Industrial Microbiology

Volumn 16, Issue 5, 1996, Pages 295-300

  Warr, Src ^a   Gershater, Cjl ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Inoculum development; Milbemycin; Seed stage fermentation; Streptomyces hygroscopicus

Indexed keywords

MILBEMYCIN;

ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; CONTROLLED STUDY; FERMENTATION; NONHUMAN; STREPTOMYCES HYGROSCOPICUS;

BACTERIA (MICROORGANISMS); STREPTOMYCES HYGROSCOPICUS;

EID: 0029900028     PISSN: 01694146     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01570037     Document Type: Article

References (23)

1. Braun S and SE Vecht-Lifschitz, 1991. Mycelial morphology and metabolite production. Tibtech 9: 63-68.
2. Buckland BC, T Brix, H Fasten, K Gbewonyo, G Hunt and D Jain, 1985. Fermentation exhaust gas analysis using mass spectrometry. Bio/Technology 3: 982-988.
3. Calam CT, 1982. Factors governing the production of penicillin by Pénicillium chrysogenum. In: FEMS Symposium No. 13. Overproduction of Microbial Products (Krumphanzl V, B Sikyta and Z Vanek, eds), pp 89-95, Academic Press, London.
4. Chaturvedi SK, GM Quazi, CN Gaind, RM Gupta, CL Chopra and CK Atal, 1978. Production of citric acid by submerged fermentation. In: Proc Indust Perm Symp, pp 40-50, Council for Scientific and Industrial Research, India.
5. Dewitt JP, JV Jackson and TJ Paulus, 1989. Actinomycetes. In: Fermentation Process Development of Industrial Microorganisms (Neway JO, ed), pp 1-71, Marcel Dekker, New York.
6. Elander RP, 1989. Bioprocess technology in industrial fungi. In: Fermentation Process Development of Industrial Microorganisms (Neway JO, ed), pp 161-219, Marcel Dekker, New York.
7. Gutierrez N and IS Maddox, 1987. The effect of some culture maintenance and inoculum development techniques on solvent production by Clostridium acetobittylicum. Can J Micro 33: 82-84.
8. Higashide E, 1984. The macrolides: properties, biosynthesis and fermentation. In: Biotechnology of Industrial Antibiotics (Drugs and the Pharmaceutical Sciences Vol 22) (Vandamme EJ, ed), pp 451-509, Marcel Dekker, New York.
9. Hood JD, RM Banks, MD Brewer, JP Fish, BR Manger and ME Poulton, 1989. A novel series of milbemycin antibiotics from Streptomyces strain E225. 1. Discovery, fermentation and anthelmintic activity. J Antibiotics 42: 1593-1598.
10. Kozina AM, EA Maximova, ES Bylinkina and SV Dmitrieva, 1982. Effect of the conditions of inoculum cultivation on biosynthesis of cephalosporin. Antibiotiki 27: 649-654.
11. Martinkova L, F Machek, E Ujcova, F Kolin and J Zajicek, 1991. Effect of age, amount of inoculum and inoculation medium composition on lactic acid production from glucose by Lactobacilhis case! subsp rhamnosus. Folia Microbiol 36: 246-248.
12. Meyreth J and AF Mclntosh, 1963. Size of inoculum and carbon metabolism in some Aspergillus species. J Gen Microbiol 33: 47-56.
13. Millan MC, J Moreno, M Medina and JM Ortega, 1991. Influence of the physiological state of the inoculum on fermentation of musts from Pedro Ximenez grapes by Saccharomyces cerevisiae. Microbios 65: 87-95.
14. Motkova MO, EG Gladkikh and TP Korobkova, 1981. Inoculum effect on biosynthesis of tobramycin. Antibiotiki 26: 491-496.
15. Nair VC and Z Duvnjak, 1990. Reduction of phytic acid content in canola meal by Aspergillits ficuum in solid state fermentation process. Appl Microbiol Biotechnol 34: 183-188.
16. Nallin-Omstead M, L Kaplan and BC Buckland, 1989. Fermentation development and process improvement. In: Ivermectin and Abamectin (Campbell WC, ed), pp 33-54, Springer-Verlag, Berlin.
17. Orlova NV and A A Prokofieva-Belgovskaya, 1961. The effect of amount and age of culture material on the development of Actinomyces rimosits and on production of oxytetracycline. Antibiotiki 6: 15-20.
18. Orlowski J and J Barford, 1987. The effect of inoculum preparation on the fully aerated growth of Saccharomyccs cerevisiae with a glucose substrate. J Gen Appl Microbiol 33: 113-121.
19. Parton C and P Willis, 1990. Strain preservation, inoculum preparation and development. In: Fermentation, A Practical Approach (McNeil B and LM Harvey, eds), pp 39-64, IRL Press, Oxford.
20. Rozman D, E Pertot, R Komel and M Prosek, 1989. Production of lysergic acid derivatives with immobilized Claviceps paspali mycelium. Appl Microbiol Biotechnol 32: 5-10.
21. Smith GM and CT Calam, 1980. Variations in inocula and their influence on the productivity pf antibiotic fermentations. Biotechnol Lett 2: 261-266.
22. Warr SRC, SJ Box, C Burbidge, H Edwards and JJ Jones, 1994. Milbemycin production by Streptomyces sp: the effect of carbohydrates. J Ind Microbiol 13: 43-48.
23. Webb C and SP Kamat, 1993. Improving inoculum consistency through better inoculum preparation. World J Microbiol Biotechnol 9: 308-312.