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Volumn 9, Issue 6, 1996, Pages 1239-1251

Gene therapy to human disease: ex vivo and in vivo studies (Review)

Author keywords

1 antitrypsin; adenosine deaminase; angiogenesis; atherosclerosis; cystic fibrosis; hemophilia; lysosomal storage disease; Parkinson's disease; restenosis; TGF ; VEGF; w ound healing

Indexed keywords

ARTICLE; ATHEROSCLEROSIS; CANCER; GENE THERAPY; HEMOPHILIA; HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0029803652     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (10)

References (112)
  • 1
    • 0029147628 scopus 로고
    • Nonviral gene therapy: The promise of genes as pharmaceutical products
    • Ledley FD: Nonviral gene therapy: The promise of genes as pharmaceutical products. Hum Gene Ther 6: 1129-1144, 1995.
    • (1995) Hum Gene Ther , vol.6 , pp. 1129-1144
    • Ledley, F.D.1
  • 3
    • 0026530097 scopus 로고
    • Human gene therapy
    • Anderson WF: Human gene therapy. Science 256: 808-813, 1992.
    • (1992) Science , vol.256 , pp. 808-813
    • Anderson, W.F.1
  • 4
    • 0029857555 scopus 로고    scopus 로고
    • Cancer gene therapy and immunotherapy
    • Boulikas T: Cancer gene therapy and immunotherapy. Int J Oncol 9: 941-954, 1996.
    • (1996) Int J Oncol , vol.9 , pp. 941-954
    • Boulikas, T.1
  • 6
    • 0029868425 scopus 로고    scopus 로고
    • Clinical protocol. Adoptive immunotherapy of cancer with activated lymph node cells primed in vivo with autologous tumor cells transduced with the GM-CSF gene
    • Chang AE, Sondak VK, Bishop DK, Nickoloff BJ, Mulligan RC and Mule JJ: Clinical protocol. Adoptive immunotherapy of cancer with activated lymph node cells primed in vivo with autologous tumor cells transduced with the GM-CSF gene. Hum Gene Ther 7: 773-792, 1996.
    • (1996) Hum Gene Ther , vol.7 , pp. 773-792
    • Chang, A.E.1    Sondak, V.K.2    Bishop, D.K.3    Nickoloff, B.J.4    Mulligan, R.C.5    Mule, J.J.6
  • 9
    • 0027946232 scopus 로고
    • Isolation of a peptide antagonist to the thrombin receptor using phage display
    • Doorbar J, Winter G: Isolation of a peptide antagonist to the thrombin receptor using phage display. J Mol Biol 244: 361-369, 1994.
    • (1994) J Mol Biol , vol.244 , pp. 361-369
    • Doorbar, J.1    Winter, G.2
  • 10
    • 0029880651 scopus 로고    scopus 로고
    • Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries
    • Barry MA, Dower WJ, Johnston SA: Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries. Nature Med 2: 299-305, 1996.
    • (1996) Nature Med , vol.2 , pp. 299-305
    • Barry, M.A.1    Dower, W.J.2    Johnston, S.A.3
  • 11
    • 0029103231 scopus 로고
    • Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice
    • Lesoon-Wood LA, Kim WH, Kleinman HK, Weintraub BD, and Mixson AJ: Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice. Hum Gene Ther 6: 395-405, 1995.
    • (1995) Hum Gene Ther , vol.6 , pp. 395-405
    • Lesoon-Wood, L.A.1    Kim, W.H.2    Kleinman, H.K.3    Weintraub, B.D.4    Mixson, A.J.5
  • 13
    • 0029027072 scopus 로고
    • Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of prostatic tumor cells
    • Yang C, Cirielli C, Capogrossi MC and Passaniti A: Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of prostatic tumor cells. Cancer Res 55: 4210-4213, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4210-4213
    • Yang, C.1    Cirielli, C.2    Capogrossi, M.C.3    Passaniti, A.4
  • 14
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH and Blaese RM: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256: 1550-1552, 1992.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldfield, E.H.5    Blaese, R.M.6
  • 15
    • 0029921190 scopus 로고    scopus 로고
    • Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene
    • Su H, Chang JC, Xu SM and Kan YW: Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther 7: 463-470, 1996.
