Development of Th 1- or Th 2-dominated immune responses: What about the polarizing signals?

International Journal of Clinical and Laboratory Research

Volumn 26, Issue 2, 1996, Pages 83-98

  Romagnani, S ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cytokines; Type 1 helper T cells; Type 2 helper T cells

Indexed keywords

ANIMALIA; VERTEBRATA;

EID: 0029783635     PISSN: 09405437     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02592350     Document Type: Review

References (175)

1. Mosman TR, Coffmann RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145.
2. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12: 227.
3. Romagnani S, Maggi E. Th1 versus Th2 responses in AIDS. Curr Opin Immunol 1994; 6: 616.
4. Romagnani S. Biology of human Th1 and Th2 cells. J Clin Immunol 1995; 15: 121.
5. Del Prete GF, De Carli M, Mastromauro C, Macchia D, Biagiotti R, Ricci M, Romagnani S. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991; 88: 346.
6. + T cells J Immunol 1991; 146: 577.
7. Evavold BD, Williams SG, Hsu BL, Buus S, Allen PM. Complete dissection of the Hb (64-76) determinant using T helper 1 and T helper 2 clones and T cell hybridomas. J Immunol 1992; 148: 347.
8. + T cells from T cell receptor transgenic mice. J Exp Med 1992; 176: 1091.
9. Hsieh C-S. Heimberger AB, Gold JS, O'Garra A, Murphy KM Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha-beta-T-cell-receptor transgenic system. Proc Natl Acad Sci USA 192; 89: 6065.
10. + T cells. Res Immunol 1991; 142: 14.
11. Kamogawa Y, Minasi LE, Carding SR, Bottomly K, Flavell RA. The relationship of IL-4- and IFN-γ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 1993; 75: 985.
12. Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and airways hyperresponsiveness in the mouse. J Allergy Clin Immunol 1992; 89: 1127.
13. Xu-Amano J, Kiyono H, Jackson RJ, Staats HF, Fujiashi K, Burrows PD, Elson CO, Pillai S, McGhee JR. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 1993; 178: 1309.
14. Weiner HL, Maklin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 1993; 259: 1321.
15. Williams JR, Unanue ER. Costimulatory requirements of murine Th1 clones. The role of accessory cell-derived signals in responses to anti-CD3 antibody. J Immunol 1990; 145: 85.
16. Magilavy DB, Fitch FW, Gajewski TF. Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones. J Exp Med 1989; 170: 985.
17. Gajewski TF, Pinnas M, Wong T, Fitch FW, Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J Immunol 1991; 146: 1750.
18. Schmilz J, Assenmacher M, Radbruch A. Regulation of T helper cell cytokine expression: functional dichotomy of antigenpresenting cells. Eur J Immunol 1993; 23: 191.
19. + T cells. J Immunol 1995; 154: 5071
20. Goodman RE, Nestle F, Naidu YM, Green JM, Thompson CB, Nickoloff BJ, Turka LA. Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-γ. J Immunol 1994; 152: 5189.
21. + cells by murine brain microvessel endothelial cells and smooth muscle/pericytes. J Immunol 1993; 151: 38.
22. Finkelman FD. Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease. J Exp Med 1995; 182: 279.
23. Hans R, Freeman GJ, Wolf ZB, Gimmi CD, Benacerraf B, Nadler LM. Murine B7 antigen provides an efficient constimulatory signal for activation of murine T lymphocytes via the T cell receptor/CD3 complex. Proc Natl Acad Sci USA 1992; 89: 271.
24. Tan P, Anasetti C, Hansen JA, Melrose J, Brunvand M, Bradshaw J, Ledbetter JA, Linsley PS. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD 28 via its natural ligand B7/BB1. J Exp Med 1993; 177: 165.
25. Lu P, Zhou X, di, Chen S-J, Moorman M, Morris SC, Finkelman FD, Linsley P, Urban JF, Cause WC. CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J Exp Med 1994; 180: 693.
26. Lu P, Zhou X, di, Chen S-J, Moorman M, Shoneveld A, Morris S, Finkelman FD, Claassen E, Gause WC. Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response. J Immuno 1995; 154: 1078.
27. Curry DB, Reiner SL, Linsley PS, Locksley RM. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J Immunol 1994; 153: 4142.
28. + cells. Eur J Immunol 1995; 25: 587.
29. Kawamura T, Furue M. Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines. Eur J Immunol 1995; 25: 1913.
30. With-Dreese FA, Dellemijin TAM, Majoor D, Jong D de. Localization in situ of the costimulatory B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue. Eur J Immunol 1995; 25: 3023.
