Kinetics of quinolone antibiotics in rats: Efflux from cerebrospinal fluid to the circulation

Pharmaceutical Research

Volumn 13, Issue 7, 1996, Pages 1065-1068

  Ooie, Tsuyoshi ^a,b   Suzuki, Hiroshi ^a   Terasaki, Tetsuya ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Blood brain barrier; Blood CSF barrer; Cerebrospinal fluid; Choroid plexus; Quinolone antibiotics

Indexed keywords

FLEROXACIN; GATIFLOXACIN; NORFLOXACIN; OFLOXACIN; PEFLOXACIN; PROBENECID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG TRANSPORT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

4-QUINOLONES; ANIMALS; ANTI-INFECTIVE AGENTS; BIOLOGICAL TRANSPORT; CHOROID PLEXUS; FLEROXACIN; FLUOROQUINOLONES; INJECTIONS, INTRAVENTRICULAR; MALE; PROBENECID; QUINOLONES; RATS; RATS, WISTAR;

EID: 0029764186     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016014909431     Document Type: Article

References (20)

1. J. S. Wolfson and D. C. Hooper. Quinolone Antimicrobial Agents, American Society for Microbiology, Washington, D.C., 1989.
2. F. Sörgel, U. Jaehde, K. Naber, and U. Stephan. Pharmacokinetic disposition of quinolones in human body fluids and tissues. Clinical Pharmacokin. 16(Suppl. 1):5-24 (1989).
3. T. Ooie, H. Suzuki, T. Terasaki, and Y. Sugiyama. Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs., J. Pharmacol. Exp. Ther., in press.
4. T. Ooie, T. Terasaki, H. Suzuki, and Y. Sugiyama. Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system., J. Pharmacol. Exp. Ther., submitted.
5. S. G. Jezequel. Central nervous system penetration of drugs: importance of physicochemical properties. In G. G. Gibson (ed.), Progress in Drug Metabolism, Volume 13, Taylor & Francis, London, U.K. 1992, pp. 141-178.
6. M. Ogawa, H. Suzuki, Y. Sawada, M. Hanano, and Y. Sugiyama. Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation. Am. J. Phvsiol. 266:R392-R399 (1994).
7. H. Suzuki, Y. Sawada, Y. Sugiyama, T. Iga, M. Hanano, and R. Spector. Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system. J. Pharmacol. Exp. Ther. 250:979-984 (1989).
8. H. Matsushita, H. Suzuki, Y. Sugiyama, Y. Sawada, T. Iga, Y. Kawaguchi, and M. Hanano. Facilitated transport of cefodizime into the rat central nervous system. J. Pharmacol. Exp. Ther. 259:620-625 (1991).
9. T. Ooie, H. Suzuki, T. Terasaki, and Y. Sugiyama. Characterization of the transport property of a new quinolone antibiotic, fleroxacin, in rat choroid plexus. Pharm. Res. 13:512-516 (1996).
10. K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4:879-885 (1981).
11. H. Suzuki, Y. Sawada, Y. Sugiyama, T. Iga, and M. Hanano. Transport of benzylpenicillin by the rat choroid plexus in vitro. J. Pharmacol. Exp. Ther. 242:660-665 (1987).
12. H. Suzuki, Y. Sawada, Y. Sugiyama, T. Iga, and M. Hanano. Saturable transport of cimetidine from cerebrospinal fluid to blood in rats. J. Pharmacobio-Dyn. 8:73-76 (1985).
13. J. M. Collins and R. L. Dedrick. Distributed model for drug delivery to CSF and brain tissue. Am. J. Physiol. 245:R303-R310 (1983).
14. E. Rechthand, Q. R. Smith, and S. I. Rapoport. Transfer of nonelectorolytes from blood into peripheral nerve endoneurium. Am. J. Physiol. 252:H1175-H1182 (1987).
15. W. M. Pardridge. Brain metabolism: a perspective from the blood-brain barrier. Physiological Rev. 63:1481-1535 (1983).
16. T. Seki, N. Sato, T. Hasegawa, T. Kawaguchi, and K. Juni. Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats. Biol. Pharm. Bull. 17:1135-1137 (1994).
17. J. R. Pappenheimer, S. R. Heisey, and E. F. Jordan. Active transport of diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood. Am. J. Physiol. 200:1-10 (1961).
18. G. W. Ashcroft, R. C. Dow, and A. T. B. Moir. The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanesthetized dog. J. Physiol. (London) 199:397-425 (1968).
19. H. Davson, C. R. Kleeman, and E. Levin. Quantitative studies of the passage of different substances out of the cerebrospinal fluid. J. Physiol. (London) 161:126-142 (1962).
20. H. Suzuki, Y. Sawada, Y. Sugiyama, T. Iga, and M. Hanano. Comparative uptake of cimetidine by rat choroid plexus between the lateral and the 4th ventricles. Pharmacobio-Dyn. 9:327-329 (1986).