    • (1996) Hum Gene Ther , vol.7 , pp. 463-470
    • Su, H.1    Chang, J.C.2    Xu, S.M.3    Kan, Y.W.4
  • 16
    • 0029924404 scopus 로고    scopus 로고
    • Prostate cancer gene therapy: Herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models
    • Eastham JA, Chen S-H, Sehgal I, Yang G, Timme TL, Hall SJ, Woo SLC and Thompson TC: Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models. Hum Gene Ther 7: 515-523, 1996.
    • (1996) Hum Gene Ther , vol.7 , pp. 515-523
    • Eastham, J.A.1    Chen, S.-H.2    Sehgal, I.3    Yang, G.4    Timme, T.L.5    Hall, S.J.6    Woo, S.L.C.7    Thompson, T.C.8
  • 17
    • 0029928282 scopus 로고    scopus 로고
    • Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: Feasibility in prevention of proliferative vitreoretinopathy
    • Kimura H, Sakamoto T, Cardillo JA, Spee C, Hinton DR, Gordon EM, Anderson WF and Ryan SJ: Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: Feasibility in prevention of proliferative vitreoretinopathy. Hum Gene Ther 7: 799-808, 1996.
    • (1996) Hum Gene Ther , vol.7 , pp. 799-808
    • Kimura, H.1    Sakamoto, T.2    Cardillo, J.A.3    Spee, C.4    Hinton, D.R.5    Gordon, E.M.6    Anderson, W.F.7    Ryan, S.J.8
  • 19
    • 0028116059 scopus 로고
    • Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene
    • Osaki T, Tanio Y, Tachibana I, Hosoe S, Kumagai T, Kawase I, Oikawa S, Kishimoto T: Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene. Cancer Res 54: 5258-5261, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5258-5261
    • Osaki, T.1    Tanio, Y.2    Tachibana, I.3    Hosoe, S.4    Kumagai, T.5    Kawase, I.6    Oikawa, S.7    Kishimoto, T.8
  • 20
    • 0028984807 scopus 로고
    • Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy
    • Richards CA, Austin EA and Huber BE: Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy. Hum Gene Ther 6: 881-893, 1995.
    • (1995) Hum Gene Ther , vol.6 , pp. 881-893
    • Richards, C.A.1    Austin, E.A.2    Huber, B.E.3
  • 22
    • 0019857583 scopus 로고
    • Bone marrow transplantation only partially restores purine metabolites to normal in adenosine deaminase-deficient patients
    • Hirschhorn R, Roegner-Maniscalco V, Kuritsky L, Rosen FS: Bone marrow transplantation only partially restores purine metabolites to normal in adenosine deaminase-deficient patients. J Clin Invest 68: 1387-1393, 1981.
    • (1981) J Clin Invest , vol.68 , pp. 1387-1393
    • Hirschhorn, R.1    Roegner-Maniscalco, V.2    Kuritsky, L.3    Rosen, F.S.4
  • 26
    • 0025724075 scopus 로고
    • Treatment of genetic defects in hematopoietic cell function by gene transfer
    • Karlsson S: Treatment of genetic defects in hematopoietic cell function by gene transfer. Blood 78: 2481-2492, 1991.
    • (1991) Blood , vol.78 , pp. 2481-2492
    • Karlsson, S.1
  • 28
    • 0026625385 scopus 로고
    • Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer
    • Yoshimura K, Rosenfeld MA, Nakamura H, Scherer EM, Pavirani A, Lecocq J-P, Crystal RG: Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer. Nucleic Acids Res 30: 3233-3240, 1992.