31. Freeman GJ, Boussiotis VA, Anumanthan A, Bernestein GM, Ke X-Y, Rennert PD, Gray GS, Gribben JG, Nadler LM. B7-1 and B7-2 do not deliver identical costimulatory signals since B7-2 but not B7-1 preferentially costitmulates the initial production of IL-4. Immunity 1995; 2: 523.
32. Kuchroo YK, Prabhu Das M, Brown A, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: application to autoimmune disease therapy. Cell 1995; 80: 707.
33. Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1: 793.
34. Chen Y, Kuchroo V, Inobe J-I, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance and suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237.
35. Lanier LL, O'Fallon S, Somoza C, Philips JH, Linsley PS, Okumura K, Ito D, Azuma MJ CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL Immunology 1995; 154: 97
36. Stuber E, Strober W, Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med 1996; 183: 693.
37. + T cell clones in human immunodeficiency virus infection. J Exp Med 1994; 180: 2407.
38. + T cells producing Th2-type cytokines. FASEB J 1995; 9: 81.
39. Smith CA, Gruss H-J, Davis T, Anderson D, Farrah T, Baker E, Sutherland GR, Brannan CI, Copeland NG, Jenkins NA, Grabstein H, Gliniak B, McAllister IB, Fanslow W, Alderson M, Falk B, Gimpel S, Gillis S, Din WS, Goodwin R, Armitage RJ. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 1993; 73: 1349.
40. Del Prete G-F, De Carl M, D'Elios MM, Daniel KC, Smith CA, Thomas E, Romagnani S. CD30-mediated Signalling promotes the development of human Th2-like T cells. J Exp Med 1995; 182: 1.
41. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni M-P, Santoni Rugiu F, De Carli M, Ricci M, Romagnani S. Reciprocal regulatory role of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992; 148: 2142.
42. + T cells to HIV-gp 120 induced anergy. Immunology 1992; 76: 1.
43. + T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J Exp Med 1995; 182: 5.
44. +T cell subsets. Clin Exp Allergy 1995; 35: 830.
45. + T cells: specificity and function. Immunol Rev 1988; 101: 39.
46. Redhead K, Watkins J, Barnard A, Mills KHG. Effective immunization against Bordetella pertussis respiratory infection in mice is dependent on induction of cell-mediated immunity. Infect Immun 1993; 61: 3190.
47. Parish CR. The relationship between humoral and cell-mediated immunity. Tissue Transplant Rev 1972; 13: 35.
48. Bretscher PA, Wei G, Menon JN. Bielefeldt OH. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 1992; 257: 539.
49. + T cells. J Exp Med 1995; 182: 1591.
50. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J Exp Med 1995; 182: 1579.
51. O'Garra A, Murphy K Role of cytokines in development of Th1 and Th2 cells. Chem Immunol 1996; 63: 1.
52. Reiner SL, Wang Z-E, Hatam F, Scott P, Locksley RM. Th1 and Th2 cell antigen receptors in experimental leishmaniasis. Science 1993; 258: 1457.
53. Liew FY, Millott SM, Schmidt JA. A repetitive peptide of Leishmania can activate T helper type 2 cells and enhance disease progression. J Exp Med 1990; 172: 1359.
54. Skeiky JAW, Gauderian JA, Renson DR, Bacelar O, Carvalho EM, Kubin M, Badaro R, Trinchieri G, Reed SG. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J Exp Med 1995; 181: 1527.
55. Soloway P, Fish S, Passmore H, Gefter M, Coffee R, Manser T. Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype. J Exp Med 1991; 174: 847.
56. Racioppi L, Ronchese F, Matis LA, Germain RN. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signalling. J Exp Med 1993; 177: 1047.
57. Pfeiffer C, Murray J, Madri J, Bottomly K. Selective activation of Th1 and Th2 like cells in vivo response to human collagen IV. Immunol Rev 1991; 123: 65.
58. Pfeiffer C, Stein J, Southwood S, Ketelaar H, Seite A, Bottomly K. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo J Exp Med 1995; 181: 1569.
59. Kumar V, Bhardwaj V, Scares L, Alexander J, Sette A, Sercarz E. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon by T cells. Proc Natl Acad Sci USA 1995; 92: 9510.
60. Chehimi J, Trinchieri G. interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J Clin Immunol 1995; 14: 149.
61. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993; 260: 547.
62. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 1993; 90: 10188.
