In vitro antimicrobial activity of NM394, an active form of NM441, and therapeutic efficacy of NM441 in respiratory tract infections

Japanese Journal of Chemotherapy

Volumn 44, Issue , 1997, Pages 249-255

  Watanabe, Akira ^a   Takahashi, Hiroshi ^a   Kikuchi, Hiroaki ^a   Tokue, Yutaka ^a,e   Nukiwa, Toshihiro ^a   Motomiya, Masakichi ^a,f   Nakagawa, Jun ^b   Hitomi, Hideaki ^b   Sato, Kazuo ^c   Konno, Kiyoshi ^d   Shoji, Satoru ^a,d  

^a TOHOKU UNIVERSITY   (Japan)

^b Tohoku Kouseinenkin Hospital   (Japan)

^c Sato Hospital   (Japan)

^d Tohoku Chuo Hospital   (Japan)

^e Department of Diagnostic Radiology   (Japan)

^f Sendai Teishin Hospital   (Japan)

Author keywords

NM394; NM441

Indexed keywords

6 FLUORO 1 METHYL 4 OXO 7 (1 PIPERAZINYL) 4H 1,3 THIAZETO[3,2 A]QUINOLINE 3 CARBOXYLIC ACID; OFLOXACIN; PRODRUG; PRULIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; TOSUFLOXACIN;

ADULT; AGED; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL PNEUMONIA; BACTERIUM CULTURE; BRONCHIOLITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE LIVER FUNCTION RELATION; DRUG EFFICACY; FEMALE; HUMAN; MALE; MINIMUM INHIBITORY CONCENTRATION; ORAL DRUG ADMINISTRATION;

EID: 0029869369     PISSN: 13407007     EISSN: None     Source Type: Journal    
DOI: 10.11250/chemotherapy1995.44.Supplement1_249     Document Type: Article

References (4)

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2. Ozaki M, et al : In vitro antibacterial activity of a new quinolone, NM394. Antimicrob Agents Chemother 35 : 2490–2495, 1991
3. Yoshida T, Mitsuhashi S : Antibacterial activity of NM394, the active form of prodrug NM441, a new quinolone. Antimcrob Agents Chemother 37 : 793–800, 1993
4. Ozaki M, et al : In vivo evaluation of NM441, a new thiazeto-quinoline derivative. Antimicrob Agents Chemother 35 : 2496–2499, 1991