    • (1992) Nucleic Acids Res , vol.30 , pp. 3233-3240
    • Yoshimura, K.1    Rosenfeld, M.A.2    Nakamura, H.3    Scherer, E.M.4    Pavirani, A.5    Lecocq, J.-P.6    Crystal, R.G.7
  • 31
    • 0029151439 scopus 로고
    • Use of sodium butyrate to enhance production of retroviral vectors expressing CFTR cDNA
    • Olsen JC, Sechelski J: Use of sodium butyrate to enhance production of retroviral vectors expressing CFTR cDNA. Hum Gene Ther 6: 1195-1202, 1995.
    • (1995) Hum Gene Ther , vol.6 , pp. 1195-1202
    • Olsen, J.C.1    Sechelski, J.2
  • 32
    • 0027237331 scopus 로고
    • Sequences in the coding region of clotting FVIII act as dominant inhibitors of RNA accumulation and protein production
    • Lynch C, Israel DI, Kaufman RJ, Miller AD: Sequences in the coding region of clotting FVIII act as dominant inhibitors of RNA accumulation and protein production. Hum Gene Ther 4: 259-272, 1993.
    • (1993) Hum Gene Ther , vol.4 , pp. 259-272
    • Lynch, C.1    Israel, D.I.2    Kaufman, R.J.3    Miller, A.D.4
  • 33
    • 0028805939 scopus 로고
    • Development and analysis of retroviral vectors expressing human factor VIII as a potential gene therapy for hemophilia A
    • Chuah MKL, Vandendriessche T and Morgan RA: Development and analysis of retroviral vectors expressing human factor VIII as a potential gene therapy for hemophilia A. Hum Gene Ther 6: 1363-1377, 1995.
    • (1995) Hum Gene Ther , vol.6 , pp. 1363-1377
    • Chuah, M.K.L.1    Vandendriessche, T.2    Morgan, R.A.3
  • 34
    • 0028290674 scopus 로고
    • In vivo production of human factor VIII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery
    • Zatloukal K, Cotten M, Berger M, Schimdt W, Wagner E, Birnstiel ML: In vivo production of human factor VIII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery. Proc Natl Acad Sci USA 91: 5148-5152, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5148-5152
    • Zatloukal, K.1    Cotten, M.2    Berger, M.3    Schimdt, W.4    Wagner, E.5    Birnstiel, M.L.6
  • 36
    • 0026486612 scopus 로고
    • Gene therapy via primary myoblasts: Long term expression of factor IX protein following transplantation in vivo
    • Dai Y, Roman M, Naviaux RK and Verma IM: Gene therapy via primary myoblasts: Long term expression of factor IX protein following transplantation in vivo. Proc Natl Acad Sci USA 89: 10892-10895, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10892-10895
    • Dai, Y.1    Roman, M.2    Naviaux, R.K.3    Verma, I.M.4
  • 40
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai Y, Schwarz EM, Gu D, Zhang W-W, Sarvetnick N and Verma IM: Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA 92: 1401-1405, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3    Zhang, W.-W.4    Sarvetnick, N.5    Verma, I.M.6
  • 41
    • 0028899401 scopus 로고
    • Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease
    • Nakao N, Frodl EM, Widner H, Carlson E, Eggerding FA, Epstein CJ, Brundin P: Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nature Med 1: 226-231, 1995.
    • (1995) Nature Med , vol.1 , pp. 226-231
    • Nakao, N.1    Frodl, E.M.2    Widner, H.3    Carlson, E.4    Eggerding, F.A.5    Epstein, C.J.6    Brundin, P.7
  • 43
    • 0025963275 scopus 로고
    • Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa
    • Fisher LJ, Jinnah HA, Kale LC, Higgins GA, Gage FH: Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron 6: 371-380, 1991.
