Prulifloxacin. Fluoroquinolone antibacterial

Drugs of the Future

Volumn 21, Issue 8, 1996, Pages 805-810

  Tracy, M ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; ENOXACIN; LOMEFLOXACIN; NONSTEROID ANTIINFLAMMATORY AGENT; OFLOXACIN; PRULIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANAEROBIC BACTERIUM; ANTIBACTERIAL ACTIVITY; BACTERIAL INFECTION; BIOASSAY; CONVULSION; DRUG METABOLISM; DRUG SAFETY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MONKEY; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; SHORT SURVEY;

EID: 0029855396     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1996.021.08.368282     Document Type: Short Survey

References (115)

1. Segawa, J., Kitano, M., Kazuno, K., Matsuoka, M., Shirahase, I., Ozaki, M., Matsuda, M., Tomii, Y., Kise, M. Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted - 6 - halo - 4 - oxo - 4H - [1,3]thiazeto[3,2-a]quinoline - 3 - carboxylic acids. J Med Chem 1992, 35: 4727-38.
2. Kise, M., Kitano, M., Ozaki, M., Kazuno, K., Matsuda, M., Shirahase, I., Segawa, J. (Nippon Shinyaku Co., Ltd.). Quinolinecarboxytic acid derivs. AU 8824673, EP 315828, JP 89294680.
3. Prous, J.R. Miscellaneous antibiotics. In: The Year's Drug News - Therapeutic Targets, 1995 Edition, Prous Science Publishers, Barcelona, 1995,431-5.
4. Nishida, H., Fujii, T, Abiru, Y, Yatsuki, K., Yamamoto, M., Shimizu, N., Kakemi, K., Mikawa, M., Kise, M. Studies on synthesis of antibacterialagent(NM441). I. Kinetics and mechanism of the reaction of 4-(bromomethyl)-5-methyl-1,3-dioxol-2-one with 1-substituted piperazine (NM394). Bull Chem Soc Jpn 1994, 67:1419-26.
5. Fujii, T, Nishida, H., Abiru, Y., Yamamoto, M., Kise, M. Studies on synthesis of the antibacterial agent NM441. II. Selection of a suitable base for alkylation of 1-substituted piperazine with4-(bromomethyl)-5-methyl- 1,3-dioxol-2-one. Chem Pharm Bull 1995,43: 1872-7.
6. Yoshida, T., Mitsuhashi, S. Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone. Antimicrob Agents Chemother 1993, 37: 793-800.
7. Yoshida, T., Mitsuhashi, S. In vitro antibacterial activity of NM394, active form of NM441, a new quinolone. Jpn J Chemother 1996, 44(Suppl. 1):8-18.
8. Asada, K., Kuwahara, K., Hiramatsu, K., Yokota, T. In vitro antibacterial activity of NM441. Jpn J Chemother 1996, 44(Suppl. 1): 19-25.
9. Sugano, T., Miyazaki, S., Tsuji, A., Kaneko, Y, Yamaguchi, K., Goto, S.Antibacterial activity of a new quinolone NM441 in vitro and in vivo. Jpn J Chemother 1996,44(Suppl. 1 ): 26-41.
10. Nakashio, S., Iwasawa, H., Susa, C., Kanemitsu, K., Shimada, J. Antimicrobial evaluation of new oral quinolone NM441 against the clinical isolates and the sessile cells of Pseudomonas aeruginosa. Jpn J Chemother 1996,44(Suppl. 1): 42-9.
11. Kato, N., Kato, H., Tanaka-Bandoh, K., Watanabe, K., Ueno, K. The in vitro activity of NM441, a new quinolone, against anaerobic bacteria. Jpn J Chemother 1996, 44(Suppl. 1): 50-5.
12. Nishino, T., Tomii, Y, Shibata, K., Kawai, M., Shiotsuki, N., Otsuki, M. In vitro and in vivo antibacterial activity of NM441. Jpn J Chemother 1996,44(Suppl. 1): 56-69.
13. Totsuka, K., Shibata, Y., Kikuchi, K., Hasegawa, H., Shimizu, K. Studies on postantibiotic effect and effective regrowth time of NM441. Jpn J Chemother 1996, 44(Suppl. 1): 70-3.
14. Tomii, Y, Matsuda, M., Sumimura, N., Ozaki, M., Kise, M. In vitro and in vivo antibacterial activities of a new quinolone, NM441. Jpn J Chemother 1996,44(Suppl. 1): 74-89.
