Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts

Journal of Experimental Medicine

Volumn 184, Issue 2, 1996, Pages 493-503

  Guehler, Sarah R ^a   Bluestone, Jeffrey A ^b   Barrett, Terrence A ^a,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; THY 1 ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INTESTINE EPITHELIUM; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029789386     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.2.493     Document Type: Article

References (53)

1. Roberts, A.I., S.M. O'Connell, L. Biancone, R.E. Brolin, and E.C. Ebert. 1993. Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes: clues to the mechanism. Clin. Exp. Immunol. 94:527-532.
2. Gramzinski, R.A., E. Adams, J.A. Gross, T.G. Goodman, J.P. Allison, and L. Lefrancois. 1993. T cell receptor-triggered activation of intraepithelial lymphocytes in vitro. Int. Immunol. 5:145-153.
3. Sydora, B.C., P.F. Mixter, H.R. Holcombe, P. Eghtesady, K. Williams, M.C. Amaral, A. Nel, and M. Kronenberg. 1993. Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J. Immunol. 150:2179-2191.
4. Cuff, C.F., C.K. Cebra, D.H. Rubin, and J.J. Cebra. 1993. Developmental relationship between cytotoxic alpha/beta T cell receptor-positive intraepithelial lymphocytes and Peyer's patch lymphocytes. Eur. J. Immunol. 23:1333-1339.
5. Poussier, P., and M. Julius. 1994. Thymus independent T cell development and selection in the intestinal epithelium. Annu. Rev. Immunol. 12:521-553.
6. Correa, I., M. Bix, N.S. Liao, M. Zijlstra, R. Jaenisch, and D. Raulet. 1992. Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. Proc. Natl. Acad. Sci. USA. 89:653-657.
7. Blumberg, R.S., T. Cox, P. Bleicher, F.C. McDermott, C.H. Allan, S.B. Landau, J.S. Trier, and S.P. Balk. 1991. Expression of a nonpolymorphic MHC class 1-like molecule, CD1-d, by human intestinal epithelial cells. J. Immunol. 147: 2518-2524.
8. Houlden, B.A., L.A. Matis, R.Q. Cron, S.M. Widacki, G.D. Brown, C. Pampeno, D. Meruelo, and J.A. Bluestone. 1989. A TCRγδ cell recognizing a novel TL-encoding gene product. Cold Spring Harbor Symp. Quant. Biol. LIV:45-55.
9. Haregewoin, A., G. Soman, R.C. Hom, and R.W. Finberg. 1989. Human γδ+ T cells respond to mycobacterial heat-shock protein. Nature (Lond.). 340:309-312.
10. Born, W., L. Hall, A. Dallas, J. Boymel, T. Shinnick, D. Young, P. Brennan, and R. O'Brien. 1990. Recognition of a peptide antigen by heat shock-reactive γδ T lymphocytes. Science (Wash. DC). 249:67-69.
11. Barrett, T.A., Y. Tatsumi, and J.B. Bluestone. 1993. Tolerance of T cell receptor γ/δ cells in the intestine. J. Exp. Med. 177:1755-1762.
12. Poussier, P., H.S. Teh, and M. Julius. 1993. Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor α/β in the intestinal epithelium. J. Exp. Med. 178:1947-1957.
13. Poussier, P., P. Edouard, C. Lee, M. Binnie, and M. Julius. 1992. Thymus-independent development and negative selection of T cells expressing T cell receptor α/β in the intestinal epithelium: evidence for distinct circulation patterns of gut-and thymus-derived T lymphocytes. J. Exp. Med. 176:187-199.
14. + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173:483-486.
15. Barrett, T.A., M.L. Delvy, D.M. Kennedy, L. Lefrancois, L.A. Matis, A.L. Dent, and J.A. Bluestone. 1992. Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. J. Exp. Med. 175:65-70.
16. Lefrancois, L., and L. Puddington. 1995. Extrathymic intestinal T-cell development: virtual reality? Immunol. Today. 16: 16-21.
17. Lefrancois, L., and S. Olson. 1994. A novel pathway of thymus-directed T lymphocyte maturation. J. Immunol. 153: 987-995.
18. + intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Eur. J. Immunol. 24:1080-1087.
19. + T cell clone. Proc. Natl. Acad. Sci. USA. 90:11272-11276.
20. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell. 69:989-998.
21. Kranz, D., D.H. Sherman, M.V. Sitkovsky, M.S. Pasternack, and H.N. Eisen. 1995. Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc. Natl. Acad. Sci. USA. 81:573-577.
22. Wu, M.X., T.J. Tsomides, and H.N. Eisen. 1995. Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions. J. Immunol. 154:4495-4502.
23. + T cells secreting Th1 or Th2 cytokines. Immunity. 2:271-279.
24. Barrett, T.A., T.F. Gajewski, D. Danielpour, E.B. Chang, K.W. Beagley, and J.A. Bluestone. 1992. Differential function of intestinal intraepithelial lymphocyte subsets. J. Immunol. 149:1124-1130.