    • (1991) Neuron , vol.6 , pp. 371-380
    • Fisher, L.J.1    Jinnah, H.A.2    Kale, L.C.3    Higgins, G.A.4    Gage, F.H.5
  • 44
    • 0027399705 scopus 로고
    • Long-term correction of rat model of Parkinson's disease by gene therapy
    • Jiao S, Gurevich V and Wolff JA: Long-term correction of rat model of Parkinson's disease by gene therapy. Nature 362: 450-453, 1993.
    • (1993) Nature , vol.362 , pp. 450-453
    • Jiao, S.1    Gurevich, V.2    Wolff, J.A.3
  • 46
    • 0028559601 scopus 로고
    • Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
    • During MJ, Naegele JR, O'Malley KL, Geller AI: Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266: 1399-1403, 1994.
    • (1994) Science , vol.266 , pp. 1399-1403
    • During, M.J.1    Naegele, J.R.2    O'Malley, K.L.3    Geller, A.I.4
  • 48
    • 0028982473 scopus 로고
    • Correction of deficient enzyme activity in a lysosomal storage disease, aspartylglucosaminuria, by enzyme replacement and retroviral gene transfer
    • Enomaa N, Danos O, Peltonen L and Jalanko A: Correction of deficient enzyme activity in a lysosomal storage disease, aspartylglucosaminuria, by enzyme replacement and retroviral gene transfer. Hum Gene Ther 6: 723-731, 1995.
    • (1995) Hum Gene Ther , vol.6 , pp. 723-731
    • Enomaa, N.1    Danos, O.2    Peltonen, L.3    Jalanko, A.4
  • 49
    • 0022729447 scopus 로고
    • The application of bone marrow transplantation to the treatment of genetic diseases
    • Parkman R: The application of bone marrow transplantation to the treatment of genetic diseases. Science 232: 1373-1378, 1986.
    • (1986) Science , vol.232 , pp. 1373-1378
    • Parkman, R.1
  • 50
    • 0025236339 scopus 로고
    • Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease
    • Barton NW, Furbish FS, Murray GJ, Garfield M, Brady RO: Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease. Proc Natl Acad Sci USA 87: 1913-1916, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1913-1916
    • Barton, N.W.1    Furbish, F.S.2    Murray, G.J.3    Garfield, M.4    Brady, R.O.5
  • 52
    • 0027231473 scopus 로고
    • Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts
    • Moullier P, Bohl D, Heard J-M, Danos O: Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts. Nature Genet 4: 154-159, 1993.
    • (1993) Nature Genet , vol.4 , pp. 154-159
    • Moullier, P.1    Bohl, D.2    Heard, J.-M.3    Danos, O.4
  • 54
    • 0025350658 scopus 로고
    • α1-antitrypsin deficiency, emphysema, and liver disease
    • Crystal RG: α1-antitrypsin deficiency, emphysema, and liver disease. J Clin Invest 85: 1343-1352, 1990.
    • (1990) J Clin Invest , vol.85 , pp. 1343-1352
    • Crystal, R.G.1
  • 56
    • 0027964292 scopus 로고
    • The human DNA repair gene, ERCC2 (XPD), corrects ultraviolet hypersensitivity and ultraviolet hypermutability of a shuttle vector replicated in xeroderma pigmentosum group D cells
    • Gözükara EM, Parris CN, Weber CA, Salazar EP, Seidman MM, Watkins JF, Prakash L, Kraemer KH: The human DNA repair gene, ERCC2 (XPD), corrects ultraviolet hypersensitivity and ultraviolet hypermutability of a shuttle vector replicated in xeroderma pigmentosum group D cells. Cancer Res 54: 3837-3844, 1994.
    • (1994) Cancer Res , vol.54 , pp. 3837-3844
    • Gözükara, E.M.1    Parris, C.N.2    Weber, C.A.3    Salazar, E.P.4    Seidman, M.M.5    Watkins, J.F.6    Prakash, L.7    Kraemer, K.H.8
  • 57
    • 0029899062 scopus 로고    scopus 로고
    • Xeroderma pigmentosum and molecular cloning of DNA repair genes
    • Boulikas T: Xeroderma pigmentosum and molecular cloning of DNA repair genes. Anticancer Res 16: 693-708, 1996.