15. Yoshida, T., Hara, T., Miyata, A., Araake, M., Kawaharajo, K. In vitro and in vivo antibacterial activity of NM441, a new quinolone, against Pseudomonas aeruginosa. Jpn J Chemother 1996, 44(Suppl. 1):90-6.
16. Ozaki, M., Matsuda, M., Tomii, Y, Kimura, K., Segawa, J., Kitano, M., Kise, M., Shibata, K., Otsuki, M., Nishino, T. In vitro evaluation of NM441, a new thiazeto-quinoline derivative. Antimicrob Agents Chemother 1991, 35: 2496-9.
17. Kura, K., Fukui, H., Fukui, T. et al. General pharmacological studies of NM441 (1). Effects on central and peripheral nervous systems, gastrointestinal tract and smooth muscle. Jpn J Chemother 1996, 44(Suppl. 1): 113-28.
18. Kura, K., Ochi, S., Tanaka, M. et al. General pharmacological studies on NM441 (2). Effects on respiratory and cardiovascular systems, renal function and others. Jpn J Chemother 1996, 44(Suppl. 1): 129-46.
19. Hori, S., Shimada, J. Effect of NM441 and its active form on GABA receptor binding. Jpn J Chemother 1996, 44(Suppl. 1): 97-101.
20. Ukai, Y, Yamazaki, A., Kurosaka, C., Ishima, T., Yoshikuni, Y., Kimura, K. Convulsant effects of NM441, a prodrug type antibacterial agent of the quinolone class. Jpn J Chemother 1996,44(Suppl. 1): 102-12.
21. Matsuda, M., Okuyama, Y., Morino, A., Ozaki, M. Assay methods for NM441 in body fluids. Jpn J Chemother 1996,44(Suppl. 1): 147-54.
22. Okuyama, Y., Momota, K., Morino, A. Absorption of NM441 in various animal species. Jpn J Chemother 1996, 44(Suppl. 1): 155-9.
23. Shibasaki, S., Kuribayashi, T., Hodoshima, N., Nakayoshi, T. Cerebrospinal fluid concentration of NM441 in dogs. Jpn J Chemother 1996,44(Suppl. 1): 160-4.
24. Shibasaki, S., Kuribayashi, T., Hodoshima, N., Nakayoshi, T. Renal excretion mechanism in rabbit and Pharmacokinetics in renal insufficient rats of NM441. Jpn J Chemother 1996, 44(Suppl. 1): 165-72.
25. Nakashima, M., Uematsu, T., Kosuge, K. Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers. Jpn J Chemother 1996, 44(Suppl. 1): 180-206.
26. Nakashima, M., Uematsu, T., Kosuge, K., Okuyama, Y., Morino, A., Ozaki, M., Takebe, Y Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers. J Clin Pharmacol 1994,34:930-7.
27. Karakida, K., Yamazaki, J., Sasaki, J. NM441, penetration in saliva and effusion level of tooth extraction wounds. Jpn J Chemother 1996, 44(Suppl. 1): 229-32.
28. Tanimura, H., Ishimoto, K., Murakami, K., Uchiyama, K., Iwakura, S. Penetration of NM441, a new quinolone, into human bile and gallbladder tissue. Drugs 1995,49(Suppl. 2): 337-40.
29. Murakami, K., Tanimura, H., Ishimoto, K., Uchiyama, K., Yukawa, H., Onishi, H., Iwakura, K. Excretion of new quinolones and their glucuronide conjugates into human bile. Drugs 1995, 49(Suppl.2):331-2.
30. Mikamo, H., Kawazoe, K., Izumi, K., Ito, K., Tamaya, T. NM441: Penetration into gynaecological tissues and in vitro activity against clinical isolates from obstetric and gynaecological patients. Drugs 1995,49(Suppl. 2): 326-30.
31. Saito, A., Tarao, F. Influence of milk on absorption of NM441, a prodrug type of quinolone antibiotic. Jpn J Chemother 1996, 44(Suppl. 1):221-8.
32. Nakabayashi, M., Hashiguchi, K., Miyashita, N., Kubota, Y., Tamada, S., Niki, Y., Soejima, R. Effect of NM441 on serum concentration of theophylline. Jpn J Chemother 1996, 44(Suppl. 1): 233-7.