25. Reiner, S.L., S. Zheng, D.B. Corry, and R.M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. [Published errata appear in J. Immunol. Methods. 1994 Jul. 12;173(1):133 and 1994 Oct. 14;175(2):275]. J. Immunol. Methods. 165:37-46.
26. Russell, J.H., P. Meleedy-Rey, D.E. McCulley, W.C. Sha, C.A. Nelson, and D.Y. Loh. 1990. Evidence for CD8-independent T cell maturation in transgenic mice. J. Immunol. 144:3318-3325.
27. Sha, W.C., C.A. Nelson, R.D. Newberry, D.M. Kranz, J.H. Russell, and D.Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature (Lond.). 336:73-76.
28. Sha, W.C., C.A. Nelson, R.D. Newberry, D.M. Kranz, J.H. Russell, and D.Y. Loh. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature (Lond.). 335:271-274.
29. Lefrancois, L. 1991. Intraepithelial lymphocytes of the intestinal mucosa: curiouser and curiouser. Sem. Immunol. 3:99-108.
30. Cerf-Bensussan, N., and D. Guy-Grand. 1991. Intestinal intraepithelial lymphocytes. Gastroenterology Clinics of North America. 20:549-576.
31. Watanabe, Y., and T. Akaike. 1994. Activation signal induces the expression of B cell-specific CD45R epitope (6B2) on murine T cells. Scand. J. Immunol. 39:419-425.
32. Serra, H.M., J.F. Krowka, J.A. Ledbetter, and L.M. Pilarski. 1988. Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event. J. Immunol. 140:1435-1441.
33. + T cells for helper activity. Int. Immunol. 5:1473-1481.
34. Cai, Z., and J. Sprent. 1994. Resting and activated T cells display different requirements for CD8 molecules. J. Exp. Med. 179:2005-2015.
35. O'Rourke, A.M., and M.F. Mescher. 1993. The roles of CD8 in cytotoxic T lymphocyte function. Immunol. Today. 14:183-188.
36. Wheeler, C.J., P. von Hoegen, and J.R. Parnes. 1992. An immunological role for the CD8 beta-chain. Nature (Lond.). 357:247-249.
37. Lee, N.A., D.Y. Loh, and E. Lacy. 1992. CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med. 175:1013-1025.
38. Robey, E.A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh, R. Axel, and B.J. Fowlkes. 1992. The level of CD8 expression can determine the outcome of thymic selection. Cell. 69: 1089-1096.
39. Vukmanovic, S., G. Stella, P.D. King, R. Dyall, K.A. Hogquist, J.T. Harty, and M.J. Bevan. 1994. A positively selecting thymic epithelial cell line lacks costimulatory activity. J. Immunol. 152:3814-3823.
40. Sanderson, I.R., A.J. Ouellette, E.A. Carter, W.A. Walker, and P.R. Harmatz. 1993. Differential regulation of B7 mRNA in enterocytes and lymphoid cells. Immunology. 79: 434-438.
41. Johnson, J.G., and M.K. Jenkins. 1994. The role of anergy in peripheral T cell unresponsiveness. Life Sci. 55:1767-1780.
42. LaSalle, J.M., and D.A. Hafler. 1994. T cell anergy. FASEB (Fed. Am. Soc. Exp. Biol.) J. 8:601-608.
43. Go, C., D.W. Lancki, F.W. Fitch, and J. Miller. 1993. Anergized T cell clones retain their cytolytic ability. J. Immunol. 150:367-376.
44. + T cell clones can provide B cell help. J. Immunol. 154:3118-3127.
45. + T cell clones secrete the Th1 pattern of cytokines. J. Immunol. 144:1744-1752.
46. Prystowsky, M.B., J.M. Ely, D.I. Beller, L. Eisenberg, J. Goldman, E. Goldwasser, J. Ihle, J. Quintans, H. Remold, S.N. Vogel, and F.W. Fitch. 1982. Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes. J. Immunol. 129:2337-2344.
47. Targan, S.R., R.L. Deem, M. Liu, S. Wang, and A. Nel. 1995. Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J. Immunol. 154:664-675.
48. Vajdy, M., and N. Lycke. 1993. Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant. Immunology. 80:197-203.
49. + lamina propria T-cell lines: phenotypic and functional characterization. Immunology, 75:66-73.
50. Bradding, P., I.H. Feather, P.H. Howarth, R. Mueller, J.A. Roberts, K. Britten, J.P. Bews, T.C. Hunt, Y. Okayama, and C.H. Heusser. 1992. Interleukin 4 is localized to and released by human mast cells. J. Exp. Med. 176:1381-1386.
51. Panja, A., Z. Zhou, G. Mullin, and L. Mayer. 1995. Secretion and regulation of IL-10 by intestinal epithelial cells. Gastroenterology. 108:890 (Abstr.).
52. Ridge, J.P., E.J. Fuchs, and P. Matzinger. 1996. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science (Wash. DC). 271:1723-1726.
53. Forsthuber, T., H.C. Yip, and P.V. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science (Wash. DC). 271:1728-1730.