    • (1996) Anticancer Res , vol.16 , pp. 693-708
    • Boulikas, T.1
  • 58
    • 0030050906 scopus 로고    scopus 로고
    • The nonuniform repair of active and inactive chromatin domains
    • Boulikas T: The nonuniform repair of active and inactive chromatin domains. Int J Oncol 8: 65-75, 1996.
    • (1996) Int J Oncol , vol.8 , pp. 65-75
    • Boulikas, T.1
  • 59
    • 0023610526 scopus 로고
    • Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia
    • Lehrman MA, Goldstein JL, Russell DW, Brown MS: Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell 48: 827-835, 1987.
    • (1987) Cell , vol.48 , pp. 827-835
    • Lehrman, M.A.1    Goldstein, J.L.2    Russell, D.W.3    Brown, M.S.4
  • 60
    • 0026355641 scopus 로고
    • Long term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits
    • Chowdhury JR, Grossman M, Gupta SJ, Chowdhury NR, Baker Jr JR, Wilson JM: Long term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 254: 1802-1805, 1991.
    • (1991) Science , vol.254 , pp. 1802-1805
    • Chowdhury, J.R.1    Grossman, M.2    Gupta, S.J.3    Chowdhury, N.R.4    Baker Jr., J.R.5    Wilson, J.M.6
  • 62
    • 0029971216 scopus 로고    scopus 로고
    • Systemic and portal vein delivery of human kallikrein gene reduces blood pressure in hypersensitive rats
    • Chao J, Jin L, Chen L-M, Chen VC and Chao L: Systemic and portal vein delivery of human kallikrein gene reduces blood pressure in hypersensitive rats. Hum Gene Ther 7: 901-911, 1996.
    • (1996) Hum Gene Ther , vol.7 , pp. 901-911
    • Chao, J.1    Jin, L.2    Chen, L.-M.3    Chen, V.C.4    Chao, L.5
  • 63
    • 0030017661 scopus 로고    scopus 로고
    • Protease inhibitors: A tale of two companies
    • Cohen J: Protease inhibitors: A tale of two companies. Science 272: 1882-1883, 1996.
    • (1996) Science , vol.272 , pp. 1882-1883
    • Cohen, J.1
  • 64
    • 0030057089 scopus 로고    scopus 로고
    • HIV therapeutics
    • Richman DD: HIV therapeutics. Science 272: 1886-1887, 1996.
    • (1996) Science , vol.272 , pp. 1886-1887
    • Richman, D.D.1
  • 65
    • 0030017740 scopus 로고    scopus 로고
    • A perspective on AIDS vaccines
    • Bloom BR: A perspective on AIDS vaccines. Science 272: 1888-1890, 1996.
    • (1996) Science , vol.272 , pp. 1888-1890
    • Bloom, B.R.1
  • 66
    • 0024299563 scopus 로고
    • Intracellular immunization
    • Baltimore D: Intracellular immunization. Nature 335: 395-396, 1988.
    • (1988) Nature , vol.335 , pp. 395-396
    • Baltimore, D.1
  • 67
    • 0024443873 scopus 로고
    • HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus
    • Trono D, Feinberg MB, Baltimore D: HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 59: 113-120, 1989.
    • (1989) Cell , vol.59 , pp. 113-120
    • Trono, D.1    Feinberg, M.B.2    Baltimore, D.3
  • 68
    • 0024382709 scopus 로고
    • Functional dissection of the HIV-I Rev trans-activator - Derivation of a trans-dominant repressor of Rev function
    • Malim MH, Böhnlein S, Hauber J, Cullen BR: Functional dissection of the HIV-I Rev trans-activator - Derivation of a trans-dominant repressor of Rev function. Cell 58: 205-214, 1989.