33. Saito, A., Tomizawa, M., Nakayama, I., Sato, K. Antimicrobial activity and clinical studies on NM441. Jpn J Chemother 1996, 44(Suppl. 1): 238-42.
34. Ohmichi, M., Hiraga, Y. Basic and clinical studies on NM441 in respiratory tract infection. Jpn J Chemother 1996, 44(Suppl. 1): 243-8.
35. Watanabe, A., Takahashi, H., Kikuchi, H. et al. In vitro antimicrobial activity of NM394, an active form of NM441, and therapeutic efficacy of NM441 in respiratory tract infections. Jpn J Chemother 1996,44(Suppl. 1): 249-55.
36. Ohishi, A., Sakauchi, M., Aosaki, N., Katsu, M. Basic and clinical studies on NM441. Jpn J Chemother 1996, 44(Suppl. 1): 256-62.
37. Shiba, K., Yoshida, M., Sakai, O., Saito, A. Pharmacokinetics and clinical studies on NM441. Jpn J Chemother 1996,44(Suppl. 1): 263-78.
38. Matsumoto, F, Sakurai, I., Imai, T., Ishida, Y., Takahashi, T, Morita, M., Sato, Y., Shimada, J., Nakamura, T. Basic and clinical studies on NM441. Jpn J Chemother 1996,44(Suppl. 1): 289-94.
39. Aoki, N., Koda, Y., Takasawa, T. et al. Clinical pharmacology and efficacy of NM441. Jpn J Chemother 1996, 44(Suppl. 1): 295-304.
40. Sato, A., Chida, K., Yagi, T. et al. Laboratory and clinical studies on NM441 in respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 305-12.
41. Okimoto, N., Yoshida, K., Nakashima, M., Niki, Y., Soejima, R. Clinical study of NM441 on respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 313-6.
42. Kurimura, O., Hiramoto, T., Nakano, K. et al. Studies on antimicrobial activity of NM394 and clinical efficacy of NM441 in respiratory tract infection. Jpn J Chemother 1996, 44(Suppl. 1 ): 317-23.
43. Matsumoto, Y., Sugimoto, Y., Yamasaki, S., Hitsuda, Y., Sasaki, T. Basic and clinical studies on NM441 in respiratory infections. Jpn J Chemoother 1996, 44(Suppl. 1): 324-8.
44. Sawae, Y., Okada, K., Shimono, N. et al. Bacteriological and clinical studies on NM441. Jpn J Chemother 1996, 44(Suppl. 1): 329-34.
45. Fukuda, M., Kakeya, H., Sawai, T. et al. Laboratory and clinical evaluation of NM441. Jpn J Chemother 1996,44(Suppl. 1 ): 335-41.
46. Rikitomi, N., Mitsushima, H., Tao, M., Nagatake, T., Shishido, H., Katayama, H., Takahashi, A. Efficacy of NM441 in bacterial respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1 ): 342-9.
47. Nasu, M., Yamasaki.T., Hiramatsu, K. et al. Laboratory and clinical studies of NM441 in respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 350-5.
48. Gaja, M., Fukuhara, H., Inadome, J., Hisagai, Y., Aragaki, M., Saito, A., Kusano, N., Tateyama, M., Uema, H. Basic and clinical studies on NM441 in respiratory infection. Jpn J Chemother 1996, 44(Suppl. 1): 356-61.
49. Kobayashi, H., Kawai, S., Sakayori, S. et al. Dose-finding study on NM441 in chronic respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 362-78.
50. Sato, Y., Hirose, T., Kumamoto, Y., Tukamoto, T. Antibacterial activity and clinical studies on NM441 in urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 379-86.
51. Goto, H., Oishi, Y., Onodera, S., Kiyota, H., Kawahara, M., Igarashi, H., Hosobe, T., Madarame, J. Antimicrobial activity of NM394 in human urine, influence of NM394 on bactericidal activity of leukocytes. Jpn J Chemother 1996, 44(Suppl. 1): 387-92.
52. Oshi, M., Asakage, H., Kawabe, K., Aso, Y., Nito, H. Fundamental and clinical studies on NM441 for urinary tract infections. Jpn J Chemother 1996,44(Suppl. 1): 393-9.
53. Saito, I., Saiko, Y., Miyamura, R., Hamaya, O. Clinical study on NM441 in male gonococcal urethritis. Jpn J Chemother 1996, 44(Suppl. 1): 400-4.
