Non nucleic acid inhibitors of protein·DNA interactions identified through combinatorial chemistry

Journal of the American Chemical Society

Volumn 118, Issue 43, 1996, Pages 10650-10651

  Stevens, Shawn Y ^a   Bunin, Barry A ^b   Plunkett, Matthew J ^b   Swanson, Patrick C ^a   Ellman, Jonathan A ^b   Glick, Gary D ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; MONOCLONAL ANTIBODY;

ARTICLE; BINDING SITE; DNA BINDING; IN VITRO STUDY; PROTEIN DNA INTERACTION;

EID: 0029818299     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja962452a     Document Type: Article

References (27)

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11. 50 values > 50 μM. Glick, G. D. Unpublished observations.
12. See Supporting Information for further details.
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14. 11
15. By stacking we refer to intercalation of a DNA base in-between two aromatic amino acids on the protein. For an example of this type of stacking, see: Swanson, P. C.; Cooper, B. C.; Glick, G. D. J. Immunol. 1994, 152, 2601-2612.
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22. These experiments were conducted using purified and fully characterized inhibitors. 10
23. As expected, the Risomer is roughly 2-fold more potent than racemic 3 in the inhibition assays.
24. The maximum quenching determined using oligo(dT) as the ligand is ≤40%.
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