    • (1989) Cell , vol.58 , pp. 205-214
    • Malim, M.H.1    Böhnlein, S.2    Hauber, J.3    Cullen, B.R.4
  • 69
    • 0025254631 scopus 로고
    • Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector
    • Venkatesh LK, Arens MQ, Subramanian T, Chinnadurai G: Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector. Proc Natl Acad Sci USA 87: 8746-8750, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8746-8750
    • Venkatesh, L.K.1    Arens, M.Q.2    Subramanian, T.3    Chinnadurai, G.4
  • 70
    • 0028036196 scopus 로고
    • Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses
    • Brady HJM, Miles CG, Pennington DJ, Dzierzak EA: Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses. Proc Natl Acad Sci USA 91: 365-369, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 365-369
    • Brady, H.J.M.1    Miles, C.G.2    Pennington, D.J.3    Dzierzak, E.A.4
  • 71
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362: 801-809, 1993.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 72
    • 0028825322 scopus 로고
    • Targeting TGF-ß for treatment of disease
    • Border WA, Noble NA: Targeting TGF-ß for treatment of disease. Nature Med 1: 1000-1001, 1995.
    • (1995) Nature Med , vol.1 , pp. 1000-1001
    • Border, W.A.1    Noble, N.A.2
  • 75
    • 0028344109 scopus 로고
    • Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic limb model
    • Takeshita S, Zheng LP, Brogi E, Kearney M, Pu L-Q, Bunting S, Ferrara N, Symes JF and Isner JM: Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic limb model. J Clin Invest 93: 662-670, 1994.
    • (1994) J Clin Invest , vol.93 , pp. 662-670
    • Takeshita, S.1    Zheng, L.P.2    Brogi, E.3    Kearney, M.4    Pu, L.-Q.5    Bunting, S.6    Ferrara, N.7    Symes, J.F.8    Isner, J.M.9
  • 76
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang W-J, Goeddel DV and Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309, 1989.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 77
    • 0027961080 scopus 로고
    • In vivo suppression of injury-induced vascular, smooth muscle cell accumulation using adenovirus-mediated, transfer of the herpes simplex virus thymidine kinase gene
    • Guzman RJ, Hirskowitz EA, Brody SL, Crystal RG, Epstein SE and Finkel T: In vivo suppression of injury-induced vascular, smooth muscle cell accumulation using adenovirus-mediated, transfer of the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci USA 91: 10732-10736, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10732-10736
    • Guzman, R.J.1    Hirskowitz, E.A.2    Brody, S.L.3    Crystal, R.G.4    Epstein, S.E.5    Finkel, T.6
  • 78
    • 0025817390 scopus 로고
    • Proliferation of smooth muscle cells after vascular injury if inhibited by an antibody, against basic fibroblast growth factor
    • Lidner V, Reidy MA: Proliferation of smooth muscle cells after vascular injury if inhibited by an antibody, against basic fibroblast growth factor. Proc Natl Acad Sci USA 88: 3739-3743, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3739-3743
    • Lidner, V.1    Reidy, M.A.2
  • 80
    • 0028902753 scopus 로고
    • Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product
    • Chang MW, Barr E, Seltzer J, Jiang Y-Q, Nabel GJ, Nabel EG, Parmacek MS and Leiden JM: Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product. Science 267: 518-522, 1995.
    • (1995) Science , vol.267 , pp. 518-522
    • Chang, M.W.1    Barr, E.2    Seltzer, J.3    Jiang, Y.-Q.4    Nabel, G.J.5    Nabel, E.G.6    Parmacek, M.S.7    Leiden, J.M.8
  • 82
    • 0025132571 scopus 로고
    • Site-specific gene expression in vivo by direct gene transfer into arterial wall
    • Nabel EG, Plautz G and Nabel GJ: Site-specific gene expression in vivo by direct gene transfer into arterial wall. Science 249: 1285-1288, 1990.