54. Suzuki, K., Horiba, M., Ishikawa, K., Naide, Y., Hoshinaga, K., Yanaoka, M., Kato, S., Ando, S., Okishio, N., Asano, H. Basic and clinical studies on NM441 in chronic bacterial prostatitis. Jpn J Chemother 1996, 44(Suppl. 1): 405-13.
55. Ishihara, S., Uno, H., Ueno, H. et al. Antibacterial activities and clinical efficacy of NM441 in urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 414-9.
56. Miyazaki, S., Arakawa, S., Kamidono, S., Kataoka, N., Yamashita, M., Ohbe, S., Takeda, M., Hazama, M. Clinical studies of NM441 in complicated urinary tract infections - On the utility and recurrence after 14-days treatment. Jpn J Chemother 1996, 44(Suppl.1). 420-8.
57. Sakuramoto, K., Fujita, R., Watanabe,T. et al. Basic and clinical studies on NM441 in urological field. Jpn J Chemother 1996, 44(Suppl. 1): 429-37.
58. Noda, S., Ueda, S., Yamashita, T., Oyabu, Y. Clinical study in urinary tract infection and pharmacokinetics in patients with renal dysfunction on NM441. Jpn J Chemother 1996, 44(Suppl. 1): 438-43.
59. Goto, T., Makinose, S., Kitagawa, T., Kawahara, K., Kawahara, M., Ohi, Y., Kawabata, T., Hayami, H., Imamura, A. In vitro activity of NM394, penetration of NM394 to cerebrospinal fluid and clinical evaluation of NM441 in urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 444-50.
60. Kumazawa, J., Matsumoto, T., Kumamoto, Y. et al. Clinical dose finding study on NM441 in complicated urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 451-61.
61. Murakami, K., Tanimura, H., Ishimoto, K. et al. Excretion into bile and gallbladder tissue level of a new quinolone, NM441, and its clinical efficacy on surgical infections. Jpn J Chemother 1996, 44(Suppl. 1): 462-70.
62. Yokoyama, T., Kodama, T., Takesue, Y. et al. Laboratory and clinical studies on NM441 in surgery. Jpn J Chemother 1996, 44(Suppl. 1):471-6.
63. Shinagawa, N., Mashita, K., Ito, A. et al. Basic and clinical studies on NM441 in the surgical field. Jpn J Chemother 1996, 44(Suppl. 1): 477-84.
64. Cho, N., Noguchi, A., Miyakawa, Z., Shimizu, A., Notake, Y., Kunii, K. Basic and clinical evaluation of NM441 in obstetrics and gynecology. Jpn J Chemother 1996, 44(Suppl. 1): 485-94.
65. Mikamo, H., Kawazoe, K., Izumi, K., Ito, K., Tamaya, T., Yamada, Y. Fundamental and clinical studies on NM441 in obstetrics and gynecology. Jpn J Chemother 1996, 44(Suppl. 1): 495-502.
66. Arata, J., Torigoe, R., Matsuura, Y. et al. Basic and clinical evaluations of NM441, a prodrug new quinolone, in dermatology. Jpn J Chemother 1996,44(Suppl. 1): 509-17.
67. Shinkawa, A., Kimura, H., Idei, N., Tamura, Y., Sakai, M., Sato, M., Takahashi, H., Yamazaki, M., Miyake, H. Pharmacokinetics and clinical studies on NM441 in otorhinolaryngology infections. Jpn J Chemother 1996,44(Suppl. 1): 518-25.
68. Miyamoto, N., Baba, S., Yokota, A., Ito, H., Motai, H., Moribe, K., Kobayashi, T. Pharmacokinetic and clinical studies of NM441 on otorhinolaryngological infections. Jpn J Chemother 1996, 44(Suppl. 1): 526-30.
69. Kawasaki, Y., Ochiai, K., Kubo, T. et al. Evaluation of NM441 in treatment of otorhinolaryngological infections. Jpn J Chemother 1996,44(Suppl. 1):531-6.
70. Matsuzaki, T., Ohyama, M., Murano, K., Hirota, J., Sakamoto, K. Basic and clinical studies on NM441 for infectious disease in the field of otorhinolaryngology. Jpn J Chemother 1996,44(Suppl. 1 ): 537-42.
71. Suzuki, A. Fundamental and clinical studies on NM441 in the field of ophthalmology. Jpn J Chemother 1996,44(Suppl. 1): 543-7.