63. + T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor β. Eur J Immunol 1994; 24: 793.
64. Openshaw P, Murph EE, Hosken NA, Mai V, Davis K, Murphy K, O'Garra A. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 1995; 182: 1357.
65. Magram J, Connaughton SE, Warrier RR, Carvajal DM, Wu C-y, Ferrante J, Stewart C, Sarmiento U, Faherty DA. Gately MK IL-12-deficient mice are defective in IFN production and type 1 cytokine responses. Immunity 1996; 4: 471.
66. Manetti R, Parronchi P, Giudizi M-G, Piccinni M-P, Maggi E, Trinchieri G, Romagnani S. Natural killer cell stimulatory factor (interleukin 12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993; 177: 1199.
67. Manetti R, Gerosa F, Giudizi M-G, Biagiotti R, Parronchi P, Piccinni M-P, Sampognar S, Maggi E, Romagnani S, Trinchieri G. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 1994; 179: 1273.
68. Mocci S, Coffman RL. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J Immunol 1995; 154: 3779.
69. Bradley LM, Yoshimoto K, Swain SL. The cytokines IL-4, IFN-γ, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J Immunol 1995; 155: 1713.
70. + T cells through an effect on antigen-presenting cells. J Immunol 1995; 154: 2578.
71. Chehimi J, Paganin C, Frank I, Chouaib S, Starr S, Trinchieri G. Interleukin 12 in the pathogenesis and the therapy of HIV infection. Res Immunol 1995; 146: 605.
72. + thymocytes into functionally mature Th2 cells. Exogenous IL-12 is required for priming thymocytes to the production of both Th1 cytokines and IL-10. Eur J Immunol. In press.
73. O'Garra A, Murphy KM. Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 1994; 6: 458.
74. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophage to stimulate IFN-γ production is IFN-γ dependent. Int Immunol 1993; 5: 1119.
75. Flesch IEA, Hess JH, Huang S, Aguet M, Rothe J, Bluethmann H, Kaufmann SHE. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor a. J Exp Med 1995; 181: 1615.
76. Wang Z-E, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM. Interferon γ-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci USA 1994; 91: 12932.
77. Dighe AS, Campbell D, Hsieh C-S, Clarke S, Greaves DR, Gordon S, Murphy KM, Schreiber RD. Tissue-specific targeting of cytokine unresponsiveness in transgenic mice. Immunity 1995; 3: 657.
78. McKnight AJ, Zimmer GJ, Folgelman I, Wolf SF, Abbas AK. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J Immunol 1994; 152: 2172.
79. Via CS, Rus V, Gately MK, Finkelman FD. IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versushost-disease. J Immunol 1994; 153: 4040.
80. Morris SC, Madden KB, Adamovicz JJ, Gause WC, Hubbard BR, Gately MK, Finkelman FD. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol 1994; 152: 1047.
81. Schijns VECJ, Haagmans BL, Rijke EO, Huang S, Aguet M, Horzinek MC. IFN-γ receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J Immunol 1994; 153: 2029.
82. + T cell response. J Exp Med 1995; 181: 961.
83. Wenner C, Guler ML, Macatonia SE, O'Garra A, Murphy KM. Roles of IFN-γ and IFN-α in IL-12-induced Th1 development. J Immunol. In press
84. Swain SL, Huston G, Tonkonogy S, Weinberg AD. Transforming growth factor beta and IL-4 cause helper T cell precursors to develop into distinct effector help cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol 1991; 147: 2991.
85. Nagelkerken L, Gollob KJ, Tielemans M, Coffman RL. Role of transforming growth factor-β in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B. Eur J Immunol 1993; 23: 2306.
86. Sad S, Mosmann TR. A single IL-2-secreting precursor CD4 T cell can develop into either a Th1 or Th2 secreting phenotype. J Immunol 1994; 153: 3514.
87. Santambrogio L, Hochwald GM, Saxena B, et al. Studies on the mechanisms by which transforming growth factor-β(TGF-β) protects against allergic encephalomyelitis. J Immunol 1993; 151: 1116.
88. + T cells isolated from different mouse strains. J Immunol 1995; 155: 3788.
89. Parronchi P, De Carli M, Manetti R, Simonelli C, Sampognaro S, Piccinni M-P, Macchia D, Maggi E, Del Prete G-F, Romagnani S. II-4 and IFN(s), (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J Immunol 1992; 149: 2977.