    • (1990) Science , vol.249 , pp. 1285-1288
    • Nabel, E.G.1    Plautz, G.2    Nabel, G.J.3
  • 83
    • 0027197246 scopus 로고
    • Recombinant fibroblast growth factor-1 promotes intimai hyperplasia and angiogenesis in arteries in vivo
    • Nabel EG, Yang Z, Plautz G, Forough R, Zhan X, Haudenschild CC, Maciag T, Nabel GJ: Recombinant fibroblast growth factor-1 promotes intimai hyperplasia and angiogenesis in arteries in vivo. Nature 362: 844-846, 1993.
    • (1993) Nature , vol.362 , pp. 844-846
    • Nabel, E.G.1    Yang, Z.2    Plautz, G.3    Forough, R.4    Zhan, X.5    Haudenschild, C.C.6    Maciag, T.7    Nabel, G.J.8
  • 84
    • 0027941421 scopus 로고
    • Time course of recombinant protein secretion after liposome-mediated gene transfer in a rabbit arterial organ culture model
    • Takeshita S, Losordo DW, Kearney M, Rossow ST and Isner JM: Time course of recombinant protein secretion after liposome-mediated gene transfer in a rabbit arterial organ culture model. Lab Invest 71: 387-391, 1994.
    • (1994) Lab Invest , vol.71 , pp. 387-391
    • Takeshita, S.1    Losordo, D.W.2    Kearney, M.3    Rossow, S.T.4    Isner, J.M.5
  • 86
    • 0026581832 scopus 로고
    • Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: A model for gene therapy
    • Lynch CM, Clowes MM, Osborne WRA, Clowes AW, Miller AD: Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: A model for gene therapy. Proc Natl Acad Sci USA 89: 1138-1142, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1138-1142
    • Lynch, C.M.1    Clowes, M.M.2    Osborne, W.R.A.3    Clowes, A.W.4    Miller, A.D.5
  • 87
    • 0027207192 scopus 로고
    • Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimal hyperplasia in vivo
    • Nabel EG, Yang Z, Liptay S, San H, Gordon D, Haudenschild CC, Nabel GJ: Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimal hyperplasia in vivo. J Clin Invest 91: 1822-1829, 1993.
    • (1993) J Clin Invest , vol.91 , pp. 1822-1829
    • Nabel, E.G.1    Yang, Z.2    Liptay, S.3    San, H.4    Gordon, D.5    Haudenschild, C.C.6    Nabel, G.J.7
  • 88
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Møller NPH, Risau W and Ullrich A: High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835-846, 1993.
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnürch, H.3    Martinez, R.4    Møller, N.P.H.5    Risau, W.6    Ullrich, A.7
  • 90
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang W-J, Goeddel DV and Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309, 1989.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 91
    • 0025999033 scopus 로고
    • The human gene for vascular, endothelial growth factor. Multiple protein forms are encoded. through alternative exon splicing
    • Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC and Abraham JA: The human gene for vascular, endothelial growth factor. Multiple protein forms are encoded. through alternative exon splicing. J Biol Chem 266: 11947-11954, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 94
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 95
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845, 1992.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 96
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Review
    • Liotta LA, Steeg PS and Stetler-Stevenson WG: Review. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64: 327-336, 1991.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 97
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J and Klagsbrun M: Angiogenic factors. Science 235: 442-447, 1987.
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 98
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N and Williams LT: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-991, 1992.
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 99
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Møller NPH, Risau W and Ullrich A: High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835-846, 1993.
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnürch, H.3    Martinez, R.4    Møller, N.P.H.5    Risau, W.6    Ullrich, A.7
  • 100
    • 0028856096 scopus 로고
    • Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis
    • Christofori G, Naik P and Hanahan D: Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 9: 1760-1770, 1995.
