Transgenic and null mutant animals for psychosomatic research

Psychosomatic Medicine

Volumn 58, Issue 6, 1996, Pages 622-632

  Crnic, Linda S ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

animal model; knock out; null mutant; psychosomatic; targeted mutation; transgenic

Indexed keywords

AGGRESSION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; PSYCHOSOMATICS; REVIEW; TRANSGENIC ANIMAL;

EID: 0029851559     PISSN: 00333174     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006842-199611000-00010     Document Type: Review

References (57)

1. Capecchi MR: Targeted gene replacement. Sci Am 270:52-59, 1994
2. Stenzel-Poore MP, Heinrichs SC, Rivest S, Koob GF, Vale WW: Overproduction of corticotropin-releasing factor in transgenic mice: A genetic model of anxiogenic behavior. J Neurosci 14:2579-2584, 1994
3. Camper SA: Research applications of transgenic mice. Biotechniques 5:638-650, 1987
4. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612, 1996
5. Gold PW, Kling MA, Demitrack MA, Whitfield H, Kalogeras K, Loriaux L, Chrousos GP: Clinical studies with corticotropin releasing hormone: Implications for hypothalamic-pituitary adrenal dysfunction in depression and related disorders. Curr Top Neuroendocrinol 8:55-76, 1988
6. Stenzel-Poore MP, Cameron VA, Vaughn J, Sawchenco PE, Vale W: Development of Cushing's syndrome in cortocotropin-releasing factor transgenic mice. Endocrinology 130: 3378-3384, 1992
7. Lee C, Rodgers RJ: Effects of benzodiazepine receptor antagonist, flumazenil, on the antinociceptive and behavioral responses to the elevated plus-maze in mice. Neuropharmacology 30:1263-1267, 1991
8. Crnic LS, Reite ML, Shucard DW: Animal models of human behavior: their application to the study of attachment. In Emde RN, Harmon RJ (eds), The Development of Attachment and Affiliative Systems. New York, Plenum Press, 1982, 31-42
9. Jaenisch R, Mintz B: Simian virus 40 DNA sequences in DNA of health adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sci USA 71:1250-1254, 1974
10. Brinster RL, Chen HY, Trumbauer ME, Senear AW, Warren R, Palmiter RD: Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27:223-231, 1981
11. Constantini F, Lacy E: Introduction of a rabbit β-globin gene into the mouse germ line. Nature 294:92-94, 1981
12. Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH: Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77:7380-7384, 1980
13. Wagner EF, Stewart TA, Mintz B: The human β-globin gene and a functional thymidine kinase gene in developing mice. Proc Natl Acad Sci USA 78:5016-5020, 1981
14. Fitzgerald LW, Ratty AK, Miller KJ, Ellsworth MK, Click SD, Gross KW: Ontogeny of hyperactivity and circling behavior in a transgenic insertional mutant mouse. Behav Neurosci 105: 755-763, 1991
15. Thomas KR, Capecchi MR: Site directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512, 1987
16. Thompson S, Clarke AR, Pow AM, Hooper ML, Melton DW: Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell 56:313-321, 1989
17. Robertson EJ: Using embryonic stem cells to introduce mutations into the mouse germ line. Biol Reprod 44:238-245, 1991
18. Picarella DE, Kratz A, Li CB, Ruddle NH, Flavell RA: Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas. Proc Natl Acad Sci USA 89:10036-10040, 1992
19. Ripps ME, Huntley GW, Hof PR, Morrison JH, Gordon JW: Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 92:689-693, 1995
20. Hanks M, Wurst W, Anson-Cartwright L, Auerback AB, Joyner AL: Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269:679-682, 1995
21. Kuhn R, Schwenk F, Aguet M, Rajewsky K: Inducible gene targeting in mice. Science 269:1427-1429, 1995
22. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MBA, Mucke L: Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci USA 90:10061-10065, 1993
23. Silva AJ, Paylor R, Wehner JM, Tonegawa S: Impaired spatial learning in α-calcium-calmodulin kinase II mutant mice. Science 257:206-211, 1992
24. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K: Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265:103-106, 1994
25. Wu CL, Melton DW: Production of a model for Lesch-Nyhan syndrome in hypoxanthine physphoribosyltransferase-defi-cient mice. Nat Genet 3:235-240, 1993
26. Jinnah HA, Page T, Friedmann T: Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 60:2036-2045, 1993
27. Phaneuf D, Wakamatsu M, Huand J-Q, Borowski A, Peterson AC, Fortunato SR, Ritter G, Igdoura SA, Morales CR, Benoit G, Akerman BR, Leclerc D, Hanai N, Marth JD, Trasler JM, Gravel RA: Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases. Hum Molec Genet 5:1-14, 1996