90. H2 response: a key role for the 'natural' immune response? Immunol Today 1992; 13: 379.
91. Parronchi P, Mohapatra S, Sampognaro S, Giannarini L, Wahn U, Chong P, Mohapatra SS, Maggi E, Renz H, Romagnani S. Modulation by IFN-α of cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells Eur J Immunol 1996; 26: 697.
92. Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol 1990; 145: 3796.
93. Swain SL. IL-4 dictates T-cell differentiation. Res Immunol 1993; 144: 616.
94. Le Gros G, Ben Sasson SZ, Seder R, Finkelman FD, Paul WE. Generation of interleukin-4 (IL-4) producing cells. J Exp Med 1990; 172: 921.
95. + T cells from T cell receptor transgenic mice. J Exp Med 1992; 176: 1091.
96. Sadick MD, Heinzel PR, Holoday BJ, Pu RT, Dawkins RS, Locksiey RM. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T-cell-dependent, Interferon gamma-independent mechanism. J Exp Med 1990; 171: 115.
97. + T-cell subset differentiation. Res Immunol 1991; 142: 36.
98. Gross A, Ben Sasson SZ, Paul WE. Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells. J Immunol 1993; 150: 2112.
99. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluthmann H, Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993; 362: 245.
100. Fargeas C, Wu C-Y, Nakajima T, Cox D, Nutman T, Delespesse G. Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokine by human T lymphocytes. Eur J Immunol 1992; 22: 2173.
101. Plaut M, Pierce JH, Watson CJ, Hanely HJ, Nordan RP, Paul WE. Mast cell lines produce lymphokines in response to cross linkage of FCεRI or to calcium ionophores. Nature 1989; 339: 64.
102. Ben Sasson SZ, Le Gros G, Conrad DH, Finkelman FD, Paul WE. Cross linking Fc receptors stimulates splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl Acad Sci USA 1990; 87: 1421.
103. Piccinni M-P, Macchia D, Parronchi P, Giudizi M-G, Bani D, Aterini R, Grossi A, Ricci M, Maggi E, Romagnani S. Human bone marrow non-B, non-T cells produce interleukin-4 in response to cross-linkage of Fc and Fc receptors. Proc Natl Acad Sci USA 1991; 88: 8656.
104. Conrad DH, Ben-Sasson SZ, LeGros GG, Finkelman FD, Paul WE. Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J Exp Med 1990; 171: 1497.
105. Aoki I, Kinzer C, Shirai A, Paul WE, Khnman DM. IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice. Proc Natl Acad Sci USA 1995; 92: 2534.
106. Bradding P, Feather IH, Howarth PH, Mueller R, Roberts JA, Britten K, Bewes JPA, Hunt TC, Okayama Y, Heusser CH, Bullock GR, Church MK, Holgate ST. Interleukin 4 IS localized and released by human mast cells. J Exp Med 1992; 176: 1381.
107. Brunner T, Heusser CH, Dahinden CA. Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J Exp Med 1993; 177: 605.
108. MacGlashan D, White JM, Huang S-K, Ono SJ, Schroeder JT, Lichtenstein LM. Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 1994; 152: 3006.
109. Okayama Y, PettéFrère C, Kassel O, Semper A, Quint D, Tunon-de-Lara MJ, Bradding P, Holgate ST, Church MK. IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells. J Immunol 1995; 155: 1796.
110. Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Vakelin M, Taborda-Barata L, Meng Q, Corrigan CJ, Durham SR, Kay AB. Identification of mRNA for interleukin-4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995; 155: 4939.
111. Wershil BK, Theodos CM, Galli SJ, Titus RG. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol 1994; 152: 4563.
112. Schmilz J, Thiel A, Kuhn R, Rajewsky K, Muller W, Assenmacher M, Radbruch A. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-T cells. J Exp Med 1994; 179: 1349.
113. Finkelman FD, Urban JF. Cytokines: making the right choice. Parasitol Today 1992; 8: 311.
114. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom BR. Different lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991; 254: 279.
115. + T cells to noncytolytic CD 4-CD8- cells that make Th2 cytokines and help B cells. Science 1993; 260: 1802.
116. + T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection. J Exp Med 1994; 180: 489.
117. + T cells secreting Th1 or Th2 cytokines. Immunity 1995; 2: 271.
118. Croft M, Carter L, Swain SL, Dutton RW. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994; 180: 1715.
119. + effector T cells in vivo: im munization results in a transient population of MEL 14-, CD45RB- helper cells that secrete interleukin-2 (IL-2), IL-3, IL-4, and Interferon-γ. J Exp Med 1991; 174: 547.