72. Yoshino, K., Kawai, Y., Fujiwara, T. Clinical efficacy of NM441 in external eye diseases and its penetration into human tear. Jpn J Chemother 1996,44(Suppl. 1): 548-50.
73. Hara, J., Kawamura, T., Yasuda, F., Kawaguchi, S., Otani, E. Clinical and basic studies on NM441 in ophthalmology. Jpn J Chemother 1996,44(Suppl. 1): 551-3.
74. Ooishi, M., Miyao, M., Abe, T. et al. Fundamental and clinical studies on NM441 in ophthalmology. Jpn J Chemother 1996, 44(Suppl. 1): 554-62.
75. Sasaki, J., Kaneko, A., Oota, Y. et al. Clinical study on NM441 in the field of dentistry and oral surgery. Jpn J Chemother 1996, 44(Suppl. 1): 563-72.
76. Isobe, H., Ogura, S., Makino, H., Yamaguchi, E., Kawakami, Y. Clinical study on NM441 in the treatment of respiratory tract infections. Jpn J Chemother 1996,44(Suppl. 1): 573-5.
77. Osonoi, T., Kuroda, H., Saito, M., Suga, S., Hirai, H., Takebe, K. Clinical study on NM441. Jpn J Chemother 1996,44(Suppl. 1 ): 576-8.
78. Yoshida, M., Mouri, T., Obara, A., Konishi, K., Inoue, H., Takeuchi, K., Hirano, H. Clinical study of NM441 in respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1 ): 579-81.
79. Hayashi, I., Sakurai, M., Shiotani, J., Inamura, N. Clinical studies of NM441 in respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1):591-3.
80. Kawai, S., Sakayori, S., Kobayashi, H. Clinical study on NM441 in respiratory tract infections. Jpn J Chemother 1996,44(Suppl. 1 ): 594-6.
81. Horiuchi, T., Kudo, K. Clinical study of NM441 in respiratory infectious diseases. Jpn J Chemother 1996, 44(Suppl. 1 ): 597-9.
82. Koyama, M. Clinical study on NM441. Jpn J Chemother 1996, 44(Suppl. 1): 600-2.
83. Obana, M., Matsuoka, Y., Irimajiri, S. Clinical study on NM441 in respiratory tract infections. Jpn J Chemother 1996,44(Suppl. 1 ): 603-4.
84. Ikeda, H., Nishiyama, H., Okubo, T. Clinical study of NM441. Jpn J Chemother 1996,44(Suppl. 1 ): 605-6.
85. Odagiri, S., Suzuki, K., Takahashi, H., Takahashi, K., Yoshiike, Y., Ogura, T., Hirai, Y. Clinical study of NM441 in respiratory tract infections. Jpn J Chemother 1996,44(Suppl. 1 ): 607-10.
86. Wada, K., Tsukada, H., Igarashi, K., Arakawa, M., Hoshino, S., Iwata, F. Clinical study of NM441. Jpn J Chemother 1996,44(Suppl. 1): 611-2.
87. Suzuki, Y., Sekine, O., Uno, K., Yagi, M., Hori, M. Clinical study on NM441. Jpn J Chemother 1996, 44(Suppl. 1): 613-6.
88. Shimokata, K., Ichiyama, S., Sakai, S. et al. Clinical study of NM441 in respiratory tract infection. Jpn J Chemother 1996, 44(Suppl. 1): 617-21.
89. Yamada, Y., Nakamura, A., Kojima, Y., Takeucni, T., Yamamoto, K., Yamakoshi, M., Yamamoto,T., Suzuki, K., Yamamoto, T. Clinical studies of NM441 in respiratory infections and urinary tract infections. Jpn J Chemother 1996,44(Suppl. 1 ): 622-5.
90. Kuze, F., Suzuki, K., Kurasawa, T., Umeda, B., Bando, K., Mochizuki, Y., Nakahara, Y., Kawamura, T., Tsuyuguchi, K., Tsunoda, A. Clinical study on NM441 against respiratory tract infection. Jpn J Chemother 1996,44(Suppl. 1): 626-9.
91. Nakanishi, M. Clinical studies on NM441 in the treatment of respiratory infections. Jpn J Chemother 1996,44(Suppl. 1 ): 630-2.