28. Engelhardt JF, Yankaskas JR, Ernst SA, Yang Y, Marino CR, Boucher RC, Cohn JA, Wilson JM: Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet 2:240-248, 1992
29. Zhou L, Dey CR, Wert SE, DuVall MD, Frizzell RA, Whitsett JA: Correction of lethal intestinal fefect in a mouse model of cystic fibrosis by human CFTR. Science 266:1705-1708, 1994
30. Wang PP, Bellugi U: Williams Syndrome, Down Syndrome, and cognitive neuroscience. Am J Dis Child 147:1246-1251, 1993
31. Hinde RA: The use of differences and similarities in comparative psychopathology. In Serban G, Kling A (eds), Animal Models in Human Psychobiology. New York, Plenum Press, 1976, 182-202
32. Richardson S: Brain and Intelligence. Hyattsville, MD, National Education Press, 1973.
33. Tybulewicz VLJ, Tremblay ML, LaMarca ME, Willemsen R, Stubblefield BK, Winfield S, Zablocka B, Sidransky E, Martin BM, Huang SP, Mintzer KA, Westphal H, Mulligan RC, Ginns EI: Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene. Nature 357:407-410, 1992
34. Hanebuth EW, Logue SF, Rasmussen DL, Wehner JM: Ideal genetic backgrounds for transgenic animals developed for assessment of cognitive function. Soc Neurosci Abstr 21:1227, 1995
35. Pittler SJ, Baehr W: Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse. Proc Natl Acad Sci USA 88:8322-8326, 1991
36. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, Lamantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T: Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269:230-234, 1995
37. Sibilia M, Wagner EF: Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-238, 1995
38. Campbell IL, Gold LH: Transgenic modeling of neuropsychiatric disorders. Mol Psychiatry 1:105-120, 1996
39. Zhang SH, Reddick RL, Piedrahita JA, Maeda N: Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258:468-471, 1992
40. Hanahan D: Transgenic mice as probes into complex systems. Science 246:1265-1275, 1989
41. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P: The brain in AIDS: Central nervous system HIV-1 infection and ADIS dementia complex. Science 239:586-592, 1988
42. Thomas FP, Chalk C, Lalonde R, Robitaille Y, Jolicoeur P: Expression of human immunodeficiency virus type 1 in the nervous sytem of transgenic mice leads to neurological disease. J Virol 68:7099-7107, 1994
43. Klotman PE, Rappaport J, Ray P, Kopp JB, Franks R, Bruggeman LA, Notkins AL: Transgenic models of HIV-1. AIDS 9:313-324, 1995
44. Vogel J, Cepeda M, Tschacler E, Napolitano LA, Jay G: UV activation of human immunodeficiency virus gene expression in transgenic mice. J Virol 66:1-5, 1992
45. Ruprecht RM, Koch JA, Sharma PL, Armany RS: Development of antiviral treatment strategies in murine models. AIDS Res Hum Retroviruses 8:997-1011, 1992
46. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA: Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262: 578-580, 1993
47. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, Shih JC, De Maeyer E: Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268:1763-1766, 1995
48. 1B receptor. Science 265:1875-1878, 1994
49. Chen C, Rainnie DG, Greene RW, Tonegawa S: Abnormal fear response and aggressive behavior in mutant mice deficient for α-calcium-calmodulin kinase II. Science 266:291-294, 1994
50. Mann CC: Behavioral genetics in transition. Science 264: 1686-1689, 1994
51. Hay EM, Black D, Huddy A, Creed F, Tomenson B, Bernstein RB, Holt PJ: Psychiatric disorder and cognitive impairment in systemic lupus erythematosus. Arth Rheum 35:411-416, 1992
52. Schrott LM, Crnic LS: The role of performance factors in the active avoidance conditioning deficit in autoimmune mice. Behav Neurosci 110:486-491, 1996
53. Fernandez-Teruel A, Escorihuela RM, Nunez JF, Zapata A, Boix F, Salazar W, Tobena A: The early acquisition of two-way (shuttlebox) avoidance as an anxiety-mediated behavior. Brain Res Bull 26:173-176, 1991
54. Schrott LM, Crnic LS: Increased anxiety behaviors in autoimmune mice. Behav Neurosci 110:492-502, 1996
55. Sakic B, Szechtman H, Talangbayan H, Denberg SD, Carbotte RM, Denberg JA: Disturbed emotionality in autoimmune MRL-lpr mice. Physiol Behav 56:609-617, 1994
56. During MJ, Naegele JR, O'Malley KL, Geller AI: Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266:1399-1403, 1994
57. Takahashi JS, Pinto LH, Vitaterna MH: Forward and reverse genetic approaches to behavior in the mouse. Science 264: 1724-1733, 1994