120. + T cells into IL-4-secretmg cells. J Immunol 1994; 152: 5180.
121. + thymocytes selected by MHC class I molecules. Science 1994; 263: 1774.
122. + cells. Curr Opin Immunol 1995; 7: 367.
123. - thymocytes with specific lymphokine secretion. Eur J Immunol 1993; 23: 307.
124. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994; 179: 1285.
125. + T cells acquire specific lymphokine secretion potential during thymic maturation. Nature 1991; 365: 68.
126. Bendelac A, Matzinger P, Seder RA, Paul WE, Schwartz RH. Activation events during thymic selection. J Exp Med 1992; 175: 731.
127. pos T cells play a key in vivo role in a Th2 response and in IgE production. Science 1995; 270: 1845.
128. Yoshimoto T, Bendelac A, Hu-Li J, Paul WE. Defective IgE production by SJL mice is linked to the absence of a subset of T cells that promptly produce IL-4. Proc Natl Acad Sci USA 1995; 92: 11931.
129. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI. Mazzaccaro J, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, Modlin RL. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 1995; 269: 227.
130. Croft M, Swain SL. Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol 1995; 154: 4269.
131. Kalinski P, Hilkens CMU, Wierenga EA, Pouw-Kraan TCTM van der, Lier RAW van, Bos JD, Kapsenberg ML, Snijdewint FGM. Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-4. J Immunol 1995; 154: 3753.
132. Demeure CE, Yang LP, Byun DG, Ishihara H, Vezzio N, Delespesse G. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur J Immunol 1995; 25: 2722.
133. Yang L-P, Demeure D-G, Vezzio CE, Delespesse G. Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5-producing effector cells. Eur J Immunol 1995; 12: 3517.
134. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon g production by suppressing natural killer cell stimulatory factor IL-12 synthesis in accessory cells. J Exp Med 1993; 178: 1041.
135. Chang T-L, Shea CM, Urioste S, Thompson RC, Boom WH, Abbas AK. Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2 and IL-4 producing (Th1 and Th2) clones to antigens presented by different accessory cells. J Immunol 1990; 145: 280.
136. Zubiaga AM, Munoz E, Huber BT. Production of IL-1 a by activated Th type 2 cells. J Immunol 1991; 146: 3849.
137. Manetti R, Barak V, Piccinni M-P, Sampognaro S, Parronchi P, Maggi E, Dinarello CA, Romagnani S. Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones. Res Immunol 1994; 145: 93.
138. Daynes RA, Araneo BA. Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factor inter-leukin 2 and interleukin 4. Eur J Immunol 1989; 19: 2319.
139. + subsets. J Immunol 1995; 155: 3322.
140. Daynes RA, Dudley DJ, Araneo BA Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. J Immunol 1990; 20: 793.
141. Araneo BA, Dowell T, Terui T, Diegel M, Daynes RA. Dihydrotestosterone exerts a depressive influence on the production of IL-4, IL-5 and IFN-g, but not IL-2 by activated murine cells. Blood 1991; 78: 688.
142. Daynes RA, Araneo BA, Ershler WB, Maloney C, Li GZ, Ryu SY. Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J Immunol 1993; 150: 5219.
143. Daynes RA, Araneo BA, Dowell TA, Huang K, Dudley D. Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J Exp Med 1990; 171: 979.
144. Daynes RA, Meikle AW, Araneo BA. Locally active steroid hormones may facilitate compartmentalization of immunity by regulating the types of lymphokines produced by helper T cells. Res Immunol 1991; 142: 40.
145. Rook GAW, Hernandez-Pando R, Lightman SL. Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance. Immunol Today 1994; 15: 301.
146. Seymour JF, Gagel RF. Calcitriol: the major humoral mediator of hypercalcemia in Hodgkin's disease and non-Hodgkin's lymphomas. Blood 1993; 82: 1383.
147. 3: specific inhibition at the level of messenger RNA. J Clin Invest 1987; 79: 1659.
148. Piccinni M-P, Giudizi M-G, Biagiotti R, Annunziato F, Manetti R, Giannarini L, Parronchi P, Sampognaro S, Romagnani S, Maggi E. Progesterone favors the development of human T helper (Th) cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD 30 expression in established Th1 clones. J Immunol 1995; 155: 128.
149. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14: 353.
150. Piccinni M-P, Romagnani S. Regulation of fetal allograft survival by hormone-controlled Th1 and Th2-type cytokines. Immunol Res. In press.