92. Miki, F., Ikuno, Y., Murata, A., Sakamoto, K., Otani, S., Nakayama, K., Tanaka, S., Hanatani, A. A clinical study on NM441. Jpn J Chemother 1996,44(Suppl. 1): 633-4.
93. Masuno, T., Tsubura, E. A clinical study of NM441. Jpn J Chemother 1996,44(Suppl. 1): 635-6.
94. Mikasa, K., Sawaki, M., Konishi, M., Maeda, K., Hamada, K., Mori, K., Teramolo, S., Sakamoto, M., Tsujimoto, M., Marita, N. NM441 in respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 637-8.
95. Kobashi, Y., Matsushima, T., Tomizawa, S. et al. Clinical evaluation of NM441 in respiratory infections. Jpn J Chemother 1996, 44(Suppl. 1): 639-41.
96. Hozawa, S., Yamakido, M., Arita, K., Daido, K., Ejima, T. Clinical study of NM441 against respiratory tract infection. Jpn J Chemother 1996, 44(Suppl. 1): 642-4.
97. Watanabe, K., Senju, S., Yoshida, M. Clinical study of NM441 in respiratory infection. Jpn J Chemother 1996,44(Suppl. 1 ): 645-7.
98. Takamoto, M., Kitahara, Y., Harada, Y., Ishibashi, T. Clinical study on NM441 in respiratory tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 648-50.
99. Yamada, H., Nakahara, Y., Aoki, Y., Kuroki, S., Katoh, O. Clinical study on NM441 in respiratory tract infection. Jpn J Chemother 1996, 44(Suppl. 1):651-3.
100. Doi, T., Suga, M., Nakamura, M., Ando, M. Clinical study of NM441 in respiratory infection. Jpn J Chemother 1996, 44(Suppl. 1): 654-5.
101. Miyagata, S., Tsuchida, S., Sasaki, S., Kizu, N., Hongo, R. Clinical study of NM441 in urinary tract infections. Jpn J Chemother 1996,44(Suppl. 1): 656-8.
102. Ito, S., Toyota, S., Oikawa, K., Katoh, S., Orikasa, S. NM441 in urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 659-62.
103. Saito, I., Saiko, Y. Clinical efficacy of NM441 in urinary tract infections and epididymitis. Jpn J Chemother 1996, 44(Suppl. 1): 663-7.
104. Fujita, K., Fujime, M. Clinical study on NM441 in urology. Jpn J Chemother 1996,44(Suppl. 1): 668-73.
105. Tanaka, M., Arihara, K., Kinoshita, H. Clinical studies on NM441 in the field of urology. Jpn J Chemother 1996,44(Suppl. 1): 674-7.
106. Suzuki, K., Horiba, M., Ishikawa, K., Naide, Y., Hoshinaga, K., Yanaoka, M., Kato, S., Ando, S., Okishio, N., Asano, H. Clinical study of NM441 on urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 678-83.
107. Yamamoto, H., Uchibayashi, T., Okawa, M. Clinical study of NM441 in urinary tract infections. Jpn J Chemother 1996,44(Suppl. 1): 684-6.
108. Muranaka, K., Okada, K. Clinical studies of NM441 in urinary tract infection. Jpn J Chemother 1996,44(Suppl. 1 ): 687-9.
109. Terai, A., Yoshida, O. NM441 in acute uncomplicated urinary tract infections. Jpn J Chemother 1996,44(Suppl. 1): 690-1.
110. Kinbara, H., Maeda, Y., Yanagawa, M., Tochigi, H., Kawamura, J. Clinical study of NM441 in complicated urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 692-4.
111. Fujiwara, S., Usui, T., Masu, C. Clinical efficacy of NM441 on urinary infection. Jpn J Chemother 1996, 44(Suppl. 1): 695-7.
112. Kan, M., Uema, K., Kagawa, S., Yuasa, M. NM441 in urinary tract infections. Jpn J Chemother 1996, 44(Suppl. 1): 698-701.
113. Tanimura, M., Kataoka, S., Yasuda, M., Fujita, Y. Clinical studies on NM441 in urology. Jpn J Chemother 1996, 44(Suppl. 1): 702-3.
114. Kumazawa, J., Matsumoto, T., Mizunoe, Y. et al. Clinical studies on NM441 in the field of urology. Jpn J Chemother 1996, 44(Suppl. 1): 704-10.
115. Nippon Shinyaku Annual Report 1994.