    • (1995) Mol Endocrinol , vol.9 , pp. 1760-1770
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 101
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G, Rossant J, Gertsenstein M, Breitman ML: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70, 1995.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 103
    • 0029929772 scopus 로고    scopus 로고
    • Ectopic expression of vascular endothelial growth factor (VEGF) by C6 glioma cells does not increase tumour growth in vivo despite an increase in angiogenesis
    • Saleh M: Ectopic expression of vascular endothelial growth factor (VEGF) by C6 glioma cells does not increase tumour growth in vivo despite an increase in angiogenesis. Int J Oncol 9: 33-41, 1996.
    • (1996) Int J Oncol , vol.9 , pp. 33-41
    • Saleh, M.1
  • 104
    • 0030029271 scopus 로고    scopus 로고
    • Inhibition of growth of C6 glioma cells in vivo by expression of antisense Vascular Endothelial Growth Factor (VEGF) sequence
    • Saleh M, Stacker SA, Wilks AF: Inhibition of growth of C6 glioma cells in vivo by expression of antisense Vascular Endothelial Growth Factor (VEGF) sequence. Cancer Res 56: 393-401, 1996.
    • (1996) Cancer Res , vol.56 , pp. 393-401
    • Saleh, M.1    Stacker, S.A.2    Wilks, A.F.3
  • 106
    • 0029944703 scopus 로고
    • Genetically modified mice as models of transplant atherosclerosis
    • Ross R: Genetically modified mice as models of transplant atherosclerosis. Nature Med 2: 527-528, 1995.
    • (1995) Nature Med , vol.2 , pp. 527-528
    • Ross, R.1
  • 107
    • 0028886032 scopus 로고
    • Entering the postgenome era
    • Nowak R: Entering the postgenome era. Science 270: 368-371, 1995.
    • (1995) Science , vol.270 , pp. 368-371
    • Nowak, R.1
  • 108
    • 0028847877 scopus 로고
    • A model of transcription/replication enhancers
    • Boulikas T: A model of transcription/replication enhancers. Oncol Rep 2: 171-181, 1995.
    • (1995) Oncol Rep , vol.2 , pp. 171-181
    • Boulikas, T.1
  • 109
    • 0029610541 scopus 로고
    • Chromatin domains and prediction of MAR sequences
    • Boulikas T: Chromatin domains and prediction of MAR sequences. Int Rev Cytol 162A: 279-388, 1995.
    • (1995) Int Rev Cytol , vol.162 A , pp. 279-388
    • Boulikas, T.1
  • 110
    • 12644301524 scopus 로고    scopus 로고
    • Nuclear localization signal peptides for the import of plasmid DNA in gene therapy
    • In press
    • Boulikas T: Nuclear localization signal peptides for the import of plasmid DNA in gene therapy. Int J Oncol (In press).
    • Int J Oncol
    • Boulikas, T.1
  • 111
    • 0029582786 scopus 로고
    • Specific recognition of a transcriptional element within the human H-ras proto-oncogene by the p53 tumor suppressor
    • Spandidos DA, Zoumpourlis V, Zachos G, Toas SH, Halazonetis TD: Specific recognition of a transcriptional element within the human H-ras proto-oncogene by the p53 tumor suppressor. Int J Oncol 7: 1029-1034, 1995.
    • (1995) Int J Oncol , vol.7 , pp. 1029-1034
    • Spandidos, D.A.1    Zoumpourlis, V.2    Zachos, G.3    Toas, S.H.4    Halazonetis, T.D.5
  • 112
    • 0029559765 scopus 로고
    • Binding of wild-type and mutant forms of p53 protein from human tumors to a specific DNA sequence of the first intron of the H-ras oncogene
    • Zoumpourlis V, Zachos G, Halazonetis TD, Ergazaki M, Spandidos DA: Binding of wild-type and mutant forms of p53 protein from human tumors to a specific DNA sequence of the first intron of the H-ras oncogene. Int J Oncol 7: 1035-1041, 1995.
    • (1995) Int J Oncol , vol.7 , pp. 1035-1041
    • Zoumpourlis, V.1    Zachos, G.2    Halazonetis, T.D.3    Ergazaki, M.4    Spandidos, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.