151. Reiner SL, Wang Z-E, Hatam F, Scott P, Locksley RM. Th1 and Th2 cell antigen receptors in experimental leishmaniasis. Science 1993; 259: 1457.
152. + T cells toward a Th1 or Th2 functional phenotype. J Immunol 1992; 148: 47.
153. Renz H, Bradley C, Saloga J, Loader J, Larsen GL, Gelfand EW. T cells expressing specific Vb elements regulate immunoglobulin E production and airways responsiveness in vivo. J Exp Med 1993; 177: 1175.
154. Mohapatra SS, Mohapatra S, Yang M, Ansari AA, Parronchi P, Maggi E, Romagnani S. Molecular basis of cross-reactivity among allergen-specific human T cells: T-cell receptor Va gene usage and epitope structure. Immunology 1994; 81: 15.
155. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 1993; 150: 5321
156. Taylor-Robinson AW, Liew FY, Severn A, Xu F, McSorley SJ, Garside P, Padron J, Phillips RS. Regulation of the immune re sponse by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol 1994; 24: 980.
157. Liew FY. Regulation of lymphocyte function by nitric oxide. Curr Opin Immunol 1995; 7: 396.
158. Brown EL, Rivas JM, Ulrich SE, Young CR, Norris SJ, Kripke ML. Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: different effects on Th1 and Th2 immune responses. Eur J Immunol 1995; 25: 3017.
159. Enk CD, Sredni D, Blauvelt A, Katz SI. Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J Immunol 1995; 54: 4851.
160. Schmitt DA, Owen-Schaub L, Ullrich SE. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 1995; 154: 5114.
161. Prigent P, Saoudi A, Pannetier C, Graber P, Bonnefoy J-Y, Druet P. Mercuric chloride, a chemical responsible for T helper cell (Th2)-mediated autoimmunity in Brown Norways rats, directly triggers T cells to produce interleukin-4. J Clin Invest 1995; 96: 1484.
162. Saoudi A, Castedo M, Nochy D, Mandet C, Pasquier R, Druet P, Pelletier L. Self-reactive anti-class II T helper type 2 cell lines derived from gold salt-injected rats trigger B cell polyclonal activation and transfer autoimmunity in CD 8-depleted normal syngeneic recipients. Eur J Immunol 1995; 25: 1972.
163. Jeannin P, Delneste Y, Lecoanet-Henchoz S, Gauchat J-F, Life P, Holmes D, Bonnefoy J-Y. Thiols decrease human interleukin (IL)-4 production and IL-4-induced immunoglobuiin synthesis. J Exp Med 1995; 182: 1785.
164. Baum CG, Szabo P, Siskind GW, Becker CG, Firpo A, Clarick CJ, Francus T. Cellular control of IgE production of a polyphenol-rich compound. J Immunol 1990; 145: 779.
165. Cantorna MT, Nashold FE, Hayes CE. In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J Immunol 1994; 152: 1515.
166. Cantorna MT, Nashold FE, Hayes CE. Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur J Immunol 1995; 25: 1673.
167. Haraguchi S, Good RA, James-Yarish M, Cianciolo GJ, Day NK. Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. Proc Natl Acad Sci USA 1995; 92: 3611
168. Hsieh C-S, Macatonia SE, O'Garra A, Murphy KM. T cell genetic background determines default T helper phenotype development in vitro. J Exp Med 1995; 181: 713.
169. Romani L, Puccetti P, Bistoni F. Biological role of Th cell subsets in candidiasis. Chem Immunol 1996; 63: 115.
170. Daugelat S, Kaufmann SHE. Role of Th1 and Th2 cells in bacterial infections. Chem Immunol 1996; 63: 66.
171. Scott B, Liblau S, Degermann S, Marconi LA, Ogata AJ, Caton HO, McDevitt HO, Lo D. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity Immunity 1994; 1: 73.
172. Else KJ, Finkelman FD, Maliszewski CR, Grencis RK. Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med 1994; 179: 347.
173. Matyniak JE, Reiner SL. T helper phenotype and genetic susceptibility in experimental Lyme disease. J Exp Med 1995; 181: 1251.
174. Romagnani S. Atopic allergy and other hypersensitivities. Editorial overview: technological advances and new insights into pathogenesis preclude novel therapeutic strategies. Curr Opin Immunol 1995; 7: 745.
175. Gorham JD, Guler ML, Steen RG, Mackey AJ, Daly MJ, Frederick K, Dietrich WF, Murphy KM. Genetic mapping of a locus controlling development of Th1/Th2 type responses. Science